PL358143A1 - Sposób syntetycznego wytwarzania związku ekteinascydynowego - Google Patents

Sposób syntetycznego wytwarzania związku ekteinascydynowego

Info

Publication number
PL358143A1
PL358143A1 PL01358143A PL35814301A PL358143A1 PL 358143 A1 PL358143 A1 PL 358143A1 PL 01358143 A PL01358143 A PL 01358143A PL 35814301 A PL35814301 A PL 35814301A PL 358143 A1 PL358143 A1 PL 358143A1
Authority
PL
Poland
Prior art keywords
hydroxy
spiroamine
compound
protecting group
bridge
Prior art date
Application number
PL01358143A
Other languages
English (en)
Other versions
PL203745B1 (pl
Inventor
Carmen Cuevas
Marta Perez
Andres Francesch
Carolina Fernandez
Jose Luis Chicharro
Pilar Gallego
Maria Zarzuelo
Ignacio Manzanares
Maria Jesus Martin
Simon Munt
Original Assignee
Pharma Mar, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2000/001852 external-priority patent/WO2000069862A2/en
Application filed by Pharma Mar, S.A. filed Critical Pharma Mar, S.A.
Publication of PL358143A1 publication Critical patent/PL358143A1/pl
Publication of PL203745B1 publication Critical patent/PL203745B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Discharging, Photosensitive Material Shape In Electrophotography (AREA)
  • Instruments For Viewing The Inside Of Hollow Bodies (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
PL358143A 2000-05-15 2001-05-15 Sposób wytwarzania związku ekteinascydynowego oraz związek pośredni w syntezie związku ekteinascydynowego PL203745B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/GB2000/001852 WO2000069862A2 (en) 1999-05-14 2000-05-15 Hemisynthetic method and intermediates thereof
PCT/GB2001/002120 WO2001087895A1 (en) 1999-05-14 2001-05-15 Synthetic process for the manufacture of an ecteinaschidin compound

Publications (2)

Publication Number Publication Date
PL358143A1 true PL358143A1 (pl) 2004-08-09
PL203745B1 PL203745B1 (pl) 2009-11-30

Family

ID=34855248

Family Applications (1)

Application Number Title Priority Date Filing Date
PL358143A PL203745B1 (pl) 2000-05-15 2001-05-15 Sposób wytwarzania związku ekteinascydynowego oraz związek pośredni w syntezie związku ekteinascydynowego

Country Status (16)

Country Link
EP (3) EP1287004B1 (pl)
KR (2) KR100830717B1 (pl)
AT (2) ATE368671T1 (pl)
AU (2) AU783563B2 (pl)
DE (3) DE60107241T2 (pl)
DK (3) DK1289999T3 (pl)
EA (2) EA006070B1 (pl)
ES (2) ES2290583T3 (pl)
GB (1) GB9918178D0 (pl)
HU (1) HU228789B1 (pl)
MX (1) MXPA02010701A (pl)
NZ (2) NZ521807A (pl)
PL (1) PL203745B1 (pl)
PT (3) PT1287004E (pl)
SI (2) SI1289999T1 (pl)
UA (1) UA75597C2 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101188691B1 (ko) 2004-10-29 2012-10-09 파르마 마르 에스.에이. 엑티나시딘 및 디사카라이드를 포함하는 제제
KR100676324B1 (ko) * 2005-03-15 2007-01-30 삼성전자주식회사 디스플레이장치
KR100676325B1 (ko) * 2005-03-15 2007-01-30 삼성전자주식회사 디스플레이장치
KR100712667B1 (ko) * 2006-04-11 2007-05-02 재단법인서울대학교산학협력재단 신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법
AU2011257277B2 (en) * 2010-05-25 2016-02-25 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds
US11332480B2 (en) 2017-04-27 2022-05-17 Pharma Mar, S.A. Antitumoral compounds
WO2020105068A1 (en) * 2018-11-24 2020-05-28 Natco Pharma Limited Process for the preparation of ecteinascidin derivative and its intermediate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
AU589282B2 (en) * 1986-06-09 1989-10-05 University Of Illinois Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US6124292A (en) * 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743

Also Published As

Publication number Publication date
DE60112286T2 (de) 2006-06-01
DE60112286D1 (de) 2005-09-01
KR100777464B1 (ko) 2007-11-27
DK1496060T3 (da) 2007-12-03
PT1496060E (pt) 2007-10-30
KR20030031481A (ko) 2003-04-21
KR100830717B1 (ko) 2008-05-20
ATE300547T1 (de) 2005-08-15
EA006369B1 (ru) 2005-12-29
EP1496060A1 (en) 2005-01-12
AU783563B2 (en) 2005-11-10
UA75597C2 (en) 2006-05-15
NZ532793A (en) 2004-10-29
EP1496060B1 (en) 2007-08-01
MXPA02010701A (es) 2003-05-14
HUP0300648A3 (en) 2006-05-29
PT1289999E (pt) 2005-03-31
DK1287004T3 (da) 2005-11-28
EA200201210A1 (ru) 2003-04-24
EP1287004B1 (en) 2005-07-27
DE60107241T2 (de) 2006-08-03
DE60129753D1 (de) 2007-09-13
AU5649301A (en) 2001-11-26
SI1496060T1 (sl) 2008-06-30
DE60107241D1 (de) 2004-12-23
ATE368671T1 (de) 2007-08-15
EA200201209A1 (ru) 2003-04-24
EA006070B1 (ru) 2005-08-25
ES2248319T3 (es) 2006-03-16
PL203745B1 (pl) 2009-11-30
DE60129753T2 (de) 2008-04-30
AU2001256496B2 (en) 2006-02-16
EP1289999B1 (en) 2004-11-17
DK1289999T3 (da) 2005-03-14
ES2290583T3 (es) 2008-02-16
GB9918178D0 (en) 1999-10-06
PT1287004E (pt) 2005-11-30
HK1050193A1 (en) 2003-06-13
HUP0300648A2 (hu) 2003-07-28
NZ521807A (en) 2004-06-25
HU228789B1 (en) 2013-05-28
EP1287004A1 (en) 2003-03-05
AU2001256496C1 (en) 2006-08-03
SI1289999T1 (en) 2005-06-30
KR20030005308A (ko) 2003-01-17
EP1289999A1 (en) 2003-03-12

Similar Documents

Publication Publication Date Title
PL358258A1 (pl) Przeciwnowotworowe analogi Et-743
LU91751I2 (fr) Asenapin et ses dérivés pharmaceutiquement acceptables (SYCREST®)
BRPI0407507A (pt) derivados de hexahidro-pirazino[1,2-a]pirimidin-4,7-diona, processos para sua preparação de sua aplicação como medicamento
WO2001052796A3 (en) Methods of using a beverage composition for treating dental erosion
DE59509565D1 (de) Verfahren zur herstellung orientierter cellulosefolien
DE60237520D1 (de) Glycoprotein sowie verfahren zu dessen herstellung
DE69527400D1 (de) Wasserlösliche camptothecin-derivate, verfahren zu deren herstellung und deren verwendung als antitumor-mittel
ATE527247T1 (de) Benzokondensierte 5gliedrige heterocyclische verbindungen, verfahren zu deren herstellung und deren verwendung
ATE138650T1 (de) Substituierte 4-phenyl-4-piperidincarboxamide mit sowohl lokalanästhetischer als auch schmerzlindernder wirkung sowie verfahren zur herstellung
DE59706808D1 (de) Verwendung von 7-(2-oxa-5,8-diazabicyclo 4.3.0]non-8-yl)-chinoloncarbonsäure- und -naphthyridoncarbonsäure-derivaten zur herstellung eines arzneimittels zur therapie von helicobacter-pylori-infektionen und den damit assoziierten gastroduodenalen erkrankungen
PT1287004E (pt) Processo sintetico para a producao de um composto ecteinascidina
NO970473D0 (no) N-substituerte 3-azabicyklo (3.2.0)heptanderivater egnet som neuroleptika
PT701449E (pt) Processo de preparacao de uma forma de dosagem solida oral contendo diclofenac
BG104034A (en) Method for the preparation of pharmaceutical compounds of antidepressive effect and against the parkinson syndrome effect
DE60224257D1 (de) Retinolderivate und verfahren zu deren herstellung
NO982107L (no) Fremstilling av et salt av klavulansyre
DE69532533D1 (de) Verfahren zur herstellung von ranitidin
EG20542A (en) Process for preparing of benzopyrons compounds
DE69104364D1 (de) Verfahren zur herstellung von streptograminderivaten.
DE69618340D1 (de) Verfahren zur herstellung von substituierten anthrachinonen und deren verwendung zur herstellung von rheinen
SE9704834D0 (sv) New process
DE69612413D1 (de) 1-(Hetero)Arylvinyl-5H-2,3-benzodiazepinderivative verwendbar zur Behandlung von Erkrankungen des Zentralnervensystems, sowie Benzopyrylium Intermediate zu ihrer Herstellung
ATE327220T1 (de) Verfahren zur herstellung von 2-hydroxymethyl- pyrolidin-3,4-diolen