NO873018L - Nye peptider. - Google Patents

Nye peptider.

Info

Publication number: NO873018L
Authority: NO; Norway
Prior art keywords: amino acid; solutions; insulin; asn; substituted
Prior art date: 1986-07-21

Application number

NO873018A

Other languages

English (en)

Other versions

NO873018D0 (no

NO170978C (no

NO170978B (no

Inventor

Jan Markussen

Kjeld Norris

Liselotte Langkjaer

Original Assignee

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-21

Filing date

1987-07-20

Publication date

1988-01-22

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8123250&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO873018(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1987-07-20 Application filed by Novo Industri As filed Critical Novo Industri As

1987-07-20 Publication of NO873018D0 publication Critical patent/NO873018D0/no

1988-01-22 Publication of NO873018L publication Critical patent/NO873018L/no

1992-09-28 Publication of NO170978B publication Critical patent/NO170978B/no

1993-01-06 Publication of NO170978C publication Critical patent/NO170978C/no

Links

102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
150000001413 amino acids Chemical class 0.000 abstract 3
230000007935 neutral effect Effects 0.000 abstract 2
239000000243 solution Substances 0.000 abstract 2
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
125000003368 amide group Chemical group 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000002843 carboxylic acid group Chemical group 0.000 abstract 1
125000004185 ester group Chemical group 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
239000003186 pharmaceutical solution Substances 0.000 abstract 1
230000002035 prolonged effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Toxicology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO873018A 1986-07-21 1987-07-20 Analogifremgangsmaate ved fremstilling av nye peptider NO170978C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK347086A DK347086D0 (da)	1986-07-21	1986-07-21	Novel peptides

Publications (4)

Publication Number	Publication Date
NO873018D0 NO873018D0 (no)	1987-07-20
NO873018L true NO873018L (no)	1988-01-22
NO170978B NO170978B (no)	1992-09-28
NO170978C NO170978C (no)	1993-01-06

Family

ID=8123250

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO873018A NO170978C (no)	1986-07-21	1987-07-20	Analogifremgangsmaate ved fremstilling av nye peptider

Country Status (20)

Country	Link
EP (1)	EP0254516B1 (no)
JP (1)	JPS6399096A (no)
KR (1)	KR880001701A (no)
CN (1)	CN87104988A (no)
AT (1)	ATE99699T1 (no)
AU (1)	AU612324B2 (no)
DD (1)	DD273839A5 (no)
DE (2)	DE3788684T2 (no)
DK (1)	DK347086D0 (no)
ES (1)	ES2061504T3 (no)
FI (1)	FI873185A7 (no)
HU (1)	HU203371B (no)
IL (1)	IL83243A (no)
MY (1)	MY102873A (no)
NL (1)	NL300018I1 (no)
NO (1)	NO170978C (no)
NZ (1)	NZ221130A (no)
PT (1)	PT85355B (no)
YU (1)	YU135387A (no)
ZA (1)	ZA875295B (no)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI884914A0 (fi) *	1987-02-25	1988-10-24	Novo Industri As	Nya insulinderivat.
DK336188D0 (da) *	1988-06-20	1988-06-20	Nordisk Gentofte	Propeptider
KR900701842A (ko) *	1988-07-20	1990-12-04	헨리 브뢰늄	인간 인슐린 동족체와 그를 포함하는 제제
DE3827533A1 (de) *	1988-08-13	1990-02-15	Hoechst Ag	Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3837825A1 (de) *	1988-11-08	1990-05-10	Hoechst Ag	Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
KR910700262A (ko) *	1988-12-23	1991-03-14	안네 제케르	사람 인슐린 유사체
US5716927A (en) *	1988-12-23	1998-02-10	Novo Nordisk A/S	Insulin analogs having a modified B-chain
US5514646A (en) *	1989-02-09	1996-05-07	Chance; Ronald E.	Insulin analogs modified at position 29 of the B chain
DK134189D0 (da) *	1989-03-20	1989-03-20	Nordisk Gentofte	Insulinforbindelser
DE3936876A1 (de) *	1989-11-06	1991-05-23	Hoechst Ag	Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5474978A (en) *	1994-06-16	1995-12-12	Eli Lilly And Company	Insulin analog formulations
US5693609A (en) *	1994-11-17	1997-12-02	Eli Lilly And Company	Acylated insulin analogs
US7316999B2 (en)	2000-06-02	2008-01-08	Novo Nordisk A/S	Glucose dependent release of insulin from glucose sensing insulin derivatives
DE10114178A1 (de)	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE60236014D1 (de)	2001-11-19	2010-05-27	Novo Nordisk As	Verfahren zur herstellung von insulinverbindungen
GB0206792D0 (en)	2002-03-22	2002-05-01	Leuven K U Res & Dev	Normoglycemia
DE10227232A1 (de)	2002-06-18	2004-01-15	Aventis Pharma Deutschland Gmbh	Saure Insulinzubereitungen mit verbesserter Stabilität
RU2381103C2 (ru)	2003-06-27	2010-02-10	Ново Нордиск А/С	Контейнер для жидких фармацевтических композиций с высокими влагозащитными свойствами
ATE483580T1 (de)	2003-12-22	2010-10-15	Novo Nordisk As	Durchsichtiger, flexibler, undurchlässiger kunststoffbehälter zur lagerung von pharmazeutischen flüssigkeiten
EP2033662B1 (en)	2004-01-21	2012-10-17	Novo Nordisk Health Care AG	Transglutaminase mediated conjugation of peptides
DE102006031955A1 (de) *	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
DE102006031962A1 (de)	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Amidiertes Insulin Glargin
WO2008049711A1 (en)	2006-10-27	2008-05-02	Novo Nordisk A/S	Peptide extended insulins
EP2229406B1 (de) *	2008-01-09	2015-04-22	Sanofi-Aventis Deutschland GmbH	Neue insulinderivate mit extrem verzögertem zeit- / wirkungsprofil
CN102007143B (zh)	2008-01-09	2015-08-26	塞诺菲-安万特德国有限公司	具有超延迟时效特征的新型胰岛素衍生物
CN102037008B (zh)	2008-03-18	2016-08-31	诺沃-诺迪斯克有限公司	蛋白酶稳定化的、酰化胰岛素类似物
TWI451876B (zh)	2008-06-13	2014-09-11	Lilly Co Eli	聚乙二醇化之離脯胰島素化合物
RU2458989C1 (ru)	2008-08-07	2012-08-20	Байокон Лимитид	Способ получения аналогов инсулина из их соответствующих предшественников (варианты)
CN102256618A (zh)	2008-10-17	2011-11-23	赛诺菲-安万特德国有限公司	胰岛素和glp-1激动剂的组合
PL2451437T3 (pl)	2009-07-06	2017-05-31	Sanofi-Aventis Deutschland Gmbh	Wodne preparaty insuliny zawierające metioninę
WO2011003820A1 (de) *	2009-07-06	2011-01-13	Sanofi-Aventis Deutschland Gmbh	Hitze- und schüttelstabile insulinzubereitungen
NZ599847A (en)	2009-11-13	2013-09-27	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a glp-1 agonist and methionine
TR201809460T4 (tr)	2009-11-13	2018-07-23	Sanofi Aventis Deutschland	Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim.
EP2460527A1 (en)	2010-01-21	2012-06-06	Sanofi	Pharmaceutical composition for treating a metabolic syndrome
TW201141513A (en)	2010-04-14	2011-12-01	Sanofi Aventis	Insulin-siRNA conjugates
WO2012028172A1 (en)	2010-08-30	2012-03-08	Sanofi-Aventis Deutschland Gmbh	Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
EP2548570A1 (en)	2011-07-19	2013-01-23	Sanofi	Pharmaceutical composition for treating a metabolic syndrome
AR087693A1 (es)	2011-08-29	2014-04-09	Sanofi Aventis Deutschland	Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
US9481721B2 (en)	2012-04-11	2016-11-01	Novo Nordisk A/S	Insulin formulations
US9656017B2 (en)	2014-06-20	2017-05-23	Howard E. Greene	Infusion delivery devices and methods
PE20171622A1 (es)	2014-12-12	2017-11-02	Sanofi Aventis Deutschland	Formulacion de relacion fija de insulina glargina/lixisenatida
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
TWI700091B (zh)	2016-12-16	2020-08-01	丹麥商諾佛儂迪克股份有限公司	含胰島素醫藥組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3033127A1 (de) *	1980-09-03	1982-04-08	Hoechst Ag, 6000 Frankfurt	Neue analoga des insulins
DE3327709A1 (de) *	1983-07-29	1985-02-07	Hoechst Ag, 6230 Frankfurt	Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DE3333640A1 (de) *	1983-09-17	1985-04-25	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DK113585D0 (da) *	1985-03-12	1985-03-12	Novo Industri As	Nye peptider
DK119785D0 (da) *	1985-03-15	1985-03-15	Nordisk Gentofte	Insulinpraeparat

1986
- 1986-07-21 DK DK347086A patent/DK347086D0/da not_active Application Discontinuation
1987
- 1987-07-20 DE DE3788684T patent/DE3788684T2/de not_active Expired - Lifetime
- 1987-07-20 MY MYPI87001062A patent/MY102873A/en unknown
- 1987-07-20 FI FI873185A patent/FI873185A7/fi not_active Application Discontinuation
- 1987-07-20 IL IL83243A patent/IL83243A/xx not_active IP Right Cessation
- 1987-07-20 AT AT87306405T patent/ATE99699T1/de not_active IP Right Cessation
- 1987-07-20 KR KR1019870007832A patent/KR880001701A/ko not_active Ceased
- 1987-07-20 NZ NZ221130A patent/NZ221130A/xx unknown
- 1987-07-20 PT PT85355A patent/PT85355B/pt not_active IP Right Cessation
- 1987-07-20 CN CN198787104988A patent/CN87104988A/zh active Pending
- 1987-07-20 YU YU01353/87A patent/YU135387A/xx unknown
- 1987-07-20 DD DD87305161A patent/DD273839A5/de not_active IP Right Cessation
- 1987-07-20 HU HU873343A patent/HU203371B/hu not_active IP Right Cessation
- 1987-07-20 AU AU75916/87A patent/AU612324B2/en not_active Ceased
- 1987-07-20 EP EP87306405A patent/EP0254516B1/en not_active Expired - Lifetime
- 1987-07-20 DE DE2000175024 patent/DE10075024I1/de active Pending
- 1987-07-20 ZA ZA875295A patent/ZA875295B/xx unknown
- 1987-07-20 ES ES87306405T patent/ES2061504T3/es not_active Expired - Lifetime
- 1987-07-20 NO NO873018A patent/NO170978C/no unknown
- 1987-07-21 JP JP62180168A patent/JPS6399096A/ja active Pending
2000
- 2000-09-15 NL NL300018C patent/NL300018I1/nl unknown

Also Published As

Publication number	Publication date
FI873185A0 (fi)	1987-07-20
NO873018D0 (no)	1987-07-20
DK347086D0 (da)	1986-07-21
AU7591687A (en)	1988-01-28
IL83243A (en)	1993-01-14
PT85355A (en)	1987-08-01
IL83243A0 (en)	1987-12-31
DE3788684D1 (de)	1994-02-17
DE3788684T2 (de)	1994-05-19
KR880001701A (ko)	1988-04-26
JPS6399096A (ja)	1988-04-30
NO170978C (no)	1993-01-06
CN87104988A (zh)	1988-03-02
EP0254516A2 (en)	1988-01-27
EP0254516B1 (en)	1994-01-05
FI873185L (fi)	1988-01-22
NO170978B (no)	1992-09-28
ZA875295B (en)	1988-01-21
NZ221130A (en)	1990-08-28
DD273839A5 (de)	1989-11-29
DE10075024I1 (de)	2000-11-09
AU612324B2 (en)	1991-07-11
YU135387A (en)	1988-10-31
MY102873A (en)	1993-03-31
EP0254516A3 (en)	1990-06-27
HU203371B (en)	1991-07-29
ATE99699T1 (de)	1994-01-15
PT85355B (pt)	1990-04-30
HUT45271A (en)	1988-06-28
NL300018I1 (nl)	2000-11-01
FI873185A7 (fi)	1988-01-22
ES2061504T3 (es)	1994-12-16

Publication	Publication Date	Title
NO873018L (no)	1988-01-22	Nye peptider.
DK113585D0 (da)	1985-03-12	Nye peptider
FI913037A0 (fi)	1991-06-20	Humana insulinanaloger.
DK105489D0 (da)	1989-03-03	Polypeptid
ES2012720A6 (es)	1990-04-01	Procedimiento para la obtencion de sales de adicion de acido de taurina o glicina amidada.
DK376187A (da)	1988-01-22	Peptider
EP0266006A3 (en)	1990-04-11	Novel hypotensive diuretic peptides