PL353539A1 - Pochodne N-heterocykliczne jako inhibitory NOS (syPochodne N-heterocykliczne jako inhibitory NOS (syntazy tlenku azotu)ntazy tlenku azotu) - Google Patents

Pochodne N-heterocykliczne jako inhibitory NOS (syPochodne N-heterocykliczne jako inhibitory NOS (syntazy tlenku azotu)ntazy tlenku azotu)

Info

Publication number: PL353539A1
Authority: PL; Poland
Prior art keywords: heterocyclic derivatives; nos inhibitors; inhibitors; compounds; nitric oxide
Prior art date: 1999-08-26

Application number

PL00353539A

Other languages

English (en)

Inventor

Damian O.Arnaiz Damian O. Arnaiz

John J.Baldwin John J. Baldwin

David D.Davey David D. Davey

James J.Devlin James J. Devlin

Roland Ellwood IIIDolle Roland Ellwood Dolle III

Shawn DavidErickson Shawn David Erickson

KirkMcMillan Kirk McMillan

Michael M.Morrissey Michael M. Morrissey

Michael H.J.Ohlmeyer Michael H.J. Ohlmeyer

GonghuaPan Gonghua Pan

Vidyadhar MadhavParadkar Vidyadhar Madhav Paradkar

JohnParkinson John Parkinson

Gary B.Phillips Gary B. Phillips

BinYe Bin Ye

ZuchunZhao Zuchun Zhao

Original Assignee

Berlex Laboratories, Inc.Berlex Laboratories, Inc.

Pharmacopeia, Inc.Pharmacopeia, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-26

Filing date

2000-08-24

Publication date

2003-12-01

2000-08-24 Application filed by Berlex Laboratories, Inc.Berlex Laboratories, Inc., Pharmacopeia, Inc.Pharmacopeia, Inc. filed Critical Berlex Laboratories, Inc.Berlex Laboratories, Inc.

2003-12-01 Publication of PL353539A1 publication Critical patent/PL353539A1/pl

Links

239000003112 inhibitor Substances 0.000 title abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 2
108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Psychology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)
Obesity (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PL00353539A 1999-08-26 2000-08-24 Pochodne N-heterocykliczne jako inhibitory NOS (syPochodne N-heterocykliczne jako inhibitory NOS (syntazy tlenku azotu)ntazy tlenku azotu) PL353539A1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/383,813 US6432947B1 (en)	1997-02-19	1999-08-26	N-heterocyclic derivatives as NOS inhibitors
PCT/US2000/023173 WO2001014371A1 (en)	1999-08-26	2000-08-24	N-heterocyclic derivatives as nos inhibitors

Publications (1)

Publication Number	Publication Date
PL353539A1 true PL353539A1 (pl)	2003-12-01

Family

ID=23514822

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL00353539A PL353539A1 (pl)	1999-08-26	2000-08-24	Pochodne N-heterocykliczne jako inhibitory NOS (syPochodne N-heterocykliczne jako inhibitory NOS (syntazy tlenku azotu)ntazy tlenku azotu)

Country Status (34)

Country	Link
US (11)	US6432947B1 (pl)
EP (1)	EP1206467B1 (pl)
JP (1)	JP4739625B2 (pl)
KR (1)	KR100708783B1 (pl)
CN (1)	CN1206228C (pl)
AT (1)	ATE256681T1 (pl)
AU (1)	AU769405B2 (pl)
BG (1)	BG65804B1 (pl)
BR (1)	BR0014144A (pl)
CA (1)	CA2376355C (pl)
CZ (1)	CZ2002642A3 (pl)
DE (1)	DE60007329T2 (pl)
DK (1)	DK1206467T3 (pl)
EE (1)	EE05199B1 (pl)
ES (1)	ES2213599T3 (pl)
HK (1)	HK1043594A1 (pl)
HR (1)	HRP20020175B1 (pl)
HU (1)	HUP0202450A3 (pl)
IL (2)	IL148313A0 (pl)
LT (1)	LT4982B (pl)
LV (1)	LV12887B (pl)
MX (1)	MXPA02002022A (pl)
NO (1)	NO323886B1 (pl)
NZ (1)	NZ517411A (pl)
PL (1)	PL353539A1 (pl)
PT (1)	PT1206467E (pl)
RO (1)	RO122202B1 (pl)
RS (1)	RS50378B (pl)
RU (1)	RU2277094C2 (pl)
SI (1)	SI20818B (pl)
SK (1)	SK2622002A3 (pl)
UA (1)	UA72930C2 (pl)
WO (1)	WO2001014371A1 (pl)
ZA (1)	ZA200201485B (pl)

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1999
- 1999-08-26 US US09/383,813 patent/US6432947B1/en not_active Expired - Fee Related
2000
- 2000-08-24 RO ROA200200205A patent/RO122202B1/ro unknown
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- 2000-08-24 IL IL14831300A patent/IL148313A0/xx active IP Right Grant
- 2000-08-24 AT AT00959333T patent/ATE256681T1/de not_active IP Right Cessation
- 2000-08-24 UA UA2002032401A patent/UA72930C2/uk unknown
- 2000-08-24 SK SK262-2002A patent/SK2622002A3/sk unknown
- 2000-08-24 WO PCT/US2000/023173 patent/WO2001014371A1/en not_active Ceased
- 2000-08-24 JP JP2001518702A patent/JP4739625B2/ja not_active Expired - Fee Related
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- 2000-08-24 BR BR0014144-5A patent/BR0014144A/pt not_active Application Discontinuation
- 2000-08-24 MX MXPA02002022A patent/MXPA02002022A/es active IP Right Grant
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- 2000-08-24 CN CNB008146691A patent/CN1206228C/zh not_active Expired - Fee Related
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- 2000-08-24 CZ CZ2002642A patent/CZ2002642A3/cs unknown
- 2000-08-24 DK DK00959333T patent/DK1206467T3/da active
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- 2002-03-15 LT LT2002028A patent/LT4982B/lt not_active IP Right Cessation
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Publication number	Publication date
US6864263B2 (en)	2005-03-08
NZ517411A (en)	2003-09-26
US20030078265A1 (en)	2003-04-24
US20020165203A1 (en)	2002-11-07
ZA200201485B (en)	2003-07-30
US20030027794A1 (en)	2003-02-06
RS50378B (sr)	2009-11-10
ES2213599T3 (es)	2004-09-01
DK1206467T3 (da)	2004-04-26
DE60007329T2 (de)	2004-06-09
EE05199B1 (et)	2009-08-17
EE200200091A (et)	2003-04-15
LT2002028A (en)	2002-09-25
US6841673B2 (en)	2005-01-11
NO323886B1 (no)	2007-07-16
KR20020062277A (ko)	2002-07-25
IL148313A0 (en)	2002-09-12
CA2376355C (en)	2009-10-27
HK1043594A1 (zh)	2002-09-20
US20030073669A1 (en)	2003-04-17
SK2622002A3 (en)	2002-09-10
DE60007329D1 (de)	2004-01-29
BG65804B1 (bg)	2009-12-31
JP2003507476A (ja)	2003-02-25
US20020183323A1 (en)	2002-12-05
SI20818A (sl)	2002-08-31
US6846829B2 (en)	2005-01-25
HUP0202450A2 (hu)	2002-11-28
MXPA02002022A (es)	2002-10-31
PT1206467E (pt)	2004-05-31
US6747031B2 (en)	2004-06-08
US6864368B2 (en)	2005-03-08
RU2277094C2 (ru)	2006-05-27
US20030060452A1 (en)	2003-03-27
KR100708783B1 (ko)	2007-04-19
US6432947B1 (en)	2002-08-13
US20030069210A1 (en)	2003-04-10
UA72930C2 (uk)	2005-05-16
NO20020925D0 (no)	2002-02-26
LT4982B (lt)	2003-01-27
US6849739B2 (en)	2005-02-01
US20030004137A1 (en)	2003-01-02
SI20818B (sl)	2009-04-30
CA2376355A1 (en)	2001-03-01
LV12887B (en)	2003-01-20
US6887865B2 (en)	2005-05-03
ATE256681T1 (de)	2004-01-15
BR0014144A (pt)	2002-05-21
US20030083332A1 (en)	2003-05-01
HRP20020175B1 (hr)	2008-07-31
US20030092678A1 (en)	2003-05-15
US6670473B2 (en)	2003-12-30
EP1206467A1 (en)	2002-05-22
JP4739625B2 (ja)	2011-08-03
EP1206467B1 (en)	2003-12-17
US6841674B2 (en)	2005-01-11
HRP20020175A2 (en)	2005-10-31
AU7067100A (en)	2001-03-19
HK1051683A1 (en)	2003-08-15
YU12002A (sh)	2005-03-15
AU769405B2 (en)	2004-01-29
CZ2002642A3 (cs)	2002-08-14
BG106440A (en)	2002-11-29
CN1206228C (zh)	2005-06-15
IL148313A (en)	2008-04-13
CN1382136A (zh)	2002-11-27
NO20020925L (no)	2002-04-16
RO122202B1 (ro)	2009-02-27
WO2001014371A1 (en)	2001-03-01
HUP0202450A3 (en)	2003-12-29

Legal Events

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2008-02-29	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
IL148313A0 (en)	2002-09-12	N-heterocyclic derivatives as nos inhibitors
GB2338957B (en)	2001-08-01	N-heterocyclic derivatives as nos inhibitors
AU2001245972A1 (en)	2001-10-08	N-heterocyclic derivatives as nos inhibitors
AU2003228678A1 (en)	2003-11-17	1-substituted imidazole derivatives as nos inhibitors
AU2002239344A1 (en)	2002-06-24	Pyrazolopyridines
AU2002239348A1 (en)	2002-06-24	Pyrazolopyridine derivatives
AU2002248531A1 (en)	2002-09-24	Pyrazolopyriadine derivatives
WO2003080631A3 (en)	2004-04-15	Plasma carboxypeptidase b inhibitors
WO2004093796A3 (en)	2005-09-09	Lactam derivatives and methods of their use
EP1795192A3 (en)	2008-05-07	1-(Pyridazin-3-yl)-imidazole derivatives as inhibitors of nitric oxide synthase (NOS)