CL2009001273A1 - Compuestos derivados de 2-morfolin-[1,3,5]triazina, 2-tetrahidropiranil-[1,3,5]triazina y 2-dihidropiranil-[1,3,5]triazina, inhibidores de quinasa pi3 y mtor; metodo de preparacion; composicion farmaceutica; combinacion farmaceutica; utiles en el tratamiento de diferentes tipos de cancer, entre otras enfermedades. - Google Patents

Compuestos derivados de 2-morfolin-[1,3,5]triazina, 2-tetrahidropiranil-[1,3,5]triazina y 2-dihidropiranil-[1,3,5]triazina, inhibidores de quinasa pi3 y mtor; metodo de preparacion; composicion farmaceutica; combinacion farmaceutica; utiles en el tratamiento de diferentes tipos de cancer, entre otras enfermedades.

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Publication number
CL2009001273A1
CL2009001273A1 CL2009001273A CL2009001273A CL2009001273A1 CL 2009001273 A1 CL2009001273 A1 CL 2009001273A1 CL 2009001273 A CL2009001273 A CL 2009001273A CL 2009001273 A CL2009001273 A CL 2009001273A CL 2009001273 A1 CL2009001273 A1 CL 2009001273A1
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CL
Chile
Prior art keywords
triazine
alkyl
cancer
disorders
cor5
Prior art date
Application number
CL2009001273A
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English (en)
Inventor
Mudumbai Venkatesan Aranapakam
Chen Zecheng
Martin Dehnhardt Christoph
Dos Santos Osvaldo
Guillermo Delos Santos Efren
Zask Arie
Cunera Verheijen Jeroen
Aaron Kaplan Joshua
James Richard David
Ayral-Kaloustian Semiramis
Suhayl Mansour Tarek
Gopalsamy Ariamala
Joseph Curran Kevin
Sh Mengxiao
Original Assignee
Wyeth Corp
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40911929&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2009001273(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CL2009001273A1 publication Critical patent/CL2009001273A1/es

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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

EN ESTA SOLICITUD SE DESCRIBEN COMPUESTOS DERIVADOS DE 2-MORFOLIN-[1,3,S,]TRIAZINA, 2-TETRAHIDROPIRANII-[1,3,S,]TRIAZINA<br /> Y 2-DIHIDROPIRANIL-[1 ,3,S)TRIAZINA DE FÓRMULA GENERAL (1), SUS SALES, UN PROCEDIMIENTO DE PREPARACIÓN; COMPOSICIONES Y<br /> COMBINACIONES FARMACÉUTICAS QUE 105 COMPRENDEN. LOS COMPUESTOS DESCRITOS PRESENTAN UNA ACCIÓN INHIBITORIA DE LA<br /> QUINASA PI3 Y MTOR Y SE PUEDEN UTILIZAR PARA TRATAR TRASTORNOS RELACIONADOS CON QUINASA PI3 Y MOTOR, TALES COMO<br /> RESTENOSIS, ATEROSCLEROSIS, TRASTORNOS ÓSEOS, ARTRITIS, RETINOPATÍA DIABÉTICA, PSORIASIS, HIPERTROFIA PROSTÁTICA BENIGNA,<br /> ATEROSCLEROSIS, INFLAMACIÓN, ANGIOGENIA, TRASTORNOS INMUNOLÓGICOS, PANCREATITIS, ENFERMEDAD RENAL Y CÁNCER.<br /> R' ES ARILO C6-14 OPCIONALMENTE SUSTITUIDO-NH-COR3, R3 ES O5', NR5R5 O NHR5,<br /> R'4SE SELECCIONA DEL GRUPO QUE CONSISTE DE:<br />  A) ALQUILO C1-6 OPCIONALMENTE SUSTITUIDO;<br />  B) ALQUENILO C3-C6<br /> C) ALQUINILO C3-C6<br />  D)-O-ALQUILO C1,-C8 OPCIONALMENTE SUSTITUIDO CON -O-ALQUILO C1,-C8 ENTRE OTROS.<br /> R6, R7,R8. R9 SON CADA UNO INDEPENDIENTEMENTE SELECCIONADOS DEL GRUPO QUE CONSISTE DE UN ÁTOMO DE HIDRÓGENO, Y<br /> UN ALQUILO C,-C, OPCIONALMENTE SUSTITUIDO CON ALQUENILO C2-C6. ALCADIENILO C-C6 O UNO DE R6 Y R7 O R8 Y R9,JUNTO<br /> CON LOS ÁTOMOS DE CARBONO A LOS CUALES ELLOS SE ADHIEREN FORMAN UN ANILLO SATURADO O INSATURADO DE 5-8 MIEMBROS<br /> OPCIONALMENTE SUSTITUIDO CONTENIENDO 0, 1 O 2  ÁTOMOS INDEPENDIENTEMENTE SELECCIONADOS DE O, NH Y S
CL2009001273A 2008-05-23 2009-05-22 Compuestos derivados de 2-morfolin-[1,3,5]triazina, 2-tetrahidropiranil-[1,3,5]triazina y 2-dihidropiranil-[1,3,5]triazina, inhibidores de quinasa pi3 y mtor; metodo de preparacion; composicion farmaceutica; combinacion farmaceutica; utiles en el tratamiento de diferentes tipos de cancer, entre otras enfermedades. CL2009001273A1 (es)

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US5566108P 2008-05-23 2008-05-23

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CL2009001273A1 true CL2009001273A1 (es) 2009-11-27

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CL2009001273A CL2009001273A1 (es) 2008-05-23 2009-05-22 Compuestos derivados de 2-morfolin-[1,3,5]triazina, 2-tetrahidropiranil-[1,3,5]triazina y 2-dihidropiranil-[1,3,5]triazina, inhibidores de quinasa pi3 y mtor; metodo de preparacion; composicion farmaceutica; combinacion farmaceutica; utiles en el tratamiento de diferentes tipos de cancer, entre otras enfermedades.
CL2009001274A CL2009001274A1 (es) 2008-05-23 2009-05-22 Compuestos derivados de triazina sustituida, mediados por la inhibicion de la kinasa p13 y mtor; composicion farmaceutica; procedimiento de preparacion; y su uso en el tratamiento de diferentes tipos de cancer.

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CL2009001274A CL2009001274A1 (es) 2008-05-23 2009-05-22 Compuestos derivados de triazina sustituida, mediados por la inhibicion de la kinasa p13 y mtor; composicion farmaceutica; procedimiento de preparacion; y su uso en el tratamiento de diferentes tipos de cancer.

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US (8) US8039469B2 (es)
EP (3) EP2294072B1 (es)
JP (2) JP2011520979A (es)
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