NO961460L - Antitrombotiske azacykloalkylalkanoylpeptider og -pseudopeptider - Google Patents

Antitrombotiske azacykloalkylalkanoylpeptider og -pseudopeptider

Info

Publication number
NO961460L
NO961460L NO961460A NO961460A NO961460L NO 961460 L NO961460 L NO 961460L NO 961460 A NO961460 A NO 961460A NO 961460 A NO961460 A NO 961460A NO 961460 L NO961460 L NO 961460L
Authority
NO
Norway
Prior art keywords
aralkyl
substituted
aryl
alkyl
alkylcycloalkyl
Prior art date
Application number
NO961460A
Other languages
English (en)
Norwegian (no)
Other versions
NO961460D0 (no
Inventor
Scott I Klein
Bruce F Molino
Original Assignee
Rhone Poulenc Rorer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Inc filed Critical Rhone Poulenc Rorer Inc
Publication of NO961460D0 publication Critical patent/NO961460D0/no
Publication of NO961460L publication Critical patent/NO961460L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO961460A 1993-10-15 1996-04-12 Antitrombotiske azacykloalkylalkanoylpeptider og -pseudopeptider NO961460L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13882093A 1993-10-15 1993-10-15
PCT/US1994/012135 WO1995010295A1 (en) 1993-10-15 1994-10-17 Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides

Publications (2)

Publication Number Publication Date
NO961460D0 NO961460D0 (no) 1996-04-12
NO961460L true NO961460L (no) 1996-06-17

Family

ID=22483811

Family Applications (1)

Application Number Title Priority Date Filing Date
NO961460A NO961460L (no) 1993-10-15 1996-04-12 Antitrombotiske azacykloalkylalkanoylpeptider og -pseudopeptider

Country Status (27)

Country Link
US (1) US5866685A (pl)
EP (1) EP0812205B1 (pl)
JP (1) JP3032297B2 (pl)
KR (1) KR100304332B1 (pl)
CN (1) CN1135717A (pl)
AT (1) ATE199727T1 (pl)
AU (1) AU703854B2 (pl)
BG (1) BG63166B1 (pl)
BR (1) BR9407839A (pl)
CA (1) CA2174097C (pl)
CZ (1) CZ291378B6 (pl)
DE (1) DE69426897T2 (pl)
DK (1) DK0812205T3 (pl)
ES (1) ES2155122T3 (pl)
FI (1) FI961634L (pl)
GR (1) GR3035581T3 (pl)
HU (1) HU222248B1 (pl)
NO (1) NO961460L (pl)
NZ (1) NZ275948A (pl)
PL (1) PL181749B1 (pl)
PT (1) PT812205E (pl)
RO (1) RO115520B1 (pl)
RU (1) RU2134695C1 (pl)
SG (1) SG64919A1 (pl)
SK (1) SK47796A3 (pl)
UA (1) UA44258C2 (pl)
WO (1) WO1995010295A1 (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274705B1 (en) 1996-05-02 2001-08-14 Aventis Pharmaceuticals Products Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
US5780590A (en) * 1993-10-15 1998-07-14 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
CN1135717A (zh) * 1993-10-15 1996-11-13 罗纳-布朗克·罗莱尔药物有限公司 抗血栓形成的氮杂环烷基链烷酰肽和假肽
PL331772A1 (en) * 1996-08-21 1999-08-02 Rhone Poulenc Rorer Pharma Stable non-hygroscopic crystalline form of n-[n-n-(4-piperidin-4-yl)-n-ethylglycin] compounds
IL129877A (en) * 1996-11-27 2004-08-31 Aventis Pharm Prod Inc A pharmaceutical preparation containing a component having an Xa antagonist activity and an antifouling agent
WO1999019294A1 (en) * 1997-05-14 1999-04-22 Aventis Pharmaceuticals Products Inc. Legal/Patents Process for the preparation of azacycloalkylalkanoyl pseudotetrapeptides
CA2306823A1 (en) * 1997-10-10 1999-04-22 Aventis Pharmaceuticals Products Inc. Process for the preparation of azacycloalkylalkanoyl pseudotetrapeptides
EP1155033A1 (en) * 1998-12-30 2001-11-21 Aventis Pharmaceuticals Products Inc. Process for preparing a stable non-hygroscopic crystalline n-[n-[n-(piperdin-4-yl)butanoyl)-n-ethylglycyl]-(l)-aspartyl]-ss-cyclohexylalanine amide
WO2001055175A2 (en) * 2000-01-28 2001-08-02 Aventis Pharma Deutschland Gmbh Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides
WO2001072297A1 (en) * 2000-03-27 2001-10-04 The Scripps Research Institute Methods for inhibiting angiogenesis and tumor growth
CN101735307B (zh) * 2008-11-18 2012-05-30 北京航空航天大学 一种血小板膜糖蛋白寡肽或其修饰物/衍生物以及它们的应用
AU2013274406B2 (en) * 2012-06-11 2017-02-02 The Cleveland Clinic Foundation Treatment and prevention of cardiovascular disease and thrombosis

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
FR2608160B1 (fr) * 1986-12-15 1989-03-31 Inst Nat Sante Rech Med Nouveaux derives peptidiques et leur application notamment en therapeutique
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
US4992463A (en) * 1988-07-20 1991-02-12 Monsanto Company Thienyl peptide mimetic compounds which are useful in inhibiting platelet aggregation
US5037808A (en) * 1988-07-20 1991-08-06 Monsanto Co. Indolyl platelet-aggregation inhibitors
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
WO1991004746A1 (en) * 1989-09-29 1991-04-18 Rhone-Poulenc Rorer International (Holdings) Inc. Anti-thrombotic peptides and pseudopeptides
US5051405A (en) * 1989-10-10 1991-09-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptides and pseudopeptides
US5064814A (en) * 1990-04-05 1991-11-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptide and pseudopeptide derivatives
IL99538A0 (en) * 1990-09-27 1992-08-18 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
IL99539A0 (en) * 1990-09-27 1992-08-18 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
EP0503203A1 (en) * 1991-03-15 1992-09-16 Merrell Dow Pharmaceuticals Inc. Novel thrombin inhibitors
AU661659B2 (en) * 1991-04-11 1995-08-03 Rhone-Poulenc Rorer International (Holdings) Inc. Anti-thrombotic peptide and pseudopeptide derivatives
SE9102462D0 (sv) * 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
CN1135717A (zh) * 1993-10-15 1996-11-13 罗纳-布朗克·罗莱尔药物有限公司 抗血栓形成的氮杂环烷基链烷酰肽和假肽

Also Published As

Publication number Publication date
DE69426897D1 (de) 2001-04-19
JPH09507213A (ja) 1997-07-22
BR9407839A (pt) 1997-05-13
ES2155122T3 (es) 2001-05-01
AU703854B2 (en) 1999-04-01
DE69426897T2 (de) 2001-07-05
HU9600983D0 (en) 1996-06-28
CZ108496A3 (en) 1996-12-11
UA44258C2 (uk) 2002-02-15
BG63166B1 (bg) 2001-05-31
JP3032297B2 (ja) 2000-04-10
FI961634A7 (fi) 1996-05-23
ATE199727T1 (de) 2001-03-15
PL181749B1 (pl) 2001-09-28
EP0812205A1 (en) 1997-12-17
PL313975A1 (en) 1996-08-05
EP0812205A4 (en) 1999-03-31
US5866685A (en) 1999-02-02
CZ291378B6 (cs) 2003-02-12
GR3035581T3 (en) 2001-06-29
HUT73856A (en) 1996-09-30
CA2174097C (en) 2002-06-04
AU8123794A (en) 1995-05-04
RU2134695C1 (ru) 1999-08-20
CN1135717A (zh) 1996-11-13
NZ275948A (en) 1997-02-24
RO115520B1 (ro) 2000-03-30
SG64919A1 (en) 1999-05-25
PT812205E (pt) 2001-08-30
BG100544A (bg) 1996-11-29
DK0812205T3 (da) 2001-04-17
HU222248B1 (hu) 2003-05-28
SK47796A3 (en) 1997-03-05
EP0812205B1 (en) 2001-03-14
FI961634L (fi) 1996-05-23
WO1995010295A1 (en) 1995-04-20
HK1006225A1 (en) 1999-02-19
KR100304332B1 (ko) 2001-11-26
FI961634A0 (fi) 1996-04-12
NO961460D0 (no) 1996-04-12
CA2174097A1 (en) 1995-04-20

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application