EE03423B1 - Kopolümeer-1, selle valmistamismeetod ja seda sisaldavad kompositsioonid - Google Patents
Kopolümeer-1, selle valmistamismeetod ja seda sisaldavad kompositsioonidInfo
- Publication number
- EE03423B1 EE03423B1 EE9600170A EE9600170A EE03423B1 EE 03423 B1 EE03423 B1 EE 03423B1 EE 9600170 A EE9600170 A EE 9600170A EE 9600170 A EE9600170 A EE 9600170A EE 03423 B1 EE03423 B1 EE 03423B1
- Authority
- EE
- Estonia
- Prior art keywords
- copolymer
- compositions
- preparation
- kilodaltons
- species
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Rehabilitation Therapy (AREA)
- Molecular Biology (AREA)
- Marine Sciences & Fisheries (AREA)
- Polymers & Plastics (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polyamides (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24803794A | 1994-05-24 | 1994-05-24 | |
| US34424894A | 1994-11-23 | 1994-11-23 | |
| PCT/US1995/006551 WO1995031990A1 (fr) | 1994-05-24 | 1995-05-23 | Ameliorations apportees a des compositions de copolymeres contenant du copolymere-1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE9600170A EE9600170A (et) | 1997-06-16 |
| EE03423B1 true EE03423B1 (et) | 2001-06-15 |
Family
ID=26939072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9600170A EE03423B1 (et) | 1994-05-24 | 1995-05-23 | Kopolümeer-1, selle valmistamismeetod ja seda sisaldavad kompositsioonid |
Country Status (30)
| Country | Link |
|---|---|
| US (11) | US5800808A (fr) |
| EP (1) | EP0762888B1 (fr) |
| JP (2) | JPH10500955A (fr) |
| KR (1) | KR100403750B1 (fr) |
| CN (2) | CN1310673C (fr) |
| AT (1) | ATE212857T1 (fr) |
| AU (1) | AU2602195A (fr) |
| BR (2) | BR9507758A (fr) |
| CA (1) | CA2191088C (fr) |
| CZ (1) | CZ292247B6 (fr) |
| DE (2) | DE10299030I1 (fr) |
| DK (1) | DK0762888T3 (fr) |
| EE (1) | EE03423B1 (fr) |
| ES (1) | ES2172586T3 (fr) |
| FI (1) | FI120236B (fr) |
| GE (1) | GEP20002205B (fr) |
| HU (1) | HU223473B1 (fr) |
| IL (2) | IL113812A (fr) |
| LU (1) | LU90987I2 (fr) |
| MD (1) | MD1443G2 (fr) |
| NL (1) | NL300096I2 (fr) |
| NO (1) | NO324528B1 (fr) |
| NZ (1) | NZ287335A (fr) |
| PL (1) | PL181026B1 (fr) |
| PT (1) | PT762888E (fr) |
| SI (1) | SI0762888T1 (fr) |
| SK (1) | SK283699B6 (fr) |
| TJ (1) | TJ392B (fr) |
| UA (1) | UA62908C2 (fr) |
| WO (1) | WO1995031990A1 (fr) |
Families Citing this family (130)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5858980A (en) * | 1990-03-30 | 1999-01-12 | Autoimmune, Inc. | Peptide fragments of myelin basic protein |
| US7090982B2 (en) | 1991-10-22 | 2006-08-15 | The Governors Of The University Of Alberta | Methods of predicting therapeutic efficacy of treatment of a multiple sclerosis patient |
| US6252040B1 (en) | 1991-10-22 | 2001-06-26 | The Governors Of The University Of Alberta | Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients |
| US5800808A (en) * | 1994-05-24 | 1998-09-01 | Veda Research And Development Co., Ltd. | Copolymer-1 improvements in compositions of copolymers |
| US5858964A (en) * | 1995-04-14 | 1999-01-12 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of GVHD |
| IL119989A0 (en) * | 1997-01-10 | 1997-04-15 | Yeda Res & Dev | Pharmaceutical compositions for oral treatment of multiple sclerosis |
| AU2868699A (en) * | 1998-02-13 | 1999-08-30 | Autoimmune, Inc. | Treatment of multiple sclerosis using cop-1 and th2-enhancing cytokines |
| ES2527760T3 (es) * | 1998-07-23 | 2015-01-29 | Yeda Research And Development Co., Ltd. | Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos |
| IL141021A0 (en) | 1998-07-23 | 2002-02-10 | Yeda Res & Dev | Treatment of autoimmune conditions with copolymer 1 and related copolymers |
| CA2336238A1 (fr) | 1998-07-23 | 2000-02-03 | The President And Fellows Of Harvard College | Peptides synthetiques et procedes d'utilisation de ceux-ci dans des therapies de maladies auto-immunes |
| US6514938B1 (en) | 1998-09-25 | 2003-02-04 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
| HU229719B1 (en) | 1998-09-25 | 2014-05-28 | Yeda Res & Dev | Copolymer-1-delated polipeptides for use as molecular weight markers and for therapeutic use |
| US6800287B2 (en) | 1998-09-25 | 2004-10-05 | Yeda Research And Development Co., Ltd. | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
| WO2000020010A1 (fr) * | 1998-10-02 | 2000-04-13 | Yeda Research And Development Co., Ltd. | Administration en jours alternes de copolymer 1 destine au traitement de maladies autoimmunes |
| US7083777B1 (en) | 1999-04-02 | 2006-08-01 | The Brigham And Women's Hospital, Inc. | Immunomodulating polymers |
| ATE302020T1 (de) * | 2000-01-20 | 2005-09-15 | Yeda Res & Dev | Verwendung von copolymer 1- und verwandten peptiden sowie von polypeptiden und damit behandelten t-zellen zur neuroprotektiven therapie |
| ZA200206457B (en) * | 2000-02-18 | 2003-08-13 | Yeda Res & Dev | Oral, nasal and pulmonary dosage formulations of copolymer 1. |
| EP1261361B1 (fr) * | 2000-02-18 | 2006-06-14 | Yeda Research And Development Company, Ltd. | Formes posologiques a administration par voie orale, nasale et pulmonaire du copolymere 1 (acetate de glatiramer) |
| IL153236A0 (en) * | 2000-06-05 | 2003-07-06 | Teva Pharma | The use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders |
| US20020077278A1 (en) * | 2000-06-05 | 2002-06-20 | Yong V. Wee | Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders |
| ES2256200T3 (es) * | 2000-06-07 | 2006-07-16 | Yeda Research And Development Co., Ltd. | El uso de copolimero 1 y peptidos y polipeptidos relacionados, y de celulas t tratadas con los mismos, para neuroproteccion frente a la toxicidad del glutamato. |
| WO2002076503A1 (fr) | 2000-06-20 | 2002-10-03 | Mayo Foundation For Medical Education And Research | Traitement de maladies du systeme nerveux central au moyen d'anticorps diriges contre l'acetate de glatiramere |
| IL148202A0 (en) * | 2000-06-20 | 2002-09-12 | Caprion Pharmaceuticals Inc | Copolymers and methods of treating prion-related diseases |
| IL137460A0 (en) * | 2000-07-24 | 2001-07-24 | Yeda Res & Dev | Identifying antigen clusters for monitoring a global state of an immune system |
| US20040037828A1 (en) | 2002-07-09 | 2004-02-26 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
| SV2003000753A (es) | 2000-12-05 | 2003-06-16 | Brigham & Womens Hospital | Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico |
| KR100442122B1 (ko) * | 2001-07-31 | 2004-07-30 | 한국전기연구원 | 영구 자석을 이용한 브러시리스 발전기 |
| NZ533327A (en) * | 2001-12-04 | 2006-11-30 | Teva Pharma | Processes for the measurement of the potency of glatiramer acetate |
| AU2002353486B2 (en) * | 2001-12-06 | 2009-01-15 | Yeda Research And Development Co. Ltd | Vaccine and method for treatment of motor neurone diseases |
| WO2003059387A2 (fr) * | 2001-12-21 | 2003-07-24 | Ilex Oncology, Inc. | Polytherapie pour la sclerose en plaques |
| CA2411786C (fr) | 2002-11-13 | 2009-01-27 | Brantford Chemicals Inc. | Methode de preparation de polypeptide 1 |
| CA2512735C (fr) | 2003-01-07 | 2016-03-08 | Yeda Research And Development Co. Ltd. | Vaccin sous forme de gouttes ophtalmiques contenant un copolymere-1 destine a l'immunisation therapeutique |
| ZA200505733B (en) * | 2003-01-21 | 2006-10-25 | Yeda Res & Dev | COP 1 for treatment of inflammatory bowel diseases |
| WO2004091573A1 (fr) * | 2003-03-04 | 2004-10-28 | Teva Pharmaceutical Industries, Ltd. | Traitement combine a base d'acetate de glatiramer et d'alphacalcidol, destine au traitement de la sclerose en plaques |
| CA2520865A1 (fr) | 2003-03-31 | 2004-10-21 | The Brigham And Women's Hospital, Inc. | Immunomodulateurs zwitterioniques destines au traitement de l'asthme et des allergies |
| EA200600877A1 (ru) * | 2003-10-31 | 2006-12-29 | Тева Фармасьютикал Индастриз, Лтд. | Наночастицы для доставки лекарств |
| EP2301569B1 (fr) | 2003-11-12 | 2018-05-02 | Yeda Research and Development Co. Ltd. | Vaccin et procédé pour le traitement des maladies neurodégénératives |
| CA2548310C (fr) | 2003-12-09 | 2014-02-18 | Yeda Research And Development Co. Ltd. | Methode et vaccin comprenant le copolymere 1 pour le traitement de troubles psychiatriques |
| CA2556152A1 (fr) * | 2004-02-02 | 2005-08-18 | Mixture Sciences, Inc. | Melanges de peptides a activite immunomodulatrice |
| MXPA06010043A (es) * | 2004-03-01 | 2007-03-07 | Peptimmune Inc | Metodos y composiciones para el tratamiento de enfermedades autoinmunologicas. |
| AU2005218625A1 (en) * | 2004-03-03 | 2005-09-15 | Teva Pharmaceutical Industries, Ltd. | Combination therapy with glatiramer acetate and riluzole |
| US20050260770A1 (en) * | 2004-04-01 | 2005-11-24 | Cohen Irun R | Antigen array and diagnostic uses thereof |
| US7655221B2 (en) * | 2004-05-07 | 2010-02-02 | Peptimmune, Inc. | Methods of treating disease with random copolymers |
| US20060194725A1 (en) * | 2004-05-07 | 2006-08-31 | James Rasmussen | Methods of treating disease with random copolymers |
| MXPA06012864A (es) | 2004-05-07 | 2007-07-18 | Peptimmune Inc | Metodo de tratamiento de enfermedades con copolimeros aleatorios. |
| EP2332569A3 (fr) | 2004-06-25 | 2011-09-14 | ID Biomedical Corporation of Quebec | Compositions et procédé de traitement de troubles neurologiques |
| ES2572811T3 (es) * | 2004-09-09 | 2016-06-02 | Yeda Research And Development Co., Ltd. | Mezclas de polipéptidos, composiciones que las contienen y procedimientos para obtener los mismos, y usos de los mismos |
| PT2361924E (pt) * | 2004-09-09 | 2014-03-13 | Teva Pharma | Processo para a preparação de misturas de acetato de glatirâmero trifluoroacetiílico utilizando ácido bromídrico purificado |
| AU2005302500B2 (en) * | 2004-10-29 | 2008-11-27 | Sandoz Ag | Processes for preparing glatiramer |
| US8324641B2 (en) * | 2007-06-29 | 2012-12-04 | Ledengin, Inc. | Matrix material including an embedded dispersion of beads for a light-emitting device |
| ES2541780T3 (es) * | 2004-11-29 | 2015-07-24 | Yeda Research And Development Co., Ltd. | Inducción de la neurogénesis y terapia con células madre en combinación con el Copolímero 1 |
| EP1838326A4 (fr) * | 2005-02-02 | 2009-09-30 | Teva Pharma | Procede de production de melanges de polypeptides par hydrogenolyse |
| PT1848415E (pt) * | 2005-02-17 | 2013-06-27 | Teva Pharma | Terapia de combinação com acetato de glatirâmero e rasagilina para o tratamento da esclerose múltipla |
| US20100167983A1 (en) * | 2007-10-22 | 2010-07-01 | Teva Pharmaceutical Industries, Ltd. | Combination therapy with glatiramer acetate and rasagiline for the treatment of multiple sclerosis |
| WO2006116602A2 (fr) * | 2005-04-25 | 2006-11-02 | Yeda Research And Development Company | Marqueurs associes a l'efficacite therapeutique d'acetate de glatiramere |
| WO2007081975A2 (fr) * | 2006-01-11 | 2007-07-19 | Teva Pharmaceutical Industries, Ltd. | Méthode de traitement de la sclérose en plaques |
| WO2007092451A2 (fr) | 2006-02-06 | 2007-08-16 | The Brigham And Women's Hospital, Inc. | Polysaccharides zwitterioniques pour favoriser la maturation du système immunitaire et la santé |
| WO2007120834A2 (fr) | 2006-04-13 | 2007-10-25 | Peptimmune, Inc. | Procédés de conception et de synthèse de compositions de polymères à séquence dirigée par expansion dirigée de la perméabilité épitopique |
| AU2007244643B2 (en) * | 2006-04-28 | 2013-05-02 | Momenta Pharmaceuticals, Inc. | Methods of evaluating peptide mixtures |
| KR100831796B1 (ko) * | 2006-05-29 | 2008-05-28 | 엘지전자 주식회사 | 타임 쉬프트 기능을 내장한 영상표시기기 및 그 재생 방법 |
| JP5412280B2 (ja) | 2006-06-28 | 2014-02-12 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | 加齢性黄斑変性症の治療法 |
| DE602007003848D1 (de) * | 2006-07-05 | 2010-01-28 | Momenta Pharmaceuticals Inc | Verbessertes verfahren zur herstellung von copolymer-1 |
| AU2008265692A1 (en) | 2007-06-21 | 2008-12-24 | Momenta Pharmaceuticals, Inc. | Copolymer assay |
| US20090029766A1 (en) * | 2007-07-26 | 2009-01-29 | Lutnick Howard W | Amusement gaming access and authorization point |
| WO2009016643A1 (fr) * | 2007-07-31 | 2009-02-05 | Natco Pharma Limited | Procédé de préparation de l'acétate de glatiramer (copolymère-1) |
| KR20170075026A (ko) | 2007-10-16 | 2017-06-30 | 펩팀문, 인코포레이티드 | 에피토프의 지정 확장에 의해 지정 서열 중합체 조성물을 포함하는 백신을 설계하고 제조하는 방법 |
| US20090124573A1 (en) | 2007-11-09 | 2009-05-14 | Sarkis Mazmanian | Immunomodulating compounds and related compositions and methods |
| EA201070656A1 (ru) * | 2007-11-28 | 2010-12-30 | Тева Фармасьютикал Индастриз, Лтд. | Способ задержки начала проявления клинически определенного рассеянного склероза |
| ES2449865T5 (es) | 2008-04-16 | 2022-11-18 | Momenta Pharmaceuticals Inc | Análisis de composiciones de copolímeros de aminoácidos |
| WO2010017075A1 (fr) * | 2008-08-07 | 2010-02-11 | Sigma-Aldrich Co. | Préparation de polylysine et de polyornithine de faible masse moléculaire dans un rendement élevé |
| CA2733500A1 (fr) * | 2008-08-07 | 2010-02-11 | Scinopharm Taiwan, Ltd. | Synthese d'acetate de glatiramere |
| US9617313B2 (en) * | 2008-12-24 | 2017-04-11 | Synthon Bv | Process for purifying a polymer mixture |
| WO2010115175A1 (fr) * | 2009-04-03 | 2010-10-07 | Momenta Pharmaceticals, Inc. | Régulation de compositions de copolymères |
| WO2010140157A1 (fr) * | 2009-06-04 | 2010-12-09 | Council Of Scientific & Industrial Research | Procede de preparation de copolymere-1 (cop-i), compose de medicament a base de l-alanine, l-lysine, l'acide l-glutamique et l-tyrosine pour le traitement de la sclerose en plaques |
| US8920373B2 (en) | 2009-07-15 | 2014-12-30 | Teva Pharmaceutical Industries, Ltd. | Reduced volume formulation of glatiramer acetate and methods of administration |
| ATE549013T1 (de) * | 2009-07-15 | 2012-03-15 | Teva Pharma | Formulierung von glatirameracetat mit verringertem volumen und verabreichungsverfahren |
| US8691790B2 (en) * | 2009-07-27 | 2014-04-08 | James Layne Boucher | Therapy of neurological inflammatory diseases with (5'-deoxy-5'-adenosyl) cobamamide, recombinant human growth hormone, interleukins IL-1, IL-6, IL-11, epidermal growth factor, and physiotherapy |
| EA019998B9 (ru) | 2009-08-20 | 2016-01-29 | Йеда Рисерч Энд Дивелопмент Ко. Лтд. | Терапия глатирамером ацетатом с низкой кратностью |
| US8377885B2 (en) | 2010-01-04 | 2013-02-19 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| DK3536333T3 (da) | 2010-01-04 | 2022-10-24 | Mapi Pharma Ltd | Depotsystem der omfatter glatirameracetat |
| US20130035390A1 (en) | 2010-01-13 | 2013-02-07 | Ramot At Tel-Aviv University Ltd. | Treatment of multiple sclerosis |
| US8759302B2 (en) * | 2010-03-16 | 2014-06-24 | Teva Pharmaceutical Industries, Ltd. | Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis |
| EP2555753B1 (fr) | 2010-04-07 | 2018-08-01 | California Institute of Technology | Véhicule destiné à distribuer un composé à une muqueuse et compositions, procédés et systèmes apparentés |
| KR20130062936A (ko) * | 2010-04-27 | 2013-06-13 | 닥터 레디스 레보러터리즈 리미티드 | 폴리펩티드 및 그의 염의 제조 |
| WO2011146910A1 (fr) | 2010-05-20 | 2011-11-24 | Round June L | Treg spécifiques d'un antigène et compositions, procédés et systèmes associés |
| WO2012016042A2 (fr) | 2010-07-29 | 2012-02-02 | Dr. Reddy's Laboratories Ltd. | Marqueurs de masse moléculaire à base d'acétate de glatiramer |
| PL2627669T3 (pl) | 2010-10-11 | 2017-02-28 | Teva Pharmaceutical Industries Ltd. | Biomarkery cytokinowe jako biomarkery prognostyczne odpowiedzi klinicznej na octan glatirameru |
| RU2604521C2 (ru) | 2011-02-14 | 2016-12-10 | Юсв Прайвит Лимитед | Сополимер-1, способы его получения и аналитические методы |
| EP2699317B1 (fr) * | 2011-04-21 | 2016-08-10 | Mapi Pharma Limited | Pentapolymère statistique pour le traitement de maladies auto-immunes |
| US20140348861A1 (en) | 2011-05-05 | 2014-11-27 | National Institute Of Immunology | Synthetic peptides and random copolymers for the treatment of autoimmune disorders |
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