ATE300547T1 - Synthetisches verfahren zur herstellung von ecteinascidin-derivaten - Google Patents

Synthetisches verfahren zur herstellung von ecteinascidin-derivaten

Info

Publication number
ATE300547T1
ATE300547T1 AT01929816T AT01929816T ATE300547T1 AT E300547 T1 ATE300547 T1 AT E300547T1 AT 01929816 T AT01929816 T AT 01929816T AT 01929816 T AT01929816 T AT 01929816T AT E300547 T1 ATE300547 T1 AT E300547T1
Authority
AT
Austria
Prior art keywords
hydroxy
synthetic process
spiroamine
protecting group
bridge
Prior art date
Application number
AT01929816T
Other languages
English (en)
Inventor
Carmen Cuevas
Marta Perez
Andres Francesch
Jose Luis Chicharro
Pilar Gallego
Maria Zarzuelo
Ignacio Manzanares
Maria Jesus Martin
Simon Munt
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2000/001852 external-priority patent/WO2000069862A2/en
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Application granted granted Critical
Publication of ATE300547T1 publication Critical patent/ATE300547T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Discharging, Photosensitive Material Shape In Electrophotography (AREA)
  • Instruments For Viewing The Inside Of Hollow Bodies (AREA)
AT01929816T 2000-05-15 2001-05-15 Synthetisches verfahren zur herstellung von ecteinascidin-derivaten ATE300547T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/GB2000/001852 WO2000069862A2 (en) 1999-05-14 2000-05-15 Hemisynthetic method and intermediates thereof
PCT/GB2001/002120 WO2001087895A1 (en) 1999-05-14 2001-05-15 Synthetic process for the manufacture of an ecteinaschidin compound

Publications (1)

Publication Number Publication Date
ATE300547T1 true ATE300547T1 (de) 2005-08-15

Family

ID=34855248

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01929816T ATE300547T1 (de) 2000-05-15 2001-05-15 Synthetisches verfahren zur herstellung von ecteinascidin-derivaten
AT04010399T ATE368671T1 (de) 2000-05-15 2001-05-15 Et-743 analoga als antitumoralverbindungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT04010399T ATE368671T1 (de) 2000-05-15 2001-05-15 Et-743 analoga als antitumoralverbindungen

Country Status (16)

Country Link
EP (3) EP1289999B1 (de)
KR (2) KR100830717B1 (de)
AT (2) ATE300547T1 (de)
AU (2) AU2001256496C1 (de)
DE (3) DE60129753T2 (de)
DK (3) DK1289999T3 (de)
EA (2) EA006369B1 (de)
ES (2) ES2290583T3 (de)
GB (1) GB9918178D0 (de)
HU (1) HU228789B1 (de)
MX (1) MXPA02010701A (de)
NZ (2) NZ532793A (de)
PL (1) PL203745B1 (de)
PT (3) PT1289999E (de)
SI (2) SI1496060T1 (de)
UA (1) UA75597C2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE368461T1 (de) 2004-10-29 2007-08-15 Pharma Mar Sa Zusammensetzungen enthaltend ecteinascidin und einen disaccharide
KR100676324B1 (ko) * 2005-03-15 2007-01-30 삼성전자주식회사 디스플레이장치
KR100676325B1 (ko) * 2005-03-15 2007-01-30 삼성전자주식회사 디스플레이장치
KR100712667B1 (ko) * 2006-04-11 2007-05-02 재단법인서울대학교산학협력재단 신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법
CN103038240A (zh) * 2010-05-25 2013-04-10 法马马有限公司 制备海鞘素化合物的合成方法
KR102491180B1 (ko) 2017-04-27 2023-01-20 파르마 마르 에스.에이. 항종양 화합물
WO2020105068A1 (en) * 2018-11-24 2020-05-28 Natco Pharma Limited Process for the preparation of ecteinascidin derivative and its intermediate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
EP0309477B1 (de) * 1986-06-09 1991-11-06 The Board Of Trustees Of The University Of Illinois Ekteinascidine 729, 743, 745, 759a, 759b und 770
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US6124292A (en) * 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743

Also Published As

Publication number Publication date
HUP0300648A3 (en) 2006-05-29
NZ521807A (en) 2004-06-25
EA006070B1 (ru) 2005-08-25
EP1289999B1 (de) 2004-11-17
EP1496060B1 (de) 2007-08-01
DE60129753T2 (de) 2008-04-30
DK1496060T3 (da) 2007-12-03
EP1496060A1 (de) 2005-01-12
HUP0300648A2 (hu) 2003-07-28
ES2290583T3 (es) 2008-02-16
DE60129753D1 (de) 2007-09-13
UA75597C2 (en) 2006-05-15
AU2001256496C1 (en) 2006-08-03
KR20030031481A (ko) 2003-04-21
PL203745B1 (pl) 2009-11-30
DK1287004T3 (da) 2005-11-28
SI1496060T1 (sl) 2008-06-30
HU228789B1 (en) 2013-05-28
GB9918178D0 (en) 1999-10-06
MXPA02010701A (es) 2003-05-14
EP1287004B1 (de) 2005-07-27
NZ532793A (en) 2004-10-29
AU2001256496B2 (en) 2006-02-16
PT1496060E (pt) 2007-10-30
AU5649301A (en) 2001-11-26
KR100830717B1 (ko) 2008-05-20
PT1287004E (pt) 2005-11-30
KR20030005308A (ko) 2003-01-17
DE60107241D1 (de) 2004-12-23
EP1289999A1 (de) 2003-03-12
DE60112286T2 (de) 2006-06-01
ES2248319T3 (es) 2006-03-16
DE60107241T2 (de) 2006-08-03
HK1050193A1 (en) 2003-06-13
EA200201210A1 (ru) 2003-04-24
EP1287004A1 (de) 2003-03-05
SI1289999T1 (en) 2005-06-30
PL358143A1 (pl) 2004-08-09
KR100777464B1 (ko) 2007-11-27
EA200201209A1 (ru) 2003-04-24
AU783563B2 (en) 2005-11-10
DK1289999T3 (da) 2005-03-14
ATE368671T1 (de) 2007-08-15
PT1289999E (pt) 2005-03-31
DE60112286D1 (de) 2005-09-01
EA006369B1 (ru) 2005-12-29

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