PH26542A - Use of X-phenyl-1,2,3,4-tetrahydro-1-naphthaleneamine derivatives in the treatment of psychosis inflammation and as immunosuppressants - Google Patents

Use of X-phenyl-1,2,3,4-tetrahydro-1-naphthaleneamine derivatives in the treatment of psychosis inflammation and as immunosuppressants Download PDF

Info

Publication number: PH26542A
Authority: PH; Philippines
Prior art keywords: tetrahydro; compound; cis; naphthalenamine; dichlorophenyl
Prior art date: 1989-03-07

Application number

PH40157A

Other languages

English (en)

Inventor

Billie Kenneth Koe

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-07

Filing date

1990-03-07

Publication date

1992-08-19

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23244506&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH26542(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-03-07 Application filed by Pfizer filed Critical Pfizer

1992-08-19 Publication of PH26542A publication Critical patent/PH26542A/en

Links

208000028017 Psychotic disease Diseases 0.000 title claims description 8
206010061218 Inflammation Diseases 0.000 title abstract description 5
230000004054 inflammatory process Effects 0.000 title abstract description 5
229960003444 immunosuppressant agent Drugs 0.000 title description 5
239000003018 immunosuppressive agent Substances 0.000 title description 5
150000001875 compounds Chemical class 0.000 claims description 31
238000000034 method Methods 0.000 claims description 16
150000003839 salts Chemical class 0.000 claims description 12
229910052739 hydrogen Inorganic materials 0.000 claims description 8
239000001257 hydrogen Substances 0.000 claims description 8
125000001309 chloro group Chemical group Cl* 0.000 claims description 7
239000002253 acid Substances 0.000 claims description 6
125000001246 bromo group Chemical group Br* 0.000 claims description 6
241000124008 Mammalia Species 0.000 claims description 5
DYLIWHYUXAJDOJ-OWOJBTEDSA-N (e)-4-(6-aminopurin-9-yl)but-2-en-1-ol Chemical compound NC1=NC=NC2=C1N=CN2C\C=C\CO DYLIWHYUXAJDOJ-OWOJBTEDSA-N 0.000 claims description 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
125000003545 alkoxy group Chemical group 0.000 claims description 4
230000000561 anti-psychotic effect Effects 0.000 claims description 4
125000001153 fluoro group Chemical group F* 0.000 claims description 4
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 4
JRZGPXSSNPTNMA-UHFFFAOYSA-N 1,2,3,4-tetrahydronaphthalen-1-amine Chemical compound C1=CC=C2C(N)CCCC2=C1 JRZGPXSSNPTNMA-UHFFFAOYSA-N 0.000 claims description 3
125000000217 alkyl group Chemical group 0.000 claims description 3
125000004432 carbon atom Chemical group C* 0.000 claims description 3
125000004093 cyano group Chemical group *C#N 0.000 claims description 2
150000002431 hydrogen Chemical class 0.000 claims 2
LTKRQOGLVNJKBK-FVRDMJKUSA-N (4s)-4-(3,4-dichlorophenyl)-n,n-dimethyl-1,2,3,4-tetrahydronaphthalen-1-amine Chemical compound C1([C@@H]2CCC(C3=CC=CC=C32)N(C)C)=CC=C(Cl)C(Cl)=C1 LTKRQOGLVNJKBK-FVRDMJKUSA-N 0.000 claims 1
IWNWWVPLTTUPBQ-UHFFFAOYSA-N 4-phenyl-1,2,3,4-tetrahydronaphthalen-1-amine Chemical class C12=CC=CC=C2C(N)CCC1C1=CC=CC=C1 IWNWWVPLTTUPBQ-UHFFFAOYSA-N 0.000 abstract description 3
HTSNFXAICLXZMA-UHFFFAOYSA-N 3-(1-propyl-3-piperidinyl)phenol Chemical compound C1N(CCC)CCCC1C1=CC=CC(O)=C1 HTSNFXAICLXZMA-UHFFFAOYSA-N 0.000 description 11
230000027455 binding Effects 0.000 description 11
239000000872 buffer Substances 0.000 description 6
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 5
230000005764 inhibitory process Effects 0.000 description 5
238000001727 in vivo Methods 0.000 description 4
239000000203 mixture Substances 0.000 description 4
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230000003110 anti-inflammatory effect Effects 0.000 description 3
210000004556 brain Anatomy 0.000 description 3
230000000694 effects Effects 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
230000001506 immunosuppresive effect Effects 0.000 description 3
239000012528 membrane Substances 0.000 description 3
241000699670 Mus sp. Species 0.000 description 2
239000000935 antidepressant agent Substances 0.000 description 2
229940005513 antidepressants Drugs 0.000 description 2
238000009395 breeding Methods 0.000 description 2
230000001488 breeding effect Effects 0.000 description 2
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
239000003814 drug Substances 0.000 description 2
125000004435 hydrogen atom Chemical class [H]* 0.000 description 2
238000000338 in vitro Methods 0.000 description 2
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238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
239000007788 liquid Substances 0.000 description 2
239000000546 pharmaceutical excipient Substances 0.000 description 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000002287 radioligand Substances 0.000 description 2
108020003175 receptors Proteins 0.000 description 2
102000005962 receptors Human genes 0.000 description 2
108010085082 sigma receptors Proteins 0.000 description 2
125000001424 substituent group Chemical group 0.000 description 2
SBRLSQHYWNDGMV-NSHDSACASA-N (4s)-4-(3,4-dichlorophenyl)-3,4-dihydro-2h-naphthalene-1,1-diamine Chemical compound C1([C@@H]2CCC(C3=CC=CC=C32)(N)N)=CC=C(Cl)C(Cl)=C1 SBRLSQHYWNDGMV-NSHDSACASA-N 0.000 description 1
208000019901 Anxiety disease Diseases 0.000 description 1
208000023275 Autoimmune disease Diseases 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
206010014557 Emotional poverty Diseases 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
229920002873 Polyethylenimine Polymers 0.000 description 1
201000004681 Psoriasis Diseases 0.000 description 1
241000700159 Rattus Species 0.000 description 1
206010041243 Social avoidant behaviour Diseases 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
239000000443 aerosol Substances 0.000 description 1
230000016571 aggressive behavior Effects 0.000 description 1
238000013019 agitation Methods 0.000 description 1
230000036506 anxiety Effects 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
206010003246 arthritis Diseases 0.000 description 1
125000004429 atom Chemical group 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
210000005013 brain tissue Anatomy 0.000 description 1
239000002775 capsule Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
239000003086 colorant Substances 0.000 description 1
125000004188 dichlorophenyl group Chemical group 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
230000035622 drinking Effects 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
239000003365 glass fiber Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
208000027866 inflammatory disease Diseases 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
238000002372 labelling Methods 0.000 description 1
239000008101 lactose Substances 0.000 description 1
206010025135 lupus erythematosus Diseases 0.000 description 1
230000010807 negative regulation of binding Effects 0.000 description 1
239000008188 pellet Substances 0.000 description 1
VOKSWYLNZZRQPF-GDIGMMSISA-N pentazocine Chemical compound C1C2=CC=C(O)C=C2[C@@]2(C)[C@@H](C)[C@@H]1N(CC=C(C)C)CC2 VOKSWYLNZZRQPF-GDIGMMSISA-N 0.000 description 1
229960005301 pentazocine Drugs 0.000 description 1
238000003359 percent control normalization Methods 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
230000029058 respiratory gaseous exchange Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
206010039073 rheumatoid arthritis Diseases 0.000 description 1
230000000698 schizophrenic effect Effects 0.000 description 1
239000000243 solution Substances 0.000 description 1
241000894007 species Species 0.000 description 1
238000012453 sprague-dawley rat model Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Transplantation (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PH40157A 1989-03-07 1990-03-07 Use of X-phenyl-1,2,3,4-tetrahydro-1-naphthaleneamine derivatives in the treatment of psychosis inflammation and as immunosuppressants PH26542A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/320,014 US4981870A (en)	1989-03-07	1989-03-07	Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation and as immunosuppressants

Publications (1)

Publication Number	Publication Date
PH26542A true PH26542A (en)	1992-08-19

Family

ID=23244506

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH40157A PH26542A (en)	1989-03-07	1990-03-07	Use of X-phenyl-1,2,3,4-tetrahydro-1-naphthaleneamine derivatives in the treatment of psychosis inflammation and as immunosuppressants

Country Status (17)

Country	Link
US (2)	US4981870A (fr)
EP (1)	EP0386997B1 (fr)
JP (2)	JPH0714870B2 (fr)
KR (1)	KR920005810B1 (fr)
AT (1)	ATE150299T1 (fr)
AU (1)	AU610036B2 (fr)
CA (1)	CA2011428C (fr)
DE (1)	DE69030212T2 (fr)
DK (1)	DK0386997T3 (fr)
HU (1)	HU221624B1 (fr)
IE (1)	IE81047B1 (fr)
IL (1)	IL93576A (fr)
MY (1)	MY106272A (fr)
NZ (1)	NZ232800A (fr)
PH (1)	PH26542A (fr)
PT (1)	PT93351B (fr)
ZA (1)	ZA901743B (fr)

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JP2009500425A (ja)	2005-07-06	2009-01-08	セプラコアインコーポレーテッド	エスゾピクロン及びトランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−ｎ−メチル−１−ナフタレンアミン又はトランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−１−ナフタレンアミンの組み合わせ、並びに閉経期並びに気分、不安、及び認知障害の治療方法
EP1940389A2 (fr)	2005-10-21	2008-07-09	Braincells, Inc.	Modulation de la neurogenese par inhibition de la pde
AU2006308889A1 (en)	2005-10-31	2007-05-10	Braincells, Inc.	GABA receptor mediated modulation of neurogenesis
BRPI0706365A2 (pt)	2006-01-06	2011-03-22	Sepracor Inc	Cicloalquilaminas como inibidores da recaptação de monoamina
NZ569608A (en) *	2006-01-06	2011-09-30	Sepracor Inc	Tetralone-based monoamine reuptake inhibitors
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
DK2816024T3 (en)	2006-03-31	2017-10-30	Sunovion Pharmaceuticals Inc	CHIRALE AMINER
JP2009536667A (ja)	2006-05-09	2009-10-15	ブレインセルス，インコーポレイティド	５ｈｔ受容体介在性の神経新生
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AU2007254751A1 (en) *	2006-05-31	2007-12-13	Sepracor Inc.	Treatment of pain disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine and its formamide
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US7884124B2 (en) *	2006-06-30	2011-02-08	Sepracor Inc.	Fluoro-substituted inhibitors of D-amino acid oxidase
AU2007292848A1 (en)	2006-09-08	2008-03-13	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
EP2063905B1 (fr)	2006-09-18	2014-07-30	Raptor Pharmaceutical Inc	Traitement des troubles hépatiques par l'administration de conjugués de protéine associée au récepteur (rap)
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
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US20090099248A1 (en) *	2007-01-18	2009-04-16	Sepracor Inc.	Inhibitors of d-amino acid oxidase
US7902252B2 (en) *	2007-01-18	2011-03-08	Sepracor, Inc.	Inhibitors of D-amino acid oxidase
AU2008259841B2 (en)	2007-05-31	2015-02-05	Sunovion Pharmaceuticals Inc.	Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
WO2010017418A1 (fr) *	2008-08-07	2010-02-11	Sepracor Inc.	Promédicaments d'inhibiteurs hétérocycliques fusionnés de la d-amino acide oxydase
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KR101909711B1 (ko)	2009-05-06	2018-12-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
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US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
JP6433482B2 (ja)	2013-03-15	2018-12-05	エージンバイオ，インコーポレイテッド	認知機能を改善するための方法および組成物
WO2014144663A1 (fr)	2013-03-15	2014-09-18	The Johns Hopkins University	Procédés et compositions pour améliorer la fonction cognitive
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US20170266133A1 (en) *	2014-05-13	2017-09-21	Sunovion Pharmaceuticals Inc.	Methods and compositions of dasotraline for treatment of adhd
WO2016046669A2 (fr) *	2014-09-27	2016-03-31	Mohan M Alapati	Compositions et méthodes de traitement de la dépression et de maladies neurologiques
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GB1420472A (en) *	1972-09-27	1976-01-07	Pfizer	Aminophenyltetralin compounds
US4536518A (en) *	1979-11-01	1985-08-20	Pfizer Inc.	Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
JPS59497B2 (ja) *	1979-11-01	1984-01-07	フアイザ−・インコ−ポレ−テツド	トランス−４−フエニル−１，２，３，４−テトラヒドロ−１−ナフタレンアミンの抗抑うつ性誘導体
US4792448A (en) *	1987-06-11	1988-12-20	Pfizer Inc.	Generic zero order controlled drug delivery system
US4981870A (en) *	1989-03-07	1991-01-01	Pfizer Inc.	Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation and as immunosuppressants

1989
- 1989-03-07 US US07/320,014 patent/US4981870A/en not_active Expired - Lifetime
1990
- 1990-02-28 IL IL9357690A patent/IL93576A/en not_active IP Right Cessation
- 1990-03-05 CA CA002011428A patent/CA2011428C/fr not_active Expired - Fee Related
- 1990-03-05 MY MYPI90000347A patent/MY106272A/en unknown
- 1990-03-06 PT PT93351A patent/PT93351B/pt not_active IP Right Cessation
- 1990-03-06 EP EP90302365A patent/EP0386997B1/fr not_active Expired - Lifetime
- 1990-03-06 DE DE69030212T patent/DE69030212T2/de not_active Expired - Fee Related
- 1990-03-06 NZ NZ232800A patent/NZ232800A/en unknown
- 1990-03-06 JP JP2054802A patent/JPH0714870B2/ja not_active Expired - Fee Related
- 1990-03-06 AU AU50796/90A patent/AU610036B2/en not_active Ceased
- 1990-03-06 KR KR1019900002912A patent/KR920005810B1/ko not_active Expired
- 1990-03-06 AT AT90302365T patent/ATE150299T1/de not_active IP Right Cessation
- 1990-03-06 DK DK90302365.3T patent/DK0386997T3/da active
- 1990-03-06 HU HU9001325A patent/HU221624B1/hu not_active IP Right Cessation
- 1990-03-07 IE IE79890A patent/IE81047B1/en not_active IP Right Cessation
- 1990-03-07 PH PH40157A patent/PH26542A/en unknown
- 1990-03-07 ZA ZA901743A patent/ZA901743B/xx unknown
- 1990-12-05 US US07/622,308 patent/US5061728A/en not_active Expired - Lifetime
1994
- 1994-07-25 JP JP6172929A patent/JP3020808B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0386997A3 (fr)	1992-04-29
AU5079690A (en)	1990-09-20
PT93351B (pt)	1996-03-29
IL93576A0 (en)	1990-11-29
MY106272A (en)	1995-04-29
CA2011428C (fr)	1994-11-08
JP3020808B2 (ja)	2000-03-15
DE69030212D1 (de)	1997-04-24
JPH07173056A (ja)	1995-07-11
PT93351A (pt)	1990-11-07
AU610036B2 (en)	1991-05-09
IE81047B1 (en)	1999-12-01
IL93576A (en)	1995-12-08
KR900013949A (ko)	1990-10-22
JPH0714870B2 (ja)	1995-02-22
ATE150299T1 (de)	1997-04-15
ZA901743B (en)	1991-10-30
US5061728A (en)	1991-10-29
JPH02300121A (ja)	1990-12-12
HUT59000A (en)	1992-04-28
IE900798L (en)	1990-09-07
DE69030212T2 (de)	1997-06-26
KR920005810B1 (ko)	1992-07-20
US4981870A (en)	1991-01-01
NZ232800A (en)	1997-07-27
EP0386997A2 (fr)	1990-09-12
HU901325D0 (en)	1990-05-28
DK0386997T3 (da)	1997-04-14
EP0386997B1 (fr)	1997-03-19
CA2011428A1 (fr)	1990-09-07
HU221624B1 (hu)	2002-12-28

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US4981870A (en)	1991-01-01	Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation and as immunosuppressants
DE69233462T2 (de)	2006-02-16	Zusammensetzung die Tramadol und ein nichtsteroides entzündungshemmenden Mittel enthält
AU670232B2 (en)	1996-07-11	Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers
JPH03500897A (ja)	1991-02-28	精神分裂病治療用組成物
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CA2138998A1 (fr)	1994-01-06	Compositions et methodes de traitement de la depression et d'autres troubles, qui contiennent de la sibutramine optiquement pure (-)
CA1228818A (fr)	1987-11-03	Traitement de l'epilepsie et composes pharmaceutiques utilises a cette fin
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