DK1496060T3 - Antitumoranaloger af ET 743 - Google Patents

Antitumoranaloger af ET 743

Info

Publication number: DK1496060T3
Authority: DK; Denmark
Prior art keywords: hydroxy; spiroamine; protecting group; bridge; ecteinascidin
Prior art date: 2000-05-15

Application number

DK04010399T

Other languages

English (en)

Inventor

Ignacio Manzanares

Maria Jesus Martin

Alberto Rodrigues

Simon Munt

Carmen Cuevas

Marta Perez

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-15

Filing date

2001-05-15

Publication date

2007-12-03

2000-05-15 Priority claimed from PCT/GB2000/001852 external-priority patent/WO2000069862A2/en

2001-05-15 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2007-12-03 Application granted granted Critical

2007-12-03 Publication of DK1496060T3 publication Critical patent/DK1496060T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Discharging, Photosensitive Material Shape In Electrophotography (AREA)
Instruments For Viewing The Inside Of Hollow Bodies (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pyrane Compounds (AREA)

DK04010399T 2000-05-15 2001-05-15 Antitumoranaloger af ET 743 DK1496060T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/GB2000/001852 WO2000069862A2 (en)	1999-05-14	2000-05-15	Hemisynthetic method and intermediates thereof

Publications (1)

Publication Number	Publication Date
DK1496060T3 true DK1496060T3 (da)	2007-12-03

Family

ID=34855248

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK01929813T DK1289999T3 (da)	2000-05-15	2001-05-15	Antitumoranaloger af ET-743
DK01929816T DK1287004T3 (da)	2000-05-15	2001-05-15	Syntetisk proces til fremstilling af en ecteinascidinforbindelse
DK04010399T DK1496060T3 (da)	2000-05-15	2001-05-15	Antitumoranaloger af ET 743

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DK01929813T DK1289999T3 (da)	2000-05-15	2001-05-15	Antitumoranaloger af ET-743
DK01929816T DK1287004T3 (da)	2000-05-15	2001-05-15	Syntetisk proces til fremstilling af en ecteinascidinforbindelse

Country Status (16)

Country	Link
EP (3)	EP1287004B1 (da)
KR (2)	KR100830717B1 (da)
AT (2)	ATE368671T1 (da)
AU (2)	AU783563B2 (da)
DE (3)	DE60107241T2 (da)
DK (3)	DK1289999T3 (da)
EA (2)	EA006070B1 (da)
ES (2)	ES2290583T3 (da)
GB (1)	GB9918178D0 (da)
HU (1)	HU228789B1 (da)
MX (1)	MXPA02010701A (da)
NZ (2)	NZ521807A (da)
PL (1)	PL203745B1 (da)
PT (3)	PT1287004E (da)
SI (2)	SI1289999T1 (da)
UA (1)	UA75597C2 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101188691B1 (ko)	2004-10-29	2012-10-09	파르마 마르 에스.에이.	엑티나시딘 및 디사카라이드를 포함하는 제제
KR100676324B1 (ko) *	2005-03-15	2007-01-30	삼성전자주식회사	디스플레이장치
KR100676325B1 (ko) *	2005-03-15	2007-01-30	삼성전자주식회사	디스플레이장치
KR100712667B1 (ko) *	2006-04-11	2007-05-02	재단법인서울대학교산학협력재단	신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법
AU2011257277B2 (en) *	2010-05-25	2016-02-25	Pharma Mar, S.A.	Synthetic process for the manufacture of ecteinascidin compounds
US11332480B2 (en)	2017-04-27	2022-05-17	Pharma Mar, S.A.	Antitumoral compounds
WO2020105068A1 (en) *	2018-11-24	2020-05-28	Natco Pharma Limited	Process for the preparation of ecteinascidin derivative and its intermediate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59225189A (ja)	1983-06-03	1984-12-18	Shionogi & Co Ltd	キノナミン誘導体およびその製造法
AU589282B2 (en) *	1986-06-09	1989-10-05	University Of Illinois	Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5721362A (en) *	1996-09-18	1998-02-24	President And Fellows Of Harvard College	Process for producing ecteinascidin compounds
US6124292A (en) *	1998-09-30	2000-09-26	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743

1999
- 1999-08-02 GB GBGB9918178.6A patent/GB9918178D0/en not_active Ceased
2001
- 2001-05-15 DK DK01929813T patent/DK1289999T3/da active
- 2001-05-15 EP EP01929816A patent/EP1287004B1/en not_active Expired - Lifetime
- 2001-05-15 PT PT01929816T patent/PT1287004E/pt unknown
- 2001-05-15 SI SI200130244T patent/SI1289999T1/xx unknown
- 2001-05-15 DK DK01929816T patent/DK1287004T3/da active
- 2001-05-15 SI SI200130777T patent/SI1496060T1/sl unknown
- 2001-05-15 PL PL358143A patent/PL203745B1/pl unknown
- 2001-05-15 DK DK04010399T patent/DK1496060T3/da active
- 2001-05-15 EP EP01929813A patent/EP1289999B1/en not_active Expired - Lifetime
- 2001-05-15 UA UA20021210093A patent/UA75597C2/uk unknown
- 2001-05-15 MX MXPA02010701A patent/MXPA02010701A/es active IP Right Grant
- 2001-05-15 AU AU56493/01A patent/AU783563B2/en not_active Expired
- 2001-05-15 NZ NZ521807A patent/NZ521807A/en not_active IP Right Cessation
- 2001-05-15 EA EA200201209A patent/EA006070B1/ru not_active IP Right Cessation
- 2001-05-15 PT PT01929813T patent/PT1289999E/pt unknown
- 2001-05-15 ES ES04010399T patent/ES2290583T3/es not_active Expired - Lifetime
- 2001-05-15 AU AU2001256496A patent/AU2001256496C1/en not_active Expired
- 2001-05-15 DE DE60107241T patent/DE60107241T2/de not_active Expired - Lifetime
- 2001-05-15 KR KR1020027015168A patent/KR100830717B1/ko not_active Expired - Fee Related
- 2001-05-15 KR KR1020027014555A patent/KR100777464B1/ko not_active Expired - Lifetime
- 2001-05-15 ES ES01929816T patent/ES2248319T3/es not_active Expired - Lifetime
- 2001-05-15 EA EA200201210A patent/EA006369B1/ru not_active IP Right Cessation
- 2001-05-15 NZ NZ532793A patent/NZ532793A/en not_active IP Right Cessation
- 2001-05-15 EP EP04010399A patent/EP1496060B1/en not_active Expired - Lifetime
- 2001-05-15 AT AT04010399T patent/ATE368671T1/de active
- 2001-05-15 AT AT01929816T patent/ATE300547T1/de active
- 2001-05-15 HU HU0300648A patent/HU228789B1/hu unknown
- 2001-05-15 DE DE60129753T patent/DE60129753T2/de not_active Expired - Lifetime
- 2001-05-15 PT PT04010399T patent/PT1496060E/pt unknown
- 2001-05-15 DE DE60112286T patent/DE60112286T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60112286T2 (de)	2006-06-01
DE60112286D1 (de)	2005-09-01
KR100777464B1 (ko)	2007-11-27
PT1496060E (pt)	2007-10-30
KR20030031481A (ko)	2003-04-21
KR100830717B1 (ko)	2008-05-20
ATE300547T1 (de)	2005-08-15
EA006369B1 (ru)	2005-12-29
EP1496060A1 (en)	2005-01-12
AU783563B2 (en)	2005-11-10
UA75597C2 (en)	2006-05-15
NZ532793A (en)	2004-10-29
EP1496060B1 (en)	2007-08-01
MXPA02010701A (es)	2003-05-14
HUP0300648A3 (en)	2006-05-29
PT1289999E (pt)	2005-03-31
DK1287004T3 (da)	2005-11-28
EA200201210A1 (ru)	2003-04-24
EP1287004B1 (en)	2005-07-27
DE60107241T2 (de)	2006-08-03
DE60129753D1 (de)	2007-09-13
AU5649301A (en)	2001-11-26
SI1496060T1 (sl)	2008-06-30
DE60107241D1 (de)	2004-12-23
ATE368671T1 (de)	2007-08-15
EA200201209A1 (ru)	2003-04-24
EA006070B1 (ru)	2005-08-25
ES2248319T3 (es)	2006-03-16
PL203745B1 (pl)	2009-11-30
DE60129753T2 (de)	2008-04-30
AU2001256496B2 (en)	2006-02-16
EP1289999B1 (en)	2004-11-17
DK1289999T3 (da)	2005-03-14
ES2290583T3 (es)	2008-02-16
GB9918178D0 (en)	1999-10-06
PT1287004E (pt)	2005-11-30
HK1050193A1 (en)	2003-06-13
HUP0300648A2 (hu)	2003-07-28
NZ521807A (en)	2004-06-25
HU228789B1 (en)	2013-05-28
EP1287004A1 (en)	2003-03-05
AU2001256496C1 (en)	2006-08-03
PL358143A1 (pl)	2004-08-09
SI1289999T1 (en)	2005-06-30
KR20030005308A (ko)	2003-01-17
EP1289999A1 (en)	2003-03-12

Publication	Publication Date	Title
PL358258A1 (en)	2004-08-09	Antitumoral analogs of et-743
BR9916027A (pt)	2001-08-28	Análogos de glp-1
LU91314I2 (fr)	2007-04-23	"Combinaison de particules viroides de papillomavirus humain de type 6, 11, 16 et 18 (GARDASIL -GilGARD )"
BR9815166A (pt)	2000-10-10	"método de inibição da replicação de vìrus, composto, método de inibição da replicação de citomegalovìrus, composto antiviral, utilização de um composto, composição farmacêutica, composição farmacêutica inibidora da replicação de vìrus e de citomegalovìrus e composição farmacêutica antiviral"
TR200002855T2 (tr)	2000-12-21	Raloksifenin solunum yolu ile veya burundan uygulanması.
AR015470A1 (es)	2001-05-02	Acido beta-arilo-alfa-alquilcarboxilico, su uso para la manufactura de un medicamento, procedimientos para su preparacion, composiciones farmaceuticas quelos contienen, compuestos intermediarios y procedimiento para su preparacion
YU40300A (sh)	2003-10-31	Aril fuzirana azapoliciklična jedinjenja
LU91206I2 (fr)	2006-05-30	Ceftiofur sous forme d'acide libre cristallin et ses dérivés pharmaceutiquement acceptables (naxcel)
BRPI0407507A (pt)	2006-02-14	derivados de hexahidro-pirazino[1,2-a]pirimidin-4,7-diona, processos para sua preparação de sua aplicação como medicamento
BR9707606B1 (pt)	2010-08-10	ácidos 8-ciano-1-ciclopropil-7-(2,8-diazabiciclo(4.3.0) nonan-8-il)-6-flúor-1,4-diidro-4-oxo-3-quinolinocarbo xìlicos, bem como medicamentos que os compreendem.
WO2001052796A3 (en)	2001-12-20	Methods of using a beverage composition for treating dental erosion
DK1021456T3 (da)	2003-08-18	Makrocykliske derivater af erythromysin A og B med 13-leddet ring
ATE527247T1 (de)	2011-10-15	Benzokondensierte 5gliedrige heterocyclische verbindungen, verfahren zu deren herstellung und deren verwendung
SE8301726D0 (sv)	1983-03-28	Nya cefalosporinderivat och forfarande for framstellning derav
DK1289999T3 (da)	2005-03-14	Antitumoranaloger af ET-743
ES2108969T3 (es)	1998-01-01	Utilizacion de analogos de didesoxinucleosidos en el tratamiento de infecciones virales.
IS3189A7 (is)	1987-07-31	Ný díhýdróbenzófúran- og króman-karboxamíð efni, aðferð við framleiðslu þeirra og notkun þeirra sem lyf
ATE319715T1 (de)	2006-03-15	Antikonvulsive pseudofructopyranose sulfamate
UA42733C2 (uk)	2001-11-15	Похідні біснафталіміду та їх фармацевтично прийнятні кислотно-адитивні солі, фармацевтична композиція з цитотоксичною активністю, яка їх містить
FI934680A0 (fi)	1993-10-22	Arylmorfolin, framstaellning och anvaending
DK1525188T3 (da)	2008-11-17	Hidtil ukendte derivater af 4,4-dithiobis-(3-aminobutan-1-sulfonater) og sammensætninger, der indeholder dem
ES2028871T3 (es)	1992-07-16	Un procedimiento para la preparacion de un glicosido de antraciclina. .
SE0004462D0 (sv)	2000-12-04	Novel method and use
BR9807785A (pt)	2000-02-22	Processo para a preparação do composto, e, composto
FR2766489B1 (fr)	1999-08-27	Derives de streptogramines, leur preparation et les compositions qui les contiennent