AR071908A1 - Compuesto triazina, composiciones que lo comprenden, metodo para elaborar el compuesto y metodo para tratar un trastorno de tipo cancerigeno - Google Patents

Compuesto triazina, composiciones que lo comprenden, metodo para elaborar el compuesto y metodo para tratar un trastorno de tipo cancerigeno

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Publication number
AR071908A1
AR071908A1 ARP090101878A ARP090101878A AR071908A1 AR 071908 A1 AR071908 A1 AR 071908A1 AR P090101878 A ARP090101878 A AR P090101878A AR P090101878 A ARP090101878 A AR P090101878A AR 071908 A1 AR071908 A1 AR 071908A1
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AR
Argentina
Prior art keywords
alkyl
optionally substituted
heterocyclyl
amino
membered
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ARP090101878A
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English (en)
Inventor
Ariamala Gopalsamy
Kevin J Curran
Santos Osvaldo Dos
Zecheng Chen
Aranapakam Venkatesan
Mengxiao Shi
Tarek S Mansour
J Verheijen
Semiramis Ayral-Kaloustian
Arie Zask
Joshua Aaron Kaplan
David James Richard
Los Santos Efren Guillermo De
Christoph M Dehnhardt
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Wyeth Corp
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40911929&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR071908(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR071908A1 publication Critical patent/AR071908A1/es

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Abstract

Estos compuestos inhiben la quinasa PI3 y mTOR, y se pueden utilizar para tratar enfermedades mediadas por quinasa PI3 e y mTOR, tal como una variedad de c nceres. Y metodos para elaborar y utilizar los compuestos de esta solicitud y composiciones que contienen los compuestos de esta solicitud. Reivindicacion 1: Un compuesto de la formula 1 caracterizado porque: R1es como en formulas (2) o (3) en donde R6, R7, R8, R9 son cada uno independientemente seleccionados del grupo que consiste de un  tomo de hidrogeno, y un alquilo C1-6 opcionalmente sustituido con alquenilo C2-6, alcadienilo C4-6, alquinilo C2-6 o alcadiinilo C4-6, o uno de R6 y R7 o R8 y R9, junto con los  tomos de carbono a los cuales ellos se adhieren forman un anillo saturado o insaturado de 5-8 miembros opcionalmente sustituido conteniendo 0, 1 o 2  tomos independientemente seleccionados de O, NH y S; la l¡nea intermitente ------- representa un segundo enlace opcional; R2 es arilo C6-14 opcionalmente sustituido-NH-COR3, heteroarilo C1-9 opcionalmente sustituido-NH-COR3, -CH=CH-arilo C6-10-NH-COR3 o -CH=CH-heteroarilo C1-9-NH-COR3; R3 es OR5, NR5R5 o NHR5; R5 se selecciona independientemente del grupo que consiste de alquilo C1-6, alquenilo C3-6, alquinilo C3-6, arilo C6-10 opcionalmente sustituido, haloalquilo C1-6, heteroarilo C1-9 opcionalmente sustituido, hidroxialquilo C1-6, cicloalquilo C3-10 saturado o C3-10 mono o bic¡clico insaturado opcionalmente sustituido con OH, NR11R11 o heterociclilo C1-6 de 3-7 miembros, y heterociclilo C1-9 mono o bic¡clico saturado o insaturado de 3-10 miembros; con la condicion que anillos cicloalquilo y heterociclilo de tres miembros son saturados; o dos grupos R5 tomados juntos con el  tomo de nitrogeno al cual ellos se adhieren para formar un sistema de anillo de 3 a 8 miembros opcionalmente sustituido con alquilo C1-6, cuyo sistema de anillo es saturado o insaturado y tiene, en adicion a dicho  tomo de nitrogeno, 0 a 2 hetero tomos miembros del anillo seleccionados de O, S, S(O), S(O)2 y NR10; R10 se selecciona del grupo que consiste de H, alquilo C1-6, -SO2(alquilo C1-6), -COO(alquilo C1-6), -CONH(alquilo C1-6), -CON(alquilo C1-6)2, -CO(alquilo C1-6), y -SO2NHR11; R11 se selecciona del grupo que consiste de H, alquilo C1-6 opcionalmente sustituido con OH, NR11R11 o a heterociclilo C1-6 de 3-7 miembros, -CO(alquilo C1-6), arilo C6-10 opcionalmente sustituido, y heteroarilo C1-9 opcionalmente sustituido; R4 se selecciona del grupo que consiste de: a) alquilo C1-6 opcionalmente sustituido con: i) heterociclilo C1-9 de 3-10 miembros opcionalmente sustituido con alquilo C1-6-, ii) H2N-, iii) (alquilo C1-6)NH-, iv) (alquilo C1-6)2N-, y) NH(CH2)aN(alquilo C-16)2 en donde a es 2, 3 o 4, y vi) CHO, b) alquenilo C3-6, c) alquinilo C3-6, d) -O-alquilo C1-8 opcionalmente sustituido con -O-alquilo C1-8, e) -O-alquenilo C3-8, f) -O-alquinilo C3-8, g) cicloalquilo C3-8 mono o bic¡clico saturado o insaturado; y -h) -O-cicloalquilo C3-12 mono o bic¡clico saturado o insaturado, todos los anteriores opcionalmente sustituidos con OH, NR11R11 o un heterociclilo C1-6 de 3-7 miembros opcionalmente sustituido con alquilo C1-6-, dado que un OH o NR11R11 no se une directamente en un  tomo de carbono que se une doble o triple a otro  tomo de carbono; i) -CH=CH-arilo C6-10; j)-CH=CH-heteroarilo C1-9, k) arilo C6-10 opcionalmente sustituido; l) heteroarilo C1-9 de 5-10 miembros opcionalmente sustituido adherido al grupo funcional triazina por v¡a del  tomo de carbono; m) heteroc¡clico C1-9 monoc¡clico saturado o insaturado de 3-10 miembros adherido al grupo funcional triazina a traves de un  tomo de nitrogeno o carbono y opcionalmente sustituido con de 1 a 3 sustituyentes seleccionados independientemente de: OH, NR11R11, alquilo C1-6, (alquilo C1-6)amido-, (alquilo C1-6)C(O)-, (alcoxi C1-6)carbonil-, adamantilo, hidroxialquilo C1-6-, (alquilo C1-6)amido-, o un heterociclilo C1-6 de 3-7 miembros, con la condicion que el heterociclilo de 3 miembros se satura y se adhiere al grupo funcional triazina a traves de un  tomo de nitrogeno, y el heterociclilo bic¡clico de 5 miembros se satura; n) -O-arilo C6-10 opcionalmente sustituido; o) -O-heteroarilo C1-9 opcionalmente sustituido; p) -O-heterociclilo C1-9 (mono o bic¡clico saturado o insaturado de 3-12 miembros) opcionalmente sustituido con (alcoxi C1-6)carbonil-, H2NS(O)2, o alquilo C1-6 adicionalmente opcionalmente sustituido con OH, NR11R11 o un heterociclilo C1-6 de 3-7 miembros, con la condicion que se sature el heterociclilo de tres miembros; q) -NHarilo C6-10, r) -NHheteroarilo C1-9, s) -NHNH2, t) -NHNHalquilo C1-6, u) -NHN(alquilo C1-6)2, v) -NHOH, w) -COOH, x) COO-alquilo C1-6, y) -CONR12R13, z) -NR12R13, el grupo de formulas (4) en donde Z es CH2, O, S(O)n o NR10 y n es 0, 1 o 2; ee) halogeno, ff) arilo C6-14-S(O)2NH-, gg) R11NHC(O)NH-O-, y hh) heteroarilo C1-4 monoc¡clico de 5 miembros opcionalmente sustituido adherido al grupo funcional triazina por v¡a de un  tomo de nitrogeno; R12 y R13 se seleccionan cada uno independientemente de H, alquilo C1-8 opcionalmente mono o disustituido, alquenilo C3-8 opcionalmente sustituido, y alquinilo C3-8 opcionalmente sustituido, los sustituyentes opcionales se seleccionan de alcoxi C1-6, OH, NR11R11, y heterociclilo C1-6 de 3-7 miembros, dado que un OH o NR11R11 no se une directamente en un  tomo de carbono que se une doble o triple a otro  tomo de carbono; o R12 y R13 tomados junto con el  tomo de nitrogeno al cual ellos se adhieren forman un sistema de anillo monoc¡clico de 3 a 8 miembros opcionalmente sustituido con alquilo C1-6, cuyo sistema de anillo es saturado o insaturado y tiene, en adicion a dicho  tomo de nitrogeno, 0 a 2 hetero tomos miembros del anillo seleccionados de O, S(O)n y NR10; o R12 y R13 tomados junto con el  tomo de nitrogeno al cual ellos se adhieren forman un compuesto como en formulas (5) en donde a y b son cada uno independientemente -CH2-, O, S, o NR10, y x es 1-3; heteroarilo C1-9 se refiere a un sistema de anillo arom tico de 5-10 miembros que tiene uno o m s anillos y 1, 2, 3 o 4 miembros del anillo independientemente seleccionados de O, NR10, y S(O)n; heterociclilo C1-9 se refiere a un sistema de anillo de 3-10 miembros que tiene uno o m s anillos y 1, 2, 3 o 4 miembros de anillo independientemente seleccionados de O, NR10, y S(O)n; y los grupos arilo y heteroarilo opcionalmente sustituidos son no sustituidos o sustituidos con 1 o 2 grupos funcionales seleccionados del grupo que consiste de: a) alquilo C1-6 opcionalmente sustituido con OH, NH2, NH(alquilo C1-6), N(alquilo C1-6)2, -NH(CH2)wN(alquilo C1-6)2 en donde w es 2, 3 o 4, o heterociclilo C1-9 de 3-10 miembros opcionalmente sustituido con de 1 a 3 sustituyentes alquilo C1-6 seleccionados independientemente; b) halogeno; c) hidroxi; d) NH2 e) NO2 f) SO2NH2 g) COOH; h) COO(alquilo C1-6); i) NHCOO(alquilo C1-6); j) NH(alquilo C1-6); k) N(alquilo C1-6)2, l) C(O)NRaRb, en donde Ra es H o alquilo C1-6, y Rb es H, alquilo C1-6, (arilo C6-14)alquil-, o (heteroarilo C1-9)alquil-; m) Y-Q, en donde y es : i) O, ii) NH, iii) N(alquilo C1-6), iv) NHSO2, v) SO2NH, vi) NHCONH, vii) NHCON(alquilo C1-6), viii) S(O)q, q es 0 1 o 2, ix) -C(O)NH-, x) -C(O)N(CH3)-, xi) -NHC(O)-, xii) C(O), o xiii) ausente, y Q se selecciona de: i) arilo C6-10, opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de: A) alcoxi C1-6- opcionalmente sustituido con 1) H2N-, 2) (alquilo C1-6)amino-, 3) di(alquilo C1-6)amino-, 4) heterociclilo C1-9- opcionalmente sustituido por alquilo C1-6-, o 5) hidroxilo, B) (alcoxi C1-6)carbonil-, C) (alcoxi C1-6)C(O)NH-, D) alquilo C1-6- opcionalmente sustituido con 1) H2N-, 2) (alquilo C1-6)amino-, o 3) di(alquilo C1-6)amino-, E) (alquilo C1-6)amino-, F) di(alquilo C1-6)amino-, G) (alquilo C1-6)amido- opcionalmente sustituido con 1) H2N-, 2) (alquilo C1-6)amino-, o 3) di(alquilo C1-6)amino-, H) (alquilo C1-6)carboxiamido-, l) heterociclilo C1-9- opcionalmente sustituido por alquilo C1-6- o hidroxialquilo C1-6-, J) heterociclilo(alquilo C1-6)- opcionalmente sustituido por alquilo C1-6-, K) halogeno. L) hidroxilo, M) hidroxialquilo C1-6-, N) perfluoroalquilo C1-6-, O) H2N-, P) O2N-, Q) H2NSO2-, R) HO2C-, y S) NC-, ii) heteroarilo C1-9 de 5-10 miembros, opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de: A) alcoxi C1-6 opcionalmente sustituido con 1) H2N-, 2) (alquilo C1-6)amino-, 3) di(alquilo C1-6)amino-, 4) heterociclilo C1-9- opcionalmente sustituido por alquilo C1-6-, o 5) hidroxilo, B) (alcoxi C1-6)carbonil-, C) (alcoxi C1-6)C(O)NH-, D) alquilo C1-6- opcionalmente sustituido con 1) H2N-, 2) (alquilo C1-6)amino-, o 3) di(alquilo C1-6)amino-, E) (alquilo C1-6)amino-, F) di(alquilo C1-6)amino-, G) (alquilo C1-6)amido- opcionalmente sustituido con 1) H2N-, 2) (alquilo C1-6)amino-, o 3) di(alquilo C1-6)amino-, H) (alquilo C1-6)carboxiamido-, I) heterociclilo C1-9- opcionalmente sustituido por alquilo C1-6- o hidroxialquilo C1-6, J) heterociclilo(alquilo C1-6)- opcionalmente sustituido por alquilo C1-6-, K) halogeno, L) hidroxilo, M) hidroxialquilo C1-6-, N) perfluoroalquilo C1-6-, O) H2N-, P) O2N-, Q) H2NSO2, R) HO2C-, y S) NC-, iii) heterociclilo C1-9 de 3-10 miembros, opcionalmente sustituido con de 1 a 3 sustituyentes independientemente seleccionados de: A) alquilo C1-6-, B) heterociclilo(alquilo C1-6)-, C) (arilo C6-14)alquil-, D) acilo C1-8-, E) (alcoxi C1-6)carbonil-, F) (alquilo C1-6)carboxil-, G) halogeno, H) haloalquilo C1-6, I) hidroxilo, J) hidroxialquilo C1-6-, K) H2N-, L) (alquilo C1-6)amino-, M) di(alquilo C1-6)amino-, N) HO2C-, O) (alcoxi C1-6)carbonil-, P) (alquilo C1-6)carboxil-, Q) (alquilo C1-6)amido-, R) H2NC(O)-, S) (alquilo C1-6)carboxiamido-, T) heteroarilo C1-9 de 5-10 miembros, U) arilo C6-14, V) cicloalquilo C3-8, W) heterociclilo C1-9 de 3-10 miembros, X) NC-; y Y) -NO2 iv) cicloalquilo C3-10, v) alquilo C1-6, vi) alquenilo C2-6, vii) alquinilo C2-6, viii) hidroxial
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Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10022381B2 (en) * 2008-05-23 2018-07-17 Pfizer Inc. Triazine compounds as PI3 kinase and mTOR inhibitors
ES2554513T3 (es) 2008-05-23 2015-12-21 Novartis Ag Derivados de quinolinas y quinoxalinas como inhibidores de la proteína tirosina quinasa
LT2294072T (lt) * 2008-05-23 2017-06-12 Wyeth Llc Triazino junginiai, kaip p13 kinazės ir mtor inhibitoriai
GB2465405A (en) * 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy
WO2010096619A1 (en) * 2009-02-23 2010-08-26 Wyeth Llc Process, purification and crystallization of 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea
TW201038567A (en) 2009-03-27 2010-11-01 Pathway Therapeutics Ltd Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy
UY32582A (es) 2009-04-28 2010-11-30 Amgen Inc Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
CA2767008C (en) 2009-07-07 2018-01-30 Pathway Therapeutics, Inc. Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy
MX2012001974A (es) * 2009-08-19 2012-04-11 Ambit Biosciences Corp Compuestos de biarilo y metodos de uso de los mismos.
WO2011087812A1 (en) * 2009-12-21 2011-07-21 Vanderbilt University Alkyl 3-((2-amidoethyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxylate analogs as selective m1 agonists and methods of making and using same
EP2542670A2 (en) 2010-03-05 2013-01-09 President and Fellows of Harvard College Induced dendritic cell compositions and uses thereof
GB201004200D0 (en) * 2010-03-15 2010-04-28 Univ Basel Spirocyclic compounds and their use as therapeutic agents and diagnostic probes
WO2012101654A2 (en) * 2011-01-25 2012-08-02 Sphaera Pharma Pvt. Ltd Novel triazine compounds
EP2667874A4 (en) * 2011-01-27 2014-07-30 Univ Princeton MTOR KINASE HEMMER AS ANTIVIRUS AGENT
RU2013138835A (ru) * 2011-02-09 2015-03-20 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения в качестве ингибиторов pi3 киназы
TWI572599B (zh) 2011-03-28 2017-03-01 Ｍｅｉ製藥公司 （α－經取代之芳烷胺基及雜芳烷胺基）嘧啶基及１，３，５－三基苯并咪唑，其醫藥組合物及其在治療增生性疾病之用途
CN102250065B (zh) * 2011-05-20 2015-05-13 浙江海正药业股份有限公司 取代的三嗪苯脲衍生物及其用途
CN102887867B (zh) * 2011-07-21 2015-04-15 中国科学院上海药物研究所 一类三嗪类化合物、该化合物的制备方法及其用途
WO2013041652A1 (en) 2011-09-21 2013-03-28 Cellzome Limited Morpholino substituted urea or carbamate derivatives as mtor inhibitors
KR20140084130A (ko) 2011-10-07 2014-07-04 셀좀 리미티드 Mtor 억제제로서의 모르폴리노 치환된 바이사이클릭 피리미딘 우레아 또는 카르바메이트 유도체
CN102659765B (zh) * 2011-12-31 2014-09-10 沈阳药科大学 嘧啶及三嗪类化合物的制备方法和应用
KR20160027219A (ko) 2012-05-23 2016-03-09 에프. 호프만-라 로슈 아게 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법
WO2014005182A1 (en) * 2012-07-04 2014-01-09 Monash University Phosphoinositide 3-kinase (pi3k) inhibitors
WO2014016849A2 (en) * 2012-07-23 2014-01-30 Sphaera Pharma Pvt. Ltd. Novel triazine compounds
GB201309807D0 (en) 2013-05-31 2013-07-17 Pharma Mar Sau Antibody drug conjugates
US9763992B2 (en) 2014-02-13 2017-09-19 Father Flanagan's Boys' Home Treatment of noise induced hearing loss
PE20170312A1 (es) 2014-03-14 2017-03-30 Pfizer Nanoparticulas terapeuticas que comprenden un agente terapeutico, y metodos para su elaboracion y uso
US20170273922A1 (en) * 2014-10-03 2017-09-28 The Royal Institution For The Advacement Of Learning/Mcgill University Urea and bis-urea based compounds and analogues thereof useful in the treatment of androgen receptor mediated diseases or disorders
AU2015329625B2 (en) * 2014-10-10 2018-04-05 Pfizer Inc. Synergistic auristatin combinations
JP6695875B2 (ja) 2014-11-20 2020-05-20 カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ 抗がん剤としての新規な１，３，５−トリアジン系ｐｉ３ｋ阻害剤及びその製造方法
ES2881214T3 (es) 2014-12-17 2021-11-29 Pfizer Formulaciones de un inhibidor de PI3K/mTOR para la administración intravenosa
CN104725361B (zh) * 2015-04-09 2017-05-31 江苏富比亚化学品有限公司 一种受阻胺类光稳定剂3346的制备方法
CA3023854A1 (en) 2016-05-12 2017-11-16 Nanjing Shiqi Pharmaceutical Co. Ltd. Novel 2,4,6-trisubstituted s-triazine compounds, preparation method therefor, and use thereof
PL3458067T3 (pl) 2016-05-18 2021-12-13 Torqur Ag Leczenie chorób neurologicznych
KR102491180B1 (ko) 2017-04-27 2023-01-20 파르마 마르 에스.에이. 항종양 화합물
IT201700047189A1 (it) * 2017-05-02 2018-11-02 Fondazione St Italiano Tecnologia Composti e composizioni per il trattamento di cancro, disordini della retina e cardiomiopatie
US11304953B2 (en) 2017-05-23 2022-04-19 Mei Pharma, Inc. Combination therapy
KR20200041358A (ko) 2017-08-14 2020-04-21 메이 파마, 아이엔씨. 병용 요법
SI3672571T1 (sl) 2017-08-25 2022-01-31 Pfizer Inc. Farmacevtska vodna raztopina, ki vsebuje 1-(4-((4-(dimetilamino) piperdin-1-il)karbonil)fenil)-3-(4-(4,6-dimorfolin-4-il-1,3, 5-triazin-2-il)fenil)sečnino
CN108191837A (zh) * 2018-01-10 2018-06-22 贵州医科大学 PI3Kα/mTOR双激酶抑制剂及其药物组合物和应用
US10596165B2 (en) 2018-02-12 2020-03-24 resTORbio, Inc. Combination therapies
KR102022323B1 (ko) 2018-03-30 2019-09-18 정하윤 트리아진 화합물 및 이의 용도
EP4249069B1 (en) 2018-06-07 2025-11-19 Pfizer Inc. Aqueous formulation comprising 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea
WO2019241789A1 (en) 2018-06-15 2019-12-19 Navitor Pharmaceuticals, Inc. Rapamycin analogs and uses thereof
US20220040324A1 (en) 2018-12-21 2022-02-10 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate and kinase inhibitor
CN109942562B (zh) * 2019-02-27 2022-02-08 江西科技师范大学 含芳基结构的五元杂环联三嗪类化合物及其制备方法和应用
AU2020397938A1 (en) 2019-12-05 2022-06-23 Janssen Pharmaceutica Nv Rapamycin analogs and uses thereof
EP4132533A1 (en) * 2020-04-07 2023-02-15 MEI Pharma, Inc. Preparation of a 1,3,5-triazinyl benzimidazole
JP2024504378A (ja) * 2021-01-25 2024-01-31 アトス セラピューティクス，インコーポレイテッド トリアジン化合物ならびにこれを作製する方法および使用する方法
KR20220138575A (ko) 2021-04-06 2022-10-13 부산대학교병원 전좌 신장암 치료 또는 예방용 약물 스크리닝 방법
CN113200969B (zh) * 2021-05-19 2022-11-25 中国药科大学 一种PI3Kα选择性抑制剂及其制备方法和应用
CA3227191A1 (en) 2021-07-26 2023-02-02 Celcuity Inc. 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea (gedatolisib) and its combinations for use in the treatment of cancer
CN115109049B (zh) * 2022-08-12 2023-08-15 江西科技师范大学 含芳基脲结构的三嗪类化合物及其应用
CN115557908B (zh) * 2022-09-28 2024-10-15 九江学院 一种含硫连接键的三嗪类衍生物及其合成方法、用途
CN116102545B (zh) * 2023-02-01 2025-03-25 贵州医科大学 一种二芳基脲类PI3K/mTOR/HDAC多靶点抑制剂及其药物组合物和应用
CN116239580B (zh) * 2023-03-06 2025-05-23 中国药科大学 三嗪类化合物及其制备方法、药物组合物和应用
WO2025116280A1 (ko) * 2023-11-29 2025-06-05 주식회사 펩토이드 새로운 대칭형 플루오로트리아진 화합물 및 이들의 의학적 또는 생물학적 용도
WO2025128712A1 (en) 2023-12-12 2025-06-19 Celcuity Inc. Treatment of ocular diseases using 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl)phenyl)-3-[4-(4,6- dimorpholin-4- yl-1,3,5-triazin-2-yl)phenyl]urea
US20260053814A1 (en) 2024-08-21 2026-02-26 Celcuity Inc. Treatment regimens for gedatolisib in hormonally-driven disorders
GB202415232D0 (en) 2024-10-16 2024-11-27 Nacamed As Composition
CN120004875A (zh) * 2025-04-22 2025-05-16 中国药科大学 靶向降解磷脂酰肌醇3-激酶的化合物及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1129597C (zh) * 1997-07-24 2003-12-03 全药工业株式会社 杂环化合物和以其为有效成分的抗肿瘤剂
DE69814151T2 (de) * 1997-12-12 2004-03-25 Abbott Laboratories, Abbott Park Triazin angiogenese-inhibitoren
DE60217322T2 (de) * 2001-04-27 2007-10-04 Zenyaku Kogyo K.K. Heterocyclische verbindung und antitumormittel, das diese als wirkstoff enthält
GB0512324D0 (en) * 2005-06-16 2005-07-27 Novartis Ag Organic compounds
GB0423653D0 (en) * 2004-10-25 2004-11-24 Piramed Ltd Pharmaceutical compounds
CA2599320A1 (en) 2005-02-25 2006-08-31 Kudos Pharmaceuticals Limited Hydrazinomethyl, hydr zonomethyl and 5-membered heterocylic compounds which act as mtor inhibitors and their use as anti cancer agents
AU2007287428B2 (en) * 2006-08-24 2011-08-11 Astrazeneca Ab Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders
LT2294072T (lt) * 2008-05-23 2017-06-12 Wyeth Llc Triazino junginiai, kaip p13 kinazės ir mtor inhibitoriai

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