PT96332A - Processo de preparacao de novos derivados de xantina, dos seus intermediarios e de composicoes farmaceuticas que os contem - Google Patents

Processo de preparacao de novos derivados de xantina, dos seus intermediarios e de composicoes farmaceuticas que os contem

Info

Publication number
PT96332A
PT96332A PT96332A PT9633290A PT96332A PT 96332 A PT96332 A PT 96332A PT 96332 A PT96332 A PT 96332A PT 9633290 A PT9633290 A PT 9633290A PT 96332 A PT96332 A PT 96332A
Authority
PT
Portugal
Prior art keywords
treating
formamide
excess
compounds
making
Prior art date
Application number
PT96332A
Other languages
English (en)
Other versions
PT96332B (pt
Inventor
Armando Vega Noverola
Jose Manuel Prieto Soto
Jacinto Moragues Mauri
Robert W Gristwood
Original Assignee
Almirall Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Lab filed Critical Almirall Lab
Publication of PT96332A publication Critical patent/PT96332A/pt
Publication of PT96332B publication Critical patent/PT96332B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processing Of Stones Or Stones Resemblance Materials (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Re-Forming, After-Treatment, Cutting And Transporting Of Glass Products (AREA)
  • Container, Conveyance, Adherence, Positioning, Of Wafer (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Peptides Or Proteins (AREA)
PT96332A 1989-12-27 1990-12-21 Processo de preparacao de novos derivados de xantina, dos seus intermediarios e de composicoes farmaceuticas que os contem PT96332B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898929208A GB8929208D0 (en) 1989-12-27 1989-12-27 New xanthine derivatives

Publications (2)

Publication Number Publication Date
PT96332A true PT96332A (pt) 1991-09-30
PT96332B PT96332B (pt) 1998-06-30

Family

ID=10668520

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96332A PT96332B (pt) 1989-12-27 1990-12-21 Processo de preparacao de novos derivados de xantina, dos seus intermediarios e de composicoes farmaceuticas que os contem

Country Status (30)

Country Link
US (1) US5223504A (pt)
EP (1) EP0435811B1 (pt)
JP (1) JPH089617B2 (pt)
KR (1) KR970001528B1 (pt)
CN (1) CN1029967C (pt)
AT (1) ATE93860T1 (pt)
AU (1) AU635104B2 (pt)
BR (1) BR9007258A (pt)
CA (1) CA2045478C (pt)
CZ (1) CZ278328B6 (pt)
DE (1) DE69003087T2 (pt)
DK (1) DK0435811T3 (pt)
EG (1) EG19436A (pt)
ES (1) ES2058864T3 (pt)
FI (1) FI96207C (pt)
GB (1) GB8929208D0 (pt)
HU (2) HU208825B (pt)
IE (1) IE64065B1 (pt)
IL (1) IL96708A (pt)
MX (1) MX23884A (pt)
MY (1) MY105303A (pt)
NO (1) NO178111C (pt)
NZ (1) NZ236517A (pt)
PL (1) PL166152B1 (pt)
PT (1) PT96332B (pt)
RU (1) RU2073679C1 (pt)
SK (1) SK278365B6 (pt)
UA (1) UA32512C2 (pt)
WO (1) WO1991009859A1 (pt)
ZA (1) ZA9010240B (pt)

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MX9203323A (es) * 1991-07-11 1994-07-29 Hoechst Ag El empleo de derivados de xantina para el tratamiento de lesiones secundarias de las celulas nerviosas y trastornos funcionales despues de traumas craneo-cerebrales.
US5521315A (en) * 1993-01-12 1996-05-28 Cell Therapeutics, Inc. Olefin substituted long chain compounds
GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5922751A (en) 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5661153A (en) * 1994-07-19 1997-08-26 Japan Energy Corporation 1-arylpyrimidine derivatives and pharmaceutical use thereof
EP0799040B1 (en) * 1994-12-13 2003-08-20 Euroceltique S.A. Trisubstituted thioxanthines
JPH10508032A (ja) 1994-12-13 1998-08-04 ユーロ−セルティーク，エス．エイ． アリールチオキサンチン類
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
WO1996036638A1 (en) * 1995-05-19 1996-11-21 Chiroscience Limited Xanthines and their therapeutic use
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en) 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5874437A (en) * 1996-11-01 1999-02-23 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
USRE37234E1 (en) * 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
CA2270118A1 (en) * 1996-11-01 1998-05-14 Nitromed Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US6331543B1 (en) * 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
GB9623859D0 (en) * 1996-11-15 1997-01-08 Chiroscience Ltd Novel compounds
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
IL132407A0 (en) * 1998-10-21 2001-03-19 Pfizer Prod Inc Method for treating congestive heart failure
ES2228512T3 (es) 1999-05-04 2005-04-16 Altana Pharma Ag Combinacion sinergica que comprende roflumilast y un inhibidor de pde-3.
PL200923B1 (pl) 1999-08-21 2009-02-27 Nycomed Gmbh Lek zawierający inhibitor PDE w połączeniu z agonistą receptoraß₂ -adrenergicznego oraz zastosowanie połączenia roflumilastu i salmeterolu
GB0005199D0 (en) * 2000-03-04 2000-04-26 Imp College Innovations Ltd Modulation of histone deacetylase
CA2402384A1 (en) * 2000-03-16 2001-09-20 Inflazyme Pharmaceuticals Ltd. Benzylated pde4 inhibitors
KR20040007583A (ko) * 2001-05-23 2004-01-24 다나베 세이야꾸 가부시키가이샤 연골 질환의 재생치료용 조성물
WO2002094321A1 (en) * 2001-05-23 2002-11-28 Tanabe Seiyaku Co., Ltd. Compositions for promoting healing of bone fracture
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
JP2006522151A (ja) 2003-04-01 2006-09-28 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 不妊症におけるホスホジエステラーゼ阻害剤
RU2395511C2 (ru) * 2004-02-14 2010-07-27 Смитклайн Бичам Корпорейшн Новые соединения
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2627848T3 (es) 2008-06-04 2017-07-31 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
MX357121B (es) 2011-03-01 2018-06-27 Synergy Pharmaceuticals Inc Star Proceso de preparacion de agonistas c de guanilato ciclasa.
EP2958577A2 (en) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Guanylate cyclase receptor agonists for use in colonic cleansing
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
PL3004138T3 (pl) 2013-06-05 2024-07-29 Bausch Health Ireland Limited Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
CA2920856C (en) 2013-08-09 2026-03-03 Ardelyx, Inc. Ph modulating compounds for inhibiting gastrointestinal phosphate uptake
EP3165224A1 (en) 2015-11-09 2017-05-10 Albert-Ludwigs-Universität Freiburg Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
AR115689A1 (es) 2018-07-05 2021-02-17 Sumitomo Chemical Co Compuestos de uracilo y su utilización
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1245969B (de) * 1967-08-03 VEB Arzneimittelwerk Dresden, Radebeul Verfahren zur Herstellung von Xanthinderivaten
CH629788A5 (de) * 1977-07-20 1982-05-14 Lonza Ag Verfahren zur herstellung von 5,6-diaminouracil.
SE416810C (sv) * 1977-10-14 1982-07-19 Draco Ab Forfarande for framstellning av xantinderivat med antiallergisk aktivitet
GB8826595D0 (en) * 1988-11-14 1988-12-21 Beecham Wuelfing Gmbh & Co Kg Active compounds

Also Published As

Publication number Publication date
NO178111B (no) 1995-10-16
CN1029967C (zh) 1995-10-11
WO1991009859A1 (en) 1991-07-11
FI96207B (fi) 1996-02-15
IE64065B1 (en) 1995-07-12
HUT57766A (en) 1991-12-30
AU6976891A (en) 1991-07-24
CA2045478A1 (en) 1991-06-28
DE69003087D1 (de) 1993-10-07
EG19436A (en) 1995-02-28
UA32512C2 (uk) 2001-02-15
IL96708A0 (en) 1991-09-16
HU208825B (en) 1994-01-28
NO913236D0 (no) 1991-08-19
JPH089617B2 (ja) 1996-01-31
DK0435811T3 (da) 1993-11-01
KR970001528B1 (ko) 1997-02-11
ATE93860T1 (de) 1993-09-15
IL96708A (en) 1994-06-24
ZA9010240B (en) 1991-10-30
PL166152B1 (en) 1995-04-28
MY105303A (en) 1994-09-30
BR9007258A (pt) 1992-02-25
CN1052858A (zh) 1991-07-10
IE904634A1 (en) 1991-07-17
NO178111C (no) 1996-01-24
SK278365B6 (en) 1997-01-08
AU635104B2 (en) 1993-03-11
GB8929208D0 (en) 1990-02-28
EP0435811B1 (en) 1993-09-01
PT96332B (pt) 1998-06-30
US5223504A (en) 1993-06-29
HU211573A9 (en) 1995-12-28
EP0435811A1 (en) 1991-07-03
JPH05500226A (ja) 1993-01-21
NZ236517A (en) 1992-09-25
RU2073679C1 (ru) 1997-02-20
CZ278328B6 (en) 1993-11-17
FI914014A0 (fi) 1991-08-26
ES2058864T3 (es) 1994-11-01
FI96207C (fi) 1996-05-27
MX23884A (es) 1993-09-01
DE69003087T2 (de) 1993-12-16
KR920701207A (ko) 1992-08-11
NO913236L (no) 1991-08-19
CA2045478C (en) 1998-12-29

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19910509

FG3A Patent granted, date of granting

Effective date: 19980327

PC3A Transfer or assignment

Free format text: 19990729 ALMIRALL-PRODESFARMA, SOCIEDAD ANONIMA ES

PD3A Change of proprietorship

Owner name: GRUPO PLAFIN S.A.

Effective date: 19990729

TE3A Change of address (patent)

Owner name: GRUPO PLAFIN, S.A.

Effective date: 19990729

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20080929