ZA200501645B - Injectable multimodel polymer depot compositions and uses thereof - Google Patents
Injectable multimodel polymer depot compositions and uses thereofInfo
- Publication number
- ZA200501645B ZA200501645B ZA200501645A ZA200501645A ZA200501645B ZA 200501645 B ZA200501645 B ZA 200501645B ZA 200501645 A ZA200501645 A ZA 200501645A ZA 200501645 A ZA200501645 A ZA 200501645A ZA 200501645 B ZA200501645 B ZA 200501645B
- Authority
- ZA
- South Africa
- Prior art keywords
- multimodel
- injectable
- depot compositions
- polymer depot
- polymer
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 229920000642 polymer Polymers 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Anesthesiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39983202P | 2002-07-31 | 2002-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200501645B true ZA200501645B (en) | 2006-05-31 |
Family
ID=31188625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200501645A ZA200501645B (en) | 2002-07-31 | 2005-02-24 | Injectable multimodel polymer depot compositions and uses thereof |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8501215B2 (fr) |
| EP (2) | EP1539101B1 (fr) |
| JP (1) | JP4639400B2 (fr) |
| KR (1) | KR20050083605A (fr) |
| CN (2) | CN1684663A (fr) |
| AR (1) | AR040753A1 (fr) |
| AT (1) | ATE419831T1 (fr) |
| AU (2) | AU2003256849A1 (fr) |
| BR (1) | BR0313539A (fr) |
| CA (1) | CA2494400A1 (fr) |
| DE (1) | DE60325742D1 (fr) |
| DK (1) | DK1539101T3 (fr) |
| ES (1) | ES2321505T3 (fr) |
| IL (1) | IL166463A0 (fr) |
| MX (1) | MXPA05001244A (fr) |
| NO (1) | NO20051025L (fr) |
| NZ (1) | NZ537953A (fr) |
| WO (1) | WO2004011054A2 (fr) |
| ZA (1) | ZA200501645B (fr) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1229940T3 (da) * | 1999-11-15 | 2014-08-18 | Piramal Healthcare Canada Ltd | Temperaturstyret og ph-afhængig selvgelerende, vandig biopolymeropløsning |
| ATE243049T1 (de) * | 1999-12-09 | 2003-07-15 | Biosyntech Canada Inc | Mineral-polymer hybrid-zusammensetzung |
| US20030158302A1 (en) * | 1999-12-09 | 2003-08-21 | Cyric Chaput | Mineral-polymer hybrid composition |
| US20050042194A1 (en) | 2000-05-11 | 2005-02-24 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| IL153490A0 (en) * | 2000-06-29 | 2003-07-06 | Biosyntech Canada Inc | Composition and method for the repair and regeneration of cartilage and other tissues |
| WO2002040070A2 (fr) * | 2000-11-15 | 2002-05-23 | Bio Syntech Canada Inc. | Procede de restauration d'un disque intervertebral endommage ou atteint de degenerescence |
| GB0116341D0 (en) | 2001-07-04 | 2001-08-29 | Smith & Nephew | Biodegradable polymer systems |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| RU2355385C2 (ru) | 2002-11-06 | 2009-05-20 | Алза Корпорейшн | Композиции пролонгированного действия с контролируемым высвобождением |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| GB0329654D0 (en) | 2003-12-23 | 2004-01-28 | Smith & Nephew | Tunable segmented polyacetal |
| US8119154B2 (en) | 2004-04-30 | 2012-02-21 | Allergan, Inc. | Sustained release intraocular implants and related methods |
| US20080038316A1 (en) | 2004-10-01 | 2008-02-14 | Wong Vernon G | Conveniently implantable sustained release drug compositions |
| KR101341359B1 (ko) * | 2004-10-01 | 2013-12-13 | 램스코르 인코포레이티드 | 편리하게 이식가능한 서방형 약물 조성물 |
| US9993558B2 (en) | 2004-10-01 | 2018-06-12 | Ramscor, Inc. | Sustained release eye drop formulations |
| US8541413B2 (en) | 2004-10-01 | 2013-09-24 | Ramscor, Inc. | Sustained release eye drop formulations |
| MX2007003789A (es) * | 2004-10-04 | 2007-07-20 | Qlt Usa Inc | Suministro ocular de formulaciones polimericas para suministro. |
| US8313763B2 (en) * | 2004-10-04 | 2012-11-20 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of rapamycin compounds |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| WO2006083761A2 (fr) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solutions de solvant/polymere utilisees comme vehicules de suspension |
| CA2619552A1 (fr) * | 2005-08-18 | 2007-02-22 | Smith & Nephew, Plc | Dispositifs et composites multimodaux a resistance elevee |
| US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
| CA2628313A1 (fr) * | 2005-11-04 | 2007-05-31 | Bio Syntech Canada Inc. | Composition et procede utilisant du chitosan pour l'administration efficace d'acides nucleiques a des cellules |
| US20070149640A1 (en) * | 2005-12-28 | 2007-06-28 | Sasa Andjelic | Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates |
| US8236904B2 (en) | 2005-12-28 | 2012-08-07 | Ethicon, Inc. | Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates |
| KR101106510B1 (ko) | 2006-05-30 | 2012-01-20 | 인타르시아 세라퓨틱스 인코포레이티드 | 투피스, 내부채널 삼투압 전달 시스템 유동 조절기 |
| EP2359808B1 (fr) | 2006-08-09 | 2013-05-22 | Intarcia Therapeutics, Inc | Système de libération osmotique avec ensemble de piston |
| WO2008094697A2 (fr) * | 2007-02-01 | 2008-08-07 | The Trustees Of The University Of Pennsylvania | Augmentation discale avec de l'acide hyaluronique |
| US7867778B2 (en) * | 2007-02-23 | 2011-01-11 | Visiongate, Inc. | Fluid focusing for positional control of a specimen for 3-D imaging |
| US9815240B2 (en) | 2007-04-18 | 2017-11-14 | Smith & Nephew, Inc. | Expansion moulding of shape memory polymers |
| ATE547129T1 (de) * | 2007-04-19 | 2012-03-15 | Smith & Nephew Inc | Multimodale formgedächtnis-polymere |
| US9770534B2 (en) | 2007-04-19 | 2017-09-26 | Smith & Nephew, Inc. | Graft fixation |
| WO2008133908A2 (fr) | 2007-04-23 | 2008-11-06 | Intarcia Therapeutics, Inc. | Formulations en suspension de peptides insulinotropes et leurs utilisations |
| EP2167039B1 (fr) | 2007-05-18 | 2016-09-28 | Durect Corporation | Formulations à dépôt amélioré |
| ES2562878T3 (es) | 2007-05-25 | 2016-03-08 | Indivior Uk Limited | Formulaciones de liberación sostenida de compuestos de risperidona |
| US8470360B2 (en) | 2008-04-18 | 2013-06-25 | Warsaw Orthopedic, Inc. | Drug depots having different release profiles for reducing, preventing or treating pain and inflammation |
| EP2240167B1 (fr) * | 2007-12-21 | 2013-11-13 | Ludwig-Maximilians-Universität | Dispositifs extrudés en forme de baguette pour la libération controlée de substances biologiques chez l'homme et l'animal |
| US20090181068A1 (en) | 2008-01-14 | 2009-07-16 | Dunn Richard L | Low Viscosity Liquid Polymeric Delivery System |
| KR101921800B1 (ko) | 2008-01-30 | 2018-11-23 | 노파르티스 아게 | 옥트레오티드 및 3종의 선형 폴리락티드-코-글리콜리드 중합체를 포함하는 서방형 제제 |
| CA2726861C (fr) | 2008-02-13 | 2014-05-27 | Intarcia Therapeutics, Inc. | Dispositifs, formulations et methodes d'administration de plusieurs agents benefiques |
| US20090263456A1 (en) * | 2008-04-18 | 2009-10-22 | Warsaw Orthopedic, Inc. | Methods and Compositions for Reducing Preventing and Treating Adhesives |
| WO2009148579A2 (fr) * | 2008-06-03 | 2009-12-10 | Qlt Usa, Inc. | Complexe d'inclusion d'hydrogel déshydraté d'un agent bioactif avec système d'administration de médicament fluide |
| US8802126B2 (en) * | 2008-06-30 | 2014-08-12 | Abbott Cardiovascular Systems Inc. | Polyester implantable medical device with controlled in vivo biodegradability |
| JP2010232895A (ja) * | 2009-03-26 | 2010-10-14 | Fuji Xerox Co Ltd | 通信制御装置及び情報処理装置 |
| RU2547990C2 (ru) | 2009-09-28 | 2015-04-10 | Интарсия Терапьютикс, Инк. | Быстрое достижение и/или прекращение существенной стабильной доставки лекарственного средства |
| EP2308478A1 (fr) * | 2009-10-06 | 2011-04-13 | Abbott GmbH & Co. KG | Système de libération prolongée d'agents bloquants des canaux calciques |
| PL2394664T3 (pl) * | 2010-05-31 | 2016-12-30 | Preparat przeciwpsychotyczny do wstrzykiwań o przedłużonym uwalnianiu | |
| US10463607B2 (en) | 2010-05-31 | 2019-11-05 | Laboratorios Farmaceutics Rofi S.A. | Antipsychotic Injectable Depot Composition |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| DE102011114986A1 (de) | 2011-09-28 | 2013-03-28 | Ethris Gmbh | Sprühsystem |
| US8735504B2 (en) * | 2012-05-02 | 2014-05-27 | Warsaw Orthopedic, Inc. | Methods for preparing polymers having low residual monomer content |
| EA033537B1 (ru) | 2013-03-11 | 2019-10-31 | Durect Corp | Инъекционная композиция с контролируемым высвобождением, содержащая жидкий носитель с высокой вязкостью |
| US20140308352A1 (en) | 2013-03-11 | 2014-10-16 | Zogenix Inc. | Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material |
| RS60093B1 (sr) | 2013-09-16 | 2020-05-29 | Astrazeneca Ab | Terapeutske polimerne nanočestice i postupci njihove pripreme i primene |
| EP3079668A1 (fr) | 2013-12-09 | 2016-10-19 | Durect Corporation | Complexes de principes pharmaceutiquement actifs, complexes de polymères, et compositions et procédés les impliquant |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| RU2730996C2 (ru) | 2015-06-03 | 2020-08-26 | Интарсия Терапьютикс, Инк. | Системы установки и извлечения имплантата |
| KR102574993B1 (ko) | 2016-05-16 | 2023-09-06 | 인타르시아 세라퓨틱스 인코포레이티드 | 글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법 |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| US10668011B2 (en) | 2016-06-30 | 2020-06-02 | Durect Corporation | Depot formulations |
| US10682340B2 (en) | 2016-06-30 | 2020-06-16 | Durect Corporation | Depot formulations |
| JP7286542B2 (ja) | 2017-01-03 | 2023-06-05 | インターシア セラピューティクス,インコーポレイティド | Glp-1受容体アゴニストの持続的投与及び薬物の同時投与を含む方法 |
| DE102017106216A1 (de) | 2017-03-22 | 2018-09-27 | Amw Gmbh | Extrudierte Depotform zur anhaltenden Wirkstofffreisetzung |
| CN115666621A (zh) | 2020-01-13 | 2023-01-31 | 度勒科特公司 | 具有减少的杂质的持续释放药物递送系统及相关方法 |
| CN112816637A (zh) * | 2020-06-17 | 2021-05-18 | 湖南慧泽生物医药科技有限公司 | 一种吗替麦考酚酯片的体外溶出方法 |
| CA3203561A1 (fr) | 2021-01-12 | 2022-07-21 | Adrian Neil Verity | Systemes d'administration de medicament a liberation prolongee et procedes associes |
| US12318387B2 (en) | 2021-07-16 | 2025-06-03 | Laboratorios Farmaceuticos Rovi, S.A. | Method of treating acute exacerbation of schizophrenia with long-acting injectable depot composition |
| US12594236B2 (en) | 2021-07-16 | 2026-04-07 | Laboratorios Farmaceuticos Rovi, S.A. | Method of treating acute exacerbation of schizophrenia with long-acting injectable depot composition |
| TW202313047A (zh) | 2021-09-21 | 2023-04-01 | 西班牙商禾霏藥品實驗室有限公司 | 抗精神病可注射儲積型組合物 |
| CA3248062A1 (fr) | 2022-05-18 | 2025-07-10 | Laboratorios Farmacéuticos Rovi, S.A. | Compositions injectables à libération prolongée destinées à être utilisées dans le traitement avec la rispéridone conjointement avec des inhibiteurs de l’enzyme cyp2d6 |
Family Cites Families (146)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US336307A (en) | 1886-02-16 | Feed-water regulator | ||
| US336254A (en) | 1886-02-16 | Eobeet t | ||
| US3797492A (en) | 1972-12-27 | 1974-03-19 | Alza Corp | Device for dispensing product with directional guidance member |
| US3923939A (en) | 1974-06-07 | 1975-12-02 | Alza Corp | Process for improving release kinetics of a monolithic drug delivery device |
| US3987790A (en) | 1975-10-01 | 1976-10-26 | Alza Corporation | Osmotically driven fluid dispenser |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| LU83485A1 (fr) * | 1981-07-09 | 1983-02-04 | Metallurgie Hoboken | Procede et installation pour couler une bande a oreilles en saillie laterale |
| US4443340A (en) | 1981-10-09 | 1984-04-17 | Betz Laboratories, Inc. | Control of iron induced fouling in water systems |
| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| US4623588A (en) | 1984-02-06 | 1986-11-18 | Biotek, Inc. | Controlled release composite core coated microparticles |
| US4568559A (en) | 1984-02-06 | 1986-02-04 | Biotek, Inc. | Composite core coated microparticles and process of preparing same |
| US4708861A (en) | 1984-02-15 | 1987-11-24 | The Liposome Company, Inc. | Liposome-gel compositions |
| US6217911B1 (en) | 1995-05-22 | 2001-04-17 | The United States Of America As Represented By The Secretary Of The Army | sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres |
| US4985404A (en) | 1984-10-04 | 1991-01-15 | Monsanto Company | Prolonged release of biologically active polypeptides |
| US4713244A (en) | 1985-08-16 | 1987-12-15 | Bausch & Lomb Incorporated | Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent |
| US4668506A (en) | 1985-08-16 | 1987-05-26 | Bausch & Lomb Incorporated | Sustained-release formulation containing and amino acid polymer |
| US4931279A (en) | 1985-08-16 | 1990-06-05 | Bausch & Lomb Incorporated | Sustained release formulation containing an ion-exchange resin |
| US4865845A (en) | 1986-03-21 | 1989-09-12 | Alza Corporation | Release rate adjustment of osmotic or diffusional delivery devices |
| US4853218A (en) | 1987-02-24 | 1989-08-01 | Schering Corporation | Zinc-protamine-alpha interferon complex |
| US4866050A (en) | 1988-04-27 | 1989-09-12 | Ben Amoz Daniel | Ultrasonic transdermal application of steroid compositions |
| US5181914A (en) | 1988-08-22 | 1993-01-26 | Zook Gerald P | Medicating device for nails and adjacent tissue |
| US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| US5085866A (en) | 1988-12-02 | 1992-02-04 | Southern Research Institute | Method of producing zero-order controlled-released devices |
| US5059423A (en) | 1988-12-13 | 1991-10-22 | Alza Corporation | Delivery system comprising biocompatible beneficial agent formulation |
| US5057318A (en) | 1988-12-13 | 1991-10-15 | Alza Corporation | Delivery system for beneficial agent over a broad range of rates |
| US5019400A (en) | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
| US5487897A (en) | 1989-07-24 | 1996-01-30 | Atrix Laboratories, Inc. | Biodegradable implant precursor |
| US5324519A (en) | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| US5112614A (en) | 1989-09-14 | 1992-05-12 | Alza Corporation | Implantable delivery dispenser |
| US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| US5300295A (en) | 1990-05-01 | 1994-04-05 | Mediventures, Inc. | Ophthalmic drug delivery with thermoreversible polyoxyalkylene gels adjustable for pH |
| US5252318A (en) | 1990-06-15 | 1993-10-12 | Allergan, Inc. | Reversible gelation compositions and methods of use |
| US5234693A (en) | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
| US5234692A (en) | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
| US5077033A (en) | 1990-08-07 | 1991-12-31 | Mediventures Inc. | Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide |
| US5151093A (en) | 1990-10-29 | 1992-09-29 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
| US5620700A (en) | 1990-10-30 | 1997-04-15 | Alza Corporation | Injectable drug delivery system and method |
| PT99345A (pt) | 1990-10-30 | 1992-09-30 | Alza Corp | Processo para a preparacao de sistemas apropriados para a libertacao de agentes terapeuticos |
| US6117425A (en) | 1990-11-27 | 2000-09-12 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, method of their production and use |
| GB9027422D0 (en) | 1990-12-18 | 1991-02-06 | Scras | Osmotically driven infusion device |
| IE920040A1 (en) | 1991-01-09 | 1992-07-15 | Alza Corp | Bioerodible devices and compositions for diffusional release¹of agents |
| DK0568651T3 (da) | 1991-02-01 | 2002-08-05 | Massachusetts Inst Technology | Bionedbrydelige polymerblandinger til afgivelse af lægemidler |
| FR2673843B1 (fr) | 1991-03-14 | 1995-01-13 | Centre Nat Rech Scient | Composition pharmaceutique implantable, bioresorbable a base de poly(acide lactique), destinee a mettre en óoeuvre une antibiotherapie interne locale. |
| US5137727A (en) | 1991-06-12 | 1992-08-11 | Alza Corporation | Delivery device providing beneficial agent stability |
| US5288214A (en) | 1991-09-30 | 1994-02-22 | Toshio Fukuda | Micropump |
| US5318780A (en) | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
| DE69207863T2 (de) | 1991-11-13 | 1996-06-05 | Glaxo Canada | Vorrichtung zur kontrollierten Wirkstoffreigabe |
| ES2139646T3 (es) | 1991-12-19 | 2000-02-16 | Mitsui Chemicals Inc | Acido polihidroxido carboxilico y su procedimiento de obtencion. |
| US5681585A (en) | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5209746A (en) | 1992-02-18 | 1993-05-11 | Alza Corporation | Osmotically driven delivery devices with pulsatile effect |
| US5308348A (en) | 1992-02-18 | 1994-05-03 | Alza Corporation | Delivery devices with pulsatile effect |
| US5456679A (en) | 1992-02-18 | 1995-10-10 | Alza Corporation | Delivery devices with pulsatile effect |
| US5656297A (en) | 1992-03-12 | 1997-08-12 | Alkermes Controlled Therapeutics, Incorporated | Modulated release from biocompatible polymers |
| WO1993019739A1 (fr) | 1992-03-30 | 1993-10-14 | Alza Corporation | Suspensions visqueuses de particules de medicament a liberation regulee |
| MX9301821A (es) | 1992-03-30 | 1994-03-31 | Alza Corp | Sistema de matriz polimerica biodegradable regulador de degradacion y metodo de tratamiento del mismo. |
| GB9211268D0 (en) * | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
| FR2693905B1 (fr) * | 1992-07-27 | 1994-09-02 | Rhone Merieux | Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues. |
| US5700485A (en) | 1992-09-10 | 1997-12-23 | Children's Medical Center Corporation | Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid |
| US5922340A (en) | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
| DK0659073T3 (da) | 1992-09-10 | 2002-03-11 | Childrens Medical Center | Bionedbrydelige polymermatrixer med vedvarerende afgivelse af lokalanæstetika |
| US5338822A (en) * | 1992-10-02 | 1994-08-16 | Cargill, Incorporated | Melt-stable lactide polymer composition and process for manufacture thereof |
| US5242910A (en) | 1992-10-13 | 1993-09-07 | The Procter & Gamble Company | Sustained release compositions for treating periodontal disease |
| CA2150803C (fr) | 1992-12-02 | 2006-01-31 | Henry Auer | Hormone de croissance a liberation controlee qui contient des microspheres |
| MY113268A (en) | 1992-12-29 | 2002-01-31 | Insite Vision Incorporated | Plasticized bioerodible controlled delivery system |
| US5340614A (en) | 1993-02-11 | 1994-08-23 | Minnesota Mining And Manufacturing Company | Methods of polymer impregnation |
| US5330452A (en) | 1993-06-01 | 1994-07-19 | Zook Gerald P | Topical medicating device |
| US5447725A (en) | 1993-06-11 | 1995-09-05 | The Procter & Gamble Company | Methods for aiding periodontal tissue regeneration |
| US5415866A (en) | 1993-07-12 | 1995-05-16 | Zook; Gerald P. | Topical drug delivery system |
| GB9321061D0 (en) | 1993-10-13 | 1993-12-01 | Chiroscience Ltd | Analgestic agent and its use |
| EP0727210B1 (fr) | 1993-10-13 | 2001-12-19 | Darwin Discovery Limited | Agent analgésique et son utilisation |
| US5849763A (en) | 1993-10-13 | 1998-12-15 | Darwin Discovery Limited | Use of levobupivacaine as an anesthetic agent |
| US5681873A (en) | 1993-10-14 | 1997-10-28 | Atrix Laboratories, Inc. | Biodegradable polymeric composition |
| JPH09510961A (ja) | 1994-01-14 | 1997-11-04 | ジュニア シャヒニアン,リー | 持続性および長期間の角膜鎮痛の方法 |
| US5760077A (en) | 1994-01-14 | 1998-06-02 | Shahinian, Jr.; Lee | Topical ophthalmic analgesic preparations for sustained and extended corneal analgesia |
| US5556905A (en) | 1994-03-30 | 1996-09-17 | Reilly Industries, Inc. | Physically-modified degradable thermoplastic compositions |
| JP4259610B2 (ja) | 1994-04-08 | 2009-04-30 | キューエルティー・ユーエスエイ・インコーポレーテッド | 液体デリバリー組成物 |
| US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| US5599534A (en) | 1994-08-09 | 1997-02-04 | University Of Nebraska | Reversible gel-forming composition for sustained delivery of bio-affecting substances, and method of use |
| US5660817A (en) | 1994-11-09 | 1997-08-26 | Gillette Canada, Inc. | Desensitizing teeth with degradable particles |
| US6333021B1 (en) | 1994-11-22 | 2001-12-25 | Bracco Research S.A. | Microcapsules, method of making and their use |
| US5660854A (en) | 1994-11-28 | 1997-08-26 | Haynes; Duncan H | Drug releasing surgical implant or dressing material |
| US5972326A (en) | 1995-04-18 | 1999-10-26 | Galin; Miles A. | Controlled release of pharmaceuticals in the anterior chamber of the eye |
| US6322548B1 (en) | 1995-05-10 | 2001-11-27 | Eclipse Surgical Technologies | Delivery catheter system for heart chamber |
| US5674292A (en) | 1995-06-07 | 1997-10-07 | Stryker Corporation | Terminally sterilized osteogenic devices and preparation thereof |
| US5747058A (en) | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
| MX9700850A (es) | 1995-06-09 | 1997-09-30 | Euro Celtique Sa | Formulaciones y metodos para proporcionar anestesia local prolongada. |
| US5897880A (en) | 1995-09-29 | 1999-04-27 | Lam Pharmaceuticals, Llc. | Topical drug preparations |
| US5787175A (en) * | 1995-10-23 | 1998-07-28 | Novell, Inc. | Method and apparatus for collaborative document control |
| US5736152A (en) | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| US5747060A (en) | 1996-03-26 | 1998-05-05 | Euro-Celtique, S.A. | Prolonged local anesthesia with colchicine |
| CN1126537C (zh) | 1996-05-23 | 2003-11-05 | 株式会社三养社 | 可局部给药,可生物降解和持续释放的用于治疗牙周炎的药物组合物及其制备方法 |
| DE69734060T2 (de) | 1996-05-24 | 2006-06-29 | Angiotech Pharmaceuticals, Inc., Vancouver | Zubereitungen und verfahren zur behandlung oder prävention von krankheiten der körperpassagewege |
| CA2180601C (fr) * | 1996-07-05 | 2007-12-18 | Chun Keung Mak | Rampes de buses d'injection chauffees situees dans un meme plan et reliees par des canalisations de distribution |
| WO1998002186A1 (fr) | 1996-07-11 | 1998-01-22 | Farmarc Nederland B.V. | Compose d'inclusion contenant un agoniste selectif de la serotonine a structure indole |
| AU4249597A (en) | 1996-09-04 | 1998-03-26 | Ht Medical Systems, Inc. | Interventional radiology interface apparatus and method |
| US6046187A (en) | 1996-09-16 | 2000-04-04 | Children's Medical Center Corporation | Formulations and methods for providing prolonged local anesthesia |
| US5766637A (en) | 1996-10-08 | 1998-06-16 | University Of Delaware | Microencapsulation process using supercritical fluids |
| JP4642946B2 (ja) | 1996-12-20 | 2011-03-02 | アルザ コーポレイション | ゲル組成物および方法 |
| GB9704351D0 (en) | 1997-03-03 | 1997-04-23 | Chiroscience Ltd | Levobupivacaine and its use |
| JPH10255221A (ja) * | 1997-03-14 | 1998-09-25 | Mitsubishi Electric Corp | 複合型磁気ヘッド及び該複合型磁気ヘッドのヘッドコアの製造方法 |
| US20020039594A1 (en) | 1997-05-13 | 2002-04-04 | Evan C. Unger | Solid porous matrices and methods of making and using the same |
| US6197327B1 (en) | 1997-06-11 | 2001-03-06 | Umd, Inc. | Device and method for treatment of dysmenorrhea |
| CA2241615A1 (fr) | 1997-06-26 | 1998-12-26 | An-Go-Gen Inc. | Catheters |
| EP1009390A4 (fr) | 1997-07-02 | 2004-05-06 | Euro Celtique Sa | Anesthesie a effet prolonge injectee dans les interlignes articulaires et corporelles |
| US6432986B2 (en) | 1997-07-21 | 2002-08-13 | Bruce H. Levin | Compositions, kits, and methods for inhibiting cerebral neurovascular disorders and muscular headaches |
| US20010004644A1 (en) | 1997-07-21 | 2001-06-21 | Levin Bruce H. | Compositions, kits, apparatus, and methods for inhibiting cephalic inflammation |
| WO1999004772A2 (fr) | 1997-07-22 | 1999-02-04 | Darwin Discovery Limited | Levobupivacine et son utilisation |
| US6306166B1 (en) | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
| US6183444B1 (en) | 1998-05-16 | 2001-02-06 | Microheart, Inc. | Drug delivery module |
| US6193991B1 (en) | 1997-10-29 | 2001-02-27 | Atul J. Shukla | Biodegradable delivery systems of biologically active substances |
| US6050986A (en) | 1997-12-01 | 2000-04-18 | Scimed Life Systems, Inc. | Catheter system for the delivery of a low volume liquid bolus |
| IT1298574B1 (it) | 1998-02-06 | 2000-01-12 | Vectorpharma Int | Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione |
| WO1999049908A1 (fr) | 1998-03-31 | 1999-10-07 | University Of Cincinnati | Systeme d'administration de solute a temperature regulee |
| US6261547B1 (en) | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
| US6103266A (en) | 1998-04-22 | 2000-08-15 | Tapolsky; Gilles H. | Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues |
| US6605294B2 (en) | 1998-08-14 | 2003-08-12 | Incept Llc | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels |
| US7662409B2 (en) | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
| US6955819B2 (en) | 1998-09-29 | 2005-10-18 | Zars, Inc. | Methods and apparatus for using controlled heat to regulate transdermal and controlled release delivery of fentanyl, other analgesics, and other medical substances |
| US6143314A (en) | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
| US6451346B1 (en) | 1998-12-23 | 2002-09-17 | Amgen Inc | Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents |
| CA2372994C (fr) | 1999-06-04 | 2010-03-23 | Alza Corporation | Compositions de gel implantables et procede de fabrication |
| US6423818B1 (en) | 1999-07-30 | 2002-07-23 | Takehisa Matsuda | Coumarin endcapped absorbable polymers |
| US6352667B1 (en) | 1999-08-24 | 2002-03-05 | Absorbable Polymer Technologies, Inc. | Method of making biodegradable polymeric implants |
| US6528086B2 (en) | 1999-09-28 | 2003-03-04 | Zars, Inc. | Methods and apparatus for drug delivery involving phase changing formulations |
| US6432415B1 (en) | 1999-12-17 | 2002-08-13 | Axrix Laboratories, Inc. | Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces |
| US6566345B2 (en) | 2000-04-28 | 2003-05-20 | Fziomed, Inc. | Polyacid/polyalkylene oxide foams and gels and methods for their delivery |
| US6899731B2 (en) | 1999-12-30 | 2005-05-31 | Boston Scientific Scimed, Inc. | Controlled delivery of therapeutic agents by insertable medical devices |
| ATE425776T1 (de) | 2000-04-28 | 2009-04-15 | Fziomed Inc | Haemostatische zusammenstellung von polysauren und polyalkylenoxyden und deren verwendungsmethoden |
| NZ523385A (en) * | 2000-06-28 | 2005-09-30 | Atul J | Biodegradable vehicles and BAS-loaded delivery systems for use as biodegradable fillers and/or spacers, e.g. artificial skin |
| WO2002005800A2 (fr) | 2000-07-17 | 2002-01-24 | Guilford Pharmaceuticals, Inc. | Compositions pour la liberation prolongee d'agents analgesiques, et procedes de production et d'utilisation de ces compositions |
| US6362308B1 (en) | 2000-08-10 | 2002-03-26 | Alkermes Controlled Therapeutics Inc. Ii | Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content |
| US6543081B1 (en) * | 2000-08-15 | 2003-04-08 | Sheldon C. Cohen | Flip-up wringer sponge mop |
| US6823084B2 (en) * | 2000-09-22 | 2004-11-23 | Sri International | Method and apparatus for portably recognizing text in an image sequence of scene imagery |
| WO2002038185A2 (fr) * | 2000-11-13 | 2002-05-16 | Atrix Laboratories, Inc. | Systeme d'administration injectable a liberation prolongee comprenant du loperamide |
| KR100446101B1 (ko) | 2000-12-07 | 2004-08-30 | 주식회사 삼양사 | 수난용성 약물의 서방성 제형 조성물 |
| US20030152637A1 (en) | 2001-01-25 | 2003-08-14 | Mark Chasin | Local anesthetic, and method of use |
| US6375659B1 (en) | 2001-02-20 | 2002-04-23 | Vita Licensing, Inc. | Method for delivery of biocompatible material |
| ATE427760T1 (de) | 2001-02-23 | 2009-04-15 | Genentech Inc | Erodierbare polymere zur injektion |
| CA2446060A1 (fr) * | 2001-05-07 | 2002-11-14 | Corium International | Compositions et systemes d'administration d'un anesthesique local |
| JP5170935B2 (ja) | 2001-11-14 | 2013-03-27 | デュレクト コーポレーション | 注入可能なデポー組成物 |
| DE60239952D1 (de) * | 2001-11-14 | 2011-06-16 | Durect Corp | Injizierbare depotzusammensetzungen und deren verwendung |
| EP1446101B1 (fr) * | 2001-11-14 | 2011-03-23 | Durect Corporation | Compositions en depot injectables par catheter et utilisations |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| RU2355385C2 (ru) | 2002-11-06 | 2009-05-20 | Алза Корпорейшн | Композиции пролонгированного действия с контролируемым высвобождением |
| CA2527664A1 (fr) | 2003-05-30 | 2004-12-16 | Alza Corporation | Compositions en depot elastomere implantables, utilisations associees et procede de fabrication |
| US20070184084A1 (en) | 2003-05-30 | 2007-08-09 | Guohua Chen | Implantable elastomeric caprolactone depot compositions and uses thereof |
-
2003
- 2003-07-28 CN CNA038225581A patent/CN1684663A/zh active Pending
- 2003-07-28 DK DK03771916T patent/DK1539101T3/da active
- 2003-07-28 MX MXPA05001244A patent/MXPA05001244A/es unknown
- 2003-07-28 KR KR1020057001821A patent/KR20050083605A/ko not_active Ceased
- 2003-07-28 US US10/628,984 patent/US8501215B2/en not_active Expired - Fee Related
- 2003-07-28 WO PCT/US2003/023439 patent/WO2004011054A2/fr not_active Ceased
- 2003-07-28 BR BR0313539-0A patent/BR0313539A/pt not_active IP Right Cessation
- 2003-07-28 JP JP2004524891A patent/JP4639400B2/ja not_active Expired - Fee Related
- 2003-07-28 CN CNA2007101096196A patent/CN101057824A/zh active Pending
- 2003-07-28 CA CA002494400A patent/CA2494400A1/fr not_active Abandoned
- 2003-07-28 EP EP03771916A patent/EP1539101B1/fr not_active Expired - Lifetime
- 2003-07-28 ES ES03771916T patent/ES2321505T3/es not_active Expired - Lifetime
- 2003-07-28 AT AT03771916T patent/ATE419831T1/de not_active IP Right Cessation
- 2003-07-28 EP EP08166077A patent/EP2030611A1/fr not_active Withdrawn
- 2003-07-28 NZ NZ537953A patent/NZ537953A/en not_active IP Right Cessation
- 2003-07-28 DE DE60325742T patent/DE60325742D1/de not_active Expired - Lifetime
- 2003-07-28 AU AU2003256849A patent/AU2003256849A1/en not_active Abandoned
- 2003-07-31 AR AR20030102760A patent/AR040753A1/es not_active Application Discontinuation
-
2005
- 2005-01-24 IL IL16646305A patent/IL166463A0/xx unknown
- 2005-02-24 ZA ZA200501645A patent/ZA200501645B/xx unknown
- 2005-02-25 NO NO20051025A patent/NO20051025L/no not_active Application Discontinuation
-
2010
- 2010-01-29 AU AU2010200348A patent/AU2010200348A1/en not_active Withdrawn
-
2013
- 2013-07-16 US US13/943,719 patent/US20140051770A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR0313539A (pt) | 2005-06-21 |
| NO20051025L (no) | 2005-02-25 |
| MXPA05001244A (es) | 2005-06-08 |
| ATE419831T1 (de) | 2009-01-15 |
| DE60325742D1 (de) | 2009-02-26 |
| WO2004011054A3 (fr) | 2004-04-01 |
| IL166463A0 (en) | 2006-01-15 |
| KR20050083605A (ko) | 2005-08-26 |
| US20040022859A1 (en) | 2004-02-05 |
| DK1539101T3 (da) | 2009-04-27 |
| US8501215B2 (en) | 2013-08-06 |
| AU2010200348A1 (en) | 2010-02-18 |
| EP1539101A2 (fr) | 2005-06-15 |
| CN101057824A (zh) | 2007-10-24 |
| HK1079443A1 (en) | 2006-04-07 |
| EP1539101B1 (fr) | 2009-01-07 |
| JP4639400B2 (ja) | 2011-02-23 |
| JP2005538107A (ja) | 2005-12-15 |
| NZ537953A (en) | 2007-02-23 |
| ES2321505T3 (es) | 2009-06-08 |
| CN1684663A (zh) | 2005-10-19 |
| WO2004011054A2 (fr) | 2004-02-05 |
| CA2494400A1 (fr) | 2004-02-05 |
| EP2030611A1 (fr) | 2009-03-04 |
| AU2003256849A1 (en) | 2004-02-16 |
| US20140051770A1 (en) | 2014-02-20 |
| AR040753A1 (es) | 2005-04-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA200501645B (en) | Injectable multimodel polymer depot compositions and uses thereof | |
| ZA200306278B (en) | Injectable depot composition | |
| IL169441A0 (en) | Hemostatic compositions and uses therefor | |
| AU2003227480A1 (en) | Modified polymers and compositions containing the same | |
| GB2386375B (en) | Polymer electrolyte composition and uses thereof | |
| PL377679A1 (pl) | Nowe preparaty typu depot do wstrzykiwania | |
| EP1556428A4 (fr) | Compositions durcissant rapidement | |
| AU2003220205A8 (en) | Ethanol-diesel fuel composition and methods thereof | |
| AU2003278795A8 (en) | Compositions containing oil silicon-polyamide polymer and short chain ester | |
| PL1682628T3 (pl) | Wykrywalne kompozycje czynnika chłodniczego i ich zastosowania | |
| PT1534760E (pt) | Polímero quaternizado bloqueado com ácido e composições que compreendem esse polímero | |
| IL166331A0 (en) | 5-arylterazole compounds compositions thereof and uses therefor | |
| GB2393963B (en) | Sliding composition and sliding member | |
| AU2003228205A8 (en) | Porous polymers: compositions and uses thereof | |
| GB2398790B (en) | Polymer compositions | |
| GB0207224D0 (en) | Tenascin-W compositions and uses thereof | |
| GB0325942D0 (en) | Compositions and uses thereof | |
| AU2003221079A1 (en) | Resin compositions and moldings | |
| GB0216170D0 (en) | Resin compositions | |
| GB0205277D0 (en) | Azetidinium-functionalised polymer and compositions containing the same | |
| AU2003229630A8 (en) | Polymer composition | |
| GB0220238D0 (en) | Novel use and compositions | |
| GB0214800D0 (en) | Novel use and compositions | |
| GB0312992D0 (en) | Peptides,compositions and uses thereof | |
| GB0218253D0 (en) | Novel composition and use |