UA78035C2 - Piperazine benzothiazole for treatment of cerebral ischemic disorders or cns disorders - Google Patents

Piperazine benzothiazole for treatment of cerebral ischemic disorders or cns disorders Download PDF

Info

Publication number: UA78035C2
Authority: UA; Ukraine
Prior art keywords: group; benzothiazol; pyrimidin; ylidene; piperazinebenzothiazole
Prior art date: 2002-04-25

Application number

UA20041008647A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-25

Filing date

2003-04-25

Publication date

2007-02-15

2003-04-25 Application filed by Applied Research Systems filed Critical Applied Research Systems

2007-02-15 Publication of UA78035C2 publication Critical patent/UA78035C2/uk

Links

238000011282 treatment Methods 0.000 title claims abstract description 13
230000000302 ischemic effect Effects 0.000 title claims abstract description 12
230000002490 cerebral effect Effects 0.000 title claims abstract description 9
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WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
239000012265 solid product Substances 0.000 description 1
238000010186 staining Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
125000003107 substituted aryl group Chemical group 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
210000001550 testis Anatomy 0.000 description 1
125000003831 tetrazolyl group Chemical group 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
150000003555 thioacetals Chemical class 0.000 description 1
125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
210000001578 tight junction Anatomy 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
230000007723 transport mechanism Effects 0.000 description 1
230000000472 traumatic effect Effects 0.000 description 1
125000004953 trihalomethyl group Chemical group 0.000 description 1
102000003390 tumor necrosis factor Human genes 0.000 description 1
125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

UA20041008647A 2002-04-25 2003-04-25 Piperazine benzothiazole for treatment of cerebral ischemic disorders or cns disorders UA78035C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02100417		2002-04-25
PCT/EP2003/004323 WO2003091249A1 (en)	2002-04-25	2003-04-25	Piperazine benzothiazoles as agents for the treatment of cerebral ischemic disorders or cns disorders

Publications (1)

Publication Number	Publication Date
UA78035C2 true UA78035C2 (en)	2007-02-15

Family

ID=29265991

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA20041008647A UA78035C2 (en)	2002-04-25	2003-04-25	Piperazine benzothiazole for treatment of cerebral ischemic disorders or cns disorders

Country Status (22)

Country	Link
US (1)	US7314878B2 (pt)
EP (1)	EP1501828B1 (pt)
JP (1)	JP4523289B2 (pt)
KR (1)	KR100948469B1 (pt)
CN (1)	CN1310911C (pt)
AT (1)	ATE383356T1 (pt)
AU (1)	AU2003233067B2 (pt)
BR (1)	BRPI0309594A8 (pt)
CA (1)	CA2481763C (pt)
CY (1)	CY1107204T1 (pt)
DE (1)	DE60318567T2 (pt)
DK (1)	DK1501828T3 (pt)
EA (1)	EA009682B1 (pt)
ES (1)	ES2297165T3 (pt)
IL (2)	IL164796A (pt)
MX (1)	MXPA04010474A (pt)
PT (1)	PT1501828E (pt)
RS (1)	RS51407B (pt)
SI (1)	SI1501828T1 (pt)
UA (1)	UA78035C2 (pt)
WO (1)	WO2003091249A1 (pt)
ZA (1)	ZA200408023B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4523289B2 (ja)	2002-04-25	2010-08-11	メルクセローノソシエテアノニム	脳虚血障害又はｃｎｓ障害の処置のための薬剤としてのピペラジンベンゾチアゾール
JP5021307B2 (ja) *	2003-09-12	2012-09-05	メルクセローノソシエテアノニム	糖尿病治療のためのベンゾチアゾール誘導体
WO2005118543A1 (ja) *	2004-06-03	2005-12-15	Ono Pharmaceutical Co., Ltd.	キナーゼ阻害薬およびその用途
ATE411817T1 (de) *	2004-11-17	2008-11-15	Ares Trading Sa	Benzothiazolformulierungen und ihre verwendung
US7838522B2 (en)	2004-11-17	2010-11-23	Ares Trading S.A.	Benzothiazole formulations and use thereof
KR20080044836A (ko)	2005-07-15	2008-05-21	라보라뚜와르 세로노 에스. 에이.	자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) *	2005-07-15	2010-12-14	Serono Lab	inibidores de jnk para o tratamento de endometriose
WO2008125518A2 (en) *	2007-04-17	2008-10-23	Merck Serono S.A.	Process for the preparation of piperazine benzothiazoles
ES2392788T3 (es) *	2008-05-16	2012-12-13	F. Hoffmann-La Roche Ag	Inhibidores de las JNK
EP2576537B1 (en) *	2010-06-04	2016-03-16	F.Hoffmann-La Roche Ag	2-amino-pyrimidine derivatives useful as inhibitors of jnk
US8471027B2 (en) *	2011-04-06	2013-06-25	Hoffmann-La Roche Inc.	Adamantyl compounds
CN104903331A (zh) *	2013-01-24	2015-09-09	山东亨利医药科技有限责任公司	Jnk抑制剂

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4153574B2 (ja)	1997-09-10	2008-09-24	トーアエイヨー株式会社	新規なピペリジン誘導体、その製造法およびそれを含有する循環器官用剤
EP1110957A1 (en) *	1999-12-24	2001-06-27	Applied Research Systems ARS Holding N.V.	Benzazole derivatives and their use as JNK modulators
EP1193256A1 (en)	2000-09-27	2002-04-03	Applied Research Systems ARS Holding N.V.	Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins
JP4523289B2 (ja)	2002-04-25	2010-08-11	メルクセローノソシエテアノニム	脳虚血障害又はｃｎｓ障害の処置のための薬剤としてのピペラジンベンゾチアゾール

2003
- 2003-04-25 JP JP2003587807A patent/JP4523289B2/ja not_active Expired - Fee Related
- 2003-04-25 SI SI200331114T patent/SI1501828T1/sl unknown
- 2003-04-25 WO PCT/EP2003/004323 patent/WO2003091249A1/en not_active Ceased
- 2003-04-25 DE DE60318567T patent/DE60318567T2/de not_active Expired - Lifetime
- 2003-04-25 IL IL164796A patent/IL164796A/en not_active IP Right Cessation
- 2003-04-25 EP EP03727365A patent/EP1501828B1/en not_active Expired - Lifetime
- 2003-04-25 MX MXPA04010474A patent/MXPA04010474A/es active IP Right Grant
- 2003-04-25 BR BRPI0309594A patent/BRPI0309594A8/pt not_active IP Right Cessation
- 2003-04-25 UA UA20041008647A patent/UA78035C2/uk unknown
- 2003-04-25 DK DK03727365T patent/DK1501828T3/da active
- 2003-04-25 KR KR1020047016871A patent/KR100948469B1/ko not_active Expired - Fee Related
- 2003-04-25 IL IL16479603A patent/IL164796A0/xx unknown
- 2003-04-25 US US10/511,438 patent/US7314878B2/en not_active Expired - Lifetime
- 2003-04-25 CN CNB03814493XA patent/CN1310911C/zh not_active Expired - Fee Related
- 2003-04-25 PT PT03727365T patent/PT1501828E/pt unknown
- 2003-04-25 AU AU2003233067A patent/AU2003233067B2/en not_active Ceased
- 2003-04-25 CA CA2481763A patent/CA2481763C/en not_active Expired - Fee Related
- 2003-04-25 RS YUP-928/04A patent/RS51407B/sr unknown
- 2003-04-25 ES ES03727365T patent/ES2297165T3/es not_active Expired - Lifetime
- 2003-04-25 EA EA200401423A patent/EA009682B1/ru not_active IP Right Cessation
- 2003-04-25 AT AT03727365T patent/ATE383356T1/de active
2004
- 2004-10-05 ZA ZA2004/08023A patent/ZA200408023B/en unknown
2008
- 2008-02-18 CY CY20081100199T patent/CY1107204T1/el unknown

Also Published As

Publication number	Publication date
EP1501828B1 (en)	2008-01-09
IL164796A0 (en)	2005-12-18
ES2297165T3 (es)	2008-05-01
ZA200408023B (en)	2005-11-30
AU2003233067B2 (en)	2009-01-08
RS51407B (sr)	2011-02-28
EP1501828A1 (en)	2005-02-02
BRPI0309594A8 (pt)	2017-04-11
CY1107204T1 (el)	2012-11-21
WO2003091249A1 (en)	2003-11-06
RS92804A (sr)	2006-12-15
KR100948469B1 (ko)	2010-03-17
US20050261304A1 (en)	2005-11-24
KR20040104572A (ko)	2004-12-10
CA2481763A1 (en)	2003-11-06
MXPA04010474A (es)	2004-12-13
IL164796A (en)	2013-02-28
JP2006504631A (ja)	2006-02-09
AU2003233067A1 (en)	2003-11-10
PT1501828E (pt)	2008-02-11
CN1310911C (zh)	2007-04-18
DE60318567T2 (de)	2009-02-19
HK1075664A1 (en)	2005-12-23
EA009682B1 (ru)	2008-02-28
CN1662528A (zh)	2005-08-31
EA200401423A1 (ru)	2005-04-28
JP4523289B2 (ja)	2010-08-11
CA2481763C (en)	2011-06-14
US7314878B2 (en)	2008-01-01
DK1501828T3 (da)	2008-03-10
BRPI0309594A2 (pt)	2016-11-16
ATE383356T1 (de)	2008-01-15
SI1501828T1 (sl)	2008-04-30
DE60318567D1 (de)	2008-02-21

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