PL3483164T3 - Kompozycje pirolopirolu jako aktywatory kinazy pirogronianowej (PKR) - Google Patents

Kompozycje pirolopirolu jako aktywatory kinazy pirogronianowej (PKR)

Info

Publication number
PL3483164T3
PL3483164T3 PL18209919T PL18209919T PL3483164T3 PL 3483164 T3 PL3483164 T3 PL 3483164T3 PL 18209919 T PL18209919 T PL 18209919T PL 18209919 T PL18209919 T PL 18209919T PL 3483164 T3 PL3483164 T3 PL 3483164T3
Authority
PL
Poland
Prior art keywords
pkr
activators
pyruvate kinase
pyrrolopyrrole
compositions
Prior art date
Application number
PL18209919T
Other languages
English (en)
Inventor
Anna Ericsson
Neal Green
Gary Gustafson
Bingsong Han
David R. LANCIA JR.
Lorna MITCHELL
David Richard
Tatiana Shelekhin
Chase C. Smith
Zhongguo Wang
Xiaozhang Zheng
Original Assignee
Forma Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Therapeutics, Inc. filed Critical Forma Therapeutics, Inc.
Publication of PL3483164T3 publication Critical patent/PL3483164T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
PL18209919T 2017-03-20 2018-03-20 Kompozycje pirolopirolu jako aktywatory kinazy pirogronianowej (PKR) PL3483164T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762473751P 2017-03-20 2017-03-20
EP18209919.2A EP3483164B1 (en) 2017-03-20 2018-03-20 Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators
EP18716455.3A EP3448859B1 (en) 2017-03-20 2018-03-20 Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators
PCT/US2018/023405 WO2018175474A1 (en) 2017-03-20 2018-03-20 Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators

Publications (1)

Publication Number Publication Date
PL3483164T3 true PL3483164T3 (pl) 2020-08-24

Family

ID=61911726

Family Applications (2)

Application Number Title Priority Date Filing Date
PL18209919T PL3483164T3 (pl) 2017-03-20 2018-03-20 Kompozycje pirolopirolu jako aktywatory kinazy pirogronianowej (PKR)
PL18716455T PL3448859T3 (pl) 2017-03-20 2018-03-20 Kompozycje pirolopirolu jako aktywatory kinazy pirogronianowej (PKR)

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL18716455T PL3448859T3 (pl) 2017-03-20 2018-03-20 Kompozycje pirolopirolu jako aktywatory kinazy pirogronianowej (PKR)

Country Status (32)

Country Link
US (8) US11014927B2 (pl)
EP (3) EP3448859B1 (pl)
JP (2) JP6594570B2 (pl)
KR (2) KR102007135B1 (pl)
CN (2) CN113456634A (pl)
AR (2) AR111295A1 (pl)
AU (4) AU2018240172C1 (pl)
CA (1) CA3024181C (pl)
CY (2) CY1122393T1 (pl)
DK (2) DK3483164T3 (pl)
EA (1) EA201992215A1 (pl)
ES (2) ES2747768T3 (pl)
HR (2) HRP20191665T1 (pl)
HU (2) HUE045261T2 (pl)
IL (2) IL269447B (pl)
LT (2) LT3448859T (pl)
MA (3) MA45614B1 (pl)
MD (2) MD3448859T2 (pl)
MX (2) MX378512B (pl)
NZ (2) NZ763766A (pl)
PL (2) PL3483164T3 (pl)
PT (2) PT3483164T (pl)
RS (2) RS59306B1 (pl)
RU (3) RU2736217C2 (pl)
SA (1) SA519410164B1 (pl)
SG (1) SG11201908670SA (pl)
SI (2) SI3448859T1 (pl)
SM (2) SMT201900517T1 (pl)
TN (2) TN2020000045A1 (pl)
TW (2) TWI772389B (pl)
WO (1) WO2018175474A1 (pl)
ZA (1) ZA201906278B (pl)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2861566T1 (sl) 2012-06-13 2017-03-31 F. Hoffmann-La Roche Ag Novi diazaspirocikloalkan in azaspirocikloalkan
PL2900669T3 (pl) 2012-09-25 2020-01-31 F. Hoffmann-La Roche Ag Pochodne heksahydropirolo[3,4-C]pirolu i związki pokrewne jako inhibitory autotaksyny (ATX) oraz inhibitory produkcji kwasu lizofosfatydowego (LPA) do leczenia np. chorób nerek
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
AU2014356583B2 (en) 2013-11-26 2019-02-28 F. Hoffmann-La Roche Ag New octahydro-cyclobuta (1,2-c;3,4-c')dipyrrol-2-yl
CR20160418A (es) 2014-03-26 2016-11-07 Hoffmann La Roche Nuevos compuestos biciclicos de 7 eslabones
MA50635A (fr) 2014-03-26 2020-08-12 Hoffmann La Roche Nouveaux composés bicycliques comme inhibiteurs de la production d'autotaxin (atx) et de l'acide lysophosphatidique
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
EP3344619B1 (en) 2015-09-04 2020-10-28 H. Hoffnabb-La Roche Ag Phenoxymethyl derivatives
MA42918A (fr) 2015-09-24 2018-08-01 Hoffmann La Roche Composés bicycliques utilisés en tant qu'inhibiteurs d'atx
AU2016328437A1 (en) 2015-09-24 2018-01-25 F. Hoffmann-La Roche Ag Bicyclic compounds as ATX inhibitors
WO2017050747A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag New bicyclic compounds as dual atx/ca inhibitors
BR112018006080A2 (pt) * 2015-09-24 2018-10-09 F. Hoffmann-La Roche Ag novos compostos bicíclicos como inibidores de dupla ação de atx/ca
EP3596060B1 (en) 2017-03-16 2023-09-20 F. Hoffmann-La Roche AG New bicyclic compounds as atx inhibitors
RU2019132254A (ru) 2017-03-16 2021-04-16 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
AR111295A1 (es) * 2017-03-20 2019-06-26 Forma Therapeutics Inc Composiciones de pirrolopirrol como activadores de piruvato quinasa (pkr)
US20210346356A1 (en) * 2018-09-19 2021-11-11 Forma Therapeutics, Inc. Inhibiting ubiquitin specific peptidase 9x
EP3852790A4 (en) * 2018-09-19 2022-08-10 Forma Therapeutics, Inc. INHIBITION OF UBIQUITIN-SPECIFIC PEPTIDASE 9X
US20200129485A1 (en) 2018-09-19 2020-04-30 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
WO2020061255A1 (en) * 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Activating pyruvate kinase r
WO2020191022A1 (en) * 2019-03-18 2020-09-24 Forma Therapeutics, Inc. Inhibiting ubiquitin specific peptidase 9x
WO2021055863A1 (en) * 2019-09-19 2021-03-25 Forma Therapeutics, Inc. Pyruvate kinase r (pkr) activating compositions
MX2022003025A (es) 2019-09-19 2022-04-07 Forma Therapeutics Inc Activacion de la piruvato cinasa r.
US12378192B2 (en) * 2019-09-29 2025-08-05 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Crystalline form of capsid protein assembly inhibitor containing N hetero five-membered ring, and application thereof
EP4126876A1 (en) * 2020-04-01 2023-02-08 Global Blood Therapeutics, Inc. Pyrrolidine-pyrazoles as pyruvate kinase activators
US20220087983A1 (en) * 2020-09-18 2022-03-24 Forma Therapeutics, Inc. Activating pyruvate kinase r
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
TWI841134B (zh) 2021-12-21 2024-05-01 大陸商賽諾哈勃藥業（成都）有限公司 含二氮雜亞基磺醯結構的化合物及其在醫藥上的用途
WO2024112764A1 (en) 2022-11-21 2024-05-30 Novo Nordisk Health Care Ag Synthesis of pyrrolo[3,4-c]pyrroles
CN115957219B (zh) * 2022-12-27 2024-04-19 北京大学 M2亚型丙酮酸激酶凝聚体的解聚剂在制备抗衰老药物中的应用
CN121511081A (zh) * 2023-05-05 2026-02-10 赛诺哈勃药业（成都）有限公司 含二氮杂亚基磺酰结构的化合物作为pkm2激动剂的新用途
WO2024245143A1 (zh) 2023-05-26 2024-12-05 赛诺哈勃药业（成都）有限公司 含二氮杂亚基磺酰结构化合物的药物组合物在治疗贫血相关疾病中的用途
WO2026008051A1 (zh) * 2024-07-05 2026-01-08 广东东阳光药业股份有限公司 杂环并环类化合物、其药物组合物及其用途

Family Cites Families (362)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007529B1 (en) 1978-07-13 1983-07-20 The Wellcome Foundation Limited Antiprotozoal oxadiazole derivatives, processes for their preparation and pharmaceutical formulations containing them
EP0036711B1 (en) 1980-03-22 1985-12-04 Fbc Limited Pesticidal heterocyclic compounds, processes for preparing them, compositions containing them, and their use
US4602093A (en) 1984-02-08 1986-07-22 Merck & Co., Inc. Novel substituted imidazoles, their preparation and use
JPS61200544A (ja) 1985-03-04 1986-09-05 Toyo Ink Mfg Co Ltd 電子写真感光体
DE3600390A1 (de) 1986-01-09 1987-07-16 Hoechst Ag Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel
EP0264883A3 (en) 1986-10-21 1990-04-04 Banyu Pharmaceutical Co., Ltd. Substituted pyridine derivatives
JPS63165376A (ja) 1986-12-27 1988-07-08 Nippon Soda Co Ltd オキサ（チア）ジアゾ−ル誘導体その製造方法及び殺ダニ剤
JPH01108006A (ja) 1987-10-21 1989-04-25 Nagasaki Pref Gov 脆性材料の割断加工方法
JPH01110376A (ja) 1987-10-24 1989-04-27 Mizuno Corp 繊維強化プラスチックス製バットの製造方法
KR910001238B1 (ko) 1988-02-26 1991-02-26 재단법인 한국화학연구소 O-아실아미드옥심 유도체
EP0338372A3 (en) 1988-04-22 1991-10-09 American Cyanamid Company Solubilized pro-drugs
CA1340821C (en) 1988-10-06 1999-11-16 Nobuyuki Fukazawa Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components
US5180719A (en) 1988-10-24 1993-01-19 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
GB8900382D0 (en) 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
DK0393607T3 (da) 1989-04-19 1996-03-18 Otsuka Pharma Co Ltd Phenylcarboxylsyrederivater med en heteroring
GB8908875D0 (en) 1989-04-19 1989-06-07 Ici Plc Fungicides
JPH0313040A (ja) 1989-06-09 1991-01-22 Sharp Corp コードレス電話機
KR910009331B1 (ko) 1989-10-23 1991-11-11 재단법인 한국화학연구소 디아자비시클로아민 화합물과 그의 제조방법
KR910009333B1 (ko) 1989-10-23 1991-11-11 재단법인 한국화학연구소 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법
KR910009330B1 (ko) 1989-10-23 1991-11-11 재단법인 한국화학연구소 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법
US5030631A (en) 1989-11-27 1991-07-09 Schering Corporation Tricylclic arylsulfonamides
US5747502A (en) 1989-12-13 1998-05-05 Nippon Kayaku Kabushiki Kaisha Process for preparing benzo c!phenanthridinium derivatives, novel compounds prepared by said process, and antitumor agents
JP3036789B2 (ja) 1990-06-22 2000-04-24 三井化学株式会社 新規な複素環式化合物及び医薬組成物
FR2664592B1 (fr) 1990-07-10 1994-09-02 Adir Nouveaux derives de la piperidine, de la tetrahydropyridine et de la pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5262565A (en) 1990-11-16 1993-11-16 Eisai Co., Ltd. Naphthalene derivatives
JP2859451B2 (ja) 1991-01-11 1999-02-17 太平洋セメント株式会社 Ｎ−フルオロピリジニウム塩の製造方法
DE4121214A1 (de) 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
JP3038065B2 (ja) 1991-11-07 2000-05-08 太平洋セメント株式会社 Ｎ−フルオロピリジニウム塩の製造方法
JPH05196976A (ja) 1991-11-18 1993-08-06 Toshiba Corp 有機非線形光学材料
CA2124206C (en) 1991-11-25 2001-02-27 John Eugene Macor Indole derivatives
HU220601B1 (hu) 1992-04-30 2002-03-28 Taiho Pharmaceutical Co. Ltd. Fenoxi-alkil-oxazolidin-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
DE4232418A1 (de) 1992-09-28 1994-03-31 Bayer Ag Verwendung von substituierten 1,2,4-Oxadiazolderivaten zur Bekämpfung von Endoparasiten, neue substituierte 1,2,4-Oxadiazolderivate und Verfahren zu ihrer Herstellung
US5262564A (en) 1992-10-30 1993-11-16 Octamer, Inc. Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
JP3130400B2 (ja) 1993-01-13 2001-01-31 信越化学工業株式会社 重合体スケール付着防止剤、及びそれを利用する重合体の製造方法
JPH07164400A (ja) 1993-12-15 1995-06-27 Nec Corp ガラス基板の切断装置
DE4401108A1 (de) 1994-01-17 1995-07-20 Bayer Ag 1,2,4-Oxadiazol-Derivate
US6878715B1 (en) 1994-02-18 2005-04-12 Cell Therapeutics, Inc. Therapeutic compounds for inhibiting interleukin-12 signals and method for using same
IT1274018B (it) 1994-02-23 1997-07-14 Riace Ets Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica
FR2732964B1 (fr) 1995-04-14 1997-05-16 Adir Nouveaux amides tricycliques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
JP3830183B2 (ja) 1995-09-29 2006-10-04 東京応化工業株式会社 オキシムスルホネート化合物及びレジスト用酸発生剤
JP3275666B2 (ja) 1995-10-18 2002-04-15 トヨタ自動車株式会社 車輌の挙動制御装置
DE19608316C2 (de) 1996-02-22 2000-11-09 Ivoclar Ag Schaan Funktionalisierte bicyclische (Meth)acrylate, Verfahren zu deren Herstellung und deren Verwendung ####
US6500885B1 (en) 1997-02-28 2002-12-31 Candescent Technologies Corporation Polycarbonate-containing liquid chemical formulation and methods for making and using polycarbonate film
WO1998038239A1 (en) 1997-02-28 1998-09-03 Candescent Technologies Corporation Polycarbonate-containing liquid chemical formulation and method for making polycarbonate film
WO1998050364A1 (en) 1997-05-03 1998-11-12 Smithkline Beecham Plc Tetrahydroisoquinoline derivatives as modulators of dopamine d3 receptors
JPH1110376A (ja) 1997-06-25 1999-01-19 Souei Tsusho Kk 割断加工方法
WO1999001442A1 (en) 1997-07-02 1999-01-14 Zeneca Limited Triazine derivatives and their use as antibacterial agents
GB9714383D0 (en) 1997-07-08 1997-09-10 Pfizer Ltd Improved process
US6100291A (en) 1998-03-16 2000-08-08 Allelix Biopharmaceuticals Inc. Pyrrolidine-indole compounds having 5-HT6 affinity
US6020525A (en) 1998-03-19 2000-02-01 Hoffmann-La Roche Inc. (2S,2'R,3'R)-2-(2,3-dicarboxyl-cyclopropyl)-glycine (DCG-1/4) and 3 H-DCG-1/4 and to process for the preparation thereof
US6214879B1 (en) 1998-03-24 2001-04-10 Virginia Commonwealth University Allosteric inhibitors of pyruvate kinase
JP2002507557A (ja) 1998-03-26 2002-03-12 デパートメント オブ ジ アーミー， ユー．エス． ガバメント 抗生物質抵抗性感染の処置のための置換芳香族化合物
DE19826671A1 (de) 1998-06-16 1999-12-23 Hoechst Schering Agrevo Gmbh 1,3-Oxazolin- und 1,3-Thiazolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel
FR2780057B1 (fr) 1998-06-18 2002-09-13 Sanofi Sa Phenoxypropanolamines, procede pour leur preparation et compositions pharmaceutiques les contenant
AUPP466598A0 (en) 1998-07-14 1998-08-06 University Of Newcastle Research Associates Limited, The Product and process
TWI250152B (en) 1998-07-21 2006-03-01 Eisai Co Ltd N,N-substituted cyclic amine compounds used as calcium antagonizer
CA2346689A1 (en) 1998-10-08 2000-04-20 Gregor James Macdonald Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents)
US6500817B1 (en) 1999-03-08 2002-12-31 Bayer Aktiengesellschaft Thiazolyl urea derivatives and their utilization as antiviral agents
WO2001010842A2 (en) 1999-08-04 2001-02-15 Millennium Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
EP1096310B1 (en) 1999-10-26 2004-06-02 Fuji Photo Film Co., Ltd. Photothermographic material
DE19955824A1 (de) 1999-11-20 2001-06-13 Schott Spezialglas Gmbh Verfahren und Vorrichtung zum Schneiden eines Werkstückes aus sprödbrüchigem Werkstoff
WO2001037826A1 (en) 1999-11-26 2001-05-31 Shionogi & Co., Ltd. Npyy5 antagonists
AU2525801A (en) 1999-12-17 2001-06-25 Sanofi-Synthelabo Phenoxypropanolamines, method for producing them and pharmaceutical compositionscontaining them
IL150650A0 (en) 2000-01-20 2003-02-12 Eisai Co Ltd Piperidine derivatives and pharmaceutical compositions containing the same
WO2001057037A1 (en) 2000-02-04 2001-08-09 Cor Therapeutics, Inc. Platelet adp receptor inhibitors
GB0004886D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
JP2001261653A (ja) 2000-03-17 2001-09-26 Sankio Chemical Co Ltd ピリジン誘導体の合成法
WO2001085728A2 (en) 2000-05-08 2001-11-15 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i, j] quinolizines, processes, compositions and methods of treatment
AU2002213467A1 (en) 2000-10-11 2002-04-22 Chemocentryx, Inc. Modulation of ccr4 function
US6939871B2 (en) 2000-10-26 2005-09-06 Smithkline Beecham P.L.C. Benzoxazinone derivatives, their preparation and use
US7439359B2 (en) 2000-11-02 2008-10-21 Sloan-Kettering Institute For Cancer Research Small molecule compositions for binding to hsp90
SE0100326D0 (sv) 2001-02-02 2001-02-02 Astrazeneca Ab New compounds
AUPR392301A0 (en) 2001-03-23 2001-04-26 University Of Newcastle Research Associates Limited, The Protein phosphatase inhibitors
DE60228233D1 (de) 2001-05-23 2008-09-25 Max Planck Gesellschaft Pyruvat-kinase als einem neuen zielmolekül
DE10139416A1 (de) 2001-08-17 2003-03-06 Aventis Pharma Gmbh Aminoalkyl substituierte aromatische Bicyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7173032B2 (en) 2001-09-21 2007-02-06 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
EP1440072A4 (en) 2001-10-30 2005-02-02 Conforma Therapeutic Corp PURINE ANALOGS HAVING HSP90 INHIBITORY ACTIVITY
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
AU2003206787A1 (en) 2002-02-06 2003-09-02 Ciba Specialty Chemicals Holding Inc. Sulfonate derivatives and the use therof as latent acids
US6995144B2 (en) 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
AR040336A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
JP2005532077A (ja) 2002-07-10 2005-10-27 オンコセラピー・サイエンス株式会社 腸型胃腫瘍の診断法
TW200403243A (en) 2002-07-18 2004-03-01 Wyeth Corp 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands
US20060100233A1 (en) 2002-07-25 2006-05-11 Manuela Villa Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
MXPA05000945A (es) 2002-07-25 2005-05-16 Pharmacia Italia Spa Biciclo-pirazoles activos como inhibidores de la cinasa, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.
IL166241A0 (en) 2002-07-29 2006-01-15 Rigel Pharmaceuticals Inc Method of treating or preventing autoimmune diseases with 2,4-pyrimidinedinediamine compounds
EP1534666A1 (de) 2002-09-06 2005-06-01 Schebo Biotech AG Verbindungen zur modulation des glykolyse-enzym-und/oder transaminase-komplexes
JP2004175674A (ja) 2002-11-25 2004-06-24 Toyo Ink Mfg Co Ltd 有機エレクトロルミネッセンス素子材料およびそれを使用した有機エレクトロルミネッセンス素子
EP1437145A1 (en) 2003-01-07 2004-07-14 Schering AG Enhanced scintigraphic imaging agents for imaging of infection and inflammation
US7189723B2 (en) 2003-02-10 2007-03-13 Cgi Pharmaceuticals, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity
BRPI0408486A (pt) 2003-03-11 2006-04-04 Pharmacia Italia Spa derivados de biciclopirazol ativos como inibidores da cinase, processo para a sua preparação e composições farmacêuticas compreendendo-os
US7449464B2 (en) 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
DE10316081A1 (de) 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
DE602004027171D1 (de) 2003-04-11 2010-06-24 High Point Pharmaceuticals Llc Verbindungen mit Aktivität an der 11Beta-Hydroxasteroiddehydrogenase
WO2004104000A1 (ja) 2003-05-23 2004-12-02 Japan Tobacco Inc. トリサイクリック縮合環化合物およびその医薬用途
EP2316973A1 (en) 2003-06-10 2011-05-04 The Trustees Of Boston University Detection methods for disorders of the lung
ES2291891T3 (es) 2003-07-03 2008-03-01 F. Hoffmann-La Roche Ag Antagonistas duales de nk1/nk3 para tratamiento de esquizofrenia.
GB0317484D0 (en) 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
KR20060037410A (ko) 2003-07-30 2006-05-03 제논 파마슈티칼스 인크. 피리다진 유도체 및 그의 치료제로서의 용도
ES2397389T3 (es) 2003-07-30 2013-03-06 Xenon Pharmaceuticals Inc. Derivados de piridilo y su uso como agentes terapéuticos
GB0319150D0 (en) 2003-08-14 2003-09-17 Glaxo Group Ltd Novel compounds
SG146624A1 (en) 2003-09-11 2008-10-30 Kemia Inc Cytokine inhibitors
NZ546611A (en) 2003-09-18 2010-02-26 Conforma Therapeutics Corp Novel heterocyclic compounds as HSP90-inhibitors
DE10353910A1 (de) 2003-11-18 2005-06-09 Studiengesellschaft Kohle Mbh Verfahren zur Synthese optisch aktiver Piperidine
ATE435222T1 (de) 2003-12-18 2009-07-15 Tibotec Pharm Ltd Aminobenzimidazole und benzimidazole als inhibitoren der replikation von respiratory syncytial virus
AR046959A1 (es) 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
AR046770A1 (es) 2003-12-18 2005-12-21 Tibotec Pharm Ltd Derivados bencimidazol 5- o 6-substituidos como inhibidores de la replicacion del virus sincitial respiratorio
MXPA06007110A (es) 2003-12-18 2006-08-23 Tibotec Pharm Ltd Derivados de los amino-bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio.
TWI349007B (en) 2003-12-18 2011-09-21 Tibotec Pharm Ltd Piperidine-amino-benzimidazole derivatives as inhibitors of respiratory syncytial virus replication
US7422837B2 (en) 2004-02-16 2008-09-09 Fujifilm Corporation Photosensitive composition
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
AU2005219438B2 (en) 2004-03-03 2011-02-17 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US20070185090A1 (en) 2004-03-17 2007-08-09 Jakob Busch-Petersen Muscarinic acetylchoine receptor antagonists
WO2005094251A2 (en) 2004-03-17 2005-10-13 Glaxo Group Limited M3muscarinic acetylcholine receptor antagonists
US7335770B2 (en) 2004-03-24 2008-02-26 Reddy U5 Therapeutics, Inc. Triazine compounds and their analogs, compositions, and methods
TWI391387B (zh) 2004-05-12 2013-04-01 Eisai R&D Man Co Ltd 具有哌啶環之吲哚衍生物
ATE488766T1 (de) 2004-06-21 2010-12-15 Progenra Inc Diagnostik und screening-methode und kit in verbindung mit proteolytischer aktivität
US7482336B2 (en) 2004-06-21 2009-01-27 Merck & Co., Inc. Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
DE102004039789A1 (de) 2004-08-16 2006-03-02 Sanofi-Aventis Deutschland Gmbh Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CA2576915A1 (en) 2004-08-18 2006-03-02 Elixir Pharmaceuticals, Inc. Growth-hormone secretagogues
DE102004041163A1 (de) 2004-08-25 2006-03-02 Morphochem Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
EP1804799B1 (en) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP2289510A1 (en) 2004-09-20 2011-03-02 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
CA2581057A1 (en) 2004-10-05 2006-04-13 Actelion Pharmaceuticals Ltd New piperidine antibiotics
JP2008521805A (ja) 2004-11-30 2008-06-26 アーテシアン セラピューティクス， インコーポレイテッド β−アドレナリン作用性受容体およびホスホジエステラーゼに対する阻害活性を有する強心性化合物
US7968574B2 (en) 2004-12-28 2011-06-28 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
US7834181B2 (en) 2005-02-01 2010-11-16 Slaon-Kettering Institute For Cancer Research Small-molecule Hsp90 inhibitors
GT200600046A (es) 2005-02-09 2006-09-25 Terapia de combinacion
JP4377942B2 (ja) 2005-02-25 2009-12-02 セレネックス， インコーポレイテッド テトラヒドロインドロン及びテトラヒドロインダゾロン誘導体
WO2006099884A1 (en) 2005-03-24 2006-09-28 Actelion Percurex Ag Beta-aminoalcohol antibiotics
EP1868601A4 (en) 2005-04-07 2008-12-10 Merck & Co Inc MITOTIC KINESINE HEMMER
GB0510204D0 (en) 2005-05-19 2005-06-22 Chroma Therapeutics Ltd Enzyme inhibitors
WO2006130469A1 (en) 2005-05-27 2006-12-07 Oregon Health & Science University Stimulation of neurite outgrowth by small molecules
EP2468743A1 (en) 2005-06-24 2012-06-27 Toyama Chemical Co., Ltd. Nitrogen-containing bicyclic compounds useful as antibacterial agents
GB0514018D0 (en) 2005-07-07 2005-08-17 Ionix Pharmaceuticals Ltd Chemical compounds
EA200800285A1 (ru) 2005-07-11 2008-08-29 Санофи-Авентис Новые производные 2,4-дианилинопиримидинов, их получение, лекарственные средства, фармацевтические композиции, содержащие указанные производные, и их применение, в частности, в качестве ингибиторов ikk
US7345178B2 (en) 2005-08-04 2008-03-18 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
WO2007042325A1 (de) 2005-10-13 2007-04-19 Morphochem Aktiengesellschaft für kombinatorische Chemie 5-chinolinderivate mit antibakterieller aktivität
GB0600967D0 (en) 2006-01-18 2006-03-01 Imp Innovations Ltd Methods
JP5111398B2 (ja) 2006-01-25 2013-01-09 メルク・シャープ・エンド・ドーム・コーポレイション 糖尿病の治療又は予防のためのジペプチジルペプチダーゼｉｖ阻害剤としてのアミノシクロヘキサン類
JP5745210B2 (ja) 2006-02-03 2015-07-08 ニコックス サイエンス アイルランド 筋ジストロフィーの治療用薬剤のニトロオキシ誘導体の使用
JP5161795B2 (ja) 2006-02-15 2013-03-13 メルク・シャープ・エンド・ドーム・コーポレイション 糖尿病の治療又は予防のためのジペプチジルペプチダーゼｉｖインヒビターとしてのアミノテトラヒドロピラン
EP1984351A1 (en) 2006-02-17 2008-10-29 Memory Pharmaceuticals Corporation Compounds having 5-ht6 receptor affinity
JP2007246885A (ja) 2006-02-20 2007-09-27 Toyo Ink Mfg Co Ltd 光機能材料
TW200806669A (en) 2006-03-28 2008-02-01 Merck & Co Inc Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
EP2019677B1 (en) 2006-05-16 2013-08-14 Merck Sharp & Dohme Corp. Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
WO2007136714A2 (en) 2006-05-16 2007-11-29 Gilead Sciences, Inc. Integrase inhibitors
KR101077295B1 (ko) 2006-05-18 2011-10-26 에프. 호프만-라 로슈 아게 아데노신 ａ2ｂ 수용체 길항물질로서의 티아졸로-피라미딘/피리딘 우레아 유도체
CN101454338A (zh) 2006-05-26 2009-06-10 卡拉治疗学股份有限公司 κ阿片样受体肽的N-氧化物
GB0610680D0 (en) 2006-05-31 2006-07-12 Istituto Di Ricerche D Biolog Therapeutic compounds
JP2007328090A (ja) 2006-06-07 2007-12-20 Fujifilm Corp 感光性組成物、感光性フィルム、パターン形成方法、及びプリント基板
ES2645095T3 (es) 2006-06-30 2017-12-04 Sloan-Kettering Institute For Cancer Research Tratamiento de enfermedades neurodegenerativas a través de la inhibición de Hsp90
JP2008031064A (ja) 2006-07-27 2008-02-14 Astellas Pharma Inc ジアシルピペラジン誘導体
WO2008094203A2 (en) 2006-08-03 2008-08-07 Microbiotix, Inc. Polar ester prodrugs of heterocyclic hybrid antibacterial compounds and salts thereof
AU2007281911B2 (en) 2006-08-04 2014-02-06 Beth Israel Deaconess Medical Center Inhibitors of pyruvate kinase and methods of treating disease
JP2008063256A (ja) 2006-09-06 2008-03-21 Astellas Pharma Inc β‐アミノ酸誘導体
WO2008032905A1 (en) 2006-09-13 2008-03-20 Hurim Biocell Co., Ltd. Genes involved in differentiation of human stem cell lines and the microarray kit containing these genes
US7875603B2 (en) 2006-09-21 2011-01-25 Nova Southeastern University Specific inhibitors for vascular endothelial growth factor receptors
TWI405763B (zh) 2006-11-02 2013-08-21 Targacept Inc 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺
JP5244810B2 (ja) 2006-11-10 2013-07-24 カラ セラピューティクス インコーポレイテッド 合成ペプチドアミド
FR2910298A1 (fr) 2006-12-20 2008-06-27 Oreal Composition tinctoriale contenant une silicone reactive, un colorant fluorescent ou azurant optique, procede de coloration utilisant la composition
MX347085B (es) 2006-12-28 2017-04-06 Abbott Laboratories * Inhibidores de la poli (adp-ribosa) polimerasa.
US8466150B2 (en) 2006-12-28 2013-06-18 Abbott Laboratories Inhibitors of poly(ADP-ribose)polymerase
EA019103B1 (ru) 2007-03-20 2014-01-30 Кьюрис, Инк. Конденсированный аминопиридин в качестве ингибиторов hsp90
WO2008120003A1 (en) 2007-04-03 2008-10-09 Astrazeneca Ab Substituted piperidines for use in the treatment of bacterial infections
JP2010524987A (ja) 2007-04-27 2010-07-22 サノフィ−アベンティス ２−ヘテロアリール−ピロロ［３，４−ｃ］ピロール誘導体及びｓｃｄ阻害剤としてのそれらの使用
WO2008139585A1 (ja) 2007-05-10 2008-11-20 Toray Engineering Co., Ltd. 初期亀裂形成機構
WO2009001126A1 (en) 2007-06-27 2008-12-31 Astrazeneca Ab Substituted piperidine derivatives and their use as antibaterial agents
FR2918061B1 (fr) 2007-06-28 2010-10-22 Sanofi Aventis Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.
US20090023727A1 (en) 2007-07-05 2009-01-22 Muhammad Hashim Javaid Phthalazinone derivatives
FR2918986B1 (fr) 2007-07-19 2009-09-04 Sanofi Aventis Sa Derives de 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]- pyridazine, leur preparation et leur application en therapeutique
EP2019318A1 (en) 2007-07-27 2009-01-28 Erasmus University Medical Center Rotterdam Protein markers for cardiovascular events
WO2009025781A1 (en) 2007-08-16 2009-02-26 Beth Israel Deaconess Medical Center Activators of pyruvate kinase m2 and methods of treating disease
EP2190428A4 (en) 2007-08-21 2012-02-29 Merck Sharp & Dohme HETEROCYCLIC COMPOUNDS AS DIPEPTIDYLPEPTIDASE IV HEMMER FOR TREATMENT OR PREVENTION OF DIABETES
JP5758630B2 (ja) 2007-11-15 2015-08-05 エンメエッセディ・イタリア・エッセ・エッレ・エッレ Ｐａｒｐ阻害剤としてのピリダジノン誘導体
US20090291921A1 (en) 2007-11-20 2009-11-26 Gilead Sciences, Inc. Integrase inhibitors
TW200938203A (en) 2007-12-17 2009-09-16 Intervet Int Bv Anthelmintic agents and their use
JP5258280B2 (ja) 2007-12-18 2013-08-07 富士フイルム株式会社 顔料分散組成物、感光性樹脂組成物、カラーフィルタおよびその製造方法
AU2008345225A1 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
FR2926555B1 (fr) 2008-01-22 2010-02-19 Sanofi Aventis Derives bicycliques de carboxamides azabicycliques, leur preparation et leur application en therapeutique
AR070221A1 (es) 2008-01-23 2010-03-25 Astrazeneca Ab Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas.
DE102008010661A1 (de) 2008-02-22 2009-09-03 Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG Verfahren zur Herstellung von Pyridin-2-Boronsäure und Derivaten davon
JP2009212473A (ja) 2008-03-06 2009-09-17 Fujifilm Corp 金属用研磨液、及び化学的機械的研磨方法
AU2009231258A1 (en) 2008-04-04 2009-10-08 Biomarin Iga Limited Compounds for treating muscular dystrophy
KR101538822B1 (ko) 2008-05-08 2015-07-22 노바 사우쓰이스턴 유니버시티 혈관 내피 성장 인자 수용체에 대한 특이적 억제제
GB0811304D0 (en) 2008-06-19 2008-07-30 Ucb Pharma Sa Therapeutic agents
US20100022581A1 (en) 2008-07-02 2010-01-28 Memory Pharmaceuticals Corporation Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity
EP2334680A2 (en) 2008-08-20 2011-06-22 Sequoia Pharmaceuticals, Inc. Hcv protease inhibitors
US20100144722A1 (en) 2008-09-03 2010-06-10 Dr. Reddy's Laboratories Ltd. Novel heterocyclic compounds as gata modulators
WO2010028761A1 (de) * 2008-09-09 2010-03-18 Sanofi-Aventis 2-heteroaryl-pyrrolo[3, 4-c]pyrrol-derivate und ihre verwendung als scd inhibitoren
ES2620634T3 (es) 2008-10-09 2017-06-29 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Activadores de piruvato quinasa humana
JO2870B1 (en) 2008-11-13 2015-03-15 ميرك شارب اند دوهم كورب Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes
WO2010058318A1 (en) 2008-11-21 2010-05-27 Pfizer Inc. 1-oxa-8-azaspiro [4, 5 ] decane- 8 -carboxamide compounds as faah inhibitors
TW201038569A (en) 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
JP2010192782A (ja) 2009-02-20 2010-09-02 Toyo Ink Mfg Co Ltd 光電変換素子用材料及び光電変換素子
US8143244B2 (en) 2009-02-26 2012-03-27 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
CN102985557B (zh) 2009-03-13 2018-06-15 安吉奥斯医药品有限公司 用于细胞增殖相关病症的方法和组合物
TW201041868A (en) 2009-03-20 2010-12-01 Intervet Int Bv Anthelmintic agents and their use
US20120010186A1 (en) 2009-03-23 2012-01-12 Merck Frosst Canada Ltd. Heterocyclic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
JP5756457B2 (ja) 2009-04-06 2015-07-29 アジオス ファーマシューティカルズ， インコーポレイテッド ピルビン酸キナーゼｍ２調節剤、治療組成物および関連する使用方法
PL2427441T3 (pl) 2009-05-04 2017-06-30 Agios Pharmaceuticals, Inc. Aktywatory PKM2 do stosowania w leczeniu raka
MX2011012190A (es) 2009-05-14 2011-12-08 Janssen Pharmaceutica Nv Compuestos con dos porciones de heteroarilo biciclico fusionado como moduladores de la leucotrieno a4 hidrolasa.
WO2010135524A1 (en) 2009-05-22 2010-11-25 Exelixis, Inc. Benzoxazepines based p13k/mt0r inhibitors against proliferative diseases
US8377639B2 (en) 2009-06-26 2013-02-19 University Of Massachusetts Compounds for modulating RNA binding proteins and uses therefor
PE20120693A1 (es) 2009-06-29 2012-07-04 Agios Pharmaceuticals Inc Compuestos heterociclos como moduladores de la piruvato cinasa m2 (pkm2)
DK2448581T3 (en) 2009-06-29 2017-03-13 Agios Pharmaceuticals Inc Therapeutic compositions and methods for their applications
WO2012174126A1 (en) 2011-06-13 2012-12-20 Universyty Of Medicine And Dentistry Of New Jesey METHOD OF INHIBITING NONSENSE-MEDIATED mRNA DECAY
NZ623069A (en) 2009-08-17 2015-11-27 Sloan Kettering Inst Cancer Heat shock protein binding compounds, compositions, and methods for making and using same
US8354403B2 (en) 2009-08-27 2013-01-15 Merck Sharp & Dohme Corp. Pyrrolidine derived beta 3 adrenergic receptor agonists
US8716482B2 (en) 2009-09-25 2014-05-06 Merck Sharp & Dohme Corp. Substituted aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
WO2011044377A2 (en) 2009-10-09 2011-04-14 Cell Point, Llc Chelator-targeting ligand conjugates for cardiovascular imaging
EP2525790B1 (en) 2009-10-21 2020-05-27 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
WO2011050210A1 (en) 2009-10-21 2011-04-28 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
US8946197B2 (en) 2009-11-16 2015-02-03 Chdi Foundation, Inc. Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof
US9017976B2 (en) 2009-11-18 2015-04-28 Myriant Corporation Engineering microbes for efficient production of chemicals
EP2538783B1 (en) 2010-02-22 2016-06-01 Merck Sharp & Dohme Corp. Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes
KR20110096442A (ko) 2010-02-22 2011-08-30 주식회사 이엔에프테크놀로지 칼라필터용 착색 감광성 수지 조성물
CN101812063B (zh) 2010-03-18 2012-04-25 中国医学科学院医药生物技术研究所 α-萘磺酰胺基五元杂环类化合物及其抑瘤活性
US9018227B2 (en) 2010-03-19 2015-04-28 Indiana State University Nicotinic acetylcholine receptor agonists
UY33288A (es) * 2010-03-25 2011-10-31 Glaxosmithkline Llc Derivados de indolina inhibidores de la proteina quinasa r del reticulo endoplasmatico
US20130109672A1 (en) 2010-04-29 2013-05-02 The United States Of America,As Represented By The Secretary, Department Of Health And Human Service Activators of human pyruvate kinase
WO2011146358A1 (en) 2010-05-21 2011-11-24 Merck Sharp & Dohme Corp. Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes
JP2011246649A (ja) 2010-05-28 2011-12-08 Mitsubishi Chemicals Corp 顔料分散液、着色樹脂組成物、カラーフィルタ、並びに液晶表示装置及び有機ｅｌディスプレイ
JP5744021B2 (ja) 2010-06-30 2015-07-01 富士フイルム株式会社 新規なニコチンアミド誘導体またはその塩
CA2804351A1 (en) 2010-07-12 2012-01-19 Pfizer Limited Chemical compounds
JP2013532184A (ja) 2010-07-12 2013-08-15 ファイザー・リミテッド 電位開口型ナトリウムチャネル阻害剤として有用なｎ−スルホニルベンズアミド誘導体
EP2593428B1 (en) 2010-07-12 2014-11-19 Pfizer Limited N-sulfonylbenzamides as inhibitors of voltage-gated sodium channels
CN102372716A (zh) 2010-08-09 2012-03-14 江苏恒瑞医药股份有限公司 酞嗪酮类衍生物、其制备方法及其在医药上的应用
CN102372706A (zh) 2010-08-09 2012-03-14 江苏恒瑞医药股份有限公司 酞嗪酮类衍生物、其制备方法及其在医药上的应用
WO2012056319A1 (en) 2010-10-27 2012-05-03 Dynamix Pharmaceuticals Ltd. Sulfonamides for the modulation of pkm2
EP2640366A2 (en) 2010-11-15 2013-09-25 Exelixis, Inc. Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture
US20120134979A1 (en) 2010-11-22 2012-05-31 Yang Xia Methods and compositions for the treatment of sickle cell disease
JP2013544829A (ja) 2010-11-24 2013-12-19 エクセリクシス， インク． ＰＩ３Ｋ／ｍＴＯＲの阻害剤としてのベンゾオキサゼピンおよびその使用と製造方法
EP2646428B1 (en) 2010-12-02 2016-06-01 Shanghai De Novo Pharmatech Co Ltd. Heterocyclic derivatives, preparation processes and medical uses thereof
EP2651405A2 (en) 2010-12-14 2013-10-23 Electrophoretics Limited Casein kinase 1 (ck1 ) inhibitors
US9221792B2 (en) 2010-12-17 2015-12-29 Agios Pharmaceuticals, Inc N-(4-(azetidine-1-carbonyl) phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase M2 (PMK2) modulators
WO2012088314A1 (en) 2010-12-21 2012-06-28 Agios Pharmaceuticals, Inc. Bicyclic pkm2 activators
TWI549947B (zh) 2010-12-29 2016-09-21 阿吉歐斯製藥公司 治療化合物及組成物
EP3225697A3 (en) 2010-12-30 2017-11-22 Foundation Medicine, Inc. Optimization of multigene analysis of tumor samples
US8969315B2 (en) 2010-12-31 2015-03-03 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
JP2012188474A (ja) 2011-03-09 2012-10-04 Toyo Ink Sc Holdings Co Ltd 顔料分散剤、それを用いた顔料組成物、着色組成物およびカラーフィルタ
JP2012188475A (ja) 2011-03-09 2012-10-04 Toyo Ink Sc Holdings Co Ltd 顔料分散剤、それを用いた顔料組成物、着色組成物およびカラーフィルタ
CN102206217A (zh) 2011-03-17 2011-10-05 盛世泰科生物医药技术(苏州)有限公司 杂环化合物作为二肽基肽酶抑制剂用于治疗或预防糖尿病
US8685966B2 (en) 2011-04-08 2014-04-01 University Of Kansas GRP94 inhibitors
PT3406251T (pt) 2011-05-03 2024-01-24 Agios Pharmaceuticals Inc Ativadores da piruvato-cinase para utilização em terapia
EP2704719B1 (en) * 2011-05-03 2018-02-21 Agios Pharmaceuticals, Inc. Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia
WO2012151440A1 (en) 2011-05-03 2012-11-08 Agios Pharmaceuticals, Inc. Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia
US9388164B2 (en) 2011-05-03 2016-07-12 Agios Pharmaceuticals, Inc Methods of using pyruvate kinase activators
EP2704720B1 (en) * 2011-05-03 2019-08-07 Agios Pharmaceuticals, Inc. Pyruvate kinase r activators for use in therapy
RU2472794C1 (ru) 2011-05-25 2013-01-20 Федеральное государственное образовательное учреждение высшего профессионального образования Астраханский государственный технический университет (ФГОУ ВПО АГТУ) Новые бициклические производные пирролидинов, обладающие антиоксидантной активностью, и способ их получения
WO2012160447A1 (en) 2011-05-25 2012-11-29 Dynamix Pharmaceuticals Ltd. 3, 5 -diphenyl- substituted pyrazolines for the treatment of cancer, proliferative, inflammatory or autoimmune diseases
GB201108825D0 (en) 2011-05-25 2011-07-06 Univ Dundee Morpholino compounds, uses and methods
JP2014518266A (ja) 2011-06-29 2014-07-28 メルク・シャープ・アンド・ドーム・コーポレーション ジペプチジルペプチダーゼ−ｉｖ阻害剤の新規結晶形
ES2624982T3 (es) 2011-07-08 2017-07-18 Sloan-Kettering Institute For Cancer Research Usos de inhibidores etiquetados HSP90
JO3611B1 (ar) 2011-08-10 2020-08-27 Janssen Sciences Ireland Uc سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم
CN102952139B (zh) 2011-08-30 2016-08-10 上海药明康德新药开发有限公司 反式-3a-氟吡咯烷[3,4-C]并环化合物及其制备方法
JP6165733B2 (ja) 2011-09-16 2017-07-19 ノバルティス アーゲー Ｎ−置換ヘテロシクリルカルボキサミド類
US20140249150A1 (en) 2011-10-13 2014-09-04 Agios Pharmaceuticals, Inc Activators of pyruvate kinase m2 and methods of treating disease
JP5468056B2 (ja) 2011-12-15 2014-04-09 富士フイルム株式会社 電気泳動組成物、マイクロカプセル、及び、電気泳動表示素子
PL2797416T3 (pl) 2011-12-28 2017-12-29 Global Blood Therapeutics, Inc. Podstawione związki benzaldehydowe i sposoby ich zastosowania do zwiększania natlenienia tkanek
US9012450B2 (en) 2011-12-28 2015-04-21 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
CA2860553C (en) 2012-01-04 2016-08-23 Pfizer Limited N-aminosulfonyl benzamides
JP2015083542A (ja) 2012-02-08 2015-04-30 大日本住友製薬株式会社 ３位置換プロリン誘導体
JP5895583B2 (ja) 2012-02-21 2016-03-30 コニカミノルタ株式会社 有機エレクトロルミネッセンス素子、照明装置および表示装置ならびに有機エレクトロルミネッセンス素子の製造方法
US9493481B2 (en) 2012-02-23 2016-11-15 Vanderbilt University Substituted 5-aminothieno[2,3—C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4
SG10201701894SA (en) 2012-03-02 2017-05-30 Genentech Inc Amido-Benzyl Sulfone and Sulfoxide Derivatives
WO2013155223A1 (en) 2012-04-10 2013-10-17 The Regents Of The University Of California Compositions and methods for treating cancer
CA2874621A1 (en) 2012-05-22 2013-11-28 Genentech, Inc. N-substituted benzamides and their use in the treatment of pain
US20150150935A1 (en) 2012-06-05 2015-06-04 Cara Therapeutics, Inc. Peripheral kappa receptor agonists for reducing pain and inflammation
US10071957B2 (en) 2012-07-06 2018-09-11 Genentech, Inc. N-substituted benzamides and methods of use thereof
CN103570722A (zh) 2012-07-19 2014-02-12 中国科学院上海药物研究所 稠环哒嗪酮类化合物及其制备方法和用途
US9758480B2 (en) 2012-07-19 2017-09-12 Sumitomo Dainippon Pharma Co., Ltd. 1-(cycloalkyl-carbonyl)proline derivative
EP2874626A4 (en) 2012-07-23 2016-03-23 Merck Sharp & Dohme TREATMENT OF DIABETES WITH DIPEPTIDYLPEPTIDASE IV INHIBITORS
WO2014023814A1 (en) 2012-08-10 2014-02-13 Janssen R&D Ireland New antibacterial compounds
AR092211A1 (es) 2012-09-24 2015-04-08 Merck Patent Ges Mit Beschränkter Haftung Derivados de hidropirrolopirrol
PL2900669T3 (pl) 2012-09-25 2020-01-31 F. Hoffmann-La Roche Ag Pochodne heksahydropirolo[3,4-C]pirolu i związki pokrewne jako inhibitory autotaksyny (ATX) oraz inhibitory produkcji kwasu lizofosfatydowego (LPA) do leczenia np. chorób nerek
EP2909181B1 (en) 2012-10-16 2017-08-09 Tolero Pharmaceuticals, Inc. Pkm2 modulators and methods for their use
TWI500613B (zh) * 2012-10-17 2015-09-21 Cadila Healthcare Ltd 新穎之雜環化合物
NZ707778A (en) 2012-11-08 2019-03-29 Agios Pharmaceuticals Inc Therapeutic compounds and compositions and their use as pkm2 modulators
US10118918B2 (en) 2012-12-21 2018-11-06 Epizyme, Inc. PRMT5 inhibitors and uses thereof
MX2015006780A (es) 2012-12-31 2015-08-06 Cadila Healthcare Ltd Derivados de ftalazin-1-(2h)-ona sustituida.
CA2900024A1 (en) 2013-01-31 2014-08-07 Marc Prentki Type 2 diabetes biomarkers and uses thereof
HK1217971A1 (zh) 2013-02-21 2017-01-27 Toma Biosciences Inc 用於核酸分析的方法、組合物和試劑盒
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
TW201524952A (zh) 2013-03-15 2015-07-01 Araxes Pharma Llc Ｋｒａｓ ｇ１２ｃ之共價抑制劑
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
WO2014145040A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
WO2014144715A1 (en) 2013-03-15 2014-09-18 Memorial Sloan-Kettering Cancer Center Hsp90-targeted cardiac imaging and therapy
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
WO2014139144A1 (en) * 2013-03-15 2014-09-18 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
BR112015021982B1 (pt) 2013-03-15 2022-12-13 Global Blood Therapeutics, Inc Compostos e seus usos para a modulação de hemoglobina
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
WO2014172638A2 (en) 2013-04-18 2014-10-23 Brandeis University Inhibitors of deubiquitinating proteases
WO2014179567A2 (en) 2013-05-01 2014-11-06 Academia Sinica Methods and compositions for treating beta-thalassemia and sickle cell disease
KR102084185B1 (ko) 2013-08-29 2020-03-04 주식회사 대웅제약 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법
JP6576929B2 (ja) 2013-09-11 2019-09-18 メルク パテント ゲーエムベーハー ヘテロ環化合物
CN110372636B (zh) 2013-09-20 2023-03-28 生物马林药物股份有限公司 用于治疗疾病的葡萄糖神经酰胺合成酶抑制剂
CA2924393A1 (en) 2013-09-25 2015-04-02 Institute For Systems Biology Markers for amyotrophic lateral sclerosis (als) and presymptomatic alzheimer's desease (psad)
US9920073B2 (en) 2013-10-04 2018-03-20 Drexel University Compositions useful for inhibiting HIV-1 infection and methods using same
US9868736B2 (en) 2013-10-10 2018-01-16 The Regents Of The University Of Michigan Deubiquitinase inhibitors and methods for use of the same
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
JP6383418B2 (ja) 2013-11-27 2018-08-29 ジェネンテック， インコーポレイテッド 置換ベンズアミド及びその使用方法
WO2015093948A2 (en) 2013-12-17 2015-06-25 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Means and methods for typing a breast cancer patient and assigning therapy based on the typing
WO2015116061A1 (en) 2014-01-29 2015-08-06 Global Blood Therapeutics, Inc. 1:1 adducts of sickle hemoglobin
US9248199B2 (en) 2014-01-29 2016-02-02 Global Blood Therapeutics, Inc. 1:1 adducts of sickle hemoglobin
SG11201607135SA (en) 2014-02-28 2016-09-29 Corning Inc Diketopyrrolopyrrole semiconducting materials, processes for their preparation and uses thereof
MA50635A (fr) 2014-03-26 2020-08-12 Hoffmann La Roche Nouveaux composés bicycliques comme inhibiteurs de la production d'autotaxin (atx) et de l'acide lysophosphatidique
CN105037367A (zh) 2014-04-18 2015-11-11 四川海思科制药有限公司 氨基六元环类衍生物及其在医药上的应用
CN105085528A (zh) 2014-05-15 2015-11-25 成都贝斯凯瑞生物科技有限公司 作为二肽基肽酶-iv抑制剂的氨基四氢吡喃衍生物
WO2015183173A1 (en) 2014-05-28 2015-12-03 Grafström Roland In vitro toxicogenomics for toxicity prediction
WO2015192701A1 (zh) 2014-06-17 2015-12-23 四川海思科制药有限公司 氨基吡喃环衍生物及其组合物和应用
CN105294694B (zh) 2014-06-18 2019-01-04 四川海思科制药有限公司 氨基六元环类衍生物及其在医药上的应用
JP2017519801A (ja) 2014-07-11 2017-07-20 インターベット インターナショナル ベー． フェー． 犬糸状虫に対する駆虫薬の使用
WO2016005576A1 (en) 2014-07-11 2016-01-14 Intervet International B.V. Use of anthelmintic agents against dirofilaria immitis
JP6574474B2 (ja) 2014-07-21 2019-09-11 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． キラルジペプチジルペプチダーゼ−ｉｖ阻害剤の製造方法
US10017463B2 (en) 2014-07-21 2018-07-10 Brandeis University Inhibitors of deubiquitinating proteases
WO2016022656A1 (en) 2014-08-05 2016-02-11 Wayne State University Compositions and methods for treatment of sickle cell disease
KR101837565B1 (ko) 2014-08-06 2018-03-12 삼성에스디아이 주식회사 유기 화합물, 유기 광전자 소자 및 표시 장치
EP3194975A4 (en) 2014-09-17 2018-05-02 Memorial Sloan Kettering Cancer Center Hsp90-targeted inflammation and infection imaging and therapy
WO2016044604A1 (en) 2014-09-17 2016-03-24 Epizyme, Inc. Carm1 inhibitors and uses thereof
WO2016044650A1 (en) 2014-09-17 2016-03-24 Epizyme, Inc. Carm1 inhibitors and uses thereof
WO2016046837A1 (en) 2014-09-22 2016-03-31 Cadila Healthcare Limited An improved process for preparation of pyrrolo[3,4- c] pyrrole compounds and intermediates thereof
JP6778112B2 (ja) 2014-09-22 2020-10-28 国立研究開発法人科学技術振興機構 抗インフルエンザウイルス剤、及び抗インフルエンザウイルス剤のスクリーニング方法
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
WO2016168647A1 (en) 2015-04-17 2016-10-20 Acetylon Pharmaceuticals Inc. Treatment of neuroblastoma with histone deacetylase inhibotrs
WO2016181408A2 (en) 2015-05-11 2016-11-17 Cadila Healthcare Limited NOVEL SHORT-CHAIN PEPTIDES AS KAPPA (κ) OPIOID RECEPTORS (KOR) AGONIST
WO2016196816A1 (en) 2015-06-03 2016-12-08 The University Of North Carolina At Chapel Hill Photoredox-catalyzed direct c-h functionalization of arenes
MX384883B (es) 2015-06-11 2025-03-14 Agios Pharmaceuticals Inc Métodos para usar activadores de piruvato cinasa.
US10577321B2 (en) 2015-07-08 2020-03-03 University Of Southern California Deoxyuridine triphosphatase inhibitors
CN105153119B (zh) 2015-09-11 2019-01-01 广州必贝特医药技术有限公司 吡啶嘧啶胺类化合物或吡啶吡啶胺类化合物及其应用
AU2016328437A1 (en) 2015-09-24 2018-01-25 F. Hoffmann-La Roche Ag Bicyclic compounds as ATX inhibitors
BR112018006080A2 (pt) 2015-09-24 2018-10-09 F. Hoffmann-La Roche Ag novos compostos bicíclicos como inibidores de dupla ação de atx/ca
CN105254628B (zh) 2015-11-13 2017-06-23 南京华威医药科技开发有限公司 吡唑并吡啶类抗肿瘤化合物及其制备方法和应用
CN105348286B (zh) 2015-11-25 2018-12-18 中山奕安泰医药科技有限公司 一种2-甲基磺酰基-2,4,5,6-四氢吡咯[3，4-c]吡唑苯磺酸盐的制备方法
WO2017191274A2 (en) 2016-05-04 2017-11-09 Curevac Ag Rna encoding a therapeutic protein
TWI663160B (zh) 2016-05-12 2019-06-21 全球血液治療公司 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
MA44037B1 (fr) 2016-06-06 2020-03-31 Arena Pharm Inc Modulateurs du récepteur adrénergique bêta 3 utile dans le traitement ou la prévention de troubles associés à ceux-ci
US20190247399A1 (en) 2016-09-09 2019-08-15 Tg Therapeutics, Inc. Combination of an anti-cd20 antibody, pi3 kinase-delta inhibitor, and anti-pd-1 or anti-pd-l1 antibody for treating hematological cancers
TW202332423A (zh) 2016-10-12 2023-08-16 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
WO2018109277A1 (en) 2016-12-14 2018-06-21 Åbo Akademi University Diagnosis of parkinson's disease on the basis of decreased overall translation
US9744145B1 (en) 2017-01-16 2017-08-29 Macau University Of Science And Technology Methods for treating lung cancer
AR111295A1 (es) 2017-03-20 2019-06-26 Forma Therapeutics Inc Composiciones de pirrolopirrol como activadores de piruvato quinasa (pkr)
CN106928222B (zh) 2017-04-25 2019-08-23 淮阴师范学院 一种3-烷基中氮茚衍生物的制备方法
EP3668513B1 (en) 2017-08-15 2021-11-10 Agios Pharmaceuticals, Inc. Pyruvate kinase activators for use in treating blood disorders
WO2019099651A1 (en) 2017-11-16 2019-05-23 Agios Pharmaceuticals, Inc. Methods of using deuterated pyruvate kinase activators
KR102682430B1 (ko) 2017-11-22 2024-07-08 아지오스 파마슈티컬스 아이엔씨. N-(4-(4-(시클로프로필메틸)피페라진-1-카르보닐)페닐)퀴놀린-8-술폰아미드의 결정 형태
CN111699189B (zh) 2017-12-06 2025-02-18 艾尼纳制药公司 可用于治疗或预防与其相关的心力衰竭和障碍的β-3肾上腺素能受体的调节剂
EP3852790A4 (en) 2018-09-19 2022-08-10 Forma Therapeutics, Inc. INHIBITION OF UBIQUITIN-SPECIFIC PEPTIDASE 9X
WO2020061255A1 (en) 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Activating pyruvate kinase r
US20200129485A1 (en) 2018-09-19 2020-04-30 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
US20210346356A1 (en) 2018-09-19 2021-11-11 Forma Therapeutics, Inc. Inhibiting ubiquitin specific peptidase 9x
JP7164400B2 (ja) 2018-10-30 2022-11-01 株式会社オカムラ 天板付什器
PT3880654T (pt) 2018-11-19 2022-04-08 Global Blood Therapeutics Inc Compostos de 2-formil-3-hidroxifeniloximetil capazes de modular hemoglobina
EP3902533A1 (en) 2018-12-26 2021-11-03 Forma Therapeutics, Inc. Inhibiting ubiquitin specific peptidase 9x
WO2020191022A1 (en) 2019-03-18 2020-09-24 Forma Therapeutics, Inc. Inhibiting ubiquitin specific peptidase 9x
CN109912610B (zh) 2019-04-04 2020-06-23 石家庄诚志永华显示材料有限公司 有机化合物及其在制备有机电致发光元件中的应用
MX2022003025A (es) 2019-09-19 2022-04-07 Forma Therapeutics Inc Activacion de la piruvato cinasa r.
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R

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US10836771B2 (en) 2020-11-17
ES2747768T3 (es) 2020-03-11
MA50589A (fr) 2021-09-15
HRP20200752T1 (hr) 2020-07-24
US11396513B2 (en) 2022-07-26
CY1122393T1 (el) 2021-01-27
US20200069643A1 (en) 2020-03-05
CN109311897B (zh) 2021-07-20
KR20190092597A (ko) 2019-08-07
RU2019137023A3 (pl) 2020-04-30
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DK3483164T3 (da) 2020-03-23
IL289175A (en) 2022-02-01
PT3448859T (pt) 2019-10-25
KR20180135494A (ko) 2018-12-20
HUE045261T2 (hu) 2019-12-30
EA201992215A1 (ru) 2020-02-06
NZ748072A (en) 2020-06-26
BR112018075312A2 (pt) 2019-10-01
AU2022241506A1 (en) 2022-10-27
DK3448859T3 (da) 2019-09-23
EP3448859B1 (en) 2019-07-10
MA44795A (fr) 2019-03-06
RS60209B1 (sr) 2020-06-30
AU2018240172B2 (en) 2019-05-16
RS59306B1 (sr) 2019-10-31
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TW201837041A (zh) 2018-10-16
EP3483164A1 (en) 2019-05-15
PL3448859T3 (pl) 2020-02-28
CA3024181A1 (en) 2018-09-27
IL269447B (en) 2022-01-01
US10472371B2 (en) 2019-11-12
US20240083901A1 (en) 2024-03-14
MA44795B1 (fr) 2019-09-30
CN109311897A (zh) 2019-02-05
MD3448859T2 (ro) 2020-03-31
JP2019521090A (ja) 2019-07-25
HUE049979T2 (hu) 2020-11-30
ZA201906278B (en) 2021-01-27
AU2021201244B2 (en) 2022-10-20
US10208052B1 (en) 2019-02-19
RU2020136402A (ru) 2022-05-06
AU2019206013A1 (en) 2019-08-01
CA3024181C (en) 2023-06-13
RU2019137023A (ru) 2019-12-24
US12071440B2 (en) 2024-08-27

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