ECSP10010623A - Compuestos triazina como inhibidores mtor y quinasa pi3 - Google Patents

Compuestos triazina como inhibidores mtor y quinasa pi3

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Publication number
ECSP10010623A
ECSP10010623A EC2010010623A ECSP10010623A ECSP10010623A EC SP10010623 A ECSP10010623 A EC SP10010623A EC 2010010623 A EC2010010623 A EC 2010010623A EC SP10010623 A ECSP10010623 A EC SP10010623A EC SP10010623 A ECSP10010623 A EC SP10010623A
Authority
EC
Ecuador
Prior art keywords
mtor
compounds
quinasa
inhibitors
triazine compounds
Prior art date
Application number
EC2010010623A
Other languages
English (en)
Inventor
Christoph Dehnhardt
Ariamala Gopalsamy
Mengxiao Shi
Tarek Suhayl Mansour
Aranapakam Mudumbai Venkatesan
Arie Zask
Joshua Aaron Kaplan
Kevin Joseph Curran
David James Richard
Semiramis Ayral-Kaloustian
Zecheng Chen
Santos Osvaldo Dos
Jeroen Cunera Verheijen
Santos Efren G Delos
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40911929&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP10010623(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of ECSP10010623A publication Critical patent/ECSP10010623A/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • C07D498/08—Bridged systems

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  • Pain & Pain Management (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

Compuestos de la Formula Ien donde:R1 es o ;y R2, R4, y R6-9 se definan aqui, y sus sales y esteres farmaceuticamente aceptables. Estos compuestos inhiben la quinasa PI3 y mTOR, y se pueden utilizar para tratar enfermedades mediadas por quinasa PI3 e y mTOR, tal como una variedad de canceres. Se describen metodos para elaborar y utilizar los compuestos de esta invencion. Tambien se describen aqui varias composiciones que contienen los compuestos de esta invencion.
EC2010010623A 2008-05-23 2010-11-22 Compuestos triazina como inhibidores mtor y quinasa pi3 ECSP10010623A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5566108P 2008-05-23 2008-05-23

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ECSP10010623A true ECSP10010623A (es) 2010-12-30

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EC2010010624A ECSP10010624A (es) 2008-05-23 2010-11-22 Compuestos triazina como inhibidores mtor y quinasa pi3
EC2010010623A ECSP10010623A (es) 2008-05-23 2010-11-22 Compuestos triazina como inhibidores mtor y quinasa pi3

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US (8) US8039469B2 (es)
EP (3) EP2300483A1 (es)
JP (2) JP2011520979A (es)
KR (1) KR101331341B1 (es)
CN (2) CN102036995B (es)
AP (2) AP2010005452A0 (es)
AR (2) AR071909A1 (es)
AU (2) AU2009248993C1 (es)
BR (1) BRPI0912294B8 (es)
CA (2) CA2721710A1 (es)
CL (2) CL2009001273A1 (es)
CO (1) CO6311070A2 (es)
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DK (2) DK2294072T3 (es)
DO (1) DOP2010000315A (es)
EA (1) EA020317B1 (es)
EC (2) ECSP10010624A (es)
ES (2) ES2625467T3 (es)
GE (1) GEP20125589B (es)
HR (2) HRP20170637T1 (es)
HU (1) HUE043331T2 (es)
IL (2) IL209061A0 (es)
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EA020317B1 (ru) * 2008-05-23 2014-10-30 УАЙТ ЭлЭлСи ТРИАЗИНЫ КАК ИНГИБИТОРЫ КИНАЗЫ PI3 И mTOR
US10022381B2 (en) * 2008-05-23 2018-07-17 Pfizer Inc. Triazine compounds as PI3 kinase and mTOR inhibitors
MY155535A (en) 2008-05-23 2015-10-30 Novartis Ag Derivatives of quinolines and quinoxalines as protien tyrosine kinase inhibitors
GB2465405A (en) * 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy
WO2010096619A1 (en) * 2009-02-23 2010-08-26 Wyeth Llc Process, purification and crystallization of 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea
US8461158B2 (en) 2009-03-27 2013-06-11 Pathway Therapeutics Inc. Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy
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