PL411471A1 - Crystalline form of the [aqua(di(2-amino-5-guanidinepentane)copper(II)] hexahydrate oxalate complex, method for producing it and applications - Google Patents
Crystalline form of the [aqua(di(2-amino-5-guanidinepentane)copper(II)] hexahydrate oxalate complex, method for producing it and applicationsInfo
- Publication number
- PL411471A1 PL411471A1 PL411471A PL41147115A PL411471A1 PL 411471 A1 PL411471 A1 PL 411471A1 PL 411471 A PL411471 A PL 411471A PL 41147115 A PL41147115 A PL 41147115A PL 411471 A1 PL411471 A1 PL 411471A1
- Authority
- PL
- Poland
- Prior art keywords
- copper
- amino
- aqua
- crystalline form
- producing
- Prior art date
Links
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- JQUBCNOCGBWPRR-UHFFFAOYSA-N oxalic acid hexahydrate Chemical compound O.O.O.O.O.O.OC(=O)C(O)=O JQUBCNOCGBWPRR-UHFFFAOYSA-N 0.000 title abstract 2
- DYOKHDPMROZFEW-UHFFFAOYSA-N 2-(4-aminopentyl)guanidine Chemical compound CC(N)CCCN=C(N)N DYOKHDPMROZFEW-UHFFFAOYSA-N 0.000 abstract 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N Arginine Chemical compound OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 2
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 229910021592 Copper(II) chloride Inorganic materials 0.000 abstract 1
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- XTVVROIMIGLXTD-UHFFFAOYSA-N copper(II) nitrate Chemical compound [Cu+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O XTVVROIMIGLXTD-UHFFFAOYSA-N 0.000 abstract 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 abstract 1
- 229910000366 copper(II) sulfate Inorganic materials 0.000 abstract 1
- -1 hexa oxalate hydrate Chemical compound 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 abstract 1
- 229940039790 sodium oxalate Drugs 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Wynalazek dotyczy krystalicznej formy kompleksu heksa hydrat szczawian [akwa(di(2-amino-5-guanidynopentano))miedzi(II)] o wzorze 1 oraz zastosowania związku będącego przedmiotem wynalazku i/lub otrzymanego sposobem do wytwarzania środka lub preparatu do leczenia lub profilaktyki infekcji bakteryjnych i/lub grzybicznych. Wynalazek ujawnia również sposób wytwarzania krystalicznej formy kompleksu heksa hydrat szczawian [akwa(di(2-amino-5-guanidynopentano))miedzi(II)] o wzorze 1, polegający na tym, że jedną część molową uwodnionej soli chlorku miedzi(II) lub soli siarczanu(VI) miedzi(II) lub soli azotanu(V) miedzi(II) rozpuszcza się w wodzie i poddaje się reakcji z dwiema częściami molowymi roztworu kwasu 2-amino-5-guanidynopentanowego oraz jedną częścią molową roztworu soli szczawianu sodu, przy czym reakcję prowadzi się na mieszadle magnetycznym przy ciągłym mieszaniu, po czym po minimum 7-18 dniach otrzymuje się krystaliczną formę kompleksu heksa hydrat szczawian [akwa(di(2-amino-5-guanidynopentano))miedzi(II)] o wzorze 1.The invention relates to the crystalline form of the hexa oxalate hydrate complex [aqua (di (2-amino-5-guanidinopentane)) copper (II)] of formula 1 and the use of the compound of the invention and / or obtained by the method for the preparation of an agent or preparation for the treatment or prevention bacterial and / or fungal infections. The invention also discloses a method for producing the crystalline form of the hexalate hydrate [aqua (di (2-amino-5-guanidinopentane)) copper (II)] formula (I), wherein one molar part of the hydrated copper (II) chloride or the copper (II) sulfate or copper (II) nitrate salt is dissolved in water and reacted with two molar parts of the 2-amino-5-guanidinopentanoic acid solution and one molar part of the sodium oxalate solution, where the reaction is carried out on a magnetic stirrer with continuous stirring, after which after a minimum of 7-18 days the crystalline form of the oxalate hexa hydrate complex [aqua (di (2-amino-5-guanidinopentane)) copper (II)] of formula 1 is obtained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL411471A PL228680B1 (en) | 2015-03-06 | 2015-03-06 | Crystalline form of the [aqua(di(2-amino-5-guanidinepentane)copper(II)] hexahydrate oxalate complex, method for producing it and applications |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL411471A PL228680B1 (en) | 2015-03-06 | 2015-03-06 | Crystalline form of the [aqua(di(2-amino-5-guanidinepentane)copper(II)] hexahydrate oxalate complex, method for producing it and applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL411471A1 true PL411471A1 (en) | 2016-07-04 |
| PL228680B1 PL228680B1 (en) | 2018-04-30 |
Family
ID=56234612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL411471A PL228680B1 (en) | 2015-03-06 | 2015-03-06 | Crystalline form of the [aqua(di(2-amino-5-guanidinepentane)copper(II)] hexahydrate oxalate complex, method for producing it and applications |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL228680B1 (en) |
-
2015
- 2015-03-06 PL PL411471A patent/PL228680B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL228680B1 (en) | 2018-04-30 |
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