PT1289999E - Analogos antitumorais de et-743 - Google Patents
Analogos antitumorais de et-743Info
- Publication number
- PT1289999E PT1289999E PT01929813T PT01929813T PT1289999E PT 1289999 E PT1289999 E PT 1289999E PT 01929813 T PT01929813 T PT 01929813T PT 01929813 T PT01929813 T PT 01929813T PT 1289999 E PT1289999 E PT 1289999E
- Authority
- PT
- Portugal
- Prior art keywords
- hydroxy
- spiroamine
- protecting group
- bridge
- ecteinascidin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Discharging, Photosensitive Material Shape In Electrophotography (AREA)
- Instruments For Viewing The Inside Of Hollow Bodies (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2000/001852 WO2000069862A2 (en) | 1999-05-14 | 2000-05-15 | Hemisynthetic method and intermediates thereof |
| PCT/GB2001/002110 WO2001087894A1 (en) | 1999-05-14 | 2001-05-15 | Antitumoral analogs of et-743 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1289999E true PT1289999E (pt) | 2005-03-31 |
Family
ID=34855248
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT01929813T PT1289999E (pt) | 2000-05-15 | 2001-05-15 | Analogos antitumorais de et-743 |
| PT04010399T PT1496060E (pt) | 2000-05-15 | 2001-05-15 | Análogos antitumurais de et-743 |
| PT01929816T PT1287004E (pt) | 2000-05-15 | 2001-05-15 | Processo sintetico para a producao de um composto ecteinascidina |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT04010399T PT1496060E (pt) | 2000-05-15 | 2001-05-15 | Análogos antitumurais de et-743 |
| PT01929816T PT1287004E (pt) | 2000-05-15 | 2001-05-15 | Processo sintetico para a producao de um composto ecteinascidina |
Country Status (16)
| Country | Link |
|---|---|
| EP (3) | EP1289999B1 (pt) |
| KR (2) | KR100830717B1 (pt) |
| AT (2) | ATE300547T1 (pt) |
| AU (2) | AU2001256496C1 (pt) |
| DE (3) | DE60129753T2 (pt) |
| DK (3) | DK1289999T3 (pt) |
| EA (2) | EA006369B1 (pt) |
| ES (2) | ES2290583T3 (pt) |
| GB (1) | GB9918178D0 (pt) |
| HU (1) | HU228789B1 (pt) |
| MX (1) | MXPA02010701A (pt) |
| NZ (2) | NZ532793A (pt) |
| PL (1) | PL203745B1 (pt) |
| PT (3) | PT1289999E (pt) |
| SI (2) | SI1496060T1 (pt) |
| UA (1) | UA75597C2 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE368461T1 (de) | 2004-10-29 | 2007-08-15 | Pharma Mar Sa | Zusammensetzungen enthaltend ecteinascidin und einen disaccharide |
| KR100676324B1 (ko) * | 2005-03-15 | 2007-01-30 | 삼성전자주식회사 | 디스플레이장치 |
| KR100676325B1 (ko) * | 2005-03-15 | 2007-01-30 | 삼성전자주식회사 | 디스플레이장치 |
| KR100712667B1 (ko) * | 2006-04-11 | 2007-05-02 | 재단법인서울대학교산학협력재단 | 신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법 |
| CN103038240A (zh) * | 2010-05-25 | 2013-04-10 | 法马马有限公司 | 制备海鞘素化合物的合成方法 |
| KR102491180B1 (ko) | 2017-04-27 | 2023-01-20 | 파르마 마르 에스.에이. | 항종양 화합물 |
| WO2020105068A1 (en) * | 2018-11-24 | 2020-05-28 | Natco Pharma Limited | Process for the preparation of ecteinascidin derivative and its intermediate |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59225189A (ja) | 1983-06-03 | 1984-12-18 | Shionogi & Co Ltd | キノナミン誘導体およびその製造法 |
| EP0309477B1 (en) * | 1986-06-09 | 1991-11-06 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759a, 759b and 770 |
| US5721362A (en) * | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
| US6124292A (en) * | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
-
1999
- 1999-08-02 GB GBGB9918178.6A patent/GB9918178D0/en not_active Ceased
-
2001
- 2001-05-15 EP EP01929813A patent/EP1289999B1/en not_active Expired - Lifetime
- 2001-05-15 PT PT01929813T patent/PT1289999E/pt unknown
- 2001-05-15 NZ NZ532793A patent/NZ532793A/en not_active IP Right Cessation
- 2001-05-15 SI SI200130777T patent/SI1496060T1/sl unknown
- 2001-05-15 NZ NZ521807A patent/NZ521807A/en not_active IP Right Cessation
- 2001-05-15 PT PT04010399T patent/PT1496060E/pt unknown
- 2001-05-15 KR KR1020027015168A patent/KR100830717B1/ko not_active Expired - Fee Related
- 2001-05-15 ES ES04010399T patent/ES2290583T3/es not_active Expired - Lifetime
- 2001-05-15 DE DE60129753T patent/DE60129753T2/de not_active Expired - Lifetime
- 2001-05-15 DE DE60112286T patent/DE60112286T2/de not_active Expired - Lifetime
- 2001-05-15 PT PT01929816T patent/PT1287004E/pt unknown
- 2001-05-15 MX MXPA02010701A patent/MXPA02010701A/es active IP Right Grant
- 2001-05-15 PL PL358143A patent/PL203745B1/pl unknown
- 2001-05-15 EA EA200201210A patent/EA006369B1/ru not_active IP Right Cessation
- 2001-05-15 EP EP04010399A patent/EP1496060B1/en not_active Expired - Lifetime
- 2001-05-15 DK DK01929813T patent/DK1289999T3/da active
- 2001-05-15 EP EP01929816A patent/EP1287004B1/en not_active Expired - Lifetime
- 2001-05-15 HU HU0300648A patent/HU228789B1/hu unknown
- 2001-05-15 UA UA20021210093A patent/UA75597C2/uk unknown
- 2001-05-15 AU AU2001256496A patent/AU2001256496C1/en not_active Expired
- 2001-05-15 AT AT01929816T patent/ATE300547T1/de active
- 2001-05-15 KR KR1020027014555A patent/KR100777464B1/ko not_active Expired - Lifetime
- 2001-05-15 SI SI200130244T patent/SI1289999T1/xx unknown
- 2001-05-15 DK DK04010399T patent/DK1496060T3/da active
- 2001-05-15 EA EA200201209A patent/EA006070B1/ru not_active IP Right Cessation
- 2001-05-15 AU AU56493/01A patent/AU783563B2/en not_active Expired
- 2001-05-15 DK DK01929816T patent/DK1287004T3/da active
- 2001-05-15 ES ES01929816T patent/ES2248319T3/es not_active Expired - Lifetime
- 2001-05-15 AT AT04010399T patent/ATE368671T1/de active
- 2001-05-15 DE DE60107241T patent/DE60107241T2/de not_active Expired - Lifetime
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