PT3652187T - Processo melhorado para a preparação de imetelstat - Google Patents

Processo melhorado para a preparação de imetelstat

Info

Publication number: PT3652187T
Authority: PT; Portugal
Prior art keywords: imetelstat; preparing; improved process; improved; preparing imetelstat
Prior art date: 2017-07-10

Application number

PT187376215T

Other languages

English (en)

Portuguese (pt)

Original Assignee

Geron Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-07-10

Filing date

2018-07-09

Publication date

2021-12-16

2018-07-09 Application filed by Geron Corp filed Critical Geron Corp

2021-12-16 Publication of PT3652187T publication Critical patent/PT3652187T/pt

Links

LVZYXEALRXBLJZ-ISQYCPACSA-N f60ne4xb53 Chemical compound N1([C@@H]2O[C@@H]([C@H](C2)NP(O)(=S)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)NP(S)(=O)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)N)COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)OCC(O)CNC(=O)CCCCCCCCCCCCCCC)N2C(NC(=O)C(C)=C2)=O)N2C3=NC=NC(N)=C3N=C2)N2C3=C(C(NC(N)=N3)=O)N=C2)N2C3=C(C(NC(N)=N3)=O)N=C2)N2C3=C(C(NC(N)=N3)=O)N=C2)N2C(NC(=O)C(C)=C2)=O)N2C(NC(=O)C(C)=C2)=O)N2C3=NC=NC(N)=C3N=C2)N2C3=C(C(NC(N)=N3)=O)N=C2)N2C3=NC=NC(N)=C3N=C2)C=CC(N)=NC1=O LVZYXEALRXBLJZ-ISQYCPACSA-N 0.000 title 1
229950004291 imetelstat Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Processes Specially Adapted For Manufacturing Cables (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PT187376215T 2017-07-10 2018-07-09 Processo melhorado para a preparação de imetelstat PT3652187T (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP17180426		2017-07-10

Publications (1)

Publication Number	Publication Date
PT3652187T true PT3652187T (pt)	2021-12-16

Family

ID=59313083

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT187376215T PT3652187T (pt)	2017-07-10	2018-07-09	Processo melhorado para a preparação de imetelstat

Country Status (30)

Country	Link
US (4)	US11332489B2 (de)
EP (1)	EP3652187B1 (de)
JP (2)	JP7199410B2 (de)
KR (2)	KR102709587B1 (de)
CN (1)	CN110891961B (de)
AU (2)	AU2018298658B2 (de)
BR (1)	BR112020000410A2 (de)
CA (2)	CA3066968C (de)
CL (1)	CL2020000054A1 (de)
CO (1)	CO2020000096A2 (de)
CY (1)	CY1125351T1 (de)
DK (1)	DK3652187T3 (de)
EA (1)	EA038579B1 (de)
ES (1)	ES2901099T3 (de)
HR (1)	HRP20211940T1 (de)
HU (1)	HUE056722T2 (de)
IL (1)	IL271388B (de)
LT (1)	LT3652187T (de)
MA (1)	MA49555A (de)
PL (1)	PL3652187T3 (de)
PT (1)	PT3652187T (de)
RS (1)	RS62705B1 (de)
SA (1)	SA520410996B1 (de)
SG (1)	SG11201912385VA (de)
SI (1)	SI3652187T1 (de)
SM (1)	SMT202100701T1 (de)
TW (1)	TWI775895B (de)
UA (1)	UA125185C2 (de)
WO (1)	WO2019011829A1 (de)
ZA (2)	ZA201908452B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN114901269A (zh)	2019-10-28	2022-08-12	美国杰龙生物医药公司	3-棕榈酰基-酰胺基-1,2-丙二醇和3-棕榈酰基-酰胺基-2-羟基-1-二甲氧基三苯基甲基醚-丙烷的结晶固体及其制备和使用方法
AU2020372865A1 (en) *	2019-10-28	2022-05-26	Geron Corporation	Amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane salts and methods of making the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1317291C (zh) *	1999-09-10	2007-05-23	杰龙公司	寡核苷酸n3′→p5′硫代氨基磷酸酯,其合成及应用
CN100393209C (zh)	2003-09-09	2008-06-11	杰龙公司	用于端粒酶抑制的改性寡核苷酸
ME02933B (de)	2004-07-02	2018-04-20	Geron Corp	Synthese geschützter 3'-aminonukleosidmonomere
PT3305302T (pt)	2009-06-17	2018-12-14	Biogen Ma Inc	Composições e métodos de modulação de excisões de smn2 em um sujeito
JOP20200257A1 (ar) *	2014-05-01	2017-06-16	Geron Corp	تركيبات أوليجو نوكليوتيد وطرق لتحضيرها
KR102722183B1 (ko)	2016-06-24	2024-10-24	바이오젠 엠에이 인코포레이티드	캡핑 단계 없이 티올화된 올리고뉴클레오타이드의 합성

2018
- 2018-07-09 MA MA049555A patent/MA49555A/fr unknown
- 2018-07-09 UA UAA201912225A patent/UA125185C2/uk unknown
- 2018-07-09 KR KR1020207003199A patent/KR102709587B1/ko active Active
- 2018-07-09 JP JP2020500591A patent/JP7199410B2/ja active Active
- 2018-07-09 HR HRP20211940TT patent/HRP20211940T1/hr unknown
- 2018-07-09 SI SI201830496T patent/SI3652187T1/sl unknown
- 2018-07-09 PT PT187376215T patent/PT3652187T/pt unknown
- 2018-07-09 PL PL18737621T patent/PL3652187T3/pl unknown
- 2018-07-09 RS RS20211534A patent/RS62705B1/sr unknown
- 2018-07-09 CN CN201880044657.4A patent/CN110891961B/zh active Active
- 2018-07-09 WO PCT/EP2018/068485 patent/WO2019011829A1/en not_active Ceased
- 2018-07-09 US US16/623,984 patent/US11332489B2/en active Active
- 2018-07-09 EP EP18737621.5A patent/EP3652187B1/de active Active
- 2018-07-09 LT LTEPPCT/EP2018/068485T patent/LT3652187T/lt unknown
- 2018-07-09 SG SG11201912385VA patent/SG11201912385VA/en unknown
- 2018-07-09 AU AU2018298658A patent/AU2018298658B2/en active Active
- 2018-07-09 ES ES18737621T patent/ES2901099T3/es active Active
- 2018-07-09 DK DK18737621.5T patent/DK3652187T3/da active
- 2018-07-09 SM SM20210701T patent/SMT202100701T1/it unknown
- 2018-07-09 BR BR112020000410-3A patent/BR112020000410A2/pt active Search and Examination
- 2018-07-09 CA CA3066968A patent/CA3066968C/en active Active
- 2018-07-09 HU HUE18737621A patent/HUE056722T2/hu unknown
- 2018-07-09 TW TW107123644A patent/TWI775895B/zh active
- 2018-07-09 EA EA202090006A patent/EA038579B1/ru unknown
- 2018-07-09 CA CA3195922A patent/CA3195922A1/en active Pending
- 2018-07-09 KR KR1020247031302A patent/KR20240144459A/ko active Pending
2019
- 2019-12-12 IL IL271388A patent/IL271388B/en unknown
- 2019-12-18 ZA ZA2019/08452A patent/ZA201908452B/en unknown
2020
- 2020-01-07 CO CONC2020/0000096A patent/CO2020000096A2/es unknown
- 2020-01-08 CL CL2020000054A patent/CL2020000054A1/es unknown
- 2020-01-08 SA SA520410996A patent/SA520410996B1/ar unknown
2021
- 2021-12-14 CY CY20211101096T patent/CY1125351T1/el unknown
- 2021-12-17 ZA ZA2021/10555A patent/ZA202110555B/en unknown
2022
- 2022-04-12 US US17/718,990 patent/US20230070069A1/en not_active Abandoned
- 2022-10-24 JP JP2022169927A patent/JP2022183382A/ja active Pending
- 2022-12-23 AU AU2022291626A patent/AU2022291626A1/en not_active Abandoned
2023
- 2023-10-16 US US18/487,919 patent/US20240199672A1/en not_active Abandoned
2024
- 2024-02-07 US US18/435,848 patent/US12264174B2/en active Active

Also Published As

Publication number	Publication date
CA3195922A1 (en)	2019-01-17
EP3652187A1 (de)	2020-05-20
AU2018298658B2 (en)	2022-09-29
DK3652187T3 (da)	2021-12-13
TWI775895B (zh)	2022-09-01
CN110891961A (zh)	2020-03-17
US20240199672A1 (en)	2024-06-20
HRP20211940T1 (hr)	2022-03-18
EA202090006A1 (ru)	2020-05-18
JP2022183382A (ja)	2022-12-08
EA038579B1 (ru)	2021-09-17
ZA201908452B (en)	2022-03-30
WO2019011829A1 (en)	2019-01-17
AU2018298658A1 (en)	2020-01-23
CA3066968C (en)	2023-06-13
US11332489B2 (en)	2022-05-17
CO2020000096A2 (es)	2020-01-17
AU2022291626A1 (en)	2023-02-02
JP7199410B2 (ja)	2023-01-05
KR20200035267A (ko)	2020-04-02
ZA202110555B (en)	2025-08-27
MA49555A (fr)	2021-04-28
EP3652187B1 (de)	2021-09-15
JP2020526524A (ja)	2020-08-31
CY1125351T1 (el)	2023-03-24
SA520410996B1 (ar)	2023-12-05
KR20240144459A (ko)	2024-10-02
HUE056722T2 (hu)	2022-03-28
SI3652187T1 (sl)	2022-01-31
US20230070069A1 (en)	2023-03-09
LT3652187T (lt)	2022-01-25
NZ760372A (en)	2024-08-30
UA125185C2 (uk)	2022-01-26
US20200369702A1 (en)	2020-11-26
TW201920228A (zh)	2019-06-01
ES2901099T3 (es)	2022-03-21
CA3066968A1 (en)	2019-01-17
BR112020000410A2 (pt)	2020-07-14
IL271388A (en)	2020-01-30
CN110891961B (zh)	2023-06-30
US20240262854A1 (en)	2024-08-08
SMT202100701T1 (it)	2022-01-10
PL3652187T3 (pl)	2022-01-31
KR102709587B1 (ko)	2024-09-27
CL2020000054A1 (es)	2020-10-02
US12264174B2 (en)	2025-04-01
IL271388B (en)	2022-03-01
SG11201912385VA (en)	2020-01-30
RS62705B1 (sr)	2022-01-31

Publication	Publication Date	Title
HUE057324T2 (hu)	2022-04-28	Eljárás poliolefin-reciklátum elõállítására
HUE052475T2 (hu)	2021-05-28	Eljárás diaril-tiohidantoin vegyület elõállítására
BR112018005406A2 (pt)	2018-10-09	métodos para preparar um catalisador.
BR112017023285A2 (pt)	2018-09-04	métodos para preparar um catalisador.
BR112015023670A2 (pt)	2017-07-18	processo para preparar um composto
PT2894243T (pt)	2016-10-25	Processo para a produção de fibras acrílicas
BR112017002873A2 (pt)	2018-07-17	processo para preparar intermediários sintéticos para preparar derivados de tetra-hidroquinolina
BR112017010699A2 (pt)	2018-06-19	processo para aprimoramento de resíduos parcialmente convertidos a vácuo
BR112018005129A2 (pt)	2018-10-02	Agentes de fosqueamento e processo para a sua produção
BR112018002617A2 (pt)	2018-10-02	Processo de metalização para um dispositivo de memória
BR112016018581A2 (pt)	2017-08-08	Processo para a fabricação de derivados de sulfamida pirimidina
BR112015021297A2 (pt)	2017-10-10	um processo para a produção de adenovírus.
PT3274188T (pt)	2019-02-14	Processo para obter uma característica de segurança impressa
FI20155096A7 (fi)	2016-07-29	Menetelmä maitopohjaisen tuotteen valmistamiseksi
BR112016026212A2 (pt)	2017-08-15	Processo para preparar cianidrina contendo fósforo
BR112018002930A2 (pt)	2018-10-02	processo para preparação de um composto.
IL264681B (en)	2021-10-31	Process for preparing substituted biphenyls
PT3256546T (pt)	2019-11-20	Processo de despolimerização
BR112016010223A2 (pt)	2018-05-02	processo para a preparação de iopamidol.
ES2684856B1 (es)	2019-07-31	Metodo para producir una matriz de tejido descelularizado
PT3337820T (pt)	2021-01-19	Processo de enrolamento melhorado para fragmentos de anticorpos
BR112017010466A2 (pt)	2018-04-03	processo para a produção de metildiclorofosfano
BR112016030604A2 (pt)	2017-08-22	Processo para preparação de ácidos 3- hidroxipicolínicos
BR112019008819A2 (pt)	2019-07-23	Processo para a recuperação de furfural
BR112016019608A2 (pt)	2017-08-15	processo para purificação de polissacarídeos de men-c