ZW20385A1 - Oxetanones - Google Patents

Oxetanones

Info

Publication number
ZW20385A1
ZW20385A1 ZW203/85A ZW20385A ZW20385A1 ZW 20385 A1 ZW20385 A1 ZW 20385A1 ZW 203/85 A ZW203/85 A ZW 203/85A ZW 20385 A ZW20385 A ZW 20385A ZW 20385 A1 ZW20385 A1 ZW 20385A1
Authority
ZW
Zimbabwe
Prior art keywords
alkyl
opt
ring
substd
atom
Prior art date
Application number
ZW203/85A
Other languages
English (en)
Inventor
Barbier Pierre
Schneider Fernand
Widmer Ulrich
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZW20385A1 publication Critical patent/ZW20385A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyesters Or Polycarbonates (AREA)
ZW203/85A 1984-12-21 1985-11-15 Oxetanones ZW20385A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH610284 1984-12-21
CH393485 1985-09-12

Publications (1)

Publication Number Publication Date
ZW20385A1 true ZW20385A1 (en) 1986-03-05

Family

ID=25694219

Family Applications (1)

Application Number Title Priority Date Filing Date
ZW203/85A ZW20385A1 (en) 1984-12-21 1985-11-15 Oxetanones

Country Status (20)

Country Link
US (2) US4931463A (fr)
EP (1) EP0185359B1 (fr)
CN (1) CN1012643B (fr)
AT (1) ATE70061T1 (fr)
AU (1) AU583569B2 (fr)
CA (1) CA1270837A (fr)
CS (1) CS262425B2 (fr)
DE (1) DE3584829D1 (fr)
DK (1) DK166724B1 (fr)
DO (1) DOP1985004386A (fr)
FI (1) FI91403C (fr)
HU (1) HU200172B (fr)
IE (1) IE58926B1 (fr)
IL (1) IL77338A (fr)
MC (1) MC1728A1 (fr)
NO (1) NO171160C (fr)
NZ (1) NZ214565A (fr)
PH (1) PH26291A (fr)
PT (1) PT81748B (fr)
ZW (1) ZW20385A1 (fr)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1328881C (fr) * 1984-12-21 1994-04-26 Pierre Barbier Procede pour la fabrication d'oxetanones
US5246960A (en) * 1984-12-21 1993-09-21 Hoffmann-La Roche Inc. Oxetanones
US4895973A (en) * 1986-08-14 1990-01-23 G. D. Searle & Company Substituted glutaric acid lactones in the treatment of hyperlipidemia
US4806564A (en) * 1987-05-26 1989-02-21 Merck & Co., Inc. Antihypercholesterolemic beta-lactones
US4816477A (en) * 1987-05-26 1989-03-28 Merck & Co., Inc. Antihypercholesterolemic β-lactones
CA2035972C (fr) * 1990-02-23 2006-07-11 Martin Karpf Procede de preparation d'oxetanones
US5260310A (en) * 1990-02-26 1993-11-09 Hoffmann-La Roche Inc. Oxetanone compounds and pharmaceutical compositions containing them
CA2098167C (fr) * 1992-06-24 2006-12-19 Dorothea Isler Aliments pour humains et animaux contenant un inhibiteur de la lipase
BR9807655A (pt) * 1997-02-05 2000-02-15 Hoffmann La Roche Uso de inibidores de lipase gastrintestinal.
ATE422359T1 (de) 1997-04-15 2009-02-15 Csir Verbindungen und pharmazeutische zusammensetzungen mit appetitunterdrückender aktivität
GB2396815B (en) * 1999-10-27 2004-09-08 Phytopharm Plc A composition comprising a pregnenone derivative and an NSAID
CA2358921A1 (fr) * 1999-10-29 2001-05-10 John Jason Gentry Mullins Derives d'oxetanone
EP1132389A1 (fr) 2000-03-06 2001-09-12 Vernalis Research Limited Nouveaux dérivés de l'azaindole pour le traitement de l'obésité
GB2363985B (en) * 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
BR0112800A (pt) 2000-07-28 2003-07-01 Hoffmann La Roche Utilização de um inibidor de lìpases e de um sequestrante de ácido de bìlis farmaceuticamente aceitáveis e processo para a prevenção e tratamento de enfermidades associadas com altos nìveis de colesterol de plasma
CA2417607C (fr) 2000-08-09 2008-01-29 Christine Feinle Utilisation d'inhibiteurs de lipase
US6900226B2 (en) 2000-09-06 2005-05-31 Hoffman-La Roche Inc. Neuropeptide Y antagonists
JP4047723B2 (ja) 2000-10-16 2008-02-13 エフ．ホフマン−ラ ロシュ アーゲー インドリン誘導体、および５−ｈｔ２受容体リガンドとしてのその使用
US6392061B1 (en) * 2000-10-16 2002-05-21 Zpro Chemical, Inc. Process for making (2S, 3S, 5S) oxetanone derivatives
GB0030710D0 (en) 2000-12-15 2001-01-31 Hoffmann La Roche Piperazine derivatives
EP1347979B1 (fr) 2000-12-27 2007-08-08 F. Hoffmann-La Roche Ag Derives d'indole et leur utilisation en tant que ligands de recepteurs 5-ht2b et 5-ht2c
GB0106177D0 (en) 2001-03-13 2001-05-02 Hoffmann La Roche Piperazine derivatives
KR100621287B1 (ko) 2001-05-21 2006-09-13 에프. 호프만-라 로슈 아게 신경 펩타이드 ｙ 수용체에 대한 리간드로서의 퀴놀린유도체
US6730319B2 (en) 2001-06-06 2004-05-04 Hoffmann-La Roche Inc. Pharmaceutical compositions having depressed melting points
US20030027786A1 (en) 2001-06-06 2003-02-06 Karsten Maeder Lipase inhibiting composition
US6787558B2 (en) 2001-09-28 2004-09-07 Hoffmann-La Roche Inc. Quinoline derivatives
GB0202015D0 (en) 2002-01-29 2002-03-13 Hoffmann La Roche Piperazine Derivatives
JP4216196B2 (ja) 2002-02-04 2009-01-28 エフ．ホフマン−ラ ロシュ アーゲー Ｎｐｙアンタゴニストとしてのキノリン誘導体
RU2004129285A (ru) 2002-02-28 2005-10-27 Ф.Хоффманн-Ля Рош Аг (Ch) Производные тиазола в качестве антагонистов рецептора npy
US7728153B2 (en) 2002-04-17 2010-06-01 The Burnham Institute For Medical Research Method for the asymmetric synthesis of beta-lactone compounds
AU2003226370A1 (en) 2002-04-17 2003-11-03 The Burnham Institute Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation
EP1560816A1 (fr) 2002-07-05 2005-08-10 F. Hoffmann-La Roche Ag Derives de quinazoline
AU2003253364B2 (en) 2002-08-07 2007-06-07 F. Hoffmann-La Roche Ag Thiazole derivatives
NZ537979A (en) 2002-09-12 2007-08-31 Hoffmann La Roche N-substituted-1H-indol-5-propionic acid compounds as PPAR agonists useful for the treatment of diabetes
US6727277B1 (en) 2002-11-12 2004-04-27 Kansas State University Research Foundation Compounds affecting cholesterol absorption
MXPA05005445A (es) 2002-11-25 2005-08-26 Hoffmann La Roche Derivados de indolilo.
GB0314967D0 (en) 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
WO2005005403A2 (fr) * 2003-07-15 2005-01-20 Ranbaxy Laboratories Limited Procede de preparation d'oxetan-2-ones
RU2006107444A (ru) 2003-08-12 2007-09-20 Ф.Хоффманн-Ля Рош Аг (Ch) 2-амино-5-бензоилтиазолы в качестве антагонистов npy
CA2533464A1 (fr) 2003-08-12 2005-02-17 F. Hoffmann-La Roche Ag Derives de thiazole utiles comme antagonistes de npy *
US7074822B2 (en) * 2004-02-23 2006-07-11 Solvay Pharmaceuticals Gmbh Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
DE102004009076A1 (de) * 2004-02-23 2005-10-27 Solvay Pharmaceuticals Gmbh Alkylcarbamat-substituierte β-Lactone, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US7121355B2 (en) * 2004-09-21 2006-10-17 Cnh America Llc Bulldozer autograding system
WO2006035296A1 (fr) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Procede de preparation d'un derive d'orlistat utile comme standard de reference dans la determination de la purete d'orlistat et procede de preparation d'orlistat
AU2006243243B2 (en) 2005-05-03 2009-05-14 F. Hoffmann-La Roche Ag Tetracyclic azapyrazinoindolines as 5-HT2 ligands
EP1945635B1 (fr) 2005-08-18 2009-05-06 F.Hoffmann-La Roche Ag Derives de thiazolyle piperidine utile comme modulateurs du recepteur h3
US20090171104A1 (en) * 2005-10-05 2009-07-02 Killol Patel Process for the preparation of orlistat
WO2007062999A2 (fr) 2005-11-30 2007-06-07 F. Hoffmann-La Roche Ag Derives de indole-2-yl amide substitues en 1,5
EP1968967B1 (fr) 2005-11-30 2011-04-27 F. Hoffmann-La Roche AG Derives de 1,1-dioxo-thiomorpholinyl indolylmethanone utilises comme modulateurs des recepteurs h3
WO2007063000A1 (fr) 2005-11-30 2007-06-07 F. Hoffmann-La Roche Ag Derives de indole-2-carboxamide substitues en 5
WO2007065820A1 (fr) 2005-12-09 2007-06-14 F. Hoffmann-La Roche Ag Dérivés d’amides tricycliques utiles pour le traitement de l’obésité
WO2007068620A1 (fr) 2005-12-15 2007-06-21 F. Hoffmann-La Roche Ag Derives de pyrrolo[2,3-c]pyridine
JP2009519293A (ja) 2005-12-16 2009-05-14 エフ．ホフマン−ラ ロシュ アーゲー Ｈ３レセプター調節剤としてのピロロ［２，３−ｂ］ピリジン誘導体
CA2635719A1 (fr) * 2006-01-13 2007-07-19 F. Hoffmann-La Roche Ag Derives de methanone de type cyclohexyle et piperazinyle et leur application en tant que modulateurs du recepteur h3 de l'histamine
DE602007008831D1 (de) * 2006-01-23 2010-10-14 Hoffmann La Roche Cyclohexyl-sulfonamid-derivate mit h3-rezeptoraktivität
US7432255B2 (en) 2006-05-16 2008-10-07 Hoffmann-La Roche Inc. 1H-indol-5-yl-piperazin-1-yl-methanone derivatives
US7902184B2 (en) * 2006-05-30 2011-03-08 Hoffmann-La Roche Inc. Piperazinyl pyrimidine derivatives
US7514433B2 (en) 2006-08-03 2009-04-07 Hoffmann-La Roche Inc. 1H-indole-6-yl-piperazin-1-yl-methanone derivatives
US20080146559A1 (en) 2006-12-08 2008-06-19 Li Chen 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives
SG182171A1 (en) * 2007-06-06 2012-07-30 Ranbaxy Lab Ltd Process for the preparation of orlistat
EP2183237A1 (fr) 2007-07-25 2010-05-12 F. Hoffmann-Roche AG Dérivés d'amide d'acide benzofurane- et benzo[b]thiophène-2-carboxylique et leur utilisation comme modulateurs du récepteur h3 de l'histamine
CA2704462A1 (fr) * 2007-10-31 2009-05-07 Burnham Institute For Medical Research Composes de beta-lactone
WO2010112569A1 (fr) 2009-03-31 2010-10-07 Robert Zimmermann Modulation de lipase de triglycérides d'adipose pour la prévention et le traitement d'une cachexie, d'une perte de poids et d'une atrophie musculaire et procédés de criblage s'y rapportant
US8993509B2 (en) 2009-03-31 2015-03-31 Robert Zimmerman Method for treatment of cachexia by administering inhibitors of adipose triglyceride lipase expression or activity
US8450350B2 (en) 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
WO2011140190A1 (fr) 2010-05-05 2011-11-10 Infinity Pharmaceuticals Tétrazolones utilisés en tant qu'inhibiteurs d'acide gras synthase (fasn)
KR102679975B1 (ko) * 2017-07-12 2024-06-28 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 지방독성 손상을 저감하기 위한 화합물
CN112079821A (zh) * 2020-09-14 2020-12-15 中山万汉制药有限公司 奥利司他与苯氨基嘧啶类化合物形成的缀合物及其制备方法与用途

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US2478388A (en) * 1945-09-28 1949-08-09 Eastman Kodak Co beta-lactones from unsaturated aldehydes and unsaturated ketones
JPS608117B2 (ja) * 1977-02-08 1985-02-28 財団法人微生物化学研究会 新生理活性物質エステラスチンおよびその製造法
GB2023604B (en) * 1978-05-25 1982-07-28 Microbial Chem Res Found Physiologically active derivatives of esterastin and production thereof
JPS56128774A (en) * 1980-03-14 1981-10-08 Microbial Chem Res Found New physiologically active substance ebelactone and its preparation
CA1247547A (fr) * 1983-06-22 1988-12-28 Paul Hadvary Derives de leucine

Also Published As

Publication number Publication date
DK600385A (da) 1986-06-22
IE58926B1 (en) 1993-12-01
IL77338A (en) 1991-04-15
FI854797A7 (fi) 1986-06-22
CA1270837A (fr) 1990-06-26
DK600385D0 (da) 1985-12-20
CS262425B2 (en) 1989-03-14
FI854797A0 (fi) 1985-12-04
NZ214565A (en) 1989-06-28
NO171160B (no) 1992-10-26
PT81748B (pt) 1988-07-29
US4931463A (en) 1990-06-05
DE3584829D1 (de) 1992-01-16
CN85108888A (zh) 1986-07-09
HUT39440A (en) 1986-09-29
ATE70061T1 (de) 1991-12-15
FI91403C (fi) 1994-06-27
EP0185359A2 (fr) 1986-06-25
AU5125985A (en) 1986-06-26
EP0185359B1 (fr) 1991-12-04
DK166724B1 (da) 1993-07-05
CN1012643B (zh) 1991-05-22
EP0185359A3 (en) 1987-08-26
HU200172B (en) 1990-04-28
IE853277L (en) 1986-06-21
AU583569B2 (en) 1989-05-04
US5175186A (en) 1992-12-29
NO855213L (no) 1986-06-23
FI91403B (fi) 1994-03-15
PT81748A (en) 1986-01-02
NO171160C (no) 1993-02-03
MC1728A1 (fr) 1986-12-15
DOP1985004386A (es) 1991-04-20
PH26291A (en) 1992-04-10

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