PL1981858T3 - 3,5-di(arylo albo heteroarylo) izoksazole oraz 1,2,4-oksadiazole jako agoniści receptora S1P1, środki immunosupresyjne i przeciwzapalne - Google Patents

3,5-di(arylo albo heteroarylo) izoksazole oraz 1,2,4-oksadiazole jako agoniści receptora S1P1, środki immunosupresyjne i przeciwzapalne

Info

Publication number: PL1981858T3
Authority: PL; Poland
Prior art keywords: immunosuppresssive; isoxazoles; oxadiazoles; heteroaryl; aryl
Prior art date: 2006-01-27

Application number

PL07703028T

Other languages

English (en)

Other versions

PL1981858T4 (pl

Inventor

Rainer Albert

Frédéric Zecri

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-01-27

Filing date

2007-01-25

Publication date

2010-12-31

2007-01-25 Application filed by Novartis Ag filed Critical Novartis Ag

2010-12-31 Publication of PL1981858T3 publication Critical patent/PL1981858T3/pl

2010-12-31 Publication of PL1981858T4 publication Critical patent/PL1981858T4/pl

Links

150000005071 1,2,4-oxadiazoles Chemical class 0.000 title 1
102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 title 1
108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 title 1
229940121363 anti-inflammatory agent Drugs 0.000 title 1
239000002260 anti-inflammatory agent Substances 0.000 title 1
125000003118 aryl group Chemical group 0.000 title 1
125000001072 heteroaryl group Chemical group 0.000 title 1
150000002545 isoxazoles Chemical class 0.000 title 1
239000000018 receptor agonist Substances 0.000 title 1
229940044601 receptor agonist Drugs 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000003367 polycyclic group Chemical group 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
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Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
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Diabetes (AREA)
Oncology (AREA)
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Communicable Diseases (AREA)
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Hematology (AREA)
Virology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
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Obesity (AREA)
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Transplantation (AREA)
AIDS & HIV (AREA)
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Molecular Biology (AREA)

PL07703028T 2006-01-27 2007-01-25 3,5-di(arylo albo heteroarylo) izoksazole oraz 1,2,4-oksadiazole jako agoniści receptora S1P1, środki immunosupresyjne i przeciwzapalne PL1981858T4 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0601744.6A GB0601744D0 (en)	2006-01-27	2006-01-27	Organic compounds
PCT/EP2007/000638 WO2007085451A2 (en)	2006-01-27	2007-01-25	3,5-di (aryl or heteroaryl) isoxazoles and 1, 2, 4-oxadiazoles as s1p1 receptor agonists, immunosuppresssive and anti -inflammatory agents
EP07703028A EP1981858B1 (en)	2006-01-27	2007-01-25	3,5-di(aryl or heteroaryl)isoxazoles and 1,2,4-oxadiazoles as s1p1 receptor agonists, immunosuppresssive and anti-inflammatory agents

Publications (2)

Publication Number	Publication Date
PL1981858T3 true PL1981858T3 (pl)	2010-12-31
PL1981858T4 PL1981858T4 (pl)	2010-12-31

Family

ID=36061049

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL07703028T PL1981858T4 (pl)	2006-01-27	2007-01-25	3,5-di(arylo albo heteroarylo) izoksazole oraz 1,2,4-oksadiazole jako agoniści receptora S1P1, środki immunosupresyjne i przeciwzapalne

Country Status (16)

Country	Link
US (1)	US7799812B2 (pl)
EP (2)	EP2233473A1 (pl)
JP (1)	JP2009524611A (pl)
KR (1)	KR20080091161A (pl)
CN (1)	CN101374821A (pl)
AT (1)	ATE471313T1 (pl)
AU (1)	AU2007209533A1 (pl)
BR (1)	BRPI0707285A2 (pl)
CA (1)	CA2637081A1 (pl)
DE (1)	DE602007007186D1 (pl)
ES (1)	ES2347015T3 (pl)
GB (1)	GB0601744D0 (pl)
PL (1)	PL1981858T4 (pl)
PT (1)	PT1981858E (pl)
RU (1)	RU2008134534A (pl)
WO (1)	WO2007085451A2 (pl)

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2006
- 2006-01-27 GB GBGB0601744.6A patent/GB0601744D0/en not_active Ceased
2007
- 2007-01-25 BR BRPI0707285-6A patent/BRPI0707285A2/pt not_active IP Right Cessation
- 2007-01-25 DE DE602007007186T patent/DE602007007186D1/de active Active
- 2007-01-25 JP JP2008551722A patent/JP2009524611A/ja active Pending
- 2007-01-25 AU AU2007209533A patent/AU2007209533A1/en not_active Abandoned
- 2007-01-25 CA CA002637081A patent/CA2637081A1/en not_active Abandoned
- 2007-01-25 AT AT07703028T patent/ATE471313T1/de active
- 2007-01-25 PT PT07703028T patent/PT1981858E/pt unknown
- 2007-01-25 WO PCT/EP2007/000638 patent/WO2007085451A2/en not_active Ceased
- 2007-01-25 US US12/162,413 patent/US7799812B2/en not_active Expired - Fee Related
- 2007-01-25 PL PL07703028T patent/PL1981858T4/pl unknown
- 2007-01-25 ES ES07703028T patent/ES2347015T3/es active Active
- 2007-01-25 CN CNA2007800036158A patent/CN101374821A/zh active Pending
- 2007-01-25 RU RU2008134534/04A patent/RU2008134534A/ru not_active Application Discontinuation
- 2007-01-25 EP EP10005624A patent/EP2233473A1/en not_active Withdrawn
- 2007-01-25 EP EP07703028A patent/EP1981858B1/en not_active Not-in-force
- 2007-01-25 KR KR1020087018321A patent/KR20080091161A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
CN101374821A (zh)	2009-02-25
EP2233473A1 (en)	2010-09-29
US20090137636A1 (en)	2009-05-28
EP1981858B1 (en)	2010-06-16
JP2009524611A (ja)	2009-07-02
WO2007085451A3 (en)	2007-12-21
WO2007085451A2 (en)	2007-08-02
CA2637081A1 (en)	2007-08-02
KR20080091161A (ko)	2008-10-09
ES2347015T3 (es)	2010-10-22
ATE471313T1 (de)	2010-07-15
PT1981858E (pt)	2010-09-07
DE602007007186D1 (de)	2010-07-29
RU2008134534A (ru)	2010-03-10
EP1981858A2 (en)	2008-10-22
US7799812B2 (en)	2010-09-21
GB0601744D0 (en)	2006-03-08
PL1981858T4 (pl)	2010-12-31
BRPI0707285A2 (pt)	2011-04-26
AU2007209533A1 (en)	2007-08-02

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