NO914292L - Forbedret innkapslingsprosess, samt produkter fra denne prosess - Google Patents

Forbedret innkapslingsprosess, samt produkter fra denne prosess

Info

Publication number
NO914292L
NO914292L NO91914292A NO914292A NO914292L NO 914292 L NO914292 L NO 914292L NO 91914292 A NO91914292 A NO 91914292A NO 914292 A NO914292 A NO 914292A NO 914292 L NO914292 L NO 914292L
Authority
NO
Norway
Prior art keywords
encapping
products
improved
agent
effective amount
Prior art date
Application number
NO91914292A
Other languages
English (en)
Other versions
NO302683B1 (no
NO914292D0 (no
Inventor
Thomas R Tice
Richard M Gilley
Original Assignee
Southern Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23363857&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO914292(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Southern Res Inst filed Critical Southern Res Inst
Publication of NO914292L publication Critical patent/NO914292L/no
Publication of NO914292D0 publication Critical patent/NO914292D0/no
Publication of NO302683B1 publication Critical patent/NO302683B1/no

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/06Making microcapsules or microballoons by phase separation
    • B01J13/12Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089Processes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Glass Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)
  • Electron Tubes For Measurement (AREA)
  • Surgical Instruments (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Press Drives And Press Lines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO914292A 1989-05-04 1991-11-01 Emulsjonsbasert fremgangsmåte for mikroinnkapsling av et middel NO302683B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34747689A 1989-05-04 1989-05-04
PCT/US1990/002439 WO1990013361A1 (en) 1989-05-04 1990-05-02 Improved encapsulation process and products therefrom

Publications (3)

Publication Number Publication Date
NO914292L true NO914292L (no) 1991-11-01
NO914292D0 NO914292D0 (no) 1991-11-01
NO302683B1 NO302683B1 (no) 1998-04-14

Family

ID=23363857

Family Applications (1)

Application Number Title Priority Date Filing Date
NO914292A NO302683B1 (no) 1989-05-04 1991-11-01 Emulsjonsbasert fremgangsmåte for mikroinnkapsling av et middel

Country Status (21)

Country Link
US (1) US5407609A (no)
EP (1) EP0471036B2 (no)
JP (1) JP2582186B2 (no)
KR (1) KR0162660B1 (no)
CN (1) CN1047223A (no)
AT (1) ATE133087T1 (no)
AU (1) AU5741590A (no)
CA (1) CA2050911C (no)
DE (1) DE69024953T3 (no)
DK (1) DK0471036T4 (no)
ES (1) ES2084698T5 (no)
FI (1) FI103183B1 (no)
GR (1) GR1000614B (no)
HK (1) HK30897A (no)
IE (1) IE69313B1 (no)
IL (1) IL94296A (no)
MX (1) MX20594A (no)
NO (1) NO302683B1 (no)
NZ (1) NZ233570A (no)
WO (1) WO1990013361A1 (no)
ZA (1) ZA903411B (no)

Families Citing this family (337)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6217911B1 (en) 1995-05-22 2001-04-17 The United States Of America As Represented By The Secretary Of The Army sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres
US20030161889A1 (en) * 1984-03-16 2003-08-28 Reid Robert H. Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
USRE40786E1 (en) 1984-03-16 2009-06-23 The United States Of America As Represented By The Secretary Of The Army Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres
US6309669B1 (en) 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US6410056B1 (en) 1984-03-16 2002-06-25 The United States Of America As Represented By The Secretary Of The Army Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix
US5693343A (en) 1984-03-16 1997-12-02 The United States Of America As Represented By The Secretary Of The Army Microparticle carriers of maximal uptake capacity by both M cells and non-M cells
US5985354A (en) 1995-06-07 1999-11-16 Brown University Research Foundation Preparation of multiwall polymeric microcapsules from hydrophilic polymers
US5840293A (en) * 1988-11-16 1998-11-24 Advanced Polymer Systems, Inc. Ionic beads for controlled release and adsorption
AU8303691A (en) 1991-04-24 1992-12-21 United States Of America, As Represented By The Secretary Of The Army, The Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
ZA93929B (en) * 1992-02-18 1993-09-10 Akzo Nv A process for the preparation of biologically active materialcontaining polymeric microcapsules.
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5346738A (en) * 1992-11-04 1994-09-13 X-Cal Corporation Identification label with micro-encapsulated etchant
DE4244122C1 (de) * 1992-12-24 1994-06-01 Sanol Arznei Schwarz Gmbh Lyophilisierte, wirkstoffhaltige Emulsion zur intravenösen Applikation
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6939546B2 (en) 1993-05-21 2005-09-06 The United States Of America As Represented By The Secretary Of The Army Model for testing immunogenicity of peptides
US5650173A (en) * 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
CN1074923C (zh) 1993-11-19 2001-11-21 詹森药业有限公司 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
CA2474701C (en) * 1993-11-19 2009-01-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradeable microparticles containing a biologically active agent
IT1265290B1 (it) * 1993-12-17 1996-10-31 Dox Al Italia Spa Miscele ad elevato contenuto di sostanze attive idonee ad essere distribuite in modo omogeneo nei mangimi per animali.
US6447796B1 (en) 1994-05-16 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US6855331B2 (en) 1994-05-16 2005-02-15 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US5622723A (en) * 1995-02-03 1997-04-22 Eurand America, Incorporated Procedure for encapsulating chlorpheniramine
US6902743B1 (en) 1995-05-22 2005-06-07 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix
US7033608B1 (en) 1995-05-22 2006-04-25 The United States Of America As Represented By The Secretary Of The Army “Burst-free” sustained release poly-(lactide/glycolide) microspheres
US5879712A (en) 1995-06-07 1999-03-09 Sri International Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced
US5883103A (en) * 1995-06-07 1999-03-16 Shire Laboratories Inc. Oral acyclovir delivery
NZ311474A (en) 1995-06-09 1997-09-22 Euro Celtique Sa Formulations for providing prolonged local anesthesia
EP0840623B1 (en) 1995-07-21 2007-07-18 Brown University Research Foundation Compositions for gene therapy comprising nucleic acid loaded polymeric microparticles
US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
US6248720B1 (en) 1996-07-03 2001-06-19 Brown University Research Foundation Method for gene therapy using nucleic acid loaded polymeric microparticles
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
GB9709900D0 (en) 1997-05-15 1997-07-09 Microbiological Res Authority Microencapsulated DNA for vaccination and gene therapy
DE69608122T3 (de) 1995-11-09 2011-06-16 Microbiological Research Authority Camr, Salisbury Mikroverkapselte dna zur impfung und gentherapie
JPH09169610A (ja) * 1995-12-20 1997-06-30 Sumitomo Chem Co Ltd マイクロカプセル化された有害生物防除剤組成物
AU1354497A (en) * 1995-12-21 1997-07-14 Drexel University Hollow polymer microcapsules and method of producing
US5792477A (en) * 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
WO1997049391A1 (en) 1996-06-24 1997-12-31 Euro-Celtique, S.A. Methods for providing safe local anesthesia
US6046187A (en) 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
US7060277B2 (en) * 1996-12-30 2006-06-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Broad spectrum antagonists and vaccines directed against pyrogenic exotoxins
IL119938A (en) * 1996-12-30 2005-08-31 Yissum Res Dev Co Peptides capable of eliciting protective immunity against toxic shock induced by pyrogenic exotoxins or of antagonizing toxin-mediated activation of t cells
US5783567A (en) * 1997-01-22 1998-07-21 Pangaea Pharmaceuticals, Inc. Microparticles for delivery of nucleic acid
US20020182258A1 (en) * 1997-01-22 2002-12-05 Zycos Inc., A Delaware Corporation Microparticles for delivery of nucleic acid
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
ES2388248T3 (es) 1997-03-31 2012-10-11 Boston Scientific Scimed Limited Forma de dosificación que comprende taxol en forma cristalina
US6248345B1 (en) 1997-07-02 2001-06-19 Euro-Celtique, S.A. Prolonged anesthesia in joints and body spaces
KR100380856B1 (ko) * 1997-07-19 2003-10-10 주식회사 엘지화학 카본블랙의고분자에의한피낭화방법
PL333331A1 (en) * 1997-09-09 1999-12-06 Select Release Coated particles, method of producing them and their application
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
SE512663C2 (sv) * 1997-10-23 2000-04-17 Biogram Ab Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
FR2771824A1 (fr) * 1997-12-01 1999-06-04 Eastman Kodak Co Utilisation de microvesicules contenant un developpateur des halogenures d'argent pour former une image photographique
US6197229B1 (en) * 1997-12-12 2001-03-06 Massachusetts Institute Of Technology Method for high supercoiled DNA content microspheres
US20020147143A1 (en) 1998-03-18 2002-10-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
WO1999051748A2 (en) 1998-04-07 1999-10-14 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
US6406719B1 (en) 1998-05-13 2002-06-18 Microbiological Research Authority Encapsulation of bioactive agents
GB9810236D0 (en) 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
US6548302B1 (en) 1998-06-18 2003-04-15 Johns Hopkins University School Of Medicine Polymers for delivery of nucleic acids
US6916490B1 (en) 1998-07-23 2005-07-12 UAB Research Center Controlled release of bioactive substances
US6264991B1 (en) 1998-08-18 2001-07-24 Southern Research Institute Compositions and methods for treating intracellular infections
ES2211151T3 (es) 1998-08-19 2004-07-01 Skyepharma Canada Inc. Dispersiones acuosas inyectables de propofol.
US6956021B1 (en) * 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US20030235557A1 (en) 1998-09-30 2003-12-25 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
US6194006B1 (en) 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
US6498153B1 (en) 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
US6204308B1 (en) 1999-03-01 2001-03-20 Novartis Ag Organic compounds
US6306425B1 (en) 1999-04-09 2001-10-23 Southern Research Institute Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol
EP1044683A1 (en) * 1999-04-15 2000-10-18 Debio Recherche Pharmaceutique S.A. One-step dispersion method for the microencapsulation of water soluble substances
US6291013B1 (en) 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
US6387986B1 (en) * 1999-06-24 2002-05-14 Ahmad Moradi-Araghi Compositions and processes for oil field applications
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
US20010036481A1 (en) * 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
AU763041B2 (en) * 1999-08-25 2003-07-10 Alkermes, Inc. Modulation of release from dry powder formulations
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
RO121631B1 (ro) 1999-08-27 2008-01-30 Southern Research Institute Compoziţie cu buprenorfină şi utilizarea acesteia pentru reducerea consumului de heroină şi/sau alcool
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
US6705757B2 (en) 1999-11-12 2004-03-16 Alkermes Controlled Therapeutics, Inc. Ii Method and apparatus for preparing microparticles using in-line solvent extraction
US6331317B1 (en) 1999-11-12 2001-12-18 Alkermes Controlled Therapeutics Ii Inc. Apparatus and method for preparing microparticles
US6495166B1 (en) 1999-11-12 2002-12-17 Alkermes Controlled Therapeutics Inc. Apparatus and method for preparing microparticles using in-line solvent extraction
US7838037B2 (en) 1999-11-17 2010-11-23 Tagra Biotechnologies Ltd. Method of microencapsulation
US20050037086A1 (en) * 1999-11-19 2005-02-17 Zycos Inc., A Delaware Corporation Continuous-flow method for preparing microparticles
WO2001041927A1 (en) * 1999-12-10 2001-06-14 Microban Products Company Antimicrobial synthetic ion exchange resins
US7029700B2 (en) * 2000-01-14 2006-04-18 Brown University Research Foundation Micronized freeze-dried particles
CZ303468B6 (cs) 2000-02-23 2012-10-03 Smithkline Beecham Biologicals S. A. Imunogenní smes a farmaceutická smes
AU2001247417A1 (en) * 2000-03-14 2001-09-24 Trustees Of Tufts College Cross-reactive sensors
CA2407154A1 (en) 2000-04-27 2001-11-01 Verion, Inc Zero order release and temperature-controlled microcapsules and process for the preparation thereof
CN1189159C (zh) 2000-05-05 2005-02-16 欧莱雅 含水溶性美容活性组分水性核的微胶囊及含其的组合物
US6264987B1 (en) * 2000-05-19 2001-07-24 Alkermes Controlled Therapeutics Inc. Ii Method for preparing microparticles having a selected polymer molecular weight
US6495164B1 (en) 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
US20040142475A1 (en) * 2000-06-02 2004-07-22 Barman Shikha P. Delivery systems for bioactive agents
JP2004513615A (ja) 2000-06-28 2004-05-13 コリクサ コーポレイション 肺癌の治療および診断のための組成物および方法
EP1299087A1 (en) * 2000-07-07 2003-04-09 Corixa Corporation Microspheres and adjuvants for dna vaccine delivery
EP1315777B1 (en) 2000-09-06 2007-10-31 AP Pharma, Inc. Degradable polyacetal polymers
RO122629B1 (ro) 2000-09-06 2009-10-30 Appleton Papers Inc. Adeziv microîncapsulat in situ şi procedeu de obţinere a acestuia
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
US6471995B1 (en) 2000-09-27 2002-10-29 Alkermes Controlled Therapeutics, Inc. Ii Apparatus and method for preparing microparticles using liquid-liquid extraction
US6962716B1 (en) * 2000-09-27 2005-11-08 Board Of Regents, The University Of Texas System Compositions and methods for biodegradable microspheres as carriers of bioactive substances
JP2004509739A (ja) 2000-09-27 2004-04-02 ベリオン インコーポレイテッド 即時水溶解性カプセルおよびその製法
SE517422C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Farmaceutiskt acceptabel stärkelse
JP2004510730A (ja) 2000-10-06 2004-04-08 ヤゴテック アーゲー 非経口的投与可能な制御放出微粒子調製物
SE517421C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav
EP1335661B1 (en) 2000-10-27 2009-05-06 Baxter Healthcare S.A. Production of microspheres
ES2382636T3 (es) * 2000-10-31 2012-06-12 Surmodics Pharmaceuticals, Inc. Método para producir composiciones para la administración mejorada de moléculas bioactivas
SE518008C2 (sv) * 2000-11-16 2002-08-13 Bioglan Ab Parenteralt administrerbara mikropartiklar och förfarande för framställning av desamma
SE518007C2 (sv) 2000-11-16 2002-08-13 Bioglan Ab Förfarande för framställning av mikropartiklar
US20020114843A1 (en) * 2000-12-27 2002-08-22 Ramstack J. Michael Preparation of microparticles having improved flowability
WO2002053190A2 (en) 2000-12-29 2002-07-11 Advanced Inhalation Research, Inc. Particles for inhalation having sustained release properties
US20020141946A1 (en) * 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
US20070142325A1 (en) * 2001-01-08 2007-06-21 Gustavsson Nils O Starch
WO2002062319A2 (en) * 2001-01-19 2002-08-15 Corixa Corporation Microsphere delivery of mucin peptides
US20030152637A1 (en) * 2001-01-25 2003-08-14 Mark Chasin Local anesthetic, and method of use
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
WO2002089747A2 (en) 2001-05-09 2002-11-14 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US6590059B2 (en) 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
US20030152630A1 (en) * 2001-05-11 2003-08-14 Ng Steven Y. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6730772B2 (en) 2001-06-22 2004-05-04 Venkatram P. Shastri Degradable polymers from derivatized ring-opened epoxides
EP2241309A3 (en) 2001-07-10 2012-12-26 Corixa Corporation Methods for encapsulation of proteins and adjuants in microspheres
EP1423175B1 (en) * 2001-08-08 2013-10-02 Brown University Research Foundation Methods for micronization of hydrophobic drugs
ATE395042T1 (de) * 2001-08-16 2008-05-15 Baxter Int Darreichungsformen welche mikropartikel und treibgas enthalten
US20080026068A1 (en) * 2001-08-16 2008-01-31 Baxter Healthcare S.A. Pulmonary delivery of spherical insulin microparticles
US7105181B2 (en) * 2001-10-05 2006-09-12 Jagotec, Ag Microparticles
US6524606B1 (en) 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
AU2002346472A1 (en) * 2001-11-20 2003-06-10 Advanced Inhalation Research, Inc. Particulate compositions for improving solubility of poorly soluble agents
CA2465675C (en) * 2001-11-20 2008-06-10 Advanced Inhalation Research, Inc. Improved particulate compositions for pulmonary delivery
CA2469718A1 (en) * 2001-12-10 2003-06-19 Spherics, Inc. Methods and products useful in the formation and isolation of microparticles
CA2860702C (en) 2001-12-17 2019-02-26 Corixa Corporation Compositions and methods for the therapy and diagnosis of inflammatory bowel disease
US7497623B2 (en) 2002-02-27 2009-03-03 Pactiv Corporation Packages with active agents
US20060286356A1 (en) * 2002-02-27 2006-12-21 Thomas Toby R Web materials with active agent
US20050220375A1 (en) * 2002-02-27 2005-10-06 Thomas Toby R Pakages with active agents
SE0201599D0 (sv) * 2002-03-21 2002-05-30 Skyepharma Ab Microparticles
US7157102B1 (en) 2002-05-31 2007-01-02 Biotek, Inc. Multi-layered microcapsules and method of preparing same
US7041320B1 (en) 2002-05-31 2006-05-09 Biotek, Inc. High drug loaded injectable microparticle compositions and methods of treating opioid drug dependence
US20040047835A1 (en) * 2002-09-06 2004-03-11 Cell Therapeutics, Inc. Combinatorial drug therapy using polymer drug conjugates
AU2003268621B2 (en) * 2002-10-02 2009-01-15 Zealand Pharma A/S Stabilized exendin-4 compounds
US6800663B2 (en) * 2002-10-18 2004-10-05 Alkermes Controlled Therapeutics Inc. Ii, Crosslinked hydrogel copolymers
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
US7691296B2 (en) * 2002-11-25 2010-04-06 Amorepacific Corporation Method for stabilizing active components using polyol/polymer microcapsule, and cosmetic composition containing the microcapsule
US20070207211A1 (en) * 2003-04-10 2007-09-06 Pr Pharmaceuticals, Inc. Emulsion-based microparticles and methods for the production thereof
EP2548550A1 (en) 2003-04-10 2013-01-23 Surmodics Pharmaceuticals, Inc. Emulsion-based micro particles
US7622269B2 (en) * 2004-03-19 2009-11-24 Tyratech, Inc. Methods of screening tyramine- and octopamine-expressing cells for compounds and compositions having potential insect control activity
RU2388225C2 (ru) * 2003-04-24 2010-05-10 "ТАЙРАТЕК, ЛЛСи" Композиции и способы борьбы с насекомыми
US20060263403A1 (en) * 2003-04-24 2006-11-23 Essam Enan Compositions and methods for controlling insects involving the tyramine receptor
US20040224030A1 (en) * 2003-05-06 2004-11-11 Shastri Venkatram R. Microsphere delivery systems
US7578916B2 (en) * 2004-05-25 2009-08-25 Applied Biosystems, Llc Emulsions of ionic liquids
EP1636270B1 (en) 2003-06-16 2016-07-20 UCB Pharma S.A. Antibodies specific for sclerostin and methods for increasing bone mineralization
US7101617B2 (en) * 2003-07-10 2006-09-05 Motorola, Inc. Silicone dispensing with a conformal film
JP5165239B2 (ja) * 2003-07-15 2013-03-21 ピーアール ファーマシューティカルズ, インコーポレイテッド 制御放出処方物の調製のための方法
RU2426590C2 (ru) * 2003-07-18 2011-08-20 Бакстер Интернэшнл Инк. Способы изготовления, применение и композиции небольших сферических частиц, приготовленных регулируемым фазовым разделением
US20050142205A1 (en) * 2003-07-18 2005-06-30 Julia Rashba-Step Methods for encapsulating small spherical particles prepared by controlled phase separation
US20070092452A1 (en) * 2003-07-18 2007-04-26 Julia Rashba-Step Methods for fabrication, uses, compositions of inhalable spherical particles
WO2005007122A2 (en) 2003-07-18 2005-01-27 Oakwood Laboratories, L.L.C. Polymer stabilization
US20050048127A1 (en) * 2003-07-22 2005-03-03 Larry Brown Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof
WO2005009357A2 (en) * 2003-07-23 2005-02-03 Pr Pharmaceuticals, Inc. Controlled release compositions
US20050245541A1 (en) * 2004-03-19 2005-11-03 Elliot Ehrich Methods for treating alcoholism
US20080226704A1 (en) * 2004-03-23 2008-09-18 Makoto Kigoshi Method of Producing Coated Fine Particles
SI2409707T1 (sl) 2004-04-15 2015-07-31 Alkermes Pharma Ireland Limited Naprava s podaljšanim sproščanjem na osnovi polimerov
US7919499B2 (en) 2004-04-22 2011-04-05 Alkermes, Inc. Naltrexone long acting formulations and methods of use
WO2005107714A2 (en) * 2004-05-05 2005-11-17 Alkermes Controlled Therapeutics, Inc. Method of forming microparticles that include a bisphosphonate and a polymer
WO2005112885A2 (en) * 2004-05-12 2005-12-01 Baxter International Inc. Oligonucleotide-containing microspheres, their use for the manufacture of a medicament for treating diabetes type 1
US8333995B2 (en) 2004-05-12 2012-12-18 Baxter International, Inc. Protein microspheres having injectable properties at high concentrations
DK2072040T3 (da) * 2004-05-12 2013-07-29 Baxter Healthcare Sa Terapeutisk anvendelse af nukleinsyremikrokugler
US8728525B2 (en) * 2004-05-12 2014-05-20 Baxter International Inc. Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
US8007814B2 (en) 2004-06-16 2011-08-30 University Of Massachusetts Therapy for lysosomal enzyme deficiencies
US7740861B2 (en) 2004-06-16 2010-06-22 University Of Massachusetts Drug delivery product and methods
JP2008509144A (ja) * 2004-08-04 2008-03-27 アルザ・コーポレーシヨン 上昇するゼロ次放出パターンを示す持続薬剤放出組成物、そのような組成物を製造する方法
PT1781264E (pt) 2004-08-04 2013-10-16 Evonik Corp Métodos para o fabrico de dispositivis de administração e dispositivos para a mesma
US20060073208A1 (en) 2004-10-01 2006-04-06 Allergan, Inc. Cosmetic neurotoxin compositions and methods
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006104625A2 (en) 2005-03-25 2006-10-05 Appleton Papers Inc. Activator means for pre-applied adhesives
AU2006241145B2 (en) * 2005-04-27 2011-04-28 Baxter Healthcare S. A. Surface-modified microparticles and methods of forming and using the same
US7803422B2 (en) * 2005-05-23 2010-09-28 Appleton Papers Inc. Water-in-oil capsule manufacture process and microcapsules produced by such process
WO2007018736A2 (en) * 2005-07-22 2007-02-15 Appleton Papers Inc. Encapsulated structural adhesive
US9693967B2 (en) * 2005-09-07 2017-07-04 Southwest Research Institute Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates
US7846445B2 (en) * 2005-09-27 2010-12-07 Amunix Operating, Inc. Methods for production of unstructured recombinant polymers and uses thereof
EP1929073A4 (en) * 2005-09-27 2010-03-10 Amunix Inc PROTEIN MEDICAMENT AND ITS USE
US20090099031A1 (en) * 2005-09-27 2009-04-16 Stemmer Willem P Genetic package and uses thereof
US7855279B2 (en) * 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
CA2626394A1 (en) * 2005-10-24 2007-05-03 University Of Massachusetts Yeast cell wall particle for delivering osteoprotegerin-encoding polynucleotide
US20070138671A1 (en) * 2005-12-15 2007-06-21 Anastasiou Theodore J Encapsulated active material with reduced formaldehyde potential
JP5738516B2 (ja) 2005-12-30 2015-06-24 ゼンサン (シャンハイ) サイエンス アンド テクノロジー リミテッド 心機能改善のためのニューレグリンの徐放
EP2010226B1 (en) 2006-04-07 2014-01-15 The Research Foundation of State University of New York Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency
CN100385063C (zh) * 2006-04-25 2008-04-30 中原工学院 具有持久抗菌芳香效果的纺织品纳米后整理试剂及其制作工艺
US20070282434A1 (en) * 2006-05-30 2007-12-06 Yunbing Wang Copolymer-bioceramic composite implantable medical devices
US7959940B2 (en) * 2006-05-30 2011-06-14 Advanced Cardiovascular Systems, Inc. Polymer-bioceramic composite implantable medical devices
US20070281031A1 (en) * 2006-06-01 2007-12-06 Guohan Yang Microparticles and methods for production thereof
MX2008016453A (es) * 2006-06-27 2009-05-15 Tyratech Inc Composiciones y metodos para tratar infecciones parasitas.
US8685471B2 (en) * 2006-07-17 2014-04-01 Tyratech, Inc. Compositions and methods for controlling insects
JP5118139B2 (ja) * 2006-08-04 2013-01-16 バクスター・インターナショナル・インコーポレイテッド 新規発症自己免疫性糖尿病を予防および/または逆転させるためのマイクロスフィアに基づく組成物
EP2049081B1 (en) 2006-08-09 2012-11-14 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies
EP2068845A2 (en) * 2006-10-06 2009-06-17 Baxter International Inc. Microencapsules containing surface-modified microparticles and methods of forming and using the same
BRPI0806666A8 (pt) * 2007-01-16 2018-02-06 Tyratech Inc Composições e método para controle de praga
AU2008231093A1 (en) * 2007-03-22 2008-10-02 Alkermes, Inc. Coacervation process
HRP20130259T1 (hr) 2007-04-23 2013-04-30 Intarcia Therapeutics, Inc. Suspenzijske formulacije inzulinotropnih peptida i njihove uporabe
JP2010530293A (ja) * 2007-05-21 2010-09-09 フイルメニツヒ ソシエテ アノニム 大きいコアセルベート化カプセル
US8425591B1 (en) 2007-06-11 2013-04-23 Abbott Cardiovascular Systems Inc. Methods of forming polymer-bioceramic composite medical devices with bioceramic particles
US10092524B2 (en) 2008-06-11 2018-10-09 Edge Therapeutics, Inc. Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage
WO2008157540A1 (en) * 2007-06-20 2008-12-24 Alkermes, Inc. Quench liquids and washing systems for production of microparticles
US8933197B2 (en) * 2007-08-15 2015-01-13 Amunix Operating Inc. Compositions comprising modified biologically active polypeptides
JP2011517279A (ja) * 2007-10-29 2011-06-02 ユニバーシティ オブ マサチューセッツ 核酸(siRNA)送達用の酵母細胞壁粒子(YCWP)多層状ナノ粒子
US9090737B2 (en) * 2007-11-13 2015-07-28 Surmodics, Inc. Viscous terpolymers as drug delivery platform
US8619257B2 (en) 2007-12-13 2013-12-31 Kimberley-Clark Worldwide, Inc. Recombinant bacteriophage for detection of nosocomial infection
ES2718612T3 (es) 2007-12-20 2019-07-03 Evonik Corp Procedimiento para preparar micropartículas que tienen un bajo volumen de disolvente residual
JP2011507969A (ja) * 2007-12-27 2011-03-10 タイラテック, インク. 相乗的抗寄生虫組成物とスクリーニング方法
KR20100112592A (ko) * 2007-12-28 2010-10-19 다우 글로벌 테크놀로지스 인크. 소규모 기능성 물질
EP2225604A1 (en) * 2007-12-28 2010-09-08 Dow Global Technologies Inc. Phase compensation film comprising polymer nanoparticles imbibed with liquid crystal material
DK2240155T3 (da) 2008-02-13 2012-09-17 Intarcia Therapeutics Inc Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
WO2009111264A2 (en) * 2008-02-29 2009-09-11 Alseres Pharmaceuticals, Inc. Systemic purine administration:modulating axonal outgrowth of central nervous system neurons
US20090274906A1 (en) * 2008-05-01 2009-11-05 Appleton Papers Inc. Particle with low permeance wall
US8067089B2 (en) * 2008-05-01 2011-11-29 Appleton Papers Inc. Cationic microcapsule particles
US8071214B2 (en) * 2008-05-01 2011-12-06 Appleton Papers Inc. Particle with selected permeance wall
JP5763525B2 (ja) * 2008-05-07 2015-08-12 サーモディクス,インコーポレイティド 粒子からの核酸複合体の送達
US8815818B2 (en) 2008-07-18 2014-08-26 Rxi Pharmaceuticals Corporation Phagocytic cell delivery of RNAI
US8367427B2 (en) * 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
US8323685B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US20100047292A1 (en) * 2008-08-20 2010-02-25 Baxter International Inc. Methods of processing microparticles and compositions produced thereby
US8323615B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
EP2334288B1 (en) * 2008-09-18 2021-05-19 Evonik Corporation Microencapsulation process with solvent and salt
CA2746527A1 (en) 2008-09-22 2010-03-25 Rxi Pharmaceuticals Corporation Rna interference in skin indications
CN102256618A (zh) 2008-10-17 2011-11-23 赛诺菲-安万特德国有限公司 胰岛素和glp-1激动剂的组合
US20110223216A1 (en) * 2008-11-17 2011-09-15 Wayne State University Nanoparticles and Porous Particles and Methods of Making the Same
US9415197B2 (en) * 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
US8951546B2 (en) * 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
WO2010075298A2 (en) 2008-12-23 2010-07-01 Surmodics Pharmaceuticals, Inc. Implantable composites and compositions comprising releasable bioactive agents
US8974808B2 (en) 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
US20100168807A1 (en) * 2008-12-23 2010-07-01 Burton Kevin W Bioactive terpolymer compositions and methods of making and using same
US9480643B2 (en) 2008-12-23 2016-11-01 Surmodics Pharmaceuticals, Inc. Implantable composites and implants comprising same
US9493774B2 (en) 2009-01-05 2016-11-15 Rxi Pharmaceuticals Corporation Inhibition of PCSK9 through RNAi
JP2012515791A (ja) * 2009-01-23 2012-07-12 サーモディクス ファーマシューティカルズ, インコーポレイテッド ポリマー混成物由来の放出制御システム
CA2749997A1 (en) * 2009-01-23 2010-07-29 Surmodics Pharmaceuticals, Inc. Polymer mixtures comprising polymers having different non-repeating units and methods for making and using same
WO2010085607A1 (en) * 2009-01-23 2010-07-29 Surmodics Pharmaceuticals, Inc. Continuous double emulsion process for making microparticles
US20100196436A1 (en) * 2009-01-30 2010-08-05 Gooberman Lance L Implants containing disulfiram and an anti-inflammatory agent
CA2748314C (en) 2009-02-03 2018-10-02 Amunix Operating Inc. Extended recombinant polypeptides and compositions comprising same
WO2010114770A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
US8455098B2 (en) * 2009-04-07 2013-06-04 Appleton Papers Inc. Encapsulated solid hydrophilic particles
US8791093B2 (en) * 2009-05-29 2014-07-29 Lance L. Gooberman Pharmaceutical delivery systems for treatment of substance abuse and other addictions
PL2451437T3 (pl) 2009-07-06 2017-05-31 Sanofi-Aventis Deutschland Gmbh Wodne preparaty insuliny zawierające metioninę
AU2010290131C1 (en) 2009-08-24 2015-12-03 Amunix Operating Inc. Coagulation factor VII compositions and methods of making and using same
SMT201700583T1 (it) 2009-09-28 2018-01-11 Intarcia Therapeutics Inc Instaurazione e/o terminazione rapida di erogazione di farmaci in modo sostanzialmente stazionario
CA2776472A1 (en) * 2009-10-01 2011-04-07 Evonik Degussa Corporation Microparticle compositions and methods for treating age-related macular degeneration
NZ599543A (en) 2009-10-30 2014-02-28 Ntf Therapeutics Inc Improved neurturin molecules
NZ599847A (en) 2009-11-13 2013-09-27 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist and methionine
TR201809460T4 (tr) 2009-11-13 2018-07-23 Sanofi Aventis Deutschland Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim.
US20110207653A1 (en) * 2009-12-21 2011-08-25 Adrian Raiche Microparticle Encapsulated Thiol-Containing Polypeptides Together with a Redox Reagent
WO2011084141A2 (en) * 2009-12-21 2011-07-14 Appleton Papers Inc. Hydrophilic liquid encapsulates
WO2011087689A2 (en) * 2009-12-22 2011-07-21 Surmodics Pharmaceuticals,Inc. Emulsion-based process for preparing microparticles and workhead assembly for use with same
US9743688B2 (en) 2010-03-26 2017-08-29 Philip Morris Usa Inc. Emulsion/colloid mediated flavor encapsulation and delivery with tobacco-derived lipids
US20110237686A1 (en) 2010-03-26 2011-09-29 Cerulean Pharma Inc Formulations and methods of use
US9993793B2 (en) 2010-04-28 2018-06-12 The Procter & Gamble Company Delivery particles
US9186642B2 (en) 2010-04-28 2015-11-17 The Procter & Gamble Company Delivery particle
US20110269657A1 (en) 2010-04-28 2011-11-03 Jiten Odhavji Dihora Delivery particles
US20110319473A1 (en) 2010-06-29 2011-12-29 Surmodics, Inc. Compositions and methods for enhancement of nucleic acid delivery
US9242857B2 (en) 2010-08-14 2016-01-26 University Of Massachusetts Yeast cell wall particles for receptor-targeted nanoparticle delivery
EA201390145A1 (ru) * 2010-08-20 2013-11-29 Серулин Фарма Инк. Конъюгаты, частицы, композиции и связанные с ними способы
WO2012030819A1 (en) 2010-08-30 2012-03-08 Surmodics Pharmaceuticals, Inc. Terpolymers as pressure-sensitive adhesives
WO2012028172A1 (en) 2010-08-30 2012-03-08 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
CN103298453A (zh) 2010-09-30 2013-09-11 赢创有限公司 制备低残留溶剂微粒的乳化法
CA2813301A1 (en) 2010-09-30 2012-04-05 Evonik Corporation Method for removing residual organic solvent from microparticles
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
EP2672983B1 (en) 2011-02-11 2017-04-19 Edge Therapeutics, Inc. Compositions and methods for improving prognosis of a human with subarachnoid hemorrhage
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
HK1198933A1 (en) 2011-04-05 2015-06-19 Edge Therapeutics Intraventricular drug delivery system for improving outcome after a brain injury affecting cerebral blood flow
WO2012138696A2 (en) 2011-04-07 2012-10-11 The Procter & Gamble Company Shampoo compositions with increased deposition of polyacrylate microcapsules
WO2012138690A2 (en) 2011-04-07 2012-10-11 The Procter & Gamble Company Conditioner compositions with increased deposition of polyacrylate microcapsules
WO2012138710A2 (en) 2011-04-07 2012-10-11 The Procter & Gamble Company Personal cleansing compositions with increased deposition of polyacrylate microcapsules
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
WO2012164480A1 (en) * 2011-05-30 2012-12-06 National Institute Of Immunology A vaccine composition capable of inducing memory antibody response from single point immunization
CA2837651A1 (en) 2011-06-21 2012-12-27 Oncofactor Corporation Compositions and methods for the therapy and diagnosis of cancer
AR087693A1 (es) 2011-08-29 2014-04-09 Sanofi Aventis Deutschland Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
KR102134932B1 (ko) 2011-11-11 2020-07-17 프레드 헛친슨 켄서 리서치 센터 암을 위한 사이클린 a1―표적화된 t―세포 면역요법
BR112014020694A2 (pt) 2012-02-15 2018-05-08 Amunix Operating Inc. proteína de fusão do fator viii compreendendo polipeptídeo do fator viii fusionado a polipeptí-deo recombinante estendido (xten) e seu método de fabricação, ácido nucleico, vetores, célula hospedeira, bem como composição farmacêutica e seu uso no tratamento de coagulopatia, episódio de hemorragia e hemofilia a
CA2864126A1 (en) 2012-02-15 2013-08-22 Biogen Idec Ma Inc. Recombinant factor viii proteins
US20130260040A1 (en) * 2012-02-28 2013-10-03 Neil Werde Microencapsulated catnip oil and methods of using the same
US9408419B2 (en) 2012-03-23 2016-08-09 Victoria's Secret Store Brand Management, Inc. Moisturizing fabric material, use thereof in moisturizing bras, and method of manufacture
US9399019B2 (en) 2012-05-09 2016-07-26 Evonik Corporation Polymorph compositions, methods of making, and uses thereof
WO2014022859A1 (en) 2012-08-03 2014-02-06 Essam Enan Antiparasitic compositions and methods
AU2012393962A1 (en) 2012-11-09 2015-05-28 Evonik Corporation Drying methods for tuning microparticle properties
TWI780236B (zh) 2013-02-04 2022-10-11 法商賽諾菲公司 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
US10548953B2 (en) 2013-08-14 2020-02-04 Bioverativ Therapeutics Inc. Factor VIII-XTEN fusions and uses thereof
CN105960249B (zh) 2014-01-09 2021-03-16 赛诺菲 胰岛素类似物和/或胰岛素衍生物的稳定化药物制剂
US9895423B2 (en) 2014-01-09 2018-02-20 Sanofi Stabilized pharmaceutical formulations of insulin aspart
JP6723921B2 (ja) 2014-01-09 2020-07-15 サノフイSanofi インスリンアナログおよび/またはインスリン誘導体の、グリセリンを含まない安定化された医薬製剤
WO2015150942A2 (en) 2014-03-29 2015-10-08 The WOCKHARDT LIMITED Improved process for preparing microparticles
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
PE20171622A1 (es) 2014-12-12 2017-11-02 Sanofi Aventis Deutschland Formulacion de relacion fija de insulina glargina/lixisenatida
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第2型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第2型糖尿病病患之治療
US10925639B2 (en) 2015-06-03 2021-02-23 Intarcia Therapeutics, Inc. Implant placement and removal systems
BR112018002150A2 (pt) 2015-08-03 2018-09-18 Bioverativ Therapeutics Inc proteínas de fusão do fator ix e métodos de fabricação e uso das mesmas
WO2017074997A1 (en) 2015-10-27 2017-05-04 Encapsys, Llc Encapsulation
BG112154A (bg) 2015-11-19 2017-05-31 СОФИЙСКИ УНИВЕРСИТЕТ "Св. Кл. Охридски" Метод за получаване на течни, по­ лутечни и твърди органични частици с контролирана форма и/или размер
EP3419596A1 (en) 2016-02-23 2019-01-02 BioDelivery Sciences International, Inc. Sustained release buprenorphine microspheres (srbm) and methods of use thereof
RU2760007C2 (ru) 2016-05-16 2021-11-22 Интарсия Терапьютикс, Инк. Полипептиды, селективные к рецепторам глюкагона, и способы их применения
WO2017199123A1 (en) 2016-05-17 2017-11-23 Ecole Polytechnique Federale De Lausanne (Epfl) Device and methods for shell phase removal of core-shell capsules
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
IL319473A (en) 2016-12-02 2025-05-01 Bioverativ Therapeutics Inc Methods for treating hemophilic arthritis using chimeric blood clotting factors
CN110225762A (zh) 2017-01-03 2019-09-10 因塔西亚制药公司 包括glp-1受体激动剂的连续施用和药物的共同施用的方法
CA3046510A1 (en) 2017-01-27 2018-08-02 Encapsys, Llc Encapsulates
WO2018195355A1 (en) 2017-04-19 2018-10-25 Rxi Pharmaceuticals Corporation Topical delivery of nucleic acid compounds
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
BR112020022164A2 (pt) 2018-05-18 2021-02-02 Bioverativ Therapeutics Inc. métodos de tratamento de hemofilia a
WO2019236669A1 (en) * 2018-06-08 2019-12-12 The United States Of America, As Represented By The Secretary Of Agriculture Compositions containing microencapsulated organic compounds
DE112018007728T5 (de) 2018-06-14 2021-03-18 Centro De Investigación En Química Aplicada Methode zur Gewinnung poröser Partikel durch Trocknung / Abkühlung in einem hybriden Pulverisierungsverfahren
CA3106374A1 (en) 2019-01-11 2020-07-16 Encapsys, Llc Incorporation of chitosan in microcapsule wall
US20200281195A1 (en) * 2019-03-04 2020-09-10 Xerox Corporation Essential oil microparticles for powder coating applications
KR20220061977A (ko) 2019-08-12 2022-05-13 퓨리노미아 바이오테크, 아이엔씨. Cd39 발현 세포의 adcc 표적화를 통해 t 세포 매개 면역 반응을 촉진 및 강화하기 위한 방법 및 조성물
WO2021074695A1 (en) 2019-10-16 2021-04-22 Avacta Life Sciences Limited PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
CN116323893A (zh) 2020-10-16 2023-06-23 宝洁公司 包含包封物群体的消费产品组合物
US12227720B2 (en) 2020-10-16 2025-02-18 The Procter & Gamble Company Consumer product compositions with at least two encapsulate populations
US12486478B2 (en) 2020-10-16 2025-12-02 The Procter & Gamble Company Consumer products comprising delivery particles with high core:wall ratios
EP4247537A4 (en) 2020-11-20 2024-10-23 Encapsys, LLC BIODEGRADABLE MICROCAPSULES WITH CONTROLLED RELEASE
WO2022234003A1 (en) 2021-05-07 2022-11-10 Avacta Life Sciences Limited Cd33 binding polypeptides with stefin a protein
TW202334196A (zh) 2021-10-07 2023-09-01 英商阿法克塔生命科學有限公司 Pd-l1結合多肽
TW202332694A (zh) 2021-10-07 2023-08-16 英商阿凡克塔生命科學公司 血清半衰期延長之pd-l1結合多肽
WO2023153876A1 (ko) 2022-02-10 2023-08-17 주식회사 아피셀테라퓨틱스 Cd40l에 특이적으로 결합하는 스테핀 a 단백질 변이체 및 이의 용도
JP2025515486A (ja) 2022-04-29 2025-05-15 ピュリノミア バイオテック, インコーポレイテッド 好酸球駆動性疾患及び障害を治療するための方法及び組成物
WO2023218243A1 (en) 2022-05-12 2023-11-16 Avacta Life Sciences Limited Lag-3/pd-l1 binding fusion proteins
US20240147990A1 (en) 2022-10-21 2024-05-09 Encapsys, Llc Delivery Particles Based On Amine-Thiol-Ene Conjugates and Derivatives
CN119790132A (zh) 2022-12-01 2025-04-08 恩盖普有限公司 来自混合酸处理的壳聚糖的可降解递送颗粒
CA3263674A1 (en) 2022-12-01 2024-06-06 Encapsys, Llc DEGRADABLE DISTRIBUTION PARTICLES MANUFACTURED FROM CHITOSAN MODIFIED BY REDOX INITIATOR
EP4627036A1 (en) 2022-12-01 2025-10-08 Encapsys, LLC Charge modified chitosan cross-linked encapsulate
WO2025006526A1 (en) 2023-06-28 2025-01-02 Encapsys, Llc Compositions of plant-based flour delivery particles
WO2025128667A1 (en) 2023-12-13 2025-06-19 Encapsys, Llc Degradable delivery particles from mixed isocyanates comprising an aromatic moiety and chitosan
WO2025128660A1 (en) 2023-12-13 2025-06-19 Encapsys, Llc Dried degradable delivery particles from mixed isocyanates comprising an aromatic moiety and chitosan
WO2025207733A1 (en) 2024-03-28 2025-10-02 Encapsys, Llc Biodegradable, controlled release microcapsules

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572869A (en) * 1967-04-20 1986-02-25 Ppg Industries, Inc. Microcapsular opacifiers and method for their production
US3644963A (en) * 1969-07-24 1972-02-29 Federico Terranova Procedure for the removal of the bones from hams and similar cuts of meat
US3780195A (en) * 1969-10-22 1973-12-18 Balchem Corp Encapsulation process
US3664963A (en) * 1969-10-22 1972-05-23 Balchem Corp Encapsulation process
DE2059494B2 (de) * 1970-12-03 1972-03-16 Licentia Gmbh Biegsamer hohlleiter
US3790497A (en) * 1971-11-24 1974-02-05 Mitsubishi Rayon Co Method for producing water containing microcapsules
JPS528795B2 (no) * 1971-12-30 1977-03-11
US4089800A (en) * 1975-04-04 1978-05-16 Ppg Industries, Inc. Method of preparing microcapsules
JPS528795A (en) * 1975-07-10 1977-01-22 Kyocera Corp Selective indication circuit
DE2930248A1 (de) * 1979-07-26 1981-02-12 Bayer Ag Verfahren zur herstellung von mikrokapseln
US4933105A (en) * 1980-06-13 1990-06-12 Sandoz Pharm. Corp. Process for preparation of microspheres
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4637905A (en) * 1982-03-04 1987-01-20 Batelle Development Corporation Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or ε-caprolactones
JPS6048923A (ja) * 1983-08-25 1985-03-16 Mitsui Toatsu Chem Inc 微小粒子の製造方法
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4818542A (en) * 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
CA1287459C (en) * 1986-10-01 1991-08-13 Mukesh Jain Process for the preparation of hollow microspheres
US5075109A (en) * 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
JPS63122620A (ja) * 1986-11-12 1988-05-26 Sanraku Inc ポリ乳酸マイクロスフエア及びその製造方法
FR2608988B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
US4897268A (en) * 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same

Also Published As

Publication number Publication date
EP0471036B2 (en) 2004-06-23
NO302683B1 (no) 1998-04-14
IE69313B1 (en) 1996-09-04
GR1000614B (el) 1992-08-31
AU5741590A (en) 1990-11-29
GR900100330A (en) 1991-10-10
NO914292D0 (no) 1991-11-01
NZ233570A (en) 1992-12-23
DE69024953D1 (de) 1996-02-29
CA2050911A1 (en) 1990-11-05
ZA903411B (en) 1991-02-27
IL94296A (en) 1995-10-31
FI103183B (fi) 1999-05-14
KR0162660B1 (en) 1998-11-16
EP0471036A4 (en) 1992-03-18
CN1047223A (zh) 1990-11-28
DE69024953T2 (de) 1996-08-14
ES2084698T5 (es) 2005-03-01
MX20594A (es) 1994-03-31
HK30897A (en) 1997-03-21
IE901616L (en) 1990-11-04
ATE133087T1 (de) 1996-02-15
DE69024953T3 (de) 2005-01-27
DK0471036T4 (da) 2004-07-19
DK0471036T3 (da) 1996-05-28
JPH04505454A (ja) 1992-09-24
FI103183B1 (fi) 1999-05-14
KR920700762A (ko) 1992-08-10
CA2050911C (en) 1997-07-15
FI915129A0 (fi) 1991-10-30
WO1990013361A1 (en) 1990-11-15
EP0471036B1 (en) 1996-01-17
EP0471036A1 (en) 1992-02-19
JP2582186B2 (ja) 1997-02-19
IL94296A0 (en) 1991-03-10
US5407609A (en) 1995-04-18
ES2084698T3 (es) 1996-05-16

Similar Documents

Publication Publication Date Title
NO914292L (no) Forbedret innkapslingsprosess, samt produkter fra denne prosess
ES8301663A1 (es) Un metodo de preparar microcapsulas cargadas con un agente activo, en particular con productos quimicos agricolas ,per- fumes,agentes de curado,colorantes-oxidantes y agentes biologicos activos.
ES8605983A1 (es) Un metodo de producir una microcapsula de liberacion prolongada de un farmaco soluble en agua
ES2084171T3 (es) Sustitutivos de grasas y metodo de preparar microglobulos organicos.
IT8319308A0 (it) Prodotto compatto carbonioso, impasto liquido contenente tale compatto e procedimento per lapreparazione di tale impasto liquido.
GB1319123A (en) Process for the production of microcapsules containing oily liquid
BR8405784A (pt) Produto de reacao soluvel em oleo,processo para a preparacao de um produto e composicao de oleo
ES2043290T3 (es) Procedimiento y aparato para introducir en un recipiente una suspension o solucion de un material en un propulsante mantenido bajo presion.
JPS57158298A (en) Oil-containing seed material solvent extraction and oil solvent extraction
ES2022247T5 (es) Material de registro sensible a la presion.
HUT35284A (en) Preparatives consisting of bipolimers and process for their production
NL187167B (nl) Werkwijze ter bereiding van gona-4,9(10)-dienen, werkwijze ter bereiding van geneesmiddelen die deze verbindingen bevatten, alsmede gevormde geneesmiddelen.
FR2253615A1 (no)
NL7707684A (nl) Werkwijze voor de bereiding van hypolypemische stoffen en preparaten die ze bevatten.
YU149281A (en) Method of filling pharmaceutical products containing phospholipides and which are highly viscid at ambient temperature, into hard capsules
BR7907449A (pt) Agente estabilizante para uma mistura oleo-agua,processo de formar o mesmo,processo de formar uma mistura oleo-agua estabilizada,e,mistura oleo-agua estabilizada
DE59007447D1 (de) Verfahren zur Abtrennung von gamma-Butyrolacton aus Gemischen, die Bernsteinsäurediethylester enthalten.
ES2021345B3 (es) Metodo para la separacion y recuperacion de un material granulado de una suspension viscosa que contiene dicho material, y aparato para llevar a cabo dicho metodo.
DE2206325B2 (de) Verfahren und vorrichtung zum ausloesen einer chemischen reaktion
GB1357952A (en) Methods of treating water catchments
NL187974C (nl) O-gesubstitueerde oximderivaten, werkwijze voor de bereiding daarvan, alsmede farmaceutische preparaten, die dergelijke verbindingen bevatten.
JPS52110708A (en) Method of oil expression and apparatus for it
NL147934B (nl) Werkwijze voor het bereiden van geneesmiddelen die als actieve stof een eventueel gesubstitueerd 2,6-dioxocyclohexaan (thio)carbonzuuranilide bevatten, alsmede gevormd geneesmiddel en werkwijze ter bereiding van de aniliden.
AU490228B2 (en) Method and apparatus for recovering the oil content of soluble oil emulsion
JPS57191313A (en) Method of making feather into down

Legal Events

Date Code Title Description
MK1K Patent expired