OA10652A - Paroxetine controlled release compositions - Google Patents

Paroxetine controlled release compositions Download PDF

Info

Publication number: OA10652A
Authority: OA; OAPI
Prior art keywords: core; deposit; controlled release; release; paroxetine
Prior art date: 1995-07-20

Application number

OA9800005A

Other languages

English (en)

Inventor

Graham Stanley Leonard

David Philip Edler

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-20

Filing date

1998-01-20

Publication date

2002-09-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10777960&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=OA10652(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-01-20 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2002-09-18 Publication of OA10652A publication Critical patent/OA10652A/en

Links

AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 title claims abstract description 46
239000000203 mixture Substances 0.000 title claims abstract description 37
238000013270 controlled release Methods 0.000 title claims abstract description 22
AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 title claims description 25
229960002296 paroxetine Drugs 0.000 title claims description 25
238000009472 formulation Methods 0.000 claims abstract description 30
230000003111 delayed effect Effects 0.000 claims abstract description 11
239000003795 chemical substances by application Substances 0.000 claims description 27
239000003826 tablet Substances 0.000 claims description 27
229920000642 polymer Polymers 0.000 claims description 14
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
239000013543 active substance Substances 0.000 claims description 11
239000000463 material Substances 0.000 claims description 7
238000000034 method Methods 0.000 claims description 7
229920000148 Polycarbophil calcium Polymers 0.000 claims description 6
229940095498 calcium polycarbophil Drugs 0.000 claims description 6
229940124834 selective serotonin reuptake inhibitor Drugs 0.000 claims description 5
239000007894 caplet Substances 0.000 claims description 4
239000012530 fluid Substances 0.000 claims description 4
239000003431 cross linking reagent Substances 0.000 claims description 3
239000007788 liquid Substances 0.000 claims description 3
239000004721 Polyphenylene oxide Substances 0.000 claims description 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
239000000470 constituent Substances 0.000 claims description 2
239000002662 enteric coated tablet Substances 0.000 claims description 2
229920001002 functional polymer Polymers 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims description 2
229920000570 polyether Polymers 0.000 claims description 2
230000000069 prophylactic effect Effects 0.000 claims description 2
230000008961 swelling Effects 0.000 claims description 2
230000036571 hydration Effects 0.000 claims 1
238000006703 hydration reaction Methods 0.000 claims 1
239000003112 inhibitor Substances 0.000 claims 1
239000001993 wax Substances 0.000 claims 1
229960005183 paroxetine hydrochloride Drugs 0.000 abstract description 11
WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 abstract description 9
229960001021 lactose monohydrate Drugs 0.000 abstract description 9
239000001267 polyvinylpyrrolidone Substances 0.000 abstract description 9
229920000036 polyvinylpyrrolidone Polymers 0.000 abstract description 9
235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract description 9
UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 abstract description 6
229920003091 Methocel™ Polymers 0.000 abstract description 6
229920003094 Methocel™ K4M Polymers 0.000 abstract description 6
239000000454 talc Substances 0.000 abstract description 5
229910052623 talc Inorganic materials 0.000 abstract description 5
DMBUODUULYCPAK-UHFFFAOYSA-N 1,3-bis(docosanoyloxy)propan-2-yl docosanoate Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCCCCCC DMBUODUULYCPAK-UHFFFAOYSA-N 0.000 abstract description 4
229920003134 Eudragit® polymer Polymers 0.000 abstract description 3
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 abstract description 3
DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 abstract description 3
238000009505 enteric coating Methods 0.000 abstract description 3
239000002702 enteric coating Substances 0.000 abstract description 3
239000001069 triethyl citrate Substances 0.000 abstract description 3
VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 abstract description 3
235000013769 triethyl citrate Nutrition 0.000 abstract description 3
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 4
235000019359 magnesium stearate Nutrition 0.000 abstract 2
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 13
239000011230 binding agent Substances 0.000 description 9
206010053317 Hydrophobia Diseases 0.000 description 8
206010028813 Nausea Diseases 0.000 description 8
230000008693 nausea Effects 0.000 description 8
206010012735 Diarrhoea Diseases 0.000 description 7
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 7
239000000017 hydrogel Substances 0.000 description 7
229960001375 lactose Drugs 0.000 description 7
239000008101 lactose Substances 0.000 description 7
239000004014 plasticizer Substances 0.000 description 7
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
208000035475 disorder Diseases 0.000 description 6
239000012458 free base Substances 0.000 description 6
229940068196 placebo Drugs 0.000 description 6
239000000902 placebo Substances 0.000 description 6
239000011248 coating agent Substances 0.000 description 5
238000000576 coating method Methods 0.000 description 5
239000003085 diluting agent Substances 0.000 description 5
230000002411 adverse Effects 0.000 description 3
239000000314 lubricant Substances 0.000 description 3
239000011159 matrix material Substances 0.000 description 3
238000011282 treatment Methods 0.000 description 3
IZHVBANLECCAGF-UHFFFAOYSA-N 2-hydroxy-3-(octadecanoyloxy)propyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCCCCCCCCCCC IZHVBANLECCAGF-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
229920003093 Methocel™ K100 LV Polymers 0.000 description 2
206010028817 Nausea and vomiting symptoms Diseases 0.000 description 2
206010036618 Premenstrual syndrome Diseases 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
239000011575 calcium Substances 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 2
FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 2
125000005456 glyceride group Chemical group 0.000 description 2
230000003993 interaction Effects 0.000 description 2
238000011321 prophylaxis Methods 0.000 description 2
239000000126 substance Substances 0.000 description 2
238000009492 tablet coating Methods 0.000 description 2
239000002700 tablet coating Substances 0.000 description 2
URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 description 1
208000007848 Alcoholism Diseases 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
208000024827 Alzheimer disease Diseases 0.000 description 1
208000019901 Anxiety disease Diseases 0.000 description 1
GUBGYTABKSRVRQ-DCSYEGIMSA-N Beta-Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-DCSYEGIMSA-N 0.000 description 1
208000032841 Bulimia Diseases 0.000 description 1
206010006550 Bulimia nervosa Diseases 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
208000000094 Chronic Pain Diseases 0.000 description 1
235000008733 Citrus aurantifolia Nutrition 0.000 description 1
229920003159 Eudragit® RS 100 Polymers 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
208000019695 Migraine disease Diseases 0.000 description 1
208000008589 Obesity Diseases 0.000 description 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 description 1
208000002193 Pain Diseases 0.000 description 1
206010039966 Senile dementia Diseases 0.000 description 1
206010041250 Social phobia Diseases 0.000 description 1
235000011941 Tilia x europaea Nutrition 0.000 description 1
206010047700 Vomiting Diseases 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
201000007930 alcohol dependence Diseases 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
208000022531 anorexia Diseases 0.000 description 1
230000036506 anxiety Effects 0.000 description 1
239000011324 bead Substances 0.000 description 1
150000001669 calcium Chemical class 0.000 description 1
239000002775 capsule Substances 0.000 description 1
229940081734 cellulose acetate phthalate Drugs 0.000 description 1
OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
206010061428 decreased appetite Diseases 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
208000024732 dysthymic disease Diseases 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
229960002464 fluoxetine Drugs 0.000 description 1
229960004038 fluvoxamine Drugs 0.000 description 1
CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
229940074045 glyceryl distearate Drugs 0.000 description 1
239000001087 glyceryl triacetate Substances 0.000 description 1
235000013773 glyceryl triacetate Nutrition 0.000 description 1
QMEZUZOCLYUADC-UHFFFAOYSA-N hydrate;dihydrochloride Chemical compound O.Cl.Cl QMEZUZOCLYUADC-UHFFFAOYSA-N 0.000 description 1
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
210000003405 ileum Anatomy 0.000 description 1
239000004571 lime Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
206010027599 migraine Diseases 0.000 description 1
239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
235000020824 obesity Nutrition 0.000 description 1
208000019906 panic disease Diseases 0.000 description 1
239000008188 pellet Substances 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
239000000843 powder Substances 0.000 description 1
229940126570 serotonin reuptake inhibitor Drugs 0.000 description 1
239000003772 serotonin uptake inhibitor Substances 0.000 description 1
229960002073 sertraline Drugs 0.000 description 1
VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
210000000813 small intestine Anatomy 0.000 description 1
229940080313 sodium starch Drugs 0.000 description 1
201000009032 substance abuse Diseases 0.000 description 1
231100000736 substance abuse Toxicity 0.000 description 1
208000011117 substance-related disease Diseases 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
208000002271 trichotillomania Diseases 0.000 description 1
230000008673 vomiting Effects 0.000 description 1
229940045860 white wax Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Polyurethanes Or Polyureas (AREA)
Hydrogenated Pyridines (AREA)

OA9800005A 1995-07-20 1998-01-20 Paroxetine controlled release compositions OA10652A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9514842.5A GB9514842D0 (en)	1995-07-20	1995-07-20	Novel formulation

Publications (1)

Publication Number	Publication Date
OA10652A true OA10652A (en)	2002-09-18

Family

ID=10777960

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA9800005A OA10652A (en)	1995-07-20	1998-01-20	Paroxetine controlled release compositions

Country Status (40)

Country	Link
EP (2)	EP1382337A1 (de)
JP (2)	JP3922392B2 (de)
KR (1)	KR100468351B1 (de)
CN (2)	CN1117567C (de)
AP (1)	AP1052A (de)
AR (1)	AR003463A1 (de)
AT (1)	ATE253361T1 (de)
AU (1)	AU6659196A (de)
BG (1)	BG64076B1 (de)
BR (1)	BR9609857A (de)
CA (2)	CA2445678C (de)
CY (1)	CY2408B1 (de)
CZ (1)	CZ294110B6 (de)
DE (1)	DE69630603T3 (de)
DK (1)	DK0839039T4 (de)
DZ (1)	DZ2074A1 (de)
EA (2)	EA003775B1 (de)
EG (1)	EG23934A (de)
ES (1)	ES2208757T5 (de)
GB (1)	GB9514842D0 (de)
HU (1)	HU228853B1 (de)
IL (1)	IL122940A0 (de)
MA (1)	MA23942A1 (de)
MX (1)	MX9800571A (de)
MY (1)	MY141373A (de)
NO (1)	NO315637B1 (de)
NZ (1)	NZ315006A (de)
OA (1)	OA10652A (de)
PE (1)	PE16098A1 (de)
PL (1)	PL184987B1 (de)
PT (1)	PT839039E (de)
RO (1)	RO119119B1 (de)
SI (1)	SI0839039T2 (de)
SK (1)	SK284117B6 (de)
TR (1)	TR199800077T1 (de)
TW (1)	TW464513B (de)
UA (1)	UA68328C2 (de)
UY (3)	UY24288A1 (de)
WO (1)	WO1997003670A1 (de)
ZA (1)	ZA966148B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6638948B1 (en)	1996-09-09	2003-10-28	Pentech Pharmaceuticals, Inc.	Amorphous paroxetine composition
US5910319A (en) *	1997-05-29	1999-06-08	Eli Lilly And Company	Fluoxetine enteric pellets and methods for their preparation and use
KR100543614B1 (ko)	1997-06-10	2006-01-20	신톤 비.브이.	4-페닐피페리딘 화합물
US5955475A (en) *	1997-06-30	1999-09-21	Endo Pharmaceuticals Inc.	Process for manufacturing paroxetine solid dispersions
SK180499A3 (en)	1997-07-01	2001-08-06	Pfizer	Sertraline salts and sustained-release dosage forms of sertraline
GB9808479D0 (en) *	1998-04-22	1998-06-17	Smithkline Beecham Plc	Method of treatment
CH689805A8 (fr) *	1998-07-02	2000-02-29	Smithkline Beecham Plc	Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
US6139875A (en) *	1998-09-29	2000-10-31	Eastman Chemical Company	Aqueous enteric coating composition and low gastric permeability enteric coating
WO2000054775A1 (de)	1999-03-12	2000-09-21	Basf Ag	Stabile pharmazeutische anwendungsform für paroxetin-anhydrat
IE990406A1 (en)	1999-05-20	2000-12-27	Elan Corp Plc	Multiparticulate controlled release selective serotonin reuptake inhibitor formulations.
ES2290027T3 (es) *	1999-05-20	2008-02-16	Elan Corporation, Plc	Formulaciones multiparticuladas y de liberacion controlada de inhibidores selectivos de la recaptacion de serotonina.
ES2159260B1 (es) *	1999-06-22	2002-05-01	Smithkline Beechan Plc	Nueva composicion de metanosulfonato de paroxetina
WO2000078290A2 (en) *	1999-06-22	2000-12-28	Smithkline Beecham P.L.C.	Pharmaceutical composition comprising a salt of paroxetine
ES2162560B1 (es) *	1999-06-25	2002-07-16	Rodriguez Concepcion Pena	Uso de fluoxetina, paroxetina y otros isrs para la fabricacion de medicamentos con el fin de aumentar la capacidad de abstenerse de substancias o actividades que crean dependencia.
AR030557A1 (es) *	2000-04-14	2003-08-27	Jagotec Ag	Una tableta en multicapa de liberacion controlada y metodo de tratamiento
US6482440B2 (en) *	2000-09-21	2002-11-19	Phase 2 Discovery, Inc.	Long acting antidepressant microparticles
WO2003013480A1 (en) *	2001-08-06	2003-02-20	Dr. Reddy's Laboratories Ltd.	Improved enteric formulation of fluoxetin
GB2392385A (en) *	2002-09-02	2004-03-03	Cipla Ltd	Pharmaceutical preparations comprising a 5HT uptake inhibitor and a homopolymer or copolymer of N-vinyl pyrrolidone
US20050095292A1 (en)	2003-10-29	2005-05-05	Wyeth	Sustained release pharmaceutical compositions
WO2005079756A2 (en) *	2004-02-13	2005-09-01	Neuromolecular, Inc.	Combination of a nmda receptor antagonist and an anti-depressive drug mao-inhibitor or a gadph-inhibitor for the treatment of psychiatric conditions
WO2005107716A1 (en) *	2004-03-25	2005-11-17	Cadila Healthcare Limited	Controlled release paroxetine-containing tablets based on a core and a coating
WO2007015270A2 (en) *	2005-08-02	2007-02-08	Lupin Limited	Novel controlled release compositions of selective serotonin reuptake inhibitors
KR100591142B1 (ko) *	2005-11-04	2006-06-20	지엘팜텍 주식회사	파록세틴을 활성물질로 함유하는 장용성 서방형 정제
US20090130206A1 (en) *	2006-05-09	2009-05-21	Umesh Nandkumar Khatavkar	Controlled Release Compositions of an Antidepressant Agent
KR100885029B1 (ko) *	2007-02-07	2009-02-23	지엘팜텍 주식회사	경구투여용 서방성 삼중정제
WO2009006299A2 (en) *	2007-06-29	2009-01-08	Dr. Reddy's Laboratories Ltd.	Multi-particulate systems
AU2008299921B2 (en)	2007-09-13	2012-03-01	Concert Pharmaceuticals, Inc.	Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof
TW201010743A (en) *	2008-09-05	2010-03-16	Otsuka Pharma Co Ltd	Pharmaceutical solid preparation
JP2013502446A (ja) *	2009-08-24	2013-01-24	ハー・ルンドベック・アクチエゼルスカベット	１−［２−（２，４−ジメチル−フェニルスルファニル）−フェニル］ピペラジンの新規組成物
CN103371982A (zh) *	2012-04-20	2013-10-30	王进京	盐酸帕罗西汀肠溶控释片新型处方组成及制备方法
CN104411368A (zh) *	2012-07-09	2015-03-11	荷兰联合利华有限公司	光防护性个人护理组合物
CN103550182B (zh) *	2013-10-29	2015-04-08	吉林省东盟制药有限公司	一种肠溶缓释组合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8626936D0 (en) *	1986-11-11	1986-12-10	Ferrosan As	Treatment
MC2025A1 (fr) *	1988-04-20	1990-04-25	Asta Pharma Ag	Medicament contenant de l'azelastine et capable de liberer celle-ci de facon controlee
IT1237904B (it) *	1989-12-14	1993-06-18	Ubaldo Conte	Compresse a rilascio a velocita' controllata delle sostanze attive
JPH0436237A (ja) *	1990-06-01	1992-02-06	Taiho Yakuhin Kogyo Kk	抗腫瘍性複合製剤
DK0497956T3 (da) *	1990-08-21	1996-08-12	Theratech Inc	Præparater med reguleret frigivelse
WO1992009281A2 (en) *	1990-11-24	1992-06-11	Beecham Group Plc	Use of paroxetine for the treatment of senile dementia, bulimia, migraine or anorexia
WO1992019241A1 (en) *	1991-05-07	1992-11-12	Dynagen, Inc.	A controlled, sustained release delivery system for smoking cessation
JPH05139964A (ja) *	1991-11-14	1993-06-08	Takada Seiyaku Kk	塩酸メキシレチン腸溶性製剤
PT654263E (pt) *	1993-11-23	2002-06-28	Euro Celtique Sa	Metodo para a preparacao de uma composicao de libertyacao prolongada
IT1274241B (it) *	1993-12-03	1997-07-15	Smithkline Beecham Farma	Complessi agente terapeutico/matrice polimerica dotati di migliorate caratteristiche di sapore e composizioni farmaceutiche che li contengono
CA2143070C (en) *	1994-02-22	2001-12-18	Pankaj Modi	Oral controlled release liquid suspension pharmaceutical formulation
GB9422154D0 (en) *	1994-11-03	1994-12-21	Euro Celtique Sa	Pharmaceutical compositions and method of producing the same
WO1996031197A1 (en) *	1995-04-03	1996-10-10	Abbott Laboratories	Homogeneous mixtures of low temperature-melting drugs and additives for controlled release

1995
- 1995-07-20 GB GBGB9514842.5A patent/GB9514842D0/en active Pending
1996
- 1996-07-17 DZ DZ960118A patent/DZ2074A1/fr active
- 1996-07-18 AR ARP960103639A patent/AR003463A1/es not_active Application Discontinuation
- 1996-07-18 EG EG68296A patent/EG23934A/xx active
- 1996-07-18 MY MYPI96002956A patent/MY141373A/en unknown
- 1996-07-18 MA MA24317A patent/MA23942A1/fr unknown
- 1996-07-19 CA CA002445678A patent/CA2445678C/en not_active Expired - Lifetime
- 1996-07-19 CZ CZ1998183A patent/CZ294110B6/cs not_active IP Right Cessation
- 1996-07-19 UY UY24288A patent/UY24288A1/es not_active IP Right Cessation
- 1996-07-19 SK SK53-98A patent/SK284117B6/sk not_active IP Right Cessation
- 1996-07-19 CN CN96196819A patent/CN1117567C/zh not_active Expired - Lifetime
- 1996-07-19 CN CNB031490468A patent/CN1282456C/zh not_active Expired - Lifetime
- 1996-07-19 JP JP50632597A patent/JP3922392B2/ja not_active Expired - Lifetime
- 1996-07-19 TR TR1998/00077T patent/TR199800077T1/xx unknown
- 1996-07-19 DK DK96926388T patent/DK0839039T4/da active
- 1996-07-19 RO RO98-00082A patent/RO119119B1/ro unknown
- 1996-07-19 EA EA199800140A patent/EA003775B1/ru not_active IP Right Cessation
- 1996-07-19 UA UA98010283A patent/UA68328C2/uk unknown
- 1996-07-19 KR KR10-1998-0700380A patent/KR100468351B1/ko not_active Expired - Lifetime
- 1996-07-19 PT PT96926388T patent/PT839039E/pt unknown
- 1996-07-19 TW TW085108758A patent/TW464513B/zh not_active IP Right Cessation
- 1996-07-19 EP EP03078259A patent/EP1382337A1/de not_active Withdrawn
- 1996-07-19 ZA ZA9606148A patent/ZA966148B/xx unknown
- 1996-07-19 ES ES96926388T patent/ES2208757T5/es not_active Expired - Lifetime
- 1996-07-19 AT AT96926388T patent/ATE253361T1/de active
- 1996-07-19 EA EA200100022A patent/EA003508B1/ru not_active IP Right Cessation
- 1996-07-19 IL IL12294096A patent/IL122940A0/xx not_active IP Right Cessation
- 1996-07-19 EP EP96926388A patent/EP0839039B2/de not_active Expired - Lifetime
- 1996-07-19 PE PE1996000548A patent/PE16098A1/es not_active IP Right Cessation
- 1996-07-19 WO PCT/EP1996/003252 patent/WO1997003670A1/en not_active Ceased
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- 1996-07-19 HU HU9900299A patent/HU228853B1/hu unknown
- 1996-07-19 PL PL96324553A patent/PL184987B1/pl unknown
- 1996-07-19 SI SI9630661T patent/SI0839039T2/sl unknown
- 1996-07-19 AP APAP/P/1998/001177A patent/AP1052A/en active
- 1996-07-19 CA CA002227298A patent/CA2227298C/en not_active Expired - Lifetime
- 1996-07-19 AU AU66591/96A patent/AU6659196A/en not_active Abandoned
- 1996-07-19 MX MX9800571A patent/MX9800571A/es active IP Right Grant
- 1996-07-19 DE DE69630603T patent/DE69630603T3/de not_active Expired - Lifetime
- 1996-07-19 NZ NZ315006A patent/NZ315006A/xx not_active IP Right Cessation
1997
- 1997-01-10 UY UY24436A patent/UY24436A1/es not_active IP Right Cessation
1998
- 1998-01-19 NO NO19980240A patent/NO315637B1/no not_active IP Right Cessation
- 1998-01-20 OA OA9800005A patent/OA10652A/en unknown
- 1998-02-17 BG BG102259A patent/BG64076B1/bg unknown
2000
- 2000-07-13 UY UY26242A patent/UY26242A1/es not_active Application Discontinuation
2004
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2006
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Also Published As

Publication number	Publication date
DZ2074A1 (fr)	2002-07-22
KR19990029076A (ko)	1999-04-15
UY26242A1 (es)	2001-01-31
MA23942A1 (fr)	1997-04-01
HUP9900299A3 (en)	1999-11-29
JP2006265258A (ja)	2006-10-05
SK5398A3 (en)	1998-07-08
CA2445678A1 (en)	1997-02-06
UA68328C2 (en)	2004-08-16
PE16098A1 (es)	1998-04-16
CZ18398A3 (cs)	1998-06-17
EA199800140A1 (ru)	1998-10-29
CA2227298C (en)	2003-12-09
UY24436A1 (es)	2001-08-27
ATE253361T1 (de)	2003-11-15
TR199800077T1 (xx)	1998-05-21
DE69630603T2 (de)	2004-09-23
HUP9900299A2 (hu)	1999-09-28
EP0839039B2 (de)	2007-06-06
SI0839039T1 (en)	2004-04-30
EA003508B1 (ru)	2003-06-26
PL324553A1 (en)	1998-06-08
EP1382337A1 (de)	2004-01-21
EA003775B1 (ru)	2003-08-28
JPH11509539A (ja)	1999-08-24
AP1052A (en)	2002-03-21
DK0839039T4 (da)	2007-10-08
KR100468351B1 (ko)	2005-03-16
CA2227298A1 (en)	1997-02-06
IL122940A0 (en)	1998-08-16
CA2445678C (en)	2009-11-24
CZ294110B6 (cs)	2004-10-13
ES2208757T5 (es)	2007-12-16
CN1195986A (zh)	1998-10-14
UY24288A1 (es)	1997-01-16
NZ315006A (en)	2000-01-28
GB9514842D0 (en)	1995-09-20
HK1010494A1 (en)	1999-06-25
PL184987B1 (pl)	2003-01-31
CN1515257A (zh)	2004-07-28
TW464513B (en)	2001-11-21
ES2208757T3 (es)	2004-06-16
EA200100022A1 (ru)	2001-06-25
DK0839039T3 (da)	2004-03-08
ZA966148B (en)	1998-01-19
PT839039E (pt)	2004-03-31
SI0839039T2 (sl)	2007-10-31
EP0839039A1 (de)	1998-05-06
NO315637B1 (no)	2003-10-06
NO980240D0 (no)	1998-01-19
DE69630603D1 (de)	2003-12-11
JP3922392B2 (ja)	2007-05-30
CY2408B1 (en)	2004-09-10
EG23934A (en)	2008-01-14
AU6659196A (en)	1997-02-18
AR003463A1 (es)	1998-08-05
BR9609857A (pt)	1999-03-16
BG102259A (en)	1998-09-30
RO119119B1 (ro)	2004-04-30
AP9801177A0 (en)	1998-01-31
MX9800571A (es)	1998-04-30
NO980240L (no)	1998-01-20
BG64076B1 (bg)	2003-12-31
WO1997003670A1 (en)	1997-02-06
HU228853B1 (en)	2013-06-28
CN1117567C (zh)	2003-08-13
DE69630603T3 (de)	2008-01-03
CN1282456C (zh)	2006-11-01
MY141373A (en)	2010-04-16
SK284117B6 (sk)	2004-09-08
EP0839039B1 (de)	2003-11-05

Publication	Publication Date	Title
US6548084B2 (en)	2003-04-15	Controlled release compositions
CA2445678C (en)	2009-11-24	Paroxetine controlled release compositions
US6300343B1 (en)	2001-10-09	Method of treatment
AU748804B2 (en)	2002-06-13	Paroxetine controlled release compositions
AU2006274565B2 (en)	2012-05-17	Novel controlled release compositions of selective serotonin reuptake inhibitors
US9138430B2 (en)	2015-09-22	Formulation and method for the release of paroxetine in the large intestine
HK1010494C (en)	2004-10-15	Paroxetine controlled release compositions
HK1010494B (en)	2004-10-15	Paroxetine controlled release compositions
HK1063006A (en)	2004-12-10	Novel formulation containing paroxetine
AU740749B2 (en)	2001-11-15	Method of treatment
SA96170336B1 (ar)	2006-03-06	تراكيب مضبوطة الاطلاق controlled release