PT89024A - Processo de preparacao de derivados da quinolona - Google Patents

Processo de preparacao de derivados da quinolona

Info

Publication number: PT89024A
Authority: PT; Portugal
Prior art keywords: preparation process; quinolone derivatives; formula; compounds; cyclisation
Prior art date: 1987-11-18

Application number

PT89024A

Other languages

English (en)

Other versions

PT89024B (pt

Inventor

Lachlan Maclean

David Lloyd Roberts

Kenneth Barron

Kenneth John Nichol

Original Assignee

Boots Co Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-18

Filing date

1988-11-17

Publication date

1988-12-01

1988-11-17 Application filed by Boots Co Plc filed Critical Boots Co Plc

1988-12-01 Publication of PT89024A publication Critical patent/PT89024A/pt

1993-02-26 Publication of PT89024B publication Critical patent/PT89024B/pt

Links

238000002360 preparation method Methods 0.000 title 1
150000007660 quinolones Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
229940125692 cardiovascular agent Drugs 0.000 abstract 1
239000002327 cardiovascular agent Substances 0.000 abstract 1
150000007529 inorganic bases Chemical class 0.000 abstract 1
150000007530 organic bases Chemical class 0.000 abstract 1
IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Heart & Thoracic Surgery (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Quinoline Compounds (AREA)
Medicinal Preparation (AREA)
Physical Or Chemical Processes And Apparatus (AREA)

PT89024A 1987-11-18 1988-11-17 Processo de preparacao de derivados da quinolona PT89024B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878726950A GB8726950D0 (en)	1987-11-18	1987-11-18	Chemical process

Publications (2)

Publication Number	Publication Date
PT89024A true PT89024A (pt)	1988-12-01
PT89024B PT89024B (pt)	1993-02-26

Family

ID=10627131

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT89024A PT89024B (pt)	1987-11-18	1988-11-17	Processo de preparacao de derivados da quinolona

Country Status (28)

Country	Link
US (2)	US5011931A (pt)
EP (2)	EP0343206A1 (pt)
JP (1)	JPH02502013A (pt)
KR (1)	KR890701563A (pt)
AT (1)	ATE69221T1 (pt)
AU (1)	AU628305B2 (pt)
BG (1)	BG50157A3 (pt)
CS (1)	CS274487B2 (pt)
DD (1)	DD290188A5 (pt)
DE (1)	DE3866086D1 (pt)
ES (1)	ES2038310T3 (pt)
FI (1)	FI91063C (pt)
GB (1)	GB8726950D0 (pt)
GR (1)	GR3003378T3 (pt)
HU (1)	HU204511B (pt)
IE (1)	IE883366L (pt)
IL (1)	IL88358A (pt)
MX (1)	MX168918B (pt)
NZ (1)	NZ227008A (pt)
PH (1)	PH27439A (pt)
PL (1)	PL157191B1 (pt)
PT (1)	PT89024B (pt)
RO (1)	RO104615B1 (pt)
SU (1)	SU1766255A3 (pt)
TW (1)	TW204344B (pt)
WO (1)	WO1989004827A1 (pt)
YU (1)	YU46989B (pt)
ZA (1)	ZA888241B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8726950D0 (en) *	1987-11-18	1987-12-23	Boots Co Plc	Chemical process
GB8804016D0 (en) *	1988-02-22	1988-03-23	Boots Co Plc	Therapeutic agents
US6132753A (en) *	1998-05-01	2000-10-17	Neal R. Cutler	Treatment of sexual dysfunction in certain patient groups
US6132757A (en) *	1998-05-01	2000-10-17	Neal R. Cutler	Treatment of sexual dysfunction in certain patient groups
US6426084B1 (en) *	2000-06-19	2002-07-30	Neal R. Cutler	Treatment of sexual dysfunction in certain patient groups
US6194433B1 (en)	1998-10-05	2001-02-27	Neal R. Cutler	Sexual dysfunction in females
US6110489A (en) *	1998-05-01	2000-08-29	Cutler; Neal R.	Use of quinolines and quinolones to treat male erectile dysfunction
US6303135B1 (en)	1999-07-08	2001-10-16	Neal R. Cutler	Use of quinolines and quinolones to treat male erectile dysfunction
US6307050B1 (en) *	2000-08-29	2001-10-23	R. T. Alamo Venture I Llc	Method of synthesizing flosequinan from 4-fluoroanthranilic acid
US6451813B1 (en)	2001-01-26	2002-09-17	R. T. Alamo Ventures I, Llc	Treatment of gastroparesis in certain patient groups
US6562838B2 (en) *	2001-01-26	2003-05-13	R. T. Alamo Ventures I, L.L.C.	Treatment of cardiovascular disease with quinolinone enantiomers
US6458804B1 (en)	2001-01-26	2002-10-01	R.T. Alamo Venturesi, Llc	Methods for the treatment of central nervous system disorders in certain patient groups
US6596871B2 (en)	2001-06-29	2003-07-22	Grayson Walker Stowell	Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6660864B2 (en)	2001-06-29	2003-12-09	Grayson Walker Stowell	Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6531603B1 (en)	2001-06-29	2003-03-11	Grayson Walker Stowell	Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6573382B2 (en)	2001-06-29	2003-06-03	Grayson Walker Stowell	Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6657061B2 (en)	2001-06-29	2003-12-02	Grayson Walker Stowell	Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6388080B1 (en)	2001-06-29	2002-05-14	Grayson Walker Stowell	Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
JP4202250B2 (ja)	2001-07-25	2008-12-24	バイオマリンファーマシューティカルインコーポレイテッド	血液脳関門輸送を調節するための組成物および方法
US6649764B2 (en) *	2001-10-25	2003-11-18	R. T. Alamo Ventures I, Llc	Stereospecific enrichment of heterocyclic enantiomers
US6730790B2 (en) *	2002-03-01	2004-05-04	R.T. Alamo Ventures I. Llc	Chlorinated heterocyclic compounds and methods of synthesis
US7041677B2 (en) *	2002-03-01	2006-05-09	R.T. Alamo Ventures I, Llc	Use of monochloroflosequinan in the treatment of sexual dysfunction
EP2671507A3 (en)	2005-04-28	2014-02-19	Proteus Digital Health, Inc.	Pharma-informatics system
MX2009002893A (es)	2006-09-18	2009-07-10	Raptor Pharmaceutical Inc	Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
CA2752373C (en)	2009-02-20	2017-10-10	To-Bbb Holding B.V.	Glutathione-based drug delivery system
IL255113B (en)	2009-05-06	2022-09-01	Laboratory Skin Care Inc	Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3920699A (en) *	1974-04-26	1975-11-18	Warner Lambert Co	Process for the cyclization of aryl(methylsulfinyl)-methyl ketones and compounds produced thereby
US4192873A (en) *	1976-11-25	1980-03-11	Ciba-Geigy Corporation	Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones
NZ193167A (en) *	1979-03-27	1984-08-24	Boots Co Plc	Quinoline derivatives and pharmaceutical compositions
IE51542B1 (en) *	1980-09-26	1987-01-07	Boots Co Ltd	Therapeutic agents
FR2532939A1 (fr) *	1982-09-13	1984-03-16	Roussel Uclaf	Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus
DE3578374D1 (de) *	1984-01-13	1990-08-02	Boots Co Ltd	Verwendung von chinolonen fuer die herstellung eines arzneimittels zur behandlung von herzerkrankungen.
FR2566405B1 (fr) *	1984-06-25	1986-09-26	Roussel Uclaf	Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
GB8515209D0 (en) *	1985-06-15	1985-07-17	Boots Co Plc	Therapeutic agents
GB8627698D0 (en) *	1986-11-20	1986-12-17	Boots Co Plc	Therapeutic agents
GB8726950D0 (en) *	1987-11-18	1987-12-23	Boots Co Plc	Chemical process

1987
- 1987-11-18 GB GB878726950A patent/GB8726950D0/en active Pending
1988
- 1988-11-03 ZA ZA888241A patent/ZA888241B/xx unknown
- 1988-11-07 RO RO140740A patent/RO104615B1/ro unknown
- 1988-11-07 US US07/378,216 patent/US5011931A/en not_active Expired - Fee Related
- 1988-11-07 KR KR1019890701326A patent/KR890701563A/ko not_active Ceased
- 1988-11-07 EP EP88909581A patent/EP0343206A1/en active Pending
- 1988-11-07 HU HU886294A patent/HU204511B/hu not_active IP Right Cessation
- 1988-11-07 AT AT88310463T patent/ATE69221T1/de not_active IP Right Cessation
- 1988-11-07 DE DE8888310463T patent/DE3866086D1/de not_active Expired - Lifetime
- 1988-11-07 EP EP88310463A patent/EP0317149B1/en not_active Expired - Lifetime
- 1988-11-07 JP JP63508842A patent/JPH02502013A/ja active Pending
- 1988-11-07 AU AU26163/88A patent/AU628305B2/en not_active Ceased
- 1988-11-07 WO PCT/GB1988/000952 patent/WO1989004827A1/en not_active Ceased
- 1988-11-07 ES ES198888310463T patent/ES2038310T3/es not_active Expired - Lifetime
- 1988-11-09 IE IE883366A patent/IE883366L/xx unknown
- 1988-11-09 PH PH37784A patent/PH27439A/en unknown
- 1988-11-10 MX MX013748A patent/MX168918B/es unknown
- 1988-11-10 IL IL88358A patent/IL88358A/xx unknown
- 1988-11-11 TW TW077107879A patent/TW204344B/zh active
- 1988-11-11 YU YU209788A patent/YU46989B/sh unknown
- 1988-11-15 CS CS748988A patent/CS274487B2/cs unknown
- 1988-11-16 DD DD88321853A patent/DD290188A5/de not_active IP Right Cessation
- 1988-11-17 PT PT89024A patent/PT89024B/pt not_active IP Right Cessation
- 1988-11-18 PL PL1988275880A patent/PL157191B1/pl unknown
- 1988-11-18 NZ NZ227008A patent/NZ227008A/en unknown
1989
- 1989-05-17 SU SU894614311A patent/SU1766255A3/ru active
- 1989-07-13 FI FI893405A patent/FI91063C/fi not_active IP Right Cessation
- 1989-07-17 BG BG089219A patent/BG50157A3/xx unknown
1991
- 1991-03-01 US US07/663,085 patent/US5079264A/en not_active Expired - Fee Related
- 1991-12-18 GR GR91402063T patent/GR3003378T3/el unknown

Also Published As

Publication number	Publication date
IE883366L (en)	1989-05-18
CS274487B2 (en)	1991-04-11
ZA888241B (en)	1989-10-25
HU204511B (en)	1992-01-28
SU1766255A3 (ru)	1992-09-30
DD290188A5 (de)	1991-05-23
PT89024B (pt)	1993-02-26
DE3866086D1 (de)	1991-12-12
EP0317149B1 (en)	1991-11-06
AU628305B2 (en)	1992-09-17
PL275880A1 (en)	1989-06-12
PH27439A (en)	1993-07-02
FI91063C (fi)	1994-05-10
YU209788A (en)	1990-08-31
WO1989004827A1 (en)	1989-06-01
PL157191B1 (pl)	1992-05-29
GB8726950D0 (en)	1987-12-23
NZ227008A (en)	1991-10-25
JPH02502013A (ja)	1990-07-05
AU2616388A (en)	1989-06-14
IL88358A0 (en)	1989-06-30
FI893405L (fi)	1989-07-13
EP0317149A1 (en)	1989-05-24
RO104615B1 (en)	1992-11-03
CS748988A2 (en)	1990-09-12
US5011931A (en)	1991-04-30
TW204344B (pt)	1993-04-21
EP0343206A1 (en)	1989-11-29
FI91063B (fi)	1994-01-31
ATE69221T1 (de)	1991-11-15
ES2038310T3 (es)	1993-07-16
YU46989B (sh)	1994-09-09
HUT53085A (en)	1990-09-28
MX168918B (es)	1993-06-14
FI893405A0 (fi)	1989-07-13
IL88358A (en)	1993-02-21
BG50157A3 (bg)	1992-05-15
KR890701563A (ko)	1989-12-21
GR3003378T3 (en)	1993-02-17
US5079264A (en)	1992-01-07

Legal Events

Date

Code

Title

Description

1993-02-26

FG3A

Patent granted, date of granting

Effective date: 19920828

1994-07-29

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19940228

Publication	Publication Date	Title
PT89024A (pt)	1988-12-01	Processo de preparacao de derivados da quinolona
DK506587D0 (da)	1987-09-25	Imidderivater
ES2088537T3 (es)	1996-08-16	Derivados de piranil cianoguanidina.
FI902555A0 (fi)	1990-05-23	Diarylstyrylkinolindisyror.
NO902394D0 (no)	1990-05-30	Fremgangsmaate for fremstilling av pyranyl-cyanoguanidin-derivater.
NO903640L (no)	1991-02-19	Fremgangsmaate for fremstilling av 2-(rs)-substituerte 2,3-dihydro-5-oksy-4,6,7-trimetylbenzofuraner.
PT99756A (pt)	1992-12-31	Processo para a preparacao de 2-aril-5-(trifluorometil)pirroles uteis como agentes pesticidas e como intermediarios para a preparacao dos referidos agentes
NO903430D0 (no)	1990-08-03	Fremgangsmaate for fremstilling av aminoketonderivater.
DK162839C (da)	1992-05-04	N,3-diacyl-2-oxindol-1-carboxamid-forbindelser og 3-acyl-2-oxindol-forbindelser til anvendelse som mellemprodukter ved deres fremstilling
SE8602523L (sv)	1986-12-06	2-alkyl- eller -aralkyltio-1-cykloalken-1-karboxamider och deras sulfoxider, sett for deras framstellning och deras anvendning for syntes av tri- och 4,5-tetrametylen-4-isotiazolin-3-oner
FI842533A0 (fi)	1984-06-21	Hexahydropyrrolo/2,1-a/isokinolin- derivat.
DE69213049D1 (de)	1996-10-02	Isoquinolinderivate
PT85547A (pt)	1988-08-17	Processo de preparacao de composicao farmaceuticas a base de derivados de 2-mercapto-imidazol e de preparacao destes derivados
NO169649C (no)	1992-07-22	Fremgangsmaate for fremstilling av substituerte guanyltiourinstoff-forbindelser
ATE104270T1 (de)	1994-04-15	Glutarsaeurederivate und ihre herstellung.
DK277787D0 (da)	1987-05-29	Azaphospholener og deres anvendelse
FR2565487B1 (fr)	1988-12-16	Compositions therapeutiques a base de nouveaux derives de l'aminomethyl-6 furo-(3,4-c)-pyridine
DK46884D0 (da)	1984-02-02	5-aminomethyl-imidazol-1-yl-1,3-dialkyl-1h-pyrazol-4-yl-aroyl-methanoner,fremgangsmaade til deres fremstilling samt deres anvendelse
ES2051722T3 (es)	1994-07-01	Procedimiento para estabilizar derivados de procaterol.