UA75322C2 - Use of mhc class ii ligands as adjuvant for vaccination and lag-3 for cancer immunotherapy - Google Patents

Use of mhc class ii ligands as adjuvant for vaccination and lag-3 for cancer immunotherapy Download PDF

Info

Publication number: UA75322C2
Authority: UA; Ukraine
Prior art keywords: cells; antigen; immune response; tumor; application according
Prior art date: 1997-07-25

Application number

UA2000020976A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Roussy Inst Gustave

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-25

Filing date

1998-07-23

Publication date

2006-04-17

1998-07-23 Application filed by Roussy Inst Gustave, Applied Research Systems filed Critical Roussy Inst Gustave

2006-04-17 Publication of UA75322C2 publication Critical patent/UA75322C2/uk

Links

239000003446 ligand Substances 0.000 title claims abstract description 25
238000002619 cancer immunotherapy Methods 0.000 title abstract 2
238000002255 vaccination Methods 0.000 title description 4
239000002671 adjuvant Substances 0.000 title description 3
101100510617 Caenorhabditis elegans sel-8 gene Proteins 0.000 title 1
239000000427 antigen Substances 0.000 claims abstract description 47
108091007433 antigens Proteins 0.000 claims abstract description 47
102000036639 antigens Human genes 0.000 claims abstract description 47
230000028993 immune response Effects 0.000 claims abstract description 37
102000043131 MHC class II family Human genes 0.000 claims abstract description 21
108091054438 MHC class II family Proteins 0.000 claims abstract description 21
230000001575 pathological effect Effects 0.000 claims abstract description 9
238000004519 manufacturing process Methods 0.000 claims abstract description 6
239000003814 drug Substances 0.000 claims abstract description 5
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 4
210000004027 cell Anatomy 0.000 claims description 98
206010028980 Neoplasm Diseases 0.000 claims description 71
210000001744 T-lymphocyte Anatomy 0.000 claims description 41
101710199257 Peripheral myelin protein 22 Proteins 0.000 claims description 28
102100035917 Peripheral myelin protein 22 Human genes 0.000 claims description 27
230000001404 mediated effect Effects 0.000 claims description 20
229960005486 vaccine Drugs 0.000 claims description 16
201000011510 cancer Diseases 0.000 claims description 11
239000012634 fragment Substances 0.000 claims description 11
229940126601 medicinal product Drugs 0.000 claims description 7
230000002265 prevention Effects 0.000 claims description 5
208000035473 Communicable disease Diseases 0.000 claims description 4
208000015181 infectious disease Diseases 0.000 claims description 4
239000013612 plasmid Substances 0.000 claims description 4
108091028043 Nucleic acid sequence Proteins 0.000 claims description 3
230000001580 bacterial effect Effects 0.000 claims description 3
229940079593 drug Drugs 0.000 claims description 3
238000009169 immunotherapy Methods 0.000 claims description 3
230000003612 virological effect Effects 0.000 claims description 3
238000011398 antitumor immunotherapy Methods 0.000 claims description 2
230000003071 parasitic effect Effects 0.000 claims description 2
102000018713 Histocompatibility Antigens Class II Human genes 0.000 claims 2
108010027412 Histocompatibility Antigens Class II Proteins 0.000 claims 2
230000002708 enhancing effect Effects 0.000 claims 2
230000001939 inductive effect Effects 0.000 claims 1
239000003795 chemical substances by application Substances 0.000 abstract description 3
230000000145 adjuvantlike effect Effects 0.000 abstract description 2
102000017578 LAG3 Human genes 0.000 abstract 2
101150030213 Lag3 gene Proteins 0.000 abstract 2
241000699670 Mus sp. Species 0.000 description 58
210000004881 tumor cell Anatomy 0.000 description 54
108090000623 proteins and genes Proteins 0.000 description 24
108700018351 Major Histocompatibility Complex Proteins 0.000 description 21
230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 21
230000014509 gene expression Effects 0.000 description 17
238000004458 analytical method Methods 0.000 description 15
238000002474 experimental method Methods 0.000 description 15
235000018102 proteins Nutrition 0.000 description 14
102000004169 proteins and genes Human genes 0.000 description 14
210000004698 lymphocyte Anatomy 0.000 description 13
238000000034 method Methods 0.000 description 13
230000002163 immunogen Effects 0.000 description 11
230000004614 tumor growth Effects 0.000 description 10
230000000694 effects Effects 0.000 description 9
230000036039 immunity Effects 0.000 description 9
230000015572 biosynthetic process Effects 0.000 description 8
238000002347 injection Methods 0.000 description 8
239000007924 injection Substances 0.000 description 8
210000004988 splenocyte Anatomy 0.000 description 8
108020004414 DNA Proteins 0.000 description 7
241000699666 Mus <mouse, genus> Species 0.000 description 7
150000001413 amino acids Chemical class 0.000 description 7
230000000259 anti-tumor effect Effects 0.000 description 7
239000004475 Arginine Substances 0.000 description 6
102000053602 DNA Human genes 0.000 description 6
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 6
241001465754 Metazoa Species 0.000 description 6
101100298048 Mus musculus Pmp22 gene Proteins 0.000 description 6
208000006265 Renal cell carcinoma Diseases 0.000 description 6
235000004279 alanine Nutrition 0.000 description 6
210000000612 antigen-presenting cell Anatomy 0.000 description 6
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 6
239000012636 effector Substances 0.000 description 6
108090000765 processed proteins & peptides Proteins 0.000 description 6
230000009885 systemic effect Effects 0.000 description 6
238000012360 testing method Methods 0.000 description 6
206010039491 Sarcoma Diseases 0.000 description 5
230000012010 growth Effects 0.000 description 5
102000004196 processed proteins & peptides Human genes 0.000 description 5
210000002966 serum Anatomy 0.000 description 5
238000001890 transfection Methods 0.000 description 5
102100034613 Annexin A2 Human genes 0.000 description 4
108090000668 Annexin A2 Proteins 0.000 description 4
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 4
102000008949 Histocompatibility Antigens Class I Human genes 0.000 description 4
108091054437 MHC class I family Proteins 0.000 description 4
235000001014 amino acid Nutrition 0.000 description 4
230000006023 anti-tumor response Effects 0.000 description 4
230000009089 cytolysis Effects 0.000 description 4
210000004443 dendritic cell Anatomy 0.000 description 4
235000013922 glutamic acid Nutrition 0.000 description 4
239000004220 glutamic acid Substances 0.000 description 4
230000005847 immunogenicity Effects 0.000 description 4
230000006698 induction Effects 0.000 description 4
239000000203 mixture Substances 0.000 description 4
239000008363 phosphate buffer Substances 0.000 description 4
229920001184 polypeptide Polymers 0.000 description 4
210000001519 tissue Anatomy 0.000 description 4
210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 description 4
206010009944 Colon cancer Diseases 0.000 description 3
241000282412 Homo Species 0.000 description 3
101001000631 Homo sapiens Peripheral myelin protein 22 Proteins 0.000 description 3
102000007056 Recombinant Fusion Proteins Human genes 0.000 description 3
108010008281 Recombinant Fusion Proteins Proteins 0.000 description 3
239000012678 infectious agent Substances 0.000 description 3
238000011081 inoculation Methods 0.000 description 3
210000002540 macrophage Anatomy 0.000 description 3
239000000463 material Substances 0.000 description 3
239000012528 membrane Substances 0.000 description 3
230000008569 process Effects 0.000 description 3
230000004044 response Effects 0.000 description 3
230000002269 spontaneous effect Effects 0.000 description 3
230000000638 stimulation Effects 0.000 description 3
238000010254 subcutaneous injection Methods 0.000 description 3
241000283707 Capra Species 0.000 description 2
VYZAMTAEIAYCRO-BJUDXGSMSA-N Chromium-51 Chemical compound [51Cr] VYZAMTAEIAYCRO-BJUDXGSMSA-N 0.000 description 2
102000016844 Immunoglobulin-like domains Human genes 0.000 description 2
108050006430 Immunoglobulin-like domains Proteins 0.000 description 2
102000013462 Interleukin-12 Human genes 0.000 description 2
108010065805 Interleukin-12 Proteins 0.000 description 2
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 2
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
108010052285 Membrane Proteins Proteins 0.000 description 2
241000283973 Oryctolagus cuniculus Species 0.000 description 2
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
230000009471 action Effects 0.000 description 2
230000004913 activation Effects 0.000 description 2
235000003704 aspartic acid Nutrition 0.000 description 2
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
239000008280 blood Substances 0.000 description 2
230000004663 cell proliferation Effects 0.000 description 2
238000010367 cloning Methods 0.000 description 2
239000002299 complementary DNA Substances 0.000 description 2
230000003750 conditioning effect Effects 0.000 description 2
238000010276 construction Methods 0.000 description 2
238000004132 cross linking Methods 0.000 description 2
230000016396 cytokine production Effects 0.000 description 2
230000001086 cytosolic effect Effects 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
238000010790 dilution Methods 0.000 description 2
239000012895 dilution Substances 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
231100000673 dose–response relationship Toxicity 0.000 description 2
230000005014 ectopic expression Effects 0.000 description 2
239000000945 filler Substances 0.000 description 2
230000006870 function Effects 0.000 description 2
108020001507 fusion proteins Proteins 0.000 description 2
102000037865 fusion proteins Human genes 0.000 description 2
210000000987 immune system Anatomy 0.000 description 2
238000010166 immunofluorescence Methods 0.000 description 2
230000005764 inhibitory process Effects 0.000 description 2
230000003993 interaction Effects 0.000 description 2
229940117681 interleukin-12 Drugs 0.000 description 2
230000007774 longterm Effects 0.000 description 2
230000007246 mechanism Effects 0.000 description 2
239000002609 medium Substances 0.000 description 2
239000013642 negative control Substances 0.000 description 2
210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 2
230000005855 radiation Effects 0.000 description 2
230000002285 radioactive effect Effects 0.000 description 2
DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 description 2
210000000952 spleen Anatomy 0.000 description 2
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
239000007929 subcutaneous injection Substances 0.000 description 2
238000006467 substitution reaction Methods 0.000 description 2
238000007910 systemic administration Methods 0.000 description 2
231100000588 tumorigenic Toxicity 0.000 description 2
230000000381 tumorigenic effect Effects 0.000 description 2
239000012646 vaccine adjuvant Substances 0.000 description 2
229940124931 vaccine adjuvant Drugs 0.000 description 2
101150042008 ACO4 gene Proteins 0.000 description 1
208000030507 AIDS Diseases 0.000 description 1
206010002961 Aplasia Diseases 0.000 description 1
208000003950 B-cell lymphoma Diseases 0.000 description 1
208000035143 Bacterial infection Diseases 0.000 description 1
206010006187 Breast cancer Diseases 0.000 description 1
101100310927 Caenorhabditis elegans sra-4 gene Proteins 0.000 description 1
201000009030 Carcinoma Diseases 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
241000689227 Cora <basidiomycete fungus> Species 0.000 description 1
102000004127 Cytokines Human genes 0.000 description 1
108090000695 Cytokines Proteins 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
238000002965 ELISA Methods 0.000 description 1
YQYJSBFKSSDGFO-UHFFFAOYSA-N Epihygromycin Natural products OC1C(O)C(C(=O)C)OC1OC(C(=C1)O)=CC=C1C=C(C)C(=O)NC1C(O)C(O)C2OCOC2C1O YQYJSBFKSSDGFO-UHFFFAOYSA-N 0.000 description 1
108010088652 Histocompatibility Antigens Class I Proteins 0.000 description 1
101001002657 Homo sapiens Interleukin-2 Proteins 0.000 description 1
101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 description 1
101000651298 Homo sapiens TRAF-interacting protein with FHA domain-containing protein A Proteins 0.000 description 1
GRRNUXAQVGOGFE-UHFFFAOYSA-N Hygromycin-B Natural products OC1C(NC)CC(N)C(O)C1OC1C2OC3(C(C(O)C(O)C(C(N)CO)O3)O)OC2C(O)C(CO)O1 GRRNUXAQVGOGFE-UHFFFAOYSA-N 0.000 description 1
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
108060003951 Immunoglobulin Proteins 0.000 description 1
102000000588 Interleukin-2 Human genes 0.000 description 1
108010002350 Interleukin-2 Proteins 0.000 description 1
102000015696 Interleukins Human genes 0.000 description 1
108010063738 Interleukins Proteins 0.000 description 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
206010024229 Leprosy Diseases 0.000 description 1
108090001030 Lipoproteins Proteins 0.000 description 1
102000004895 Lipoproteins Human genes 0.000 description 1
102100020862 Lymphocyte activation gene 3 protein Human genes 0.000 description 1
102000043129 MHC class I family Human genes 0.000 description 1
102000018697 Membrane Proteins Human genes 0.000 description 1
PPQNQXQZIWHJRB-UHFFFAOYSA-N Methylcholanthrene Chemical compound C1=CC=C2C3=CC4=CC=C(C)C(CC5)=C4C5=C3C=CC2=C1 PPQNQXQZIWHJRB-UHFFFAOYSA-N 0.000 description 1
101000686985 Mouse mammary tumor virus (strain C3H) Protein PR73 Proteins 0.000 description 1
241000699660 Mus musculus Species 0.000 description 1
101001000630 Mus musculus Peripheral myelin protein 22 Proteins 0.000 description 1
208000030852 Parasitic disease Diseases 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
206010038389 Renal cancer Diseases 0.000 description 1
230000006044 T cell activation Effects 0.000 description 1
102100027651 TRAF-interacting protein with FHA domain-containing protein A Human genes 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
241000700605 Viruses Species 0.000 description 1
230000003213 activating effect Effects 0.000 description 1
208000009956 adenocarcinoma Diseases 0.000 description 1
230000005809 anti-tumor immunity Effects 0.000 description 1
230000030741 antigen processing and presentation Effects 0.000 description 1
230000000890 antigenic effect Effects 0.000 description 1
230000005975 antitumor immune response Effects 0.000 description 1
238000013459 approach Methods 0.000 description 1
210000003719 b-lymphocyte Anatomy 0.000 description 1
208000022362 bacterial infectious disease Diseases 0.000 description 1
201000008274 breast adenocarcinoma Diseases 0.000 description 1
239000000872 buffer Substances 0.000 description 1
244000309466 calf Species 0.000 description 1
229940030156 cell vaccine Drugs 0.000 description 1
210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
210000000349 chromosome Anatomy 0.000 description 1
230000001461 cytolytic effect Effects 0.000 description 1
210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
230000001472 cytotoxic effect Effects 0.000 description 1
230000003013 cytotoxicity Effects 0.000 description 1
231100000135 cytotoxicity Toxicity 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
230000002950 deficient Effects 0.000 description 1
238000012217 deletion Methods 0.000 description 1
230000037430 deletion Effects 0.000 description 1
230000000779 depleting effect Effects 0.000 description 1
238000001514 detection method Methods 0.000 description 1
238000011161 development Methods 0.000 description 1
230000018109 developmental process Effects 0.000 description 1
230000006806 disease prevention Effects 0.000 description 1
238000004520 electroporation Methods 0.000 description 1
MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
239000007850 fluorescent dye Substances 0.000 description 1
238000001215 fluorescent labelling Methods 0.000 description 1
238000001415 gene therapy Methods 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
238000010353 genetic engineering Methods 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
229960002743 glutamine Drugs 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
208000006454 hepatitis Diseases 0.000 description 1
231100000283 hepatitis Toxicity 0.000 description 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
102000055277 human IL2 Human genes 0.000 description 1
GRRNUXAQVGOGFE-NZSRVPFOSA-N hygromycin B Chemical compound O[C@@H]1[C@@H](NC)C[C@@H](N)[C@H](O)[C@H]1O[C@H]1[C@H]2O[C@@]3([C@@H]([C@@H](O)[C@@H](O)[C@@H](C(N)CO)O3)O)O[C@H]2[C@@H](O)[C@@H](CO)O1 GRRNUXAQVGOGFE-NZSRVPFOSA-N 0.000 description 1
229940097277 hygromycin b Drugs 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
102000018358 immunoglobulin Human genes 0.000 description 1
229940072221 immunoglobulins Drugs 0.000 description 1
230000002055 immunohistochemical effect Effects 0.000 description 1
238000012151 immunohistochemical method Methods 0.000 description 1
238000012744 immunostaining Methods 0.000 description 1
230000001024 immunotherapeutic effect Effects 0.000 description 1
230000006872 improvement Effects 0.000 description 1
229940047122 interleukins Drugs 0.000 description 1
230000003834 intracellular effect Effects 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
230000002601 intratumoral effect Effects 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
210000004153 islets of langerhan Anatomy 0.000 description 1
210000001821 langerhans cell Anatomy 0.000 description 1
231100000518 lethal Toxicity 0.000 description 1
230000001665 lethal effect Effects 0.000 description 1
208000032839 leukemia Diseases 0.000 description 1
230000000527 lymphocytic effect Effects 0.000 description 1
238000002803 maceration Methods 0.000 description 1
230000003211 malignant effect Effects 0.000 description 1
210000004962 mammalian cell Anatomy 0.000 description 1
239000003550 marker Substances 0.000 description 1
235000019988 mead Nutrition 0.000 description 1
201000001441 melanoma Diseases 0.000 description 1
210000005087 mononuclear cell Anatomy 0.000 description 1
230000035772 mutation Effects 0.000 description 1
239000007922 nasal spray Substances 0.000 description 1
244000052769 pathogen Species 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
230000007170 pathology Effects 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
230000001817 pituitary effect Effects 0.000 description 1
238000012545 processing Methods 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
229940021993 prophylactic vaccine Drugs 0.000 description 1
238000012342 propidium iodide staining Methods 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
229960000856 protein c Drugs 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000008844 regulatory mechanism Effects 0.000 description 1
201000010174 renal carcinoma Diseases 0.000 description 1
230000003362 replicative effect Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
238000009738 saturating Methods 0.000 description 1
210000005212 secondary lymphoid organ Anatomy 0.000 description 1
210000003491 skin Anatomy 0.000 description 1
229940054269 sodium pyruvate Drugs 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
231100000617 superantigen Toxicity 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
229940126585 therapeutic drug Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000002992 thymic effect Effects 0.000 description 1
238000011830 transgenic mouse model Methods 0.000 description 1
201000008827 tuberculosis Diseases 0.000 description 1
230000005748 tumor development Effects 0.000 description 1
230000005740 tumor formation Effects 0.000 description 1
230000005851 tumor immunogenicity Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Microbiology (AREA)
Mycology (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Tropical Medicine & Parasitology (AREA)
Cell Biology (AREA)
Gastroenterology & Hepatology (AREA)
Virology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

UA2000020976A 1997-07-25 1998-07-23 Use of mhc class ii ligands as adjuvant for vaccination and lag-3 for cancer immunotherapy UA75322C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97401800A EP0893507A1 (en)	1997-07-25	1997-07-25	Use of MHC class II ligands (CD4 and LAG-3) as adjuvant for vaccination and of LAG-3 in cancer treatment
PCT/EP1998/004621 WO1999004810A2 (en)	1997-07-25	1998-07-23	Use of mhc class ii ligands as adjuvant for vaccination and of lag-3 in cancer treatment

Publications (1)

Publication Number	Publication Date
UA75322C2 true UA75322C2 (en)	2006-04-17

Family

ID=8229825

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2000020976A UA75322C2 (en)	1997-07-25	1998-07-23	Use of mhc class ii ligands as adjuvant for vaccination and lag-3 for cancer immunotherapy

Country Status (19)

Country	Link
US (2)	US6410509B1 (zh)
EP (3)	EP0893507A1 (zh)
JP (1)	JP4723722B2 (zh)
KR (1)	KR100603075B1 (zh)
CN (1)	CN1184320C (zh)
AT (2)	ATE324455T1 (zh)
AU (1)	AU753738B2 (zh)
BR (1)	BR9811037A (zh)
CA (2)	CA2732570C (zh)
DE (2)	DE69841866D1 (zh)
DK (1)	DK1002108T3 (zh)
EA (3)	EA200300092A1 (zh)
EE (1)	EE200000039A (zh)
ES (1)	ES2262242T3 (zh)
IL (2)	IL134212A0 (zh)
NO (1)	NO20000378D0 (zh)
PT (1)	PT1002108E (zh)
UA (1)	UA75322C2 (zh)
WO (1)	WO1999004810A2 (zh)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1295895B1 (en) *	2001-09-19	2011-08-10	Institut Gustave Roussy	Peptides and proteins binding to glu-pro motifs, therapeutical compositions containing the same and applications thereof
PL1897548T5 (pl)	2003-02-28	2025-03-17	The Johns Hopkins University	Regulacja komórek T
KR20050082389A (ko) *	2004-02-18	2005-08-23	메덱스젠 주식회사	직렬 연쇄체를 갖는 면역접합체를 포함하는 장기이식합병증 치료용 약제학적 조성물
FR2868781B1 (fr)	2004-04-13	2008-02-22	Immutep	Composition de vaccin comprenant un ligand cmh de classe ii couple a un antigene, procede de preparation et utilisations
EP1777523A1 (en) *	2005-10-19	2007-04-25	INSERM (Institut National de la Santé et de la Recherche Médicale)	An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method
EP2044949A1 (en) *	2007-10-05	2009-04-08	Immutep	Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
WO2011031139A1 (en)	2009-09-09	2011-03-17	Universiteit Utrecht Holding B.V.	An ataq protein or a part thereof as a vaccine
SA110310855B1 (ar)	2009-11-13	2014-09-16	Laboratories Leti S L Unipersonal	استخدام مصدر l3 و/ أو l5 كلقاح أو كوسيلة تشخيصية لمرض طفيلي
SG190222A1 (en)	2010-11-10	2013-06-28	Leti Sl Lab	New adjuvant
GB201322626D0 (en)	2013-12-19	2014-02-05	Immutep S A	Combined preparations for the treatment of cancer
PE20170255A1 (es)	2014-01-24	2017-03-22	Dana Farber Cancer Inst Inc	Moleculas de anticuerpo que se unen a pd-1 y usos de las mismas
CN103751778B (zh) *	2014-01-28	2016-09-28	复旦大学	3′-脱氧腺苷在制备广谱疫苗增效的免疫佐剂中的应用
KR102442436B1 (ko)	2014-03-14	2022-09-15	노파르티스 아게	Lag-3에 대한 항체 분자 및 그의 용도
EP3925968A3 (en)	2014-10-07	2022-03-02	Cytlimic Inc.	Hsp70-derived peptide, pharmaceutical composition for treating or preventing cancer using same, immunity inducer, and method for producing antigen-presenting cell
WO2016094639A1 (en) *	2014-12-10	2016-06-16	Wisconsin Alumni Research Foundation	Mini-intronic plasmid dna vaccines in combination with lag3 blockade
GB201500374D0 (en) *	2015-01-09	2015-02-25	Immutep S A	Combined preparations for the treatment of cancer
CN113388021A (zh)	2015-03-09	2021-09-14	Cytlimic公司	源于gpc3的肽、使用其的医药组合物、免疫诱导剂、及抗原呈递细胞的制造方法
RU2709015C2 (ru) *	2015-04-07	2019-12-13	Ситлимик Инк.	Лекарственное средство
EA201792501A1 (ru)	2015-05-13	2018-10-31	Эйдженус Инк.	Вакцины для лечения и профилактики рака
US10786547B2 (en)	2015-07-16	2020-09-29	Biokine Therapeutics Ltd.	Compositions, articles of manufacture and methods for treating cancer
HRP20211058T8 (hr)	2015-07-29	2021-11-26	Novartis Ag	Kombinirane terapije koje sadrže molekule antitijela protiv lag-3
US10265379B2 (en)	2015-09-16	2019-04-23	Annabelle Rodriguez Oquendo	Use of recombinant lymphocyte activation gene-3 as a companion therapeutic for patients at risk for cardiovascular disease and other chronic inflammatory diseases
US20180256633A1 (en)	2015-09-18	2018-09-13	Rijksuniversiteit Groningen	Long chain inulin for stimulating an immune response
US11291718B2 (en)	2016-10-11	2022-04-05	Cytlimic Inc.	Method for treating cancer by administering a toll-like receptor agonist and LAG-3 IgG fusion protein
CN108204958A (zh) *	2016-12-19	2018-06-26	伊缪泰普有限公司	结合测定
MA52363A (fr)	2018-04-26	2021-03-03	Agenus Inc	Compositions peptidiques de liaison à une protéine de choc thermique (hsp) et leurs méthodes d'utilisation
CA3114585A1 (en) *	2018-09-27	2020-04-02	Genocea Biosciences, Inc.	Treatment methods
JP2020138940A (ja)	2019-02-28	2020-09-03	テルモ株式会社	治療方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT88641B (pt) *	1987-10-02	1993-04-30	Genentech Inc	Metodo para a preparacao de uma variante de adesao
AU647013B2 (en) *	1988-08-22	1994-03-17	United States of America, as represented by the Secretary, U.S. Department of Commerce, The	Retroviral vectors expressing soluble CD4: a gene therapy for aids
JPH02231083A (ja) *	1988-08-31	1990-09-13	Eisai Co Ltd	組換ナチュラルキラー細胞活性化因子
DE69010523D1 (de) *	1989-03-03	1994-08-18	Microgenesys Inc	Kit oder Zusammensetzung zur Vorbeugung oder Behandlung von HIV-1 Infektionen.
EP0394827A1 (en) *	1989-04-26	1990-10-31	F. Hoffmann-La Roche Ag	Chimaeric CD4-immunoglobulin polypeptides
FR2656800B1 (fr) *	1990-01-08	1992-05-15	Roussy Inst Gustave	Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques.
US5851828A (en) *	1991-03-07	1998-12-22	The General Hospital Corporation	Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
HU219767B (hu) *	1993-01-26	2001-07-30	Leslie R. Coney	Készítmények és eljárások genetikai anyag sejtbe történő beviteléhez
SE510135C2 (sv) *	1994-05-05	1999-04-19	Berol Nobel Ab	Vattenhaltig suspension av en cellulosaeter, sätt för dess framställning samt komposition
CA2189657C (fr) *	1994-05-06	2002-03-12	Florence Faure	Fractions polypeptidiques solubles de la proteine lag-3; procede de production; composition therapeutique; anticorps anti-idiotype
WO1996004386A1 (en) *	1994-08-05	1996-02-15	Warner-Lambert Company	Method of using transdominant negative retroviral integrase in the treatment of retroviral infection
WO1996017874A1 (en) *	1994-12-07	1996-06-13	F. Hoffmann-La Roche Ag	Monoclonal antibody fragments having immunosuppressant activity
JPH10511652A (ja) *	1994-12-23	1998-11-10	ラボラトワール・オン・ソシエテ・アノニム	炎症性疾患の予防および／または治療に対するｍｈｃ−ｉｉ結合および／またはｍｈｃ−ｉｉ模倣分子の使用
JP2000502711A (ja) *	1995-12-28	2000-03-07	ザジョンズホプキンズユニヴァーシティスクールオブメディシン	同種異系パラクリンサイトカイン腫瘍ワクチン

1997
- 1997-07-25 EP EP97401800A patent/EP0893507A1/en not_active Withdrawn
1998
- 1998-07-23 EE EEP200000039A patent/EE200000039A/xx unknown
- 1998-07-23 BR BR9811037-3A patent/BR9811037A/pt not_active IP Right Cessation
- 1998-07-23 PT PT98945090T patent/PT1002108E/pt unknown
- 1998-07-23 AT AT98945090T patent/ATE324455T1/de active
- 1998-07-23 EP EP06008545A patent/EP1698701B1/en not_active Expired - Lifetime
- 1998-07-23 EP EP98945090A patent/EP1002108B1/en not_active Expired - Lifetime
- 1998-07-23 EA EA200300092A patent/EA200300092A1/ru unknown
- 1998-07-23 DK DK98945090T patent/DK1002108T3/da active
- 1998-07-23 AT AT06008545T patent/ATE478956T1/de not_active IP Right Cessation
- 1998-07-23 DE DE69841866T patent/DE69841866D1/de not_active Expired - Lifetime
- 1998-07-23 JP JP2000503862A patent/JP4723722B2/ja not_active Expired - Lifetime
- 1998-07-23 CA CA2732570A patent/CA2732570C/en not_active Expired - Lifetime
- 1998-07-23 DE DE69834330T patent/DE69834330T2/de not_active Expired - Lifetime
- 1998-07-23 WO PCT/EP1998/004621 patent/WO1999004810A2/en not_active Ceased
- 1998-07-23 CN CNB988075474A patent/CN1184320C/zh not_active Expired - Lifetime
- 1998-07-23 UA UA2000020976A patent/UA75322C2/uk unknown
- 1998-07-23 ES ES98945090T patent/ES2262242T3/es not_active Expired - Lifetime
- 1998-07-23 CA CA2293805A patent/CA2293805C/en not_active Expired - Lifetime
- 1998-07-23 KR KR1020007000265A patent/KR100603075B1/ko not_active Expired - Fee Related
- 1998-07-23 EA EA200200565A patent/EA005405B1/ru not_active IP Right Cessation
- 1998-07-23 EA EA200000161A patent/EA003740B1/ru not_active IP Right Cessation
- 1998-07-23 IL IL13421298A patent/IL134212A0/xx unknown
- 1998-07-23 AU AU92547/98A patent/AU753738B2/en not_active Expired
2000
- 2000-01-24 IL IL134212A patent/IL134212A/en not_active IP Right Cessation
- 2000-01-25 NO NO20000378A patent/NO20000378D0/no not_active Application Discontinuation
- 2000-01-27 US US09/492,113 patent/US6410509B1/en not_active Expired - Lifetime
2002
- 2002-01-10 US US10/041,600 patent/US7109026B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP4723722B2 (ja)	2011-07-13
EA005405B1 (ru)	2005-02-24
DE69841866D1 (de)	2010-10-07
NO20000378L (no)	2000-01-25
DE69834330T2 (de)	2007-03-29
CN1265149A (zh)	2000-08-30
WO1999004810A2 (en)	1999-02-04
EP1002108A2 (en)	2000-05-24
ES2262242T3 (es)	2006-11-16
EA200300092A1 (ru)	2003-06-26
KR20010021706A (ko)	2001-03-15
EP0893507A1 (en)	1999-01-27
CA2732570A1 (en)	1999-02-04
US7109026B2 (en)	2006-09-19
EP1698701B1 (en)	2010-08-25
HK1030014A1 (zh)	2001-04-20
BR9811037A (pt)	2000-08-01
US20020192195A1 (en)	2002-12-19
PT1002108E (pt)	2006-09-29
ATE478956T1 (de)	2010-09-15
EE200000039A (et)	2000-10-16
CA2732570C (en)	2014-11-18
AU9254798A (en)	1999-02-16
DE69834330D1 (de)	2006-06-01
IL134212A0 (en)	2001-04-30
IL134212A (en)	2012-03-29
EA200000161A1 (ru)	2000-10-30
EP1698701A1 (en)	2006-09-06
US6410509B1 (en)	2002-06-25
EP1002108B1 (en)	2006-04-26
NO20000378D0 (no)	2000-01-25
AU753738B2 (en)	2002-10-24
CN1184320C (zh)	2005-01-12
CA2293805A1 (en)	1999-02-04
EA003740B1 (ru)	2003-08-28
CA2293805C (en)	2011-05-03
WO1999004810A3 (en)	1999-07-08
KR100603075B1 (ko)	2006-07-20
DK1002108T3 (da)	2006-08-21
JP2001510806A (ja)	2001-08-07
ATE324455T1 (de)	2006-05-15
EA200200565A1 (ru)	2002-10-31

Publication	Publication Date	Title
UA75322C2 (en)	2006-04-17	Use of mhc class ii ligands as adjuvant for vaccination and lag-3 for cancer immunotherapy
AP1261A (en)	2004-03-19	Composition containing an OX-40 receptor binding agent or a nucleic acid encoding the same and methods for enhancing antigen-specific immune response.
CA2169635C (en)	2002-11-12	Method, compositions and devices for administration of naked polynucleotides which encode biologically active peptides
JP4059920B2 (ja)	2008-03-12	癌自己関連抗原特異的ヒト細胞障害性ｔ細胞の産生とその使用
JP4900884B2 (ja)	2012-03-21	腫瘍抗原
AU2006277295B2 (en)	2011-08-11	Glypican-3 (GPC3)-derived tumor rejection antigenic peptides useful for HLA-A2-positive patients and pharmaceutical comprising the same
JP2002515734A (ja)	2002-05-28	遺伝子改変された樹状細胞により媒介される免疫刺激
JP2022553192A (ja)	2022-12-22	癌ワクチン
WO1999061068A9 (en)	2000-09-08	Anti-prostate cancer vaccines, and methods of making, using and evaluating the same
Bronte et al.	2003	Effective genetic vaccination with a widely shared endogenous retroviral tumor antigen requires CD40 stimulation during tumor rejection phase
KR20020001865A (ko)	2002-01-09	면역반응을 증강시키기 위한 가용성 공동자극 분자의 용도
US20040191761A1 (en)	2004-09-30	Modified adenoviral E1A constructs and methods of use thereof
CA2321974A1 (en)	1999-09-02	Tumor associated antigen 791tgp72
JP4223813B2 (ja)	2009-02-12	免疫増強特性を有するムチンペプチド
Ludvíková et al.	2005	Use of polyclonal rabbit antibodies for detection of the bcr-abl fusion zone in cells transfected with experimental bcr-abl DNA vaccines
WO2024052542A2 (en)	2024-03-14	A peptide cocktail
EP0725828A1 (en)	1996-08-14	Methods relating to ir-95
WO2001032843A9 (en)	2002-08-15	Enhanced immune recognition of pathogenic cells by icsbp expression
HK40088792A (zh)	2023-10-06	用於癌症免疫疗法的重组痘病毒
MXPA99012024A (en)	2000-08-01	Use of mhc class ii ligands as adjuvant for vaccination and of lag-3 in cancer treatment
Sukumar	2008	Mechanisms of Rejection of High Grade B Cell Lymphoma in Mice