SG155251A1 - Process for production of 1-(3-(2-(1-benzothiophen-5-yl)- ethoxy)propyl)azetidin-3-ol or salts thereof - Google Patents

Process for production of 1-(3-(2-(1-benzothiophen-5-yl)- ethoxy)propyl)azetidin-3-ol or salts thereof

Info

Publication number
SG155251A1
SG155251A1 SG200905724-1A SG2009057241A SG155251A1 SG 155251 A1 SG155251 A1 SG 155251A1 SG 2009057241 A SG2009057241 A SG 2009057241A SG 155251 A1 SG155251 A1 SG 155251A1
Authority
SG
Singapore
Prior art keywords
benzothiophen
azetidin
ethoxy
propyl
salts
Prior art date
Application number
SG200905724-1A
Other languages
English (en)
Inventor
Akihito Saitoh
Yoshiaki Suzuki
Kenji Yonezawa
Mitsuhide Kawamura
Takahiko Kusanagi
Takashi Nakai
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of SG155251A1 publication Critical patent/SG155251A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG200905724-1A 2005-03-28 2006-03-27 Process for production of 1-(3-(2-(1-benzothiophen-5-yl)- ethoxy)propyl)azetidin-3-ol or salts thereof SG155251A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2005090831 2005-03-28
JP2005174738 2005-06-15
JP2005206808 2005-07-15
JP2005230666 2005-08-09

Publications (1)

Publication Number Publication Date
SG155251A1 true SG155251A1 (en) 2009-09-30

Family

ID=37053344

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200905724-1A SG155251A1 (en) 2005-03-28 2006-03-27 Process for production of 1-(3-(2-(1-benzothiophen-5-yl)- ethoxy)propyl)azetidin-3-ol or salts thereof

Country Status (22)

Country Link
US (2) US7951963B2 (pl)
EP (4) EP2348022B1 (pl)
JP (1) JP5031554B2 (pl)
KR (2) KR101337382B1 (pl)
CN (1) CN101151257B (pl)
AT (2) ATE557020T1 (pl)
AU (1) AU2006229271B2 (pl)
BR (1) BRPI0609496C8 (pl)
CA (2) CA2799659C (pl)
CY (3) CY1112956T1 (pl)
DK (2) DK2248809T3 (pl)
ES (3) ES2384312T3 (pl)
IL (2) IL186044A (pl)
MX (1) MX2007011938A (pl)
NO (3) NO340071B1 (pl)
NZ (2) NZ583580A (pl)
PL (3) PL2348022T3 (pl)
PT (3) PT2348022E (pl)
SG (1) SG155251A1 (pl)
SI (3) SI2348022T1 (pl)
WO (1) WO2006104088A1 (pl)
ZA (1) ZA200708262B (pl)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2464358C (en) 2001-10-19 2011-05-24 Toyama Chemical Co., Ltd. Alkyl ether derivatives or their salts
SI2348022T1 (sl) * 2005-03-28 2013-05-31 Toyama Chemical Co., Ltd. Postopek proizvodnje 1-(3-(2-(1-benzotiofen-5-il)etoksi)propil)azetidin-3-ola ali soli le-tega
JP4902247B2 (ja) * 2005-04-08 2012-03-21 富山化学工業株式会社 ２−（１−ベンゾチオフェン−５−イル）エタノールの新規製造法およびその中間体
USRE50453E1 (en) 2006-04-07 2025-06-10 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
JP5420395B2 (ja) 2006-04-07 2014-02-19 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｐ結合カセット輸送体の調節剤
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
ATE491705T1 (de) * 2006-08-04 2011-01-15 Toyama Chemical Co Ltd Verstärker der aktivität von proteinkinase c, enthaltend ein alkyletherderivat oder ein salz davon
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
JP5763313B2 (ja) * 2009-09-03 2015-08-12 富山化学工業株式会社 ２−（１−ベンゾチオフェン−５−イル）エタノールの製造法
JP5592205B2 (ja) * 2009-09-03 2014-09-17 富山化学工業株式会社 （１−ベンゾチオフェン−５−イル）酢酸またはその塩の製造法
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
RU2569678C2 (ru) * 2010-04-22 2015-11-27 Вертекс Фармасьютикалз Инкорпорейтед Способ получения циклоалкилкарбоксамидо-индольных соединений
JP6004307B2 (ja) * 2010-07-26 2016-10-05 富山化学工業株式会社 ３−（２−（１−ベンゾチオフェン−５−イル）エトキシ）プロピオン酸の塩またはその水和物およびその製造法
KR101927556B1 (ko) * 2011-03-02 2018-12-10 바이엘 인텔렉쳐 프로퍼티 게엠베하 아릴- 및 헤테로아릴아세트산 유도체의 제조 방법
KR20140072061A (ko) 2011-09-30 2014-06-12 니폰 가세이 가부시키가이샤 중합성 무기 입자 분산제, 그 중합성 무기 입자 분산제를 포함하는 무기 유기 복합 입자, 및 무기 유기 수지 복합재
BR112014020434B1 (pt) * 2012-02-22 2021-10-13 Fujifilm Toyama Chemical Co., Ltd. Composição farmacêutica sólida
AU2013290444B2 (en) 2012-07-16 2018-04-26 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
AU2015211753B2 (en) 2014-01-31 2019-09-12 Fujifilm Toyama Chemical Co., Ltd. Post nerve injury rehabilitation effect-enhancing agent comprising alkyl ether derivative or salt thereof
PL3925607T5 (pl) 2014-04-15 2026-06-01 Vertex Pharmaceuticals Incorporated Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa
EP3444243B1 (en) 2016-03-31 2020-09-02 FUJIFILM Toyama Chemical Co., Ltd. Method for producing 5-(bromomethyl)-1-benzothiophene

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA844616B (en) 1983-06-20 1986-02-26 Merck & Co Inc 2-sulfamoylbenzo(b)thiophene derivatives for the treatment of elevated intraocular pressure
IL72070A (en) 1983-06-20 1988-11-30 Merck & Co Inc 2-sulfamoylbenzo(b)-thiophene derivatives,their preparation and pharmaceutical compositions containing them
US4668697A (en) 1983-10-31 1987-05-26 Merck & Co., Inc. Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor
CH673100A5 (pl) 1987-08-10 1990-02-15 Josef Paul Huser
JPH04182463A (ja) 1990-11-17 1992-06-30 Sumitomo Seika Chem Co Ltd ハロゲノチオフェノール類およびその誘導体の製造方法
JPH05140086A (ja) 1991-09-26 1993-06-08 Sumitomo Seika Chem Co Ltd ハロゲノチオフエノールの製造方法および精製方法
JPH05178816A (ja) 1991-12-28 1993-07-20 Sumitomo Seika Chem Co Ltd ハロゲノチオフェノールの製造方法
JP2641363B2 (ja) 1992-04-22 1997-08-13 三共株式会社 新規なフェネチルアルコール及びその製法
GB9404775D0 (en) 1994-03-11 1994-04-27 Payne P P Ltd Improvements in or relating to article tagging
JPH08143533A (ja) 1994-11-24 1996-06-04 Sumitomo Seika Chem Co Ltd ハロチオフェノール類の製造方法
JPH1043967A (ja) 1996-08-06 1998-02-17 Calsonic Corp カシメ装置
AU6519798A (en) 1997-03-31 1998-10-22 Toyama Chemical Co. Ltd. Process for producing 2-(benzo{b}thiophen-5-yl)-2-hydroxyacetic acid derivatives, optically active compounds thereof, or salts of both
GB9706574D0 (en) 1997-04-01 1997-05-21 Zeneca Ltd Cyano substituted cycloalkanes
JPH1112238A (ja) 1997-06-23 1999-01-19 Kao Corp １−（β−ヒドロキシエチル）−２，５−ジアミノベンゼン又はその塩の製造法
JPH1143455A (ja) 1997-07-25 1999-02-16 Mitsubishi Chem Corp ハロゲン化アルコールの製造方法
WO1999031056A1 (en) 1997-12-12 1999-06-24 Toyama Chemical Co., Ltd. Alkyl ether derivatives or salts thereof and calcium antagonists containing the same
EP0993105B1 (en) 1998-10-07 2003-01-08 STMicroelectronics S.r.l. Control of power transfer in a flyback converter by modulating the off-phase in function of the load
JP4182463B2 (ja) 2000-07-19 2008-11-19 富士電機デバイステクノロジー株式会社 磁気ディスク評価装置およびその方法
WO2002100850A1 (en) 2001-06-08 2002-12-19 Kuraray Co., Ltd. Processes for preparation of heterocyclic compounds
CA2464358C (en) * 2001-10-19 2011-05-24 Toyama Chemical Co., Ltd. Alkyl ether derivatives or their salts
ZA200508166B (en) * 2003-04-17 2007-03-28 Toyama Chemical Co Ltd Preventive/remedy for retinal nerve diseases containing alkyl ether derivatives or salts thereof
JP2005012291A (ja) 2003-06-17 2005-01-13 National Institute Of Information & Communication Technology Ｔｖ会議用モバイル動画通信端末
US20050032873A1 (en) 2003-07-30 2005-02-10 Wyeth 3-Amino chroman and 2-amino tetralin derivatives
WO2005019200A2 (en) * 2003-08-14 2005-03-03 Icos Corporation Aryl piperidine derivatives as vla-1 integrin antagonists and uses thereof
SI2348022T1 (sl) * 2005-03-28 2013-05-31 Toyama Chemical Co., Ltd. Postopek proizvodnje 1-(3-(2-(1-benzotiofen-5-il)etoksi)propil)azetidin-3-ola ali soli le-tega
ES2518371T3 (es) * 2006-04-26 2014-11-05 Toyama Chemical Co., Ltd. Inductor de la neurogénesis o agente terapéutico para la neuropatía que comprende un derivado de éter alquílico o una sal del mismo

Also Published As

Publication number Publication date
CN101151257B (zh) 2012-07-18
BRPI0609496C1 (pt) 2021-05-11
WO2006104088A1 (ja) 2006-10-05
NO340366B1 (no) 2017-04-10
EP2348022B1 (en) 2013-01-09
BRPI0609496B1 (pt) 2020-11-24
SI2210884T1 (sl) 2012-06-29
EP2248809A1 (en) 2010-11-10
EP2210884B1 (en) 2012-02-22
US20110098484A1 (en) 2011-04-28
PT2348022E (pt) 2013-02-13
PL2210884T3 (pl) 2012-07-31
NO340420B1 (no) 2017-04-18
NO20161418A1 (no) 2007-10-25
BRPI0609496A2 (pt) 2011-10-18
IL214245A0 (en) 2011-08-31
AU2006229271B2 (en) 2012-02-09
AU2006229271A1 (en) 2006-10-05
IL186044A0 (en) 2008-02-09
US8273902B2 (en) 2012-09-25
DK2248809T3 (da) 2012-06-18
NO20161419A1 (no) 2016-06-07
KR101283930B1 (ko) 2013-07-16
US20090069576A1 (en) 2009-03-12
EP2210884A2 (en) 2010-07-28
PL2248809T3 (pl) 2012-10-31
IL214245A (en) 2014-12-31
ZA200708262B (en) 2009-01-28
NZ561672A (en) 2010-04-30
CN101151257A (zh) 2008-03-26
CY1113571T1 (el) 2016-06-22
IL186044A (en) 2013-12-31
JP5031554B2 (ja) 2012-09-19
KR20080008334A (ko) 2008-01-23
NO20074618L (no) 2007-10-25
EP1864978A4 (en) 2009-07-01
NO340071B1 (no) 2017-03-06
CA2799659A1 (en) 2006-10-05
SI2348022T1 (sl) 2013-05-31
KR20130010090A (ko) 2013-01-25
US7951963B2 (en) 2011-05-31
NZ583580A (en) 2010-10-29
ES2398934T3 (es) 2013-03-22
ES2384312T3 (es) 2012-07-03
JPWO2006104088A1 (ja) 2008-09-04
DK2210884T3 (da) 2012-03-26
PL2348022T3 (pl) 2013-06-28
ATE557020T1 (de) 2012-05-15
MX2007011938A (es) 2008-03-14
EP2248809B1 (en) 2012-05-09
KR101337382B1 (ko) 2013-12-06
EP2210884A3 (en) 2010-09-22
CY1112885T1 (el) 2016-04-13
CY1112956T1 (el) 2016-04-13
ES2380443T3 (es) 2012-05-11
EP2348022A1 (en) 2011-07-27
PT2248809E (pt) 2012-07-02
CA2799659C (en) 2014-12-02
SI2248809T1 (sl) 2012-09-28
BRPI0609496C8 (pt) 2021-05-25
CA2600381A1 (en) 2006-10-05
CA2600381C (en) 2013-11-12
EP1864978A1 (en) 2007-12-12
ATE546443T1 (de) 2012-03-15
PT2210884E (pt) 2012-04-10

Similar Documents

Publication Publication Date Title
CY1113571T1 (el) Μεθοδος για την παραγωγη 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)-αιθοξυ)προπυλ)αζετιδιν-3-ολης ή αλατων αυτης
PL1801082T3 (pl) Sposób wytwarzania włókien nieorganicznych
PL2088218T3 (pl) Blacha stalowa gruba o wysokim module Younga i sposób jej wytwarzania
TW200727899A (en) Method of treating abnormal cell growth
HUE057369T2 (hu) Kommunikációs séma csatornaminõség információ számára
IL199124A (en) A process for preparing fluoromethyl-converted heterocyclic compounds
ZA200809118B (en) Process for hydrogen production
IL196885A0 (en) Use of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment of mantle cell lymphomas
TW200639162A (en) Pure duloxetine hydrochloride
EP2006290A4 (en) IMPROVED PROCESS FOR PRODUCING CARBAPENEM COMPOUND
SG146569A1 (en) Process for producing methionine
IL187155A0 (en) Process for production of 4-biphenylazetidin-2-ones
SG136920A1 (en) Process for producing methionine
MX2009012706A (es) Proceso para preparar triazolonas.
EP1948587A4 (en) PROCESS FOR THE PREPARATION OF DIARYLE CARBONATE
ZA200710066B (en) Process for production of 4-biphenylylazetidin-2-ones
EP2332932A4 (en) NEW CRYSTALLINE FORMS OF 4- (2-AMINOPYRIDIN-4-YL) -3- (4-fluoro-PHENYL) -1- (1,4,5,6-TETRAHYDRO-6-OXOPYRIDAZIN-3-YL) -1H-PYRAZOLE -METHANESULPHONATE AND METHOD OF MANUFACTURING THEREOF
EP1852436A4 (en) PROCESS FOR PREPARING A CABAPENEM DERIVATIVE AND CRYSTALLINE INTERMEDIATE PRODUCT THEREFOR
FR2910500B1 (fr) Procede de fabrication d'un papier calque
TW200734321A (en) Benzo [b] thiophen derivatives and a process for producing benzo [b] thiophen derivatives
IL181075A0 (en) Process for producing 2-(4-methyl-2-phenylpiperazine-1-yl)-3-cyanopiridine
DK2348022T3 (da) Fremgangsmåde til fremstilling af 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol eller salte deraf
IL206613A0 (en) Process for the production of 4-(substituted phenyl) hexahydropyrido[2,1-c][1,4]oxazin-6-one
ZA200810321B (en) Crystalline (3-cyano-1H-indol-7-yl)-[4-(4-fluorophenethyl) piperazin-1-yl]methanone phosphate
PL379536A3 (pl) Sposób wytwarzania 3-[2-(2-dipropyloaminoetylo)-6-nitrofenylo]-2-oksopropionianu etylu