SK55890A3 - TISSUE ACTIVATOR OF PLASMINOGEN T-PA, METHOD FOR PRODUCING THEì SAME AND PHARMACEUTICAL COMPOSITION CONTAINING SAME - Google Patents

TISSUE ACTIVATOR OF PLASMINOGEN T-PA, METHOD FOR PRODUCING THEì SAME AND PHARMACEUTICAL COMPOSITION CONTAINING SAME Download PDF

Info

Publication number: SK55890A3
Authority: SK; Slovakia
Prior art keywords: plasmid; derivative; protein; mmol; arginine
Prior art date: 1989-02-07

Application number

SK558-90A

Other languages

English (en)

Slovak (sk)

Other versions

SK279029B6 (sk

Inventor

Anne Stern

Ulrich Kohnert

Rainer Rudolph

Stephan Fischer

Ulrich Martin

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-07

Filing date

1990-02-06

Publication date

1998-05-06

1990-02-06 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1998-05-06 Publication of SK279029B6 publication Critical patent/SK279029B6/sk

1998-05-06 Publication of SK55890A3 publication Critical patent/SK55890A3/sk

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract 3
238000004519 manufacturing process Methods 0.000 title claims description 7
102000013566 Plasminogen Human genes 0.000 title description 8
108010051456 Plasminogen Proteins 0.000 title description 8
239000012190 activator Substances 0.000 title 1
108090000623 proteins and genes Proteins 0.000 claims abstract description 20
102000004169 proteins and genes Human genes 0.000 claims abstract description 19
108091028043 Nucleic acid sequence Proteins 0.000 claims abstract description 4
239000013612 plasmid Substances 0.000 claims description 53
108090000373 Tissue Plasminogen Activator Proteins 0.000 claims description 36
238000000034 method Methods 0.000 claims description 25
239000000203 mixture Substances 0.000 claims description 24
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235000018102 proteins Nutrition 0.000 claims description 16
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ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims description 7
238000010828 elution Methods 0.000 claims description 7
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235000014852 L-arginine Nutrition 0.000 claims description 5
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YPZRWBKMTBYPTK-BJDJZHNGSA-N glutathione disulfide Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(=O)NCC(O)=O)CSSC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O YPZRWBKMTBYPTK-BJDJZHNGSA-N 0.000 claims description 4
PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 claims description 4
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QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 11
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239000004475 Arginine Substances 0.000 description 9
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IBAOFQIOOBQLHE-UHFFFAOYSA-N 2-amino-3,9-dihydropurin-9-ium-6-one;chloride Chemical compound Cl.N1C(N)=NC(=O)C2=C1N=CN2 IBAOFQIOOBQLHE-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

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Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
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General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Plant Pathology (AREA)
Analytical Chemistry (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Detergent Compositions (AREA)
Cosmetics (AREA)
Saccharide Compounds (AREA)

SK558-90A 1989-02-07 1990-02-06 TISSUE ACTIVATOR OF PLASMINOGEN T-PA, METHOD FOR PRODUCING THEì SAME AND PHARMACEUTICAL COMPOSITION CONTAINING SAME SK55890A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3903581A DE3903581A1 (de)	1989-02-07	1989-02-07	Gewebs-plasminogenaktivator-derivat

Publications (2)

Publication Number	Publication Date
SK279029B6 SK279029B6 (sk)	1998-05-06
SK55890A3 true SK55890A3 (en)	1998-05-06

Family

ID=6373566

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK558-90A SK55890A3 (en)	1989-02-07	1990-02-06	TISSUE ACTIVATOR OF PLASMINOGEN T-PA, METHOD FOR PRODUCING THEì SAME AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

Country Status (29)

Country	Link
US (1)	US5223256A (fr)
EP (1)	EP0382174B1 (fr)
JP (1)	JP2559538B2 (fr)
KR (1)	KR970008485B1 (fr)
AT (1)	ATE126270T1 (fr)
AU (1)	AU623228B2 (fr)
CA (1)	CA2025900C (fr)
CZ (1)	CZ281836B6 (fr)
DD (1)	DD291779A5 (fr)
DE (2)	DE3903581A1 (fr)
DK (1)	DK0382174T3 (fr)
ES (1)	ES2031804T3 (fr)
FI (1)	FI100244B (fr)
GR (2)	GR900300140T1 (fr)
HK (1)	HK153396A (fr)
HU (1)	HU218092B (fr)
IE (1)	IE61077B1 (fr)
IL (1)	IL93280A (fr)
LU (1)	LU90025I2 (fr)
LV (1)	LV10302B (fr)
NL (1)	NL970008I2 (fr)
NO (2)	NO306563B1 (fr)
NZ (1)	NZ232337A (fr)
PT (1)	PT93082B (fr)
RU (1)	RU2107094C1 (fr)
SK (1)	SK55890A3 (fr)
UA (1)	UA27111A1 (fr)
WO (1)	WO1990009437A1 (fr)
ZA (1)	ZA90861B (fr)

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GB9019120D0 (en) *	1990-09-01	1990-10-17	Beecham Group Plc	Novel compounds
DE4037196A1 (de) *	1990-11-22	1992-05-27	Boehringer Mannheim Gmbh	Verfahren zur reaktivierung von denaturiertem protein
DE4123845A1 (de) *	1991-07-18	1993-01-21	Boehringer Mannheim Gmbh	Pharmazeutische verpackungseinheit enthaltend plasminogenaktivatoren zur mehrfachbolusgabe
WO1992018157A1 (fr) *	1991-04-16	1992-10-29	Boehringer Mannheim Gmbh	Unite de conditionnement pharmaceutique contenant des activateurs de plasminogene destines a etre administres en plusieurs bols
US5510330A (en) *	1994-03-25	1996-04-23	Boehringer Mannheim Gmbh	Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
DE4423574A1 (de) *	1994-07-05	1996-01-11	Boehringer Mannheim Gmbh	Nicht-glykosylierte Plasminogenaktivator-Derivate und ihre Verwendung bei erhöhtem Blutungsrisiko
US5723122A (en) *	1995-06-01	1998-03-03	Boehringer Mannheim Gmbh	Use of the protease domain of human plasminogen activator for the treatment of thromboembolic diseases
AU4259496A (en) *	1994-12-06	1996-06-26	Boehringer Mannheim Gmbh	Use of the protease domain of human plasminogen activator for the treatment of thromboembolic diseases
AU2660397A (en) *	1996-04-05	1997-10-29	Board Of Regents, The University Of Texas System	Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
US6083715A (en) *	1997-06-09	2000-07-04	Board Of Regents, The University Of Texas System	Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
BR9811531A (pt)	1997-07-23	2000-08-22	Roche Diagnostics Gmbh	Preparação de proteìnas mutadas humanas em células humanas por meio de recombinação homóloga
WO1999009184A1 (fr) *	1997-08-13	1999-02-25	Roche Diagnostics Gmbh	Activateur du plasminogene a pouvoir zymogene ameliore et a liaison a la fibrine reduite
AU9162198A (en) *	1997-08-13	1999-03-08	Boehringer Mannheim Gmbh	Plasminogen activator with improved zymogenity
DE10105912A1 (de) *	2001-02-09	2002-08-14	Roche Diagnostics Gmbh	Rekombinante Proteinase K
DE10153601A1 (de) *	2001-11-02	2003-05-22	Paion Gmbh	DSPA zur Behandlung von Schlaganfall
RU2323001C1 (ru) *	2007-05-30	2008-04-27	Общество с ограниченной ответственностью "Научно-производственное предприятие "Техноген"	Фармацевтическая композиция, обладающая фибринолитическим действием
TWI482628B (zh) *	2007-10-18	2015-05-01	Lundbeck & Co As H	新穎之血栓溶解病患次群
EP2289541A1 (fr)	2009-08-31	2011-03-02	PAION Deutschland GmbH	Traitement des troubles neurologiques ou neuro-dégénératifs
EP2289542A1 (fr)	2009-08-31	2011-03-02	PAION Deutschland GmbH	Traitement des troubles neurologiques ou neuro-dégénératifs
MX2019009137A (es)	2017-02-03	2019-12-19	Acticor Biotech	Inhibicion de agregacion plaquetaria usando anticuerpos gpvi antihumanos.
WO2018210860A1 (fr)	2017-05-16	2018-11-22	INSERM (Institut National de la Santé et de la Recherche Médicale)	Méthodes et compositions pharmaceutiques pour le traitement d'un accident vasculaire ischémique cérébral aigu
EP3806833A1 (fr)	2018-06-15	2021-04-21	INSERM (Institut National de la Santé et de la Recherche Médicale)	Utilisation d'inhibiteurs de pi3kc2b pour la préservation de l'intégrité d'une barrière cellulaire de l'endothélium vasculaire
WO2021148439A1 (fr)	2020-01-21	2021-07-29	INSERM (Institut National de la Santé et de la Recherche Médicale)	Procédés de stimulation de la fonction cérébrovasculaire
WO2021249974A1 (fr)	2020-06-09	2021-12-16	INSERM (Institut National de la Santé et de la Recherche Médicale)	Particules de polysaccharide fonctionnalisées avec du fucoïdane avec t-pa pour un traitement thrombolytique ciblé
US20250154252A1 (en)	2022-02-21	2025-05-15	Acticor Biotech	Treatment of cardiovascular diseases using anti-human gpvi antibodies
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1989
- 1989-02-07 DE DE3903581A patent/DE3903581A1/de not_active Withdrawn
1990
- 1990-01-30 IE IE34390A patent/IE61077B1/en not_active IP Right Cessation
- 1990-02-01 NZ NZ232337A patent/NZ232337A/xx unknown
- 1990-02-02 DD DD90337557A patent/DD291779A5/de not_active IP Right Cessation
- 1990-02-05 IL IL9328090A patent/IL93280A/en not_active IP Right Cessation
- 1990-02-06 UA UA4831496A patent/UA27111A1/uk unknown
- 1990-02-06 ES ES90102329T patent/ES2031804T3/es not_active Expired - Lifetime
- 1990-02-06 CA CA002025900A patent/CA2025900C/fr not_active Expired - Lifetime
- 1990-02-06 KR KR1019900702203A patent/KR970008485B1/ko not_active Expired - Lifetime
- 1990-02-06 HU HU644/90A patent/HU218092B/hu unknown
- 1990-02-06 LU LU90025C patent/LU90025I2/fr unknown
- 1990-02-06 JP JP2502957A patent/JP2559538B2/ja not_active Expired - Lifetime
- 1990-02-06 RU SU4831496A patent/RU2107094C1/ru active
- 1990-02-06 ZA ZA90861A patent/ZA90861B/xx unknown
- 1990-02-06 US US07/585,129 patent/US5223256A/en not_active Expired - Lifetime
- 1990-02-06 CZ CS90558A patent/CZ281836B6/cs not_active IP Right Cessation
- 1990-02-06 AU AU50470/90A patent/AU623228B2/en not_active Expired
- 1990-02-06 DE DE59009487T patent/DE59009487D1/de not_active Expired - Lifetime
- 1990-02-06 SK SK558-90A patent/SK55890A3/sk not_active IP Right Cessation
- 1990-02-06 AT AT90102329T patent/ATE126270T1/de active
- 1990-02-06 WO PCT/EP1990/000194 patent/WO1990009437A1/fr not_active Ceased
- 1990-02-06 EP EP90102329A patent/EP0382174B1/fr not_active Expired - Lifetime
- 1990-02-06 DK DK90102329.1T patent/DK0382174T3/da active
- 1990-02-07 PT PT93082A patent/PT93082B/pt not_active IP Right Cessation
- 1990-09-27 NO NO904211A patent/NO306563B1/no not_active IP Right Cessation
- 1990-10-08 FI FI904951A patent/FI100244B/fi active IP Right Grant
1991
- 1991-09-27 GR GR90300140T patent/GR900300140T1/el unknown
1993
- 1993-06-01 LV LVP-93-448A patent/LV10302B/xx unknown
1995
- 1995-08-10 GR GR950402065T patent/GR3017099T3/el unknown
1996
- 1996-08-08 HK HK153396A patent/HK153396A/xx not_active IP Right Cessation
1997
- 1997-02-17 NL NL970008C patent/NL970008I2/nl unknown
2000
- 2000-05-19 NO NO2000002C patent/NO2000002I1/no unknown

Also Published As

Publication number	Publication date
LV10302A (lv)	1994-10-20
DK0382174T3 (da)	1996-01-02
CZ281836B6 (cs)	1997-02-12
LV10302B (en)	1995-04-20
RU2107094C1 (ru)	1998-03-20
ES2031804T3 (es)	1995-11-01
NL970008I2 (nl)	1997-07-01
NO2000002I1 (no)	2000-05-19
DE3903581A1 (de)	1990-08-16
NZ232337A (en)	1991-09-25
GR900300140T1 (en)	1991-09-27
ATE126270T1 (de)	1995-08-15
KR910700336A (ko)	1991-03-14
GR3017099T3 (en)	1995-11-30
UA27111A1 (uk)	2000-02-28
PT93082B (pt)	1996-03-29
SK279029B6 (sk)	1998-05-06
WO1990009437A1 (fr)	1990-08-23
DE59009487D1 (de)	1995-09-14
IL93280A (en)	1995-08-31
FI100244B (fi)	1997-10-31
JPH03500724A (ja)	1991-02-21
EP0382174B1 (fr)	1995-08-09
ZA90861B (en)	1990-11-28
NL970008I1 (nl)	1997-04-01
FI904951A0 (fi)	1990-10-08
KR970008485B1 (ko)	1997-05-24
CA2025900A1 (fr)	1990-08-08
HU901644D0 (en)	1991-04-29
IE61077B1 (en)	1994-09-21
HK153396A (en)	1996-08-16
NO904211D0 (no)	1990-09-27
NO306563B1 (no)	1999-11-22
EP0382174A1 (fr)	1990-08-16
HU218092B (hu)	2000-05-28
IE900343L (en)	1990-08-07
JP2559538B2 (ja)	1996-12-04
US5223256A (en)	1993-06-29
LU90025I2 (fr)	1997-04-22
IL93280A0 (en)	1990-11-29
ES2031804T1 (es)	1993-01-01
HUT58813A (en)	1992-03-30
NO904211L (no)	1990-09-27
AU5047090A (en)	1990-09-05
PT93082A (pt)	1990-08-31
AU623228B2 (en)	1992-05-07
CZ55890A3 (en)	1996-10-16
DD291779A5 (de)	1991-07-11
CA2025900C (fr)	1999-01-19

Legal Events

Date	Code	Title	Description
2010-04-07	MK4A	Patent expired	Expiry date: 20100206

Publication	Publication Date	Title
SK55890A3 (en)	1998-05-06	TISSUE ACTIVATOR OF PLASMINOGEN T-PA, METHOD FOR PRODUCING THEì SAME AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
EP1232252B1 (fr)	2009-05-13	Plasmine acidifiee inactivee de maniere reversible
JP2631645B2 (ja)	1997-07-16	新規化合物、その製法及びそれを含む医薬組成物
US20090130714A1 (en)	2009-05-21	Process for purifying recombinanat tissue plasminogen activator (TPA)
CA2807749C (fr)	2023-02-28	Proteines de fusion recombinants possedant des proprietes thrombolytiques et anticoagulantes
HU217101B (hu)	1999-11-29	Javított fibrinolitikus tulajdonságokkal és thrombingátló hatással rendelkező bifunkciós urokinázvariánsok
JP3329340B2 (ja)	2002-09-30	トロンビン活性化プラスミノーゲン誘導体
JPH08231595A (ja)	1996-09-10	繊維素溶解性のトロンビン阻害性質を有するキメラたん白質
CZ282035B6 (cs)	1997-04-16	Derivát tkáňového aktivátoru plasminogenu, kódový řetězec, způsob výroby derivátu, způsob výroby plasmidu a prostředek k rozpouštění krevních sraženin
CA2162986A1 (fr)	1996-05-18	Proteines possedant des proprietes fibrinolytiques et anticoagulantes
US5723122A (en)	1998-03-03	Use of the protease domain of human plasminogen activator for the treatment of thromboembolic diseases
TW201306861A (zh)	2013-02-16	具有血栓溶解與抗凝血劑特性之蛋白質融合構造
HK1010110A (en)	1999-06-11	Proteins with fibrinolytic and coagulation inhibiting characteristics
HK1010111A (en)	1999-06-11	Chimera proteins with fibrinolytic and coagulation inhibiting characteristics