OA12150A - Hydroxylation of compactin to pravastatin by micromonospora. - Google Patents

Hydroxylation of compactin to pravastatin by micromonospora. Download PDF

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Publication number
OA12150A
OA12150A OA1200200015A OA1200200015A OA12150A OA 12150 A OA12150 A OA 12150A OA 1200200015 A OA1200200015 A OA 1200200015A OA 1200200015 A OA1200200015 A OA 1200200015A OA 12150 A OA12150 A OA 12150A
Authority
OA
OAPI
Prior art keywords
compound
strain
formula
micromonospora
pravastatin
Prior art date
Application number
OA1200200015A
Other languages
English (en)
Inventor
Gyula Horvath
Iidiko Horvath
Eva Ilkoy
Antonia Jekkel
Attila Konya
Julia Mozes
Zsuzsanna Nagy
Janos Salat
Gyorgy Somogyi
Istvan Mihaly Szabo
Gabor Ambrus
Istvan Barta
Sandor Boros
Original Assignee
Ivax Drug Res Inst Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Drug Res Inst Ltd filed Critical Ivax Drug Res Inst Ltd
Publication of OA12150A publication Critical patent/OA12150A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/29—Micromonospora

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
OA1200200015A 1999-07-12 2000-06-29 Hydroxylation of compactin to pravastatin by micromonospora. OA12150A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9902352A HUP9902352A1 (hu) 1999-07-12 1999-07-12 Eljárás pravasztatin mikrobiológiai előállítására

Publications (1)

Publication Number Publication Date
OA12150A true OA12150A (en) 2006-05-05

Family

ID=89998701

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200200015A OA12150A (en) 1999-07-12 2000-06-29 Hydroxylation of compactin to pravastatin by micromonospora.

Country Status (32)

Country Link
US (2) US6905851B1 (is)
EP (3) EP1190087B1 (is)
JP (2) JP4531315B2 (is)
KR (2) KR100479837B1 (is)
CN (2) CN1590555A (is)
AP (1) AP1405A (is)
AT (1) ATE243262T1 (is)
AU (2) AU773633B2 (is)
BG (1) BG65109B1 (is)
BR (1) BR0013156A (is)
CA (2) CA2379015A1 (is)
CZ (2) CZ297009B6 (is)
DE (1) DE60003424T2 (is)
DK (1) DK1190087T3 (is)
ES (1) ES2200891T3 (is)
HR (1) HRP20020028B1 (is)
HU (1) HUP9902352A1 (is)
IL (2) IL147583A0 (is)
IS (1) IS2138B (is)
MX (1) MXPA02000356A (is)
NO (1) NO20020119L (is)
NZ (1) NZ516563A (is)
OA (1) OA12150A (is)
PL (2) PL353493A1 (is)
PT (1) PT1190087E (is)
RU (2) RU2235780C2 (is)
SK (2) SK285726B6 (is)
TR (1) TR200200726T2 (is)
UA (1) UA67854C2 (is)
WO (2) WO2001004340A1 (is)
YU (1) YU2002A (is)
ZA (1) ZA200200273B (is)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9800046A (sl) 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
RU2002114072A (ru) 1999-11-30 2004-07-20 Биогал Джиоджисзерджиар РТ (HU) Способ выделения соединений статина из ферментационного бульона
CA2394200C (en) 1999-12-14 2006-10-03 Biogal Gyogyszergyar Rt. Novel forms of pravastatin sodium
IL155194A0 (en) * 2000-10-05 2003-11-23 Biogal Pharmaceutical Co Ltd Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
JP3236282B1 (ja) * 2000-10-16 2001-12-10 三共株式会社 プラバスタチンを精製する方法
AU2002235885A1 (en) * 2001-02-09 2002-08-28 Unilever N.V. Process for the preparation of one or more statins by fermentation
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
US6716615B2 (en) 2002-02-27 2004-04-06 Yung Shin Pharmaceutical Ind. Co., Ltd. Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase
JP3422791B2 (ja) 2002-08-06 2003-06-30 三共株式会社 プラバスタチンの単離・精製方法
EP1452602A1 (en) * 2003-02-25 2004-09-01 Antibiotic Co., Method for production of pravastatin by fermentation
CN1244688C (zh) * 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
DE202004020671U1 (de) 2003-11-24 2005-12-08 Teva Gyogyszergyar Reszvenytarsasag Pravastatin
WO2009113099A2 (en) * 2008-02-06 2009-09-17 Biocon Limited Fermentation medias and processes thereof
RU2522806C1 (ru) * 2012-11-27 2014-07-20 Федеральное государственное бюджетное учреждение науки Центр "Биоинженерия" Российской академии наук Усовершенствованный способ очистки правастатина
JP6441599B2 (ja) * 2014-07-14 2018-12-19 合同酒精株式会社 プラバスタチンの製造法
GB2574048B (en) 2018-05-24 2021-06-16 Oxford Nanopore Tech Ltd Nanopore sensor component with electrostatic discharge protection
CN114031496B (zh) * 2021-11-30 2024-09-27 广东蓝宝制药有限公司 一种高纯度普伐他汀1,1,3,3-四甲基丁胺的制备方法
CN114133331A (zh) * 2021-12-10 2022-03-04 广东蓝宝制药有限公司 一种回收获得高纯度普伐他汀酯的方法
CN116694497B (zh) * 2022-12-25 2024-10-18 塔里木大学 一株转化甘油和甘氨酸的放线菌

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
JPS5810572A (ja) 1981-07-07 1983-01-21 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体およびその製造法
JPS5889191A (ja) 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS59175450A (ja) * 1983-03-24 1984-10-04 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体
US5179013A (en) * 1987-02-02 1993-01-12 Sankyo Company, Limited Cytochrome P-450 enzymes
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
IL108432A (en) * 1993-01-29 1997-09-30 Sankyo Co DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JPH06253853A (ja) * 1993-03-09 1994-09-13 Asahi Chem Ind Co Ltd マクロライド抗生物質生合成遺伝子を含有するｄｎａ
US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
JPH0889277A (ja) * 1994-09-28 1996-04-09 Taisho Pharmaceut Co Ltd １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法
JPH08149986A (ja) * 1994-09-28 1996-06-11 Taisho Pharmaceut Co Ltd １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法
US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
IN191580B (is) * 1999-12-17 2003-12-06 Ranbaxy Lab Ltd

Also Published As

Publication number Publication date
KR100479837B1 (ko) 2005-03-31
CZ2002119A3 (cs) 2003-02-12
UA67854C2 (en) 2004-07-15
IL147583A0 (en) 2002-08-14
EP1190087A1 (en) 2002-03-27
KR20020048927A (ko) 2002-06-24
CZ297009B6 (cs) 2006-08-16
SK492002A3 (sk) 2005-03-04
DE60003424D1 (de) 2003-07-24
US20050124051A1 (en) 2005-06-09
IS6227A (is) 2002-01-11
EP1190087B1 (en) 2003-06-18
US6905851B1 (en) 2005-06-14
RU2004114667A (ru) 2005-10-27
ATE243262T1 (de) 2003-07-15
BR0013156A (pt) 2002-04-02
RU2235780C2 (ru) 2004-09-10
HRP20020028A2 (en) 2003-06-30
HRP20020028B1 (en) 2005-04-30
NO20020119D0 (no) 2002-01-10
HUP9902352A1 (hu) 2000-09-28
DE60003424T2 (de) 2004-05-19
TR200200726T2 (tr) 2002-06-21
CA2373544A1 (en) 2001-01-18
PL353493A1 (en) 2003-11-17
JP4531315B2 (ja) 2010-08-25
DK1190087T3 (da) 2003-10-13
WO2001003647A3 (en) 2001-06-28
CN1590555A (zh) 2005-03-09
WO2001004340A1 (en) 2001-01-18
NO20020119L (no) 2002-02-21
MXPA02000356A (es) 2005-06-06
PT1190087E (pt) 2003-10-31
EP1198448A2 (en) 2002-04-24
WO2001003647A2 (en) 2001-01-18
JP2003504071A (ja) 2003-02-04
AP2002002404A0 (en) 2002-03-31
CN1399686A (zh) 2003-02-26
BG65109B1 (bg) 2007-02-28
BG106302A (en) 2002-10-31
AU773633B2 (en) 2004-05-27
CA2379015A1 (en) 2001-01-18
CZ2002127A3 (cs) 2003-06-18
ES2200891T3 (es) 2004-03-16
ZA200200273B (en) 2003-06-25
IL147588A0 (en) 2002-08-14
SK285726B6 (sk) 2007-07-06
IS2138B (is) 2006-08-15
AP1405A (en) 2005-04-28
EP1327689A1 (en) 2003-07-16
JP2003528576A (ja) 2003-09-30
YU2002A (sh) 2004-12-31
KR20020060150A (ko) 2002-07-16
PL364872A1 (en) 2004-12-27
SK612002A3 (en) 2002-12-03
EP1198448A4 (en) 2003-05-28
AU6349200A (en) 2001-01-30
AU5835500A (en) 2001-01-30
NZ516563A (en) 2002-11-26
HU9902352D0 (en) 1999-09-28

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