ATE198775T1 - Selbst dämpfende fluorescenz probe und verfahren - Google Patents

Selbst dämpfende fluorescenz probe und verfahren

Info

Publication number
ATE198775T1
ATE198775T1 AT95941402T AT95941402T ATE198775T1 AT E198775 T1 ATE198775 T1 AT E198775T1 AT 95941402 T AT95941402 T AT 95941402T AT 95941402 T AT95941402 T AT 95941402T AT E198775 T1 ATE198775 T1 AT E198775T1
Authority
AT
Austria
Prior art keywords
fluorescence
reporter molecule
target polynucleotide
molecule
oligonucleotide sequence
Prior art date
Application number
AT95941402T
Other languages
English (en)
Inventor
Kenneth J Livak
Susan J A Flood
Jeffrey Maramaro
Khairuzzaman Bashar Mullah
Original Assignee
Perkin Elmer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23333909&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE198775(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Perkin Elmer Corp filed Critical Perkin Elmer Corp
Application granted granted Critical
Publication of ATE198775T1 publication Critical patent/ATE198775T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6818Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AT95941402T 1994-11-16 1995-11-15 Selbst dämpfende fluorescenz probe und verfahren ATE198775T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/340,558 US5538848A (en) 1994-11-16 1994-11-16 Method for detecting nucleic acid amplification using self-quenching fluorescence probe
PCT/US1995/014882 WO1996015270A1 (en) 1994-11-16 1995-11-15 Self-quenching fluorescence probe and method

Publications (1)

Publication Number Publication Date
ATE198775T1 true ATE198775T1 (de) 2001-02-15

Family

ID=23333909

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95941402T ATE198775T1 (de) 1994-11-16 1995-11-15 Selbst dämpfende fluorescenz probe und verfahren

Country Status (7)

Country Link
US (5) US5538848A (de)
EP (2) EP0972848A3 (de)
JP (3) JP4131749B2 (de)
AT (1) ATE198775T1 (de)
CA (1) CA2201756C (de)
DE (1) DE69519940T2 (de)
WO (1) WO1996015270A1 (de)

Families Citing this family (1165)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837453A (en) * 1992-05-13 1998-11-17 Geron Corporation Telomerase activity assays
US6576419B1 (en) * 1993-07-23 2003-06-10 University Of Utah Research Foundation Assay procedure using fluorogenic tracers
US5863726A (en) * 1993-11-12 1999-01-26 Geron Corporation Telomerase activity assays
US5804380A (en) * 1993-11-12 1998-09-08 Geron Corporation Telomerase activity assays
US5925517A (en) * 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US6821727B1 (en) 1993-11-15 2004-11-23 Applera Corporation Hybridization assay using self-quenching fluorescence probe
US6028190A (en) * 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US5547861A (en) 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
CA2159830C (en) * 1994-04-29 2001-07-03 Applied Biosystems, Llc System for real time detection of nucleic acid amplification products
US20070269799A9 (en) * 1994-06-22 2007-11-22 Zhang David Y Nucleic acid amplification methods
US6787304B1 (en) 1994-12-28 2004-09-07 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US20030165908A1 (en) * 1994-12-30 2003-09-04 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US6312894B1 (en) * 1995-04-03 2001-11-06 Epoch Pharmaceuticals, Inc. Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
US5801155A (en) * 1995-04-03 1998-09-01 Epoch Pharmaceuticals, Inc. Covalently linked oligonucleotide minor grove binder conjugates
EP0826066B1 (de) * 1995-05-05 2000-09-13 The Perkin-Elmer Corporation Methoden and reagentien fuer die kombination einer pcr-amplifizierung mit einem hybridisierungs-assay
JPH11507839A (ja) * 1995-06-07 1999-07-13 ジェロン コーポレイション テロメラーゼ活性検定
KR100463475B1 (ko) * 1995-06-08 2005-06-22 로셰 디아그노스틱스 게엠베하 자기성피그먼트
EP0833936A4 (de) * 1995-06-23 2005-03-02 Baylor College Medicine Alternative farbstoff-markierte primer, ribonucleotide, deoxyribonucleotide und dideoxyribonucleotide zur automatischen dna analyse und homogenen amplifikations-/detektionsnachweisen
US5994063A (en) * 1995-06-23 1999-11-30 Metzker; Michael L. Substituted 4,4-difluoro-4-bora-3A,4A-diaza-s-indacene compounds for homogenous amplification/detection assays
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
IL124967A (en) 1995-12-18 2000-07-26 Univ Washington Method for nucleic acid analysis using fluorescence resonance energy transfer
US5721123A (en) * 1996-01-05 1998-02-24 Microfab Technology, Inc. Methods and apparatus for direct heating of biological material
AU713667B2 (en) * 1996-04-12 1999-12-09 Phri Properties, Inc. Detection probes, kits and assays
AU2735797A (en) * 1996-04-12 1998-03-26 Public Health Research Institute Of The City Of New York, Inc., The Detection probes, kits and assays
US5955268A (en) * 1996-04-26 1999-09-21 Abbott Laboratories Method and reagent for detecting multiple nucleic acid sequences in a test sample
AU3116997A (en) * 1996-05-02 1997-11-19 Immunological Associates Of Denver Quantitation of rna transcripts using genomic dna as the internal amplification competitor
US5736333A (en) * 1996-06-04 1998-04-07 The Perkin-Elmer Corporation Passive internal references for the detection of nucleic acid amplification products
AU726821B2 (en) * 1996-07-16 2000-11-23 Gen-Probe Incorporated Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific Tm
US7070925B1 (en) * 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
US5853990A (en) * 1996-07-26 1998-12-29 Edward E. Winger Real time homogeneous nucleotide assay
US5691145A (en) * 1996-08-27 1997-11-25 Becton, Dickinson And Company Detection of nucleic acids using G-quartets
US5853992A (en) * 1996-10-04 1998-12-29 The Regents Of The University Of California Cyanine dyes with high-absorbance cross section as donor chromophores in energy transfer labels
GB2333597B (en) 1996-10-29 2001-04-18 Univ Nebraska At Lincoln Method for detecting point mutations in dna utilizing fluorescence energy transfer
US6017702A (en) * 1996-12-05 2000-01-25 The Perkin-Elmer Corporation Chain-termination type nucleic acid sequencing method including 2'-deoxyuridine-5'-triphosphate
US6312886B1 (en) 1996-12-06 2001-11-06 The Secretary Of State For Defence In Her Brittanic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Reaction vessels
GB9716052D0 (en) 1996-12-06 1997-10-01 Secr Defence Reaction vessels
US6403311B1 (en) 1997-02-12 2002-06-11 Us Genomics Methods of analyzing polymers using ordered label strategies
EP1009802B1 (de) 1997-02-12 2004-08-11 Eugene Y. Chan Verfahren zur analyse von polymeren
AU6822598A (en) * 1997-02-24 1998-09-09 Georgia Tech Research Corporation Method for determining a nucleic acid
US6117973A (en) 1997-02-24 2000-09-12 Georgia Tech Research Corp. PNA monomers with electron donor or acceptor
US6046004A (en) * 1997-02-27 2000-04-04 Lorne Park Research, Inc. Solution hybridization of nucleic acids with antisense probes having modified backbones
US5846729A (en) * 1997-02-27 1998-12-08 Lorne Park Research, Inc. Assaying nucleotides in solution using a fluorescent intensity quenching effect
US6251591B1 (en) 1997-02-27 2001-06-26 Lorne Park Research, Inc. Quantitative method for detecting nucleotide concentration
US6060242A (en) * 1997-02-27 2000-05-09 Lorne Park Research, Inc. PNA diagnostic methods
JP3016759B2 (ja) * 1997-02-28 2000-03-06 スミスクライン・ビーチャム・コーポレイション 競争的ハイブリダイゼーションによる蛍光エネルギー転移
EP1666609B1 (de) * 1997-02-28 2012-09-26 Quest Diagnostics Investments Incorporated Fluoreszens-Energie-Transfer durch kompetitive Hybridisierung
US7803528B1 (en) 1997-02-28 2010-09-28 Quest Diagnostics Incorporated Fluorescence energy transfer by competitive hybridization
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US5846726A (en) * 1997-05-13 1998-12-08 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
WO1999011813A2 (en) * 1997-09-04 1999-03-11 Bayer Corporation Oligonucleotide probes bearing quenchable fluorescent labels, and methods of use thereof
US6342350B1 (en) * 1997-09-05 2002-01-29 The General Hospital Corporation Alpha-2-macroglobulin diagnostic test
EP1012344A4 (de) 1997-09-12 2004-08-11 Public Health Res Instituteof Nicht-kompetitive co-amplifizierungsmethoden
EP1015635A2 (de) * 1997-09-18 2000-07-05 Erasmus Universiteit Rotterdam Nachweis von minimalen resterkrankungen bei lymphoid-malignität
US5935791A (en) * 1997-09-23 1999-08-10 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
DE19743518A1 (de) * 1997-10-01 1999-04-15 Roche Diagnostics Gmbh Automatisierbare universell anwendbare Probenvorbereitungsmethode
US6355421B1 (en) * 1997-10-27 2002-03-12 Boston Probes, Inc. Methods, kits and compositions pertaining to PNA molecular beacons
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
WO1999023250A2 (de) * 1997-11-04 1999-05-14 Roche Diagnostics Gmbh Spezifisches und sensitives nukleinsäurenachweisverfahren
US6294326B1 (en) 1997-11-07 2001-09-25 Abbott Laboratories Analyte detection process using dual labeled probes
US6583168B1 (en) 1997-11-25 2003-06-24 Applera Corporation Sulfonated diarylrhodamine dyes
DE19752898A1 (de) * 1997-11-28 1999-08-05 Centeon Pharma Gmbh Verfahren zum Nachweis hoher Vierenkonzentrationen im Blutplasma und/oder Blutserum mittels der Polymerasekettenreaktion
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
US6080868A (en) 1998-01-23 2000-06-27 The Perkin-Elmer Corporation Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
CA2318880C (en) * 1998-02-04 2010-07-27 Applied Biosystems, Llc Determination of a genotype of an amplification product at multiple allelic sites
WO1999044045A1 (en) * 1998-02-27 1999-09-02 Massachusetts Institute Of Technology Single molecule detection with surface-enhanced raman scattering and applications in dna or rna sequencing
US6270973B1 (en) 1998-03-13 2001-08-07 Promega Corporation Multiplex method for nucleic acid detection
US6268146B1 (en) 1998-03-13 2001-07-31 Promega Corporation Analytical methods and materials for nucleic acid detection
US7090975B2 (en) 1998-03-13 2006-08-15 Promega Corporation Pyrophosphorolysis and incorporation of nucleotide method for nucleic acid detection
US6277578B1 (en) 1998-03-13 2001-08-21 Promega Corporation Deploymerization method for nucleic acid detection of an amplified nucleic acid target
US6312902B1 (en) 1998-03-13 2001-11-06 Promega Corporation Nucleic acid detection
US6391551B1 (en) 1998-03-13 2002-05-21 Promega Corporation Detection of nucleic acid hybrids
US6235480B1 (en) * 1998-03-13 2001-05-22 Promega Corporation Detection of nucleic acid hybrids
US6703211B1 (en) 1998-03-13 2004-03-09 Promega Corporation Cellular detection by providing high energy phosphate donor other than ADP to produce ATP
US6270974B1 (en) 1998-03-13 2001-08-07 Promega Corporation Exogenous nucleic acid detection
DE19811730A1 (de) * 1998-03-18 1999-09-23 November Ag Molekulare Medizin Verfahren und Vorrichtung zum Identifizieren einer Markierung
DE19811731A1 (de) * 1998-03-18 1999-09-23 November Ag Molekulare Medizin Verfahren zum Nachweis einer Nukleotidsequenz
DE19811729C2 (de) * 1998-03-18 2000-05-18 November Ag Molekulare Medizin Verfahren und Vorrichtung zum Nachweis einer Nukleotidsequenz
WO1999049293A2 (en) 1998-03-24 1999-09-30 Boston Probes, Inc. Methods, kits and compositions pertaining to detection complexes
US5952202A (en) * 1998-03-26 1999-09-14 The Perkin Elmer Corporation Methods using exogenous, internal controls and analogue blocks during nucleic acid amplification
US6387652B1 (en) 1998-04-15 2002-05-14 U.S. Environmental Protection Agency Method of identifying and quantifying specific fungi and bacteria
US6287772B1 (en) * 1998-04-29 2001-09-11 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
ES2322859T3 (es) * 1998-05-01 2009-06-30 Gen-Probe Incorporated Analizador de diagnostico automatizado.
WO1999058640A2 (en) 1998-05-11 1999-11-18 Philadelphia Health And Education Corporation Mct-1, a human oncogene
US6255050B1 (en) 1998-05-22 2001-07-03 Lorne Park Research, Inc. Dynamic hybridization system
US20020061522A1 (en) 2000-02-29 2002-05-23 Glucksmann Maria Alexandra 1983, 52881, 2398, 45449, 50289, and 52872 novel G protein-coupled receptors and uses therefor
GB9812768D0 (en) * 1998-06-13 1998-08-12 Zeneca Ltd Methods
JP4646404B2 (ja) 1998-07-02 2011-03-09 ジェン−プローブ・インコーポレーテッド 分子トーチ(torch)
GB9815933D0 (en) * 1998-07-23 1998-09-23 Secr Defence Detection method
US6037130A (en) * 1998-07-28 2000-03-14 The Public Health Institute Of The City Of New York, Inc. Wavelength-shifting probes and primers and their use in assays and kits
US6210896B1 (en) 1998-08-13 2001-04-03 Us Genomics Molecular motors
US6500650B1 (en) * 1998-10-01 2002-12-31 Variagenics, Inc. Method for identifying polymorphisms
US6153411A (en) 1998-10-30 2000-11-28 American Water Works Company, Inc. Methods and kits for detection of Cryptosporidium parvum using immunomagnetic separation and amplification
US6245518B1 (en) * 1998-12-11 2001-06-12 Hyseq, Inc. Polynucleotide arrays and methods of making and using the same
JP4638043B2 (ja) * 1998-12-14 2011-02-23 パシフィック バイオサイエンシーズ オブ カリフォルニア, インコーポレイテッド ポリメラーゼ合成による、単一分子の核酸の配列決定のためのシステムおよび方法
US6858390B2 (en) 1998-12-31 2005-02-22 Ingeneus Corporation Aptamers containing sequences of nucleic acid or nucleic acid analogues bound homologously, or in novel complexes
US6403313B1 (en) 1999-12-21 2002-06-11 Ingeneus Corporation Fluorescent intensity assay for duplex and triplex nucleic acid hybridization solution utilizing fluorescent intercalators
US6420115B1 (en) 1999-12-21 2002-07-16 Ingeneus Corporation Cation mediated triplex hybridization assay
US6656692B2 (en) 1999-12-21 2003-12-02 Ingeneus Corporation Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes
US6432642B1 (en) * 1999-01-15 2002-08-13 Pe Corporation (Ny) Binary probe and clamp composition and methods for a target hybridization detection
NZ513390A (en) 1999-03-19 2003-01-31 Genencor Int Multi-through hole testing plate for high throughput screening
US6951722B2 (en) * 1999-03-19 2005-10-04 Takara Bio Inc. Method for amplifying nucleic acid sequence
US6322980B1 (en) 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US20040248150A1 (en) * 1999-04-02 2004-12-09 Sharat Singh Methods employing oligonucleotide-binding e-tag probes
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US6573047B1 (en) 1999-04-13 2003-06-03 Dna Sciences, Inc. Detection of nucleotide sequence variation through fluorescence resonance energy transfer label generation
DE60045059D1 (de) * 1999-04-20 2010-11-18 Nat Inst Of Advanced Ind Scien Verfahren und Sonden zur Bestimmung der Konzentration von Nukleinsäure-Molekülen und Verfahren zur Analyse der gewonnenen Daten
US6673550B2 (en) 1999-04-30 2004-01-06 Aclara Biosciences, Inc. Electrophoretic tag reagents comprising fluorescent compounds
US7001725B2 (en) 1999-04-30 2006-02-21 Aclara Biosciences, Inc. Kits employing generalized target-binding e-tag probes
US20030235832A1 (en) * 2000-06-21 2003-12-25 Ahmed Chenna Multiplexed analysis by chromatographic separation of molecular tags
US7037654B2 (en) 1999-04-30 2006-05-02 Aclara Biosciences, Inc. Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
US6180349B1 (en) 1999-05-18 2001-01-30 The Regents Of The University Of California Quantitative PCR method to enumerate DNA copy number
EP1681357A3 (de) * 1999-05-19 2006-07-26 Cornell Research Foundation, Inc. Methode zur Nukleinsäuresequenzierung
US7056661B2 (en) * 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6277607B1 (en) 1999-05-24 2001-08-21 Sanjay Tyagi High specificity primers, amplification methods and kits
US7097973B1 (en) 1999-06-14 2006-08-29 Alpha Mos Method for monitoring molecular species within a medium
WO2000077248A1 (de) * 1999-06-15 2000-12-21 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Vorrichtung und verfahren zum speichern von informationen
JP2003510017A (ja) 1999-06-22 2003-03-18 インビトロジェン コーポレイション 核酸の検出および識別のために改良されたプライマーおよび方法
US6645733B1 (en) 1999-06-25 2003-11-11 Ingeneus Corporation Fluorescent intensity method for assaying binding between proteins or peptides
US6258593B1 (en) * 1999-06-30 2001-07-10 Agilent Technologies Inc. Apparatus for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
EP1210358A4 (de) * 1999-08-13 2005-01-05 Univ Brandeis Nachweis von nukleinsäuren
ES2245947T3 (es) 1999-08-20 2006-02-01 Stiftung Fur Diagnostische Forschung Procedimiento para determinar sustancias mediante el metodo de campo evanescente.
AU780156B2 (en) * 1999-09-22 2005-03-03 Wakunaga Pharmaceutical Co., Ltd Hybridization self-recognition type probe
EP1088590B1 (de) 1999-09-29 2003-04-16 Tecan Trading AG Thermocycler sowie Hebeelement für Mikrotiterplatte
US6272939B1 (en) 1999-10-15 2001-08-14 Applera Corporation System and method for filling a substrate with a liquid sample
US7534568B2 (en) 1999-10-29 2009-05-19 Hologic Inc. Methods for detection of a target nucleic acid by forming a cleavage structure with a cleavage resistant probe
US7824859B2 (en) * 1999-10-29 2010-11-02 Cytyc Corporation Methods for detection of a target nucleic acid by forming a cleavage structure using an RNA polymerase
US7838225B2 (en) * 1999-10-29 2010-11-23 Hologic, Inc. Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase
US7381532B2 (en) * 1999-10-29 2008-06-03 Stratagene California Compositions and methods for the detection of a nucleic acid using a cleavage reaction
US7118860B2 (en) * 1999-10-29 2006-10-10 Stratagene California Methods for detection of a target nucleic acid by capture
US6893819B1 (en) * 2000-11-21 2005-05-17 Stratagene California Methods for detection of a nucleic acid by sequential amplification
US7585632B2 (en) * 1999-10-29 2009-09-08 Hologic, Inc. Compositions and methods for the detection of a nucleic acid using a cleavage reaction
ATE315826T1 (de) * 1999-11-17 2006-02-15 Roche Diagnostics Gmbh Magnetische glasteilchen, herstellungsverfahren und benutzung
WO2001038585A2 (en) 1999-11-24 2001-05-31 The Regents Of The University Of California Polymer arrays and methods of using labeled probe molecules to identify and quantify target molecule expression
JP2003517309A (ja) 1999-12-02 2003-05-27 ディーエヌエー サイエンシーズ インコーポレーテッド 単一ヌクレオチドの変異及びジェノタイピングの決定方法
US6274321B1 (en) * 1999-12-03 2001-08-14 The Regents Of The University Of California High throughput functional screening of cDNAs
US20040081959A9 (en) * 1999-12-08 2004-04-29 Epoch Biosciences, Inc. Fluorescent quenching detection reagents and methods
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
GB2359625B (en) 1999-12-10 2004-10-20 Molecular Light Tech Res Ltd Monitoring oligonucleotide binding process using chemiluminescence quenching
US7052844B2 (en) * 1999-12-21 2006-05-30 Ingeneus, Inc. Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism
US6927027B2 (en) 1999-12-21 2005-08-09 Ingeneus Corporation Nucleic acid multiplex formation
US6924108B2 (en) 1999-12-21 2005-08-02 Ingeneus Corporation Nucleic acid binding enhancement by conjugation with nucleotides, nucleosides, bases and/or their analogues
US7309569B2 (en) 1999-12-21 2007-12-18 Ingeneus, Inc. Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes
US6911536B1 (en) 1999-12-21 2005-06-28 Ingeneus Corporation Triplex and quadruplex catalytic hybridization
US20030181412A1 (en) * 1999-12-21 2003-09-25 Ingeneus Corporation Method for modifying transcription and/or translation in an organism for therapeutic, prophylactic and/or analytic uses
US6613524B1 (en) * 2000-01-24 2003-09-02 Ingeneus Corporation Amperometric affinity assay and electrically stimulated complexes of nucleic acids
US20030170659A1 (en) * 2000-01-24 2003-09-11 Ingeneus Corporation Electrical treatment of binding media to encourage, discourage and/or study biopolymer binding
US6265170B1 (en) 2000-01-24 2001-07-24 Ingeneus Corporation Homogenous assay of duplex of triplex hybridization by means of multiple measurements under varied conditions
US6982147B2 (en) * 2000-01-24 2006-01-03 Ingeneus Corporation Apparatus for assaying biopolymer binding by means of multiple measurements under varied conditions
US7220541B2 (en) * 2000-01-24 2007-05-22 Ingeneus, Inc. Homogeneous assay of biopolymer binding by means of multiple measurements under varied conditions
US7169355B1 (en) 2000-02-02 2007-01-30 Applera Corporation Apparatus and method for ejecting sample well trays
US6221604B1 (en) 2000-02-07 2001-04-24 Pe Corporation Electron-deficient nitrogen heterocycle-substituted fluorescein dyes
US6418383B1 (en) * 2000-02-11 2002-07-09 Perkinelmer Instruments Llc Method and apparatus for iterative spectral compensation
FI20000333A0 (fi) * 2000-02-16 2000-02-16 Jussi Nurmi Homogeeninen menetelmä polynukleotidin havaitsemiseksi
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
FR2805348B1 (fr) * 2000-02-23 2002-07-12 Commissariat Energie Atomique Analyse de cibles biologiques utilisant une biopuce comportant un marqueur fluorescent
GB0005281D0 (en) * 2000-03-07 2000-04-26 Secr Defence Analytical method
US7205104B2 (en) * 2000-03-24 2007-04-17 Eppendorf Array Technologies Sa (Eat) Identification of biological (micro) organisms by detection of their homologous nucleotide sequences on arrays
US20080085515A1 (en) * 2000-03-24 2008-04-10 Eppendorf Array Technologies Sa (Eat) Identification of multiple biological (micro) organisms by detection of their nucleotide sequences on arrays
US7829313B2 (en) * 2000-03-24 2010-11-09 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
US7875442B2 (en) * 2000-03-24 2011-01-25 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
US7202026B2 (en) * 2000-03-24 2007-04-10 Eppendorf Array Technologies Sa (Eat) Identification of a large number of biological (micro)organisms groups at different levels by their detection on a same array
JP2003528627A (ja) * 2000-03-27 2003-09-30 アプレラ コーポレイション 改善された侵襲アッセイ
DK1715063T3 (da) * 2000-03-29 2011-05-16 Lgc Ltd Hydridiseringsbeacon og fremgangsmåde til hurtig sekvensdetektion og distinktion
US7998673B2 (en) * 2000-03-29 2011-08-16 Lgc Limited Hybridisation beacon and method of rapid sequence detection and discrimination
US7537938B2 (en) 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US7160735B2 (en) * 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US7771929B2 (en) * 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
US20030207300A1 (en) * 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
US7019129B1 (en) * 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
US6686188B2 (en) * 2000-05-26 2004-02-03 Amersham Plc Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle
US6656700B2 (en) * 2000-05-26 2003-12-02 Amersham Plc Isoforms of human pregnancy-associated protein-E
US6355433B1 (en) 2000-06-02 2002-03-12 Dna Sciences, Inc. Determination of nucleotide sequence variations through limited primer extension
US7087414B2 (en) 2000-06-06 2006-08-08 Applera Corporation Methods and devices for multiplexing amplification reactions
US6605451B1 (en) 2000-06-06 2003-08-12 Xtrana, Inc. Methods and devices for multiplexing amplification reactions
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
EP2351853A1 (de) 2000-06-06 2011-08-03 Life Technologies Corporation Methode und Vorrichtungen für multiplex Amplifizierungsreaktionen
US6936702B2 (en) * 2000-06-07 2005-08-30 Li-Cor, Inc. Charge-switch nucleotides
US6869764B2 (en) 2000-06-07 2005-03-22 L--Cor, Inc. Nucleic acid sequencing using charge-switch nucleotides
EP1164201A1 (de) * 2000-06-14 2001-12-19 Facultés Universitaires Notre-Dame de la Paix Umgekehrter nachweis zur Identifizierung und/oder Quantifizierung von Nukleotid-Zielsequenzen mittels Biochips
US6719949B1 (en) 2000-06-29 2004-04-13 Applera Corporation Apparatus and method for transporting sample well trays
ATE399216T1 (de) 2000-07-11 2008-07-15 Kirk Hogan Verfahren und zusammensetzungen zur perioperativen genomischen profilerstellung
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US20080194022A1 (en) * 2000-08-03 2008-08-14 Clarke Michael F Isolation and use of solid tumor stem cells
US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
DE60121342T2 (de) 2000-08-11 2007-06-28 Idaho Technology, Inc., Salt Lake City Einfach markierte oligonukleotidsonden
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
AU2001278783B2 (en) * 2000-08-23 2006-04-27 Takara Bio Inc. Method of amplifying nucleic acid
US6358679B1 (en) * 2000-08-24 2002-03-19 Pe Corporation (Ny) Methods for external controls for nucleic acid amplification
US20020123474A1 (en) * 2000-10-04 2002-09-05 Shannon Mark E. Human GTP-Rho binding protein2
EP1334113A4 (de) * 2000-10-20 2007-08-08 Expression Diagnostics Inc Erstellen von leukozytenexpressionsprofilen
US7060442B2 (en) * 2000-10-30 2006-06-13 Regents Of The University Of Michigan Modulators on Nod2 signaling
JP2004515229A (ja) * 2000-11-27 2004-05-27 スローン−ケッタリング インスティテュート フォー キャンサー リサーチ 核酸の切断を検出するための蛍光エネルギー変換プローブの使用方法
US6821731B2 (en) 2000-11-28 2004-11-23 Wyeth Expression analysis of FKBP nucleic acids and polypeptides useful in the diagnosis of prostate cancer
WO2002044419A2 (en) 2000-11-28 2002-06-06 Wyeth Expression analysis of kiaa nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
US20080261220A1 (en) * 2000-11-30 2008-10-23 Third Wave Technologies, Inc. Nucleic Acid Detection Assays
US7211414B2 (en) * 2000-12-01 2007-05-01 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
ATE465272T1 (de) * 2001-01-31 2010-05-15 Mayo Foundation Nachweis von herpex-simplex-virus
GB0105789D0 (en) * 2001-03-08 2001-04-25 Expresson Biosystems Ltd Detecting interactions between oligonucleotides and RNA using fluorescence resonance energy transfer (FRET)
US7267945B2 (en) * 2001-03-26 2007-09-11 Applera Corporation Methods of determining the presence of polynucleotides employing amplification
JPWO2002077282A1 (ja) * 2001-03-27 2004-07-15 国際試薬株式会社 遺伝子検出方法
HUP0501021A3 (en) 2001-05-21 2006-06-28 Aclara Biosciences Inc Mountai Methods and compositions for analyzing proteins
WO2002095356A2 (en) 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
US7358052B2 (en) * 2001-05-26 2008-04-15 Monogram Biosciences, Inc. Catalytic amplification of multiplexed assay signals
US6770440B1 (en) * 2001-05-31 2004-08-03 The United States Of America As Represented By The Secretary Of Agriculture Polymerase chain reaction assay for the detection of Toxoplasma gondii
US20040005543A1 (en) * 2002-01-18 2004-01-08 Abraham Grossman Compositions and methods for binding agglomeration proteins
US20050261486A1 (en) * 2001-05-31 2005-11-24 Q-Rna Compositions and methods for binding agglomeration proteins
US6534646B2 (en) 2001-06-04 2003-03-18 Barrskogen, Inc. Oligonucleotide labeling reagents
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7297494B2 (en) * 2001-06-25 2007-11-20 Georgia Tech Research Corporation Activatable probes and methods for in vivo gene detection
CA2451614C (en) * 2001-06-25 2011-01-04 Georgia Tech Research Corporation Dual resonance energy transfer nucleic acid probes
EP1537235B1 (de) * 2001-06-28 2015-04-01 Grifols Worldwide Operations Limited Diagnostische assays für parvovirus b19
KR100439168B1 (ko) * 2001-07-02 2004-07-05 (주)넥스젠 유전자 변형 식물체의 정량적 검출용 dna 증폭 키트 및이를 이용한 유전자 변형 식물체의 정량적 검출방법
US6514750B2 (en) * 2001-07-03 2003-02-04 Pe Corporation (Ny) PCR sample handling device
GB0118758D0 (en) * 2001-08-01 2001-09-26 Sybesma Wilbert F H Chimeric primed based real time rt-pcr for qualification of rna or dna templates in a crude sample
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
US20040078837A1 (en) * 2001-08-02 2004-04-22 Shannon Mark E. Four human zinc-finger-containing proteins: MDZ3, MDZ4, MDZ7 and MDZ12
JP2005500856A (ja) * 2001-08-23 2005-01-13 メルク エンド カムパニー インコーポレーテッド 多重フルオロフォアを使用する蛍光多重hpvpcrアッセイ
CA2458405A1 (en) * 2001-08-23 2003-03-06 Qtl Biosystems, Llc Bio-sensing platforms for detection and quantitation of biological molecules
US20030082547A1 (en) 2001-08-27 2003-05-01 Ewing Gregory J. Non-fluorescent quencher compounds and biomolecular assays
US20030108972A1 (en) * 2001-12-06 2003-06-12 Zweig Stephen Eliot Tethered receptor-ligand reagent and assay
US20050042629A1 (en) 2002-09-13 2005-02-24 Applera Corporation Thermus scotoductus nucleic acid polymerases
US7108975B2 (en) * 2001-09-21 2006-09-19 Regents Of The University Of Michigan Atlastin
US7582425B2 (en) * 2001-09-21 2009-09-01 The Regents Of The University Of Michigan Atlastin
US6593091B2 (en) 2001-09-24 2003-07-15 Beckman Coulter, Inc. Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer
US6744502B2 (en) * 2001-09-28 2004-06-01 Pe Corporation (Ny) Shaped illumination geometry and intensity using a diffractive optical element
US20040014067A1 (en) * 2001-10-12 2004-01-22 Third Wave Technologies, Inc. Amplification methods and compositions
US6942836B2 (en) * 2001-10-16 2005-09-13 Applera Corporation System for filling substrate chambers with liquid
US6902900B2 (en) * 2001-10-19 2005-06-07 Prolico, Llc Nucleic acid probes and methods to detect and/or quantify nucleic acid analytes
US20030165859A1 (en) 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
US20040029105A1 (en) * 2001-11-02 2004-02-12 Smith Thomas F. Detection of variola virus
DE10153829A1 (de) * 2001-11-05 2003-05-28 Bayer Ag Assay basierend auf dotierten Nanoteilchen
AU2002362013B2 (en) 2001-11-21 2008-04-24 Applied Biosystems, Llc. Digital assay
WO2003048295A1 (en) 2001-11-30 2003-06-12 Fluidigm Corporation Microfluidic device and methods of using same
WO2003048332A2 (en) 2001-11-30 2003-06-12 The Johns Hopkins University METHODS FOR ANALYZING METHYLATED CpG ISLANDS AND GC RICH REGIONS
AU2002346498A1 (en) 2001-11-30 2003-06-17 Applera Corporation Thermus brockianus nucleic acid polymerases
US6946245B2 (en) 2001-12-04 2005-09-20 Quest Diagnostics Investments Incorporated Oligonucleotides and methods for detecting hepatitis C viral nucleic acids
US6686162B2 (en) 2001-12-04 2004-02-03 Quest Diagnostics Investments, Incorporated Oligonucleotides and methods for detecting Borrelia burgdorferi
US6635428B2 (en) 2001-12-04 2003-10-21 Quest Diagnostics Investments Incorporated Oligonucleotides and methods for detecting hepatitis B viral nucleic acids
US7198897B2 (en) 2001-12-19 2007-04-03 Brandeis University Late-PCR
WO2003053363A2 (en) * 2001-12-19 2003-07-03 Millennium Pharmaceuticals, Inc. Human diacylglycerol acyltransferase 2 (dgat2) family members and uses therefor
WO2003057916A2 (en) 2002-01-09 2003-07-17 Riken Cancer profiles
US7255986B2 (en) * 2002-01-31 2007-08-14 The Board Of Trustees Operating Michigan State University Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets
US20040166492A1 (en) * 2002-02-05 2004-08-26 Engel Stacia R. Quantitative detection of dekkera and saccharomyces
AU2003217749A1 (en) * 2002-02-26 2003-09-09 Pharmacia Corporation Sequence detection system calculator
US6818420B2 (en) 2002-02-27 2004-11-16 Biosource International, Inc. Methods of using FET labeled oligonucleotides that include a 3′-5′ exonuclease resistant quencher domain and compositions for practicing the same
CA2472554A1 (en) * 2002-02-27 2003-09-04 Invitrogen Corporation Methods of using fet labeled oligonucleotides that include a 3' 5' exonuclease resistant quencher domain and compositions for practicing the same
US6977162B2 (en) * 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
NZ535044A (en) 2002-03-01 2008-12-24 Ravgen Inc Non-invasive method to determine the genetic sequence of foetal DNA from a sample from a pregnant female thereby detecting any alternation in gene sequence as compared with the wild type sequence
ATE412777T1 (de) * 2002-03-04 2008-11-15 Us Army Med Res Mat Command Interne positive kontrolle für auf sonden basierende nukleinsäuremolekül-assays und verfahren zur herstellung und verwendung davon
US7052848B2 (en) * 2002-03-04 2006-05-30 The United States Of America As Represented By The Secretary Of The Army Internal positive control for probe-based nucleic acid molecule assays and methods of making and using thereof
ES2253461T3 (es) * 2002-03-05 2006-06-01 Epigenomics Ag Procedimiento y dispositivo para la determinacion de la especificidad del tejido y del adn que flota libre en tejidos corporales.
GB0205455D0 (en) * 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
US20040115688A1 (en) * 2002-04-19 2004-06-17 Cheung Irene Y. Detection of gd2 synthase mrna and uses thereof
EP1497303A2 (de) * 2002-04-22 2005-01-19 Joseph F. Lawler Jr. Verbindungen zur überwachung von nuklein säuere amplification und verfahren zu dessen verwendung
US20070178478A1 (en) * 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
US7442506B2 (en) * 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
US7727720B2 (en) * 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US20030215814A1 (en) * 2002-05-17 2003-11-20 Cockerill Franklin R. Detection of Shiga toxin- or Shiga-like toxin-producing organisms
AU2003238796A1 (en) * 2002-05-28 2003-12-12 U.S. Genomics, Inc. Methods and apparati using single polymer analysis
CN102660539A (zh) * 2002-06-12 2012-09-12 诺华疫苗和诊断公司 用于甲型肝炎病毒核酸捕捉、检测和定量的寡核苷酸的鉴定
AU2003244135A1 (en) * 2002-06-21 2004-01-06 Hinode Co, . Ltd. Device for removing raindrops on umrella and system for promoting installation of the device
DE60335116D1 (de) * 2002-06-28 2011-01-05 Primeradx Inc Verfahren zum nachweis von sequenzunterschieden
WO2004013606A2 (en) 2002-08-02 2004-02-12 Stratatech Corporation Species specific dna detection
WO2004018999A2 (en) 2002-08-20 2004-03-04 Millenium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
CA2498320A1 (en) * 2002-09-20 2004-04-01 Integrated Dna Technologies, Inc. Anthraquinone quencher dyes, their methods of preparation and use
US7074598B2 (en) * 2002-09-25 2006-07-11 Mayo Foundation For Medical Education And Research Detection of vancomycin-resistant enterococcus spp.
US20070184453A1 (en) * 2002-10-02 2007-08-09 Roche Molecular Systems, Inc Fret process
US20040067492A1 (en) * 2002-10-04 2004-04-08 Allan Peng Reverse transcription on microarrays
US7384743B2 (en) * 2002-10-16 2008-06-10 University Of Miami BRCA1/BCRA2 screening panel
US6863731B2 (en) * 2002-10-18 2005-03-08 Controls Corporation Of America System for deposition of inert barrier coating to increase corrosion resistance
JP4898119B2 (ja) * 2002-11-22 2012-03-14 エフ.ホフマン−ラ ロシュ アーゲー 検出できるラベルされたヌクレオシド類似体及びその使用方法
EP2112229A3 (de) 2002-11-25 2009-12-02 Sequenom, Inc. Verfahren zum Identifizieren des Brustkrebsrisikos und zugehörige Behandlungen
EP3000899A1 (de) 2002-12-04 2016-03-30 Applied Biosystems, LLC Multiplexverstärkung von polynucleotiden
EP1581629B1 (de) 2002-12-06 2015-04-01 Millennium Pharmaceuticals, Inc. Verfahren zur identifizierung,beurteilung und behandlung von patienten mit einer proteasomen inhibitions therapie
CN1506471A (zh) * 2002-12-09 2004-06-23 核酸检测方法
US7291459B2 (en) * 2002-12-10 2007-11-06 University Of Alabama At Huntsville Nucleic acid detector and method of detecting targets within a sample
MXPA05006158A (es) 2002-12-12 2005-08-26 Chiron Corp Identificacion de oligonucleotidos para la captura, deteccion y cuantificacion del virus del nilo occidental.
ATE525469T1 (de) 2002-12-18 2011-10-15 Third Wave Tech Inc Nachweis kleiner nukleinsäuren
US8206904B2 (en) 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
WO2004074818A2 (en) 2002-12-20 2004-09-02 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
US7482117B2 (en) 2002-12-20 2009-01-27 Celera Corporation Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
WO2004061132A1 (en) * 2002-12-20 2004-07-22 Stratagene Compositions and methods for polynucleotide detection
DE10261468A1 (de) * 2002-12-31 2004-07-15 Bundesrepublik Deutschland, vertreten durch das Bundesministerium der Verteidigung, dieses vertreten durch das Bundesamt für Wehrtechnik und Beschaffung Testkit zum Nachweis von Brucella melitensis und Brucella abortus
US7297780B2 (en) 2003-01-06 2007-11-20 Third Wave Technologies, Inc. Reactive functional groups for preparation of modified nucleic acid
US8088897B2 (en) * 2003-01-30 2012-01-03 BellBrook Labs, Inc. Assay method for group transfer reactions
US7355010B2 (en) * 2003-01-30 2008-04-08 Bellbrook Labs, Llc Assay method for group transfer reactions
US7332278B2 (en) * 2003-01-30 2008-02-19 Bellbrook Labs, Llc Assay methods for group transfer reactions
EP1601955B1 (de) * 2003-03-07 2013-01-09 Luxcel Biosciences Limited Sauerstoffempfindliche Sonde und Verfahren zum Messen der Sauerstoffaufnahme
KR20070121853A (ko) 2003-03-31 2007-12-27 에프. 호프만-라 로슈 아게 일본 뇌염 바이러스 혈청군의 구성원을 포함하는, 특정플라비바이러스 검출용 조성물 및 방법
WO2006102264A1 (en) 2005-03-18 2006-09-28 Fluidigm Corporation Thermal reaction device and method for using the same
WO2004089810A2 (en) 2003-04-03 2004-10-21 Fluidigm Corp. Microfluidic devices and methods of using same
WO2004087950A2 (en) 2003-04-04 2004-10-14 Roche Diagnostics Gmbh Improved system for multi color real time pcr
WO2004092330A2 (en) * 2003-04-11 2004-10-28 Applera Corporation Method of generating long nucleic acid molecules of defined sequence
WO2004092327A2 (en) * 2003-04-11 2004-10-28 Applera Corporation Method of generating size standard nucleic acids
WO2004094986A2 (en) * 2003-04-16 2004-11-04 Handylab, Inc. System and method for electrochemical detection of biological compounds
CN1537954A (zh) * 2003-04-18 2004-10-20 ������������ʽ���� 表达基因分析方法以及用于表达基因分析的探针试剂盒
US20040214176A1 (en) * 2003-04-22 2004-10-28 Osborne James C. Multiplexed DNA assays using structure-specific endonucleases
US7892745B2 (en) 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
CA2524572C (en) * 2003-05-01 2018-07-10 Gen-Probe Incorporated Oligonucleotides comprising a molecular switch having enhanced sensitivity to the presence of a mismatch
ES2355899T3 (es) * 2003-05-19 2011-04-01 Brandeis University Procedimientos, kits y dispositivos de tratamiento de ácidos nucleicos.
DE602004007382T2 (de) 2003-05-20 2008-04-17 Bayer Pharmaceuticals Corp., West Haven Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten
CA2528669A1 (en) * 2003-06-09 2005-01-20 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20070269803A1 (en) * 2003-06-26 2007-11-22 Khalil Arar Fluorogenic Nucleic Acid Probes Including Lna for Methods to Detect and/or Quantify Nucleic Acid Analytes
US20050233314A1 (en) * 2003-06-30 2005-10-20 National Health Research Institutes Sensitive and quantitative detection of pathogens by real-time nested PCR
EP1502961B1 (de) * 2003-08-01 2010-09-08 Roche Diagnostics GmbH Neues Format zur Detektion von Heissstart- und Echtzeit-Polymerasekettenreaktion
EP1502958A1 (de) * 2003-08-01 2005-02-02 Roche Diagnostics GmbH Neues Format zur Detektion von Heissstart- und Echtzeit-Polymerasekettenreaktion
US7417726B2 (en) * 2003-09-19 2008-08-26 Applied Biosystems Inc. Normalization of data using controls
WO2005029041A2 (en) * 2003-09-19 2005-03-31 Applera Corporation High density sequence detection methods and apparatus
US20060029948A1 (en) * 2003-09-19 2006-02-09 Gary Lim Sealing cover and dye compatibility selection
CN102517381A (zh) 2003-10-07 2012-06-27 千年药品公司 用于鉴定、评价、预防和治疗卵巢癌的核酸分子和蛋白质
WO2005038041A2 (en) * 2003-10-16 2005-04-28 Third Wave Technologies, Inc. Direct nucleic acid detection in bodily fluids
WO2005045061A2 (en) * 2003-10-27 2005-05-19 Hybridon, Inc. Hybridization-based fluorescence assay
WO2005045058A2 (en) * 2003-10-27 2005-05-19 Monogram Biosciences, Inc. Detecting human anti-therapeutic antibodies
WO2005043127A2 (en) 2003-10-28 2005-05-12 Epoch Biosciences, Inc. Fluorescent probes for dna detection by hybridization with improved sensitivity and low background
JP2007528213A (ja) * 2003-11-06 2007-10-11 ユニバーシティ・オブ・ネバダ・リノ 特定の核酸配列の検出および測定の改良された方法
WO2005049849A2 (en) 2003-11-14 2005-06-02 Integrated Dna Technologies, Inc. Fluorescence quenching azo dyes, their methods of preparation and use
US7427475B2 (en) * 2003-11-18 2008-09-23 Mayo Foundation For Medical Education And Research Detection of group B streptococcus
WO2005051967A2 (en) * 2003-11-19 2005-06-09 Allelogic Biosciences Corp. Oligonucleotides labeled with a plurality of fluorophores
CA2921196C (en) 2003-11-26 2019-03-05 Celera Corporation Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
US8304189B2 (en) 2003-12-01 2012-11-06 Life Technologies Corporation Nucleic acid molecules containing recombination sites and methods of using the same
CA2494571C (en) * 2003-12-02 2010-02-09 F.Hoffmann-La Roche Ag Oligonucleotides containing molecular rods
EP1709200B1 (de) * 2003-12-03 2012-05-09 Abbott Laboratories Doppelsträngige lineare nukleinsäuresonde und deren verwendung
JP5227515B2 (ja) * 2003-12-06 2013-07-03 アボット・ラボラトリーズ 情報システムを用いて反応を解析する方法およびシステム
US8697433B2 (en) * 2003-12-10 2014-04-15 Samsung Electronics Co., Ltd. Polymerase chain reaction (PCR) module and multiple PCR system using the same
US20050147976A1 (en) * 2003-12-29 2005-07-07 Xing Su Methods for determining nucleotide sequence information
WO2005067692A2 (en) 2004-01-13 2005-07-28 U.S. Genomics, Inc. Detection and quantification of analytes in solution using polymers
US7432057B2 (en) * 2004-01-30 2008-10-07 Michigan State University Genetic test for PSE-susceptible turkeys
US7344701B2 (en) * 2004-02-03 2008-03-18 Biosearch Technologies, Inc. Xanthene dyes
CA2554779A1 (en) * 2004-02-03 2005-08-18 The Regents Of The University Of Michigan Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
WO2005077125A2 (en) * 2004-02-11 2005-08-25 Applera Corporation Methods and compositions for detecting nucleic acids
WO2005080596A1 (en) * 2004-02-19 2005-09-01 University College Cork - National University Of Ireland, Cork Detection of biologically active compounds
US7892794B2 (en) * 2004-02-26 2011-02-22 Delta, Dansk Elektronik, Lys & Akustik Method, chip, device and integrated system for detection biological particles
CA2564612A1 (en) * 2004-02-26 2005-09-09 Thomsen Bioscience A/S Method, chip, device and system for collection of biological particles
WO2005083078A1 (en) * 2004-02-26 2005-09-09 Thomsen Bioscience A/S Method, chip, device and system for extraction of biological materials
EP2208797A3 (de) 2004-03-01 2010-11-24 Applied Biosystems, LLC Verfahren, Zusammensetzungen und Kits für Polynukleotidamplifikation
CA2559171A1 (en) 2004-03-12 2005-09-29 Biotrove, Inc. Nanoliter array loading
GB0406015D0 (en) * 2004-03-17 2004-04-21 Dynal Biotech Asa Improvements in magnetic polymer particles
KR100906749B1 (ko) * 2004-03-25 2009-07-09 (주)바이오니아 인터컬레이팅 형광염료가 표지된 프로브를 이용한 핵산 증폭 측정 방법
US7445898B2 (en) * 2004-04-01 2008-11-04 Bio-Rad Laboratories, Inc. Quantitative amplification with a labeled probe and 3′ to 5′ exonuclease activity
JP4903689B2 (ja) * 2004-04-08 2012-03-28 サンガモ バイオサイエンシズ インコーポレイテッド 神経障害および神経変性症状を治療するための方法と組成物
EP1732945B1 (de) * 2004-04-08 2014-12-24 Sangamo BioSciences, Inc. Verfahren und zusammensetzungen zur modulation der kardialen kontraktivität
US7462451B2 (en) * 2004-04-26 2008-12-09 Third Wave Technologies, Inc. Compositions for modifying nucleic acids
US8044184B2 (en) * 2004-04-26 2011-10-25 Wako Pure Chemical Industries, Ltd. Probe and primer for tubercle bacillus detection, and method of detecting human tubercle bacillus therewith
EP2412826B1 (de) 2004-05-07 2014-01-08 Celera Corporation Genetischer Polymorphismus und Leberfibrose, Verfahren zur Erkennung und Verwendung davon
EP1747236A1 (de) * 2004-05-12 2007-01-31 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nectin 4 (n4) als prognostischer krebs-marker
US20050255485A1 (en) * 2004-05-14 2005-11-17 Livak Kenneth J Detection of gene duplications
WO2005113773A1 (en) * 2004-05-20 2005-12-01 Warnex Research Inc. Polynucleotides for the detection of escherichia coli 0157:h7 and escherichia coli 0157:nm verotoxin producers
US7618780B2 (en) * 2004-05-20 2009-11-17 Trillion Genomics Limited Use of mass labelled probes to detect target nucleic acids using mass spectrometry
US7575863B2 (en) 2004-05-28 2009-08-18 Applied Biosystems, Llc Methods, compositions, and kits comprising linker probes for quantifying polynucleotides
EP2290073A3 (de) * 2004-05-28 2011-08-31 Asuragen, Inc. Verfahren und Zusammensetzungen mit MicroRNA
US20060135455A1 (en) 2004-06-01 2006-06-22 Reza Sheikhnejad Methods and compositions for the inhibition of gene expression
WO2005118872A2 (en) * 2004-06-01 2005-12-15 The Regents Of The University Of Michigan Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases
US7338763B2 (en) * 2004-06-02 2008-03-04 Eppendorf Array Technologies S.A. Method and kit for the detection and/or quantification of homologous nucleotide sequences on arrays
WO2005121864A2 (en) 2004-06-07 2005-12-22 Fluidigm Corporation Optical lens system and method for microfluidic devices
US20060003337A1 (en) * 2004-06-30 2006-01-05 John Brandis Detection of small RNAS
DK1778867T3 (da) 2004-07-01 2010-08-02 Gen Probe Inc Fremgangsmåder og sammensætninger til detektering af nucleinsyrer i en biologisk prøve
PL1787126T3 (pl) * 2004-07-20 2010-03-31 Symphogen As Sposób charakteryzowania poliklonalnej linii komórkowej
MX2007000644A (es) * 2004-07-20 2007-03-28 Symphogen As Anticuerpo policlonal recombinante anti-rhesus d y metodos de fabricacion.
WO2006020933A2 (en) * 2004-08-13 2006-02-23 Stratagene California Dual labeled fluorescent probes
EP2093297A3 (de) 2004-09-07 2009-11-18 Telethon Institute for Child Health Research Wirkstoffe zur Behandlung oder Vorbeugung einer allergischen Störung
WO2006029184A2 (en) * 2004-09-08 2006-03-16 Expression Diagnostics, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
EP1634965B1 (de) 2004-09-09 2010-01-20 Roche Diagnostics GmbH Echtzeit-PCR unter Zusatz von Pyrophosphatase
US20060051796A1 (en) * 2004-09-09 2006-03-09 Inga Boell Real time PCR with the addition of pyrophosphatase
US7910753B2 (en) * 2004-09-10 2011-03-22 Anaspec Incorporated Cyanine dyes and their applications as luminescence quenching compounds
EP1791982B1 (de) * 2004-09-21 2011-01-05 Life Technologies Corporation Zweifarbige echtzeit/endpunkt-quantifizierung von mikro-rnas (mirnas)
US7851152B2 (en) * 2004-09-25 2010-12-14 Yaodong Chen Fluorescent base analogues' usage in the characterization of nucleic acid molecules and their interactions
US20060078894A1 (en) * 2004-10-12 2006-04-13 Winkler Matthew M Methods and compositions for analyzing nucleic acids
ES2668467T3 (es) * 2004-10-18 2018-05-18 Brandeis University Métodos de amplificación LATE y secuenciación de un ácido nucleico
US20060115838A1 (en) * 2004-10-19 2006-06-01 Trevigen Inc. Real-time detection of amplicons using nucleic acid repair enzymes
US20060147954A1 (en) * 2004-10-19 2006-07-06 Wallac Oy Novel probe and its use in bioaffinity assays
US20060194222A1 (en) * 2004-10-20 2006-08-31 Stratagene California Triplex probe compositions and methods for polynucleotide detection
US20090197249A1 (en) 2004-11-01 2009-08-06 George Mason University Compositions and methods for diagnosing colon disorders
JP2008518621A (ja) * 2004-11-03 2008-06-05 サード・ウェーブ・テクノロジーズ・インク 一段階検出アッセイ法
CA2857878A1 (en) 2004-11-12 2006-12-28 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
US20060275792A1 (en) * 2004-11-15 2006-12-07 Lee Jun E Enhancement of nucleic acid amplification using double-stranded DNA binding proteins
US20060105348A1 (en) * 2004-11-15 2006-05-18 Lee Jun E Compositions and methods for the detection and discrimination of nucleic acids
JP4190562B2 (ja) * 2004-12-08 2008-12-03 健 山本 遺伝子配列検査法
US20060228726A1 (en) * 2005-01-06 2006-10-12 Martin Patrick K Polypeptides having nucleic acid binding activity and compositions and methods for nucleic acid amplification
US7315376B2 (en) * 2005-01-07 2008-01-01 Advanced Molecular Systems, Llc Fluorescence detection system
ES2284087T3 (es) * 2005-01-18 2007-11-01 F. Hoffmann-La Roche Ag Generacion de imagenes de señales de fluorescencia mediante opticas telecentricas de excitacion y de generacion de imagenes.
ATE359500T1 (de) * 2005-01-18 2007-05-15 Hoffmann La Roche Fluoreszenzabbildung mittels telezentrizität
US20070020644A1 (en) * 2005-01-26 2007-01-25 Kolykhalov Alexander A Method for detection and characterization of short nucleic acids
AU2006213907A1 (en) * 2005-02-09 2006-08-17 Stratagene California Key probe compositions and methods for polynucleotide detection
CA2599013A1 (en) * 2005-02-28 2006-09-08 Gen-Probe Incorporated Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe
EP1869075B1 (de) * 2005-02-28 2012-04-11 Sangamo BioSciences, Inc. Antiangiogene methoden und zusammensetzungen
JP4398886B2 (ja) * 2005-03-07 2010-01-13 ソニー株式会社 通信端末装置、通信システム、通信方法、およびプログラム
US8263330B1 (en) 2005-03-08 2012-09-11 Quest Diagnostics Investments Incorporated Detection of Mycobacterium tuberculosis complex nucleic acids
EP1700922B1 (de) 2005-03-10 2016-08-24 Roche Diagnostics GmbH 3-Substituierte 5-Nitroindolderivate und diese enthaltende markierte Oligonukleotidsonden
US7759469B2 (en) 2005-03-10 2010-07-20 Roche Diagnostics Operations, Inc. Labeling reagent
CA2842402C (en) 2005-03-10 2016-02-23 Gen-Probe Incorporated Systems and methods to perform assays for detecting or quantifying analytes within samples
WO2006099365A2 (en) 2005-03-11 2006-09-21 Applera Corporation Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
US7601498B2 (en) 2005-03-17 2009-10-13 Biotium, Inc. Methods of using dyes in association with nucleic acid staining or detection and associated technology
US7776567B2 (en) 2005-03-17 2010-08-17 Biotium, Inc. Dimeric and trimeric nucleic acid dyes, and associated systems and methods
US20060246493A1 (en) 2005-04-04 2006-11-02 Caliper Life Sciences, Inc. Method and apparatus for use in temperature controlled processing of microfluidic samples
US20060275798A1 (en) * 2005-04-04 2006-12-07 Steichen John C Detection of organisms using a media sachet and primer directed nucleic acid amplification
AU2006235364A1 (en) * 2005-04-08 2006-10-19 Marina Biotech, Inc. RNAi therapeutic for respiratory virus infection
US20070213293A1 (en) * 2005-04-08 2007-09-13 Nastech Pharmaceutical Company Inc. Rnai therapeutic for respiratory virus infection
JP2008538922A (ja) * 2005-04-28 2008-11-13 メルク エンド カムパニー インコーポレーテッド 蛍光多重hpvpcrアッセイ
CA2604761A1 (en) * 2005-04-28 2006-11-02 Merck & Co., Inc. Real-time hpv pcr assays
US20070015180A1 (en) * 2005-05-02 2007-01-18 Stratagene California Oligonucleotide probe/primer compositions and methods for polynucleotide detection
EP1886145A2 (de) 2005-05-03 2008-02-13 Applera Corporation Fluoreszenznachweissystem und farbstoffsatz zur verwendung damit
CN1862258B (zh) 2005-05-12 2012-05-30 清华大学 核仁素辅助的癌症诊断与治疗方法
CA2608348A1 (en) * 2005-05-12 2006-11-23 Third Wave Technologies, Inc. Polymorphic ghsr nucleic acids and uses thereof
US8242249B2 (en) 2005-05-13 2012-08-14 Wako Pure Chemical Industries, Ltd. Primer and probe for use in detection of Mycobacterium kansasii and method for detection of Mycobacterium kansasii using the same
CA2601554A1 (en) * 2005-05-20 2006-11-30 Integrated Dna Technologies, Inc. Compounds and methods for labeling oligonucleotides
US8357801B2 (en) 2005-05-24 2013-01-22 Enzo Life Sciences, Inc. Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits
US7737281B2 (en) * 2005-05-24 2010-06-15 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Purine based fluorescent dyes
US8362250B2 (en) 2005-05-24 2013-01-29 Enzo Biochem, Inc. Fluorescent dyes and compounds, methods and kits useful for identifying specific organelles and regions in cells of interest
US7569695B2 (en) * 2005-05-24 2009-08-04 Enzo Life Sciences, Inc. Dyes for the detection or quantification of desirable target molecules
GB0510979D0 (en) 2005-05-28 2005-07-06 Kbiosciences Ltd Detection system for PCR assay
US7439024B2 (en) 2005-06-01 2008-10-21 The United States Of America As Represented By The Department Of Veterans Affairs Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases
US20090317798A1 (en) 2005-06-02 2009-12-24 Heid Christian A Analysis using microfluidic partitioning devices
US20070105133A1 (en) * 2005-06-13 2007-05-10 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
AU2005333512A1 (en) 2005-06-16 2006-12-28 Biotools Biotechnological & Medical Laboratories, S.A. Nucleic acid detection method involving the direct generation of a measurable signal
ATE501277T1 (de) 2005-07-01 2011-03-15 Dako Denmark As Monomere und polymere linker zur konjugierung von biologischen molekülen und anderen stoffen
US7977108B2 (en) * 2005-07-25 2011-07-12 Roche Molecular Systems, Inc. Method for detecting a mutation in a repetitive nucleic acid sequence
AU2006272568B2 (en) 2005-07-26 2012-06-28 Merck Sharp & Dohme Corp. Assays for resistance to echinocandin-class drugs
US7892795B2 (en) * 2005-08-02 2011-02-22 Focus Diagnostics, Inc. Methods and compositions for detecting BK virus
WO2007019410A2 (en) * 2005-08-05 2007-02-15 The Board Of Trustees Of The Leland Stanford Junior University Mammalian obestatin receptors
ES2494922T3 (es) * 2005-09-01 2014-09-16 Ausdiagnostics Pty Ltd. Métodos para la amplificación, cuantificación e identificación de ácidos nucleicos
US20070059713A1 (en) 2005-09-09 2007-03-15 Lee Jun E SSB-DNA polymerase fusion proteins
US7799530B2 (en) 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
US8831887B2 (en) * 2005-10-12 2014-09-09 The Research Foundation For The State University Of New York Absolute PCR quantification
EP1777298A1 (de) * 2005-10-13 2007-04-25 Roche Diagnostics GmbH Multiplex Festphasenassay für Nukleinsäureamplifizierung
WO2007047907A2 (en) * 2005-10-14 2007-04-26 The Regents Of The University Of Michigan Dek protein compositions and methods of using the same
US7781165B2 (en) 2005-10-19 2010-08-24 Roche Diagnostics Operations, Inc. Benzimidazolium compounds and salts of benzimidazolium compounds for nucleic acid amplification
WO2007045890A1 (en) * 2005-10-21 2007-04-26 Primerdesign Ltd Probe
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
US7723112B2 (en) * 2005-10-31 2010-05-25 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
EP2511298B1 (de) 2005-10-31 2019-01-16 Oncomed Pharmaceuticals, Inc. Zusammensetzungen und Verfahren zur Behandlung von Krebs unter Verwendung von menschlichen FZD Rezeptoren
WO2007056250A2 (en) * 2005-11-04 2007-05-18 U.S. Genomics, Inc. Heterogeneous assay of analytes in solution using polymers
US20090068643A1 (en) * 2005-11-23 2009-03-12 Integrated Dna Technologies, Inc. Dual Function Primers for Amplifying DNA and Methods of Use
EP1801114B8 (de) 2005-11-23 2009-12-02 Roche Diagnostics GmbH Polynukleotid mit Phosphatmimetikum
US7824858B2 (en) 2006-01-23 2010-11-02 Quest Diagnostics Investments Incorporated Assay for mycobacterium avium/intracellulare nucleic acid
EP1998785A4 (de) * 2006-02-21 2009-06-17 Univ Michigan Krebsbehandlung mithilfe eines hedgehog-signalisierungspfades
CN103172700B (zh) * 2006-02-27 2014-12-17 霍夫曼-拉罗奇有限公司 经由镁螯合的pcr热启动
BRPI0708477B8 (pt) 2006-03-01 2022-12-06 Pioneer Hi Bred Int Método para identificar uma primeira planta de milho ou um primeiro germoplasma de milho compreendendo em seu genoma um gene de diaglicerol o-aciltransferase do tipo 1 (dgat), polinucleotídeo isolado, método para produzir uma planta ou parte de planta possuindo um fenótipo selecionado, método para identificar a presença de um lócus marcador
CN101400806A (zh) 2006-03-13 2009-04-01 和光纯药工业株式会社 突变基因的检测方法
RU2394915C2 (ru) * 2006-03-24 2010-07-20 Александр Борисович Четверин Бесконтактные способы обнаружения молекулярных колоний, наборы реагентов и устройство для их осуществления
CA2648580A1 (en) * 2006-04-07 2008-05-02 Xdx, Inc. Steroid responsive nucleic acid expression and prediction of disease activity
US20070238093A1 (en) * 2006-04-11 2007-10-11 Espy Mark J Detection of influenza A virus
US20070238095A1 (en) * 2006-04-11 2007-10-11 Mayo Foundation For Medical Education And Research , A Minnesota Corporation Detection of Influenza A Virus
US8828661B2 (en) * 2006-04-24 2014-09-09 Fluidigm Corporation Methods for detection and quantification of nucleic acid or protein targets in a sample
WO2007127999A2 (en) * 2006-04-28 2007-11-08 Igor Kutyavin Use of products of pcr amplification carrying elements of secondary structure to improve pcr-based nucleic acid detection
CA2650820C (en) 2006-04-28 2014-09-16 Igor Kutyavin Use of base-modified deoxynucleoside triphosphates to improve nucleic acid detection
US8188256B2 (en) 2006-05-02 2012-05-29 Wako Pure Chemical Industries, Ltd. Primer and probe for detection of Mycobacterium intracellulare
US8232091B2 (en) * 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
EP2029774B1 (de) 2006-06-01 2015-04-01 Third Wave Technologies, Inc. Nachweis von nukleinsäuren
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
WO2007140599A1 (en) 2006-06-05 2007-12-13 Cancer Care Ontario Assessment of risk for colorectal cancer
US7759062B2 (en) * 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
US7951995B2 (en) 2006-06-28 2011-05-31 Pioneer Hi-Bred International, Inc. Soybean event 3560.4.3.5 and compositions and methods for the identification and detection thereof
CA2657576C (en) 2006-07-14 2023-10-31 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
WO2008011004A2 (en) 2006-07-17 2008-01-24 Brandeis University Specialized oligonucleotides and their use in nucleic acid amplification and detection
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US8048626B2 (en) 2006-07-28 2011-11-01 California Institute Of Technology Multiplex Q-PCR arrays
EP2484781B1 (de) 2006-08-01 2017-08-23 Applied Biosystems, LLC Nachweis von Analyten und Nukleinsäuren
JP5088034B2 (ja) * 2006-08-14 2012-12-05 ソニー株式会社 物質の検出等に有用な核酸鎖とその方法
WO2008021431A2 (en) * 2006-08-14 2008-02-21 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
EP2059614A4 (de) * 2006-08-15 2010-06-30 Zygene Biotech Llc Sonden-gegensonden-zusammensetzungen und verfahren für dna- oder rna-nachweis
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
WO2008030605A2 (en) * 2006-09-08 2008-03-13 The Regents Of The University Of Michigan Herv group ii viruses in lymphoma and cancer
US8050516B2 (en) * 2006-09-13 2011-11-01 Fluidigm Corporation Methods and systems for determining a baseline during image processing
US8055034B2 (en) * 2006-09-13 2011-11-08 Fluidigm Corporation Methods and systems for image processing of microfluidic devices
JP2010510964A (ja) * 2006-09-19 2010-04-08 アシュラジェン インコーポレイテッド 治療的介入の標的としての、miR−15、miR−26、miR−31、miR−145、miR−147、miR−188、miR−215、miR−216、miR−331、mmu−miR−292−3pによって調節される遺伝子および経路
AU2007307171B2 (en) * 2006-10-04 2012-01-19 Third Wave Technologies, Inc. Snap-back primers and detectable hairpin structures
WO2008045952A2 (en) * 2006-10-10 2008-04-17 The Regents Of The University Of Michigan Photoreceptor precursor cells
US7910303B2 (en) 2006-10-20 2011-03-22 Celera Corporation Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof
EP2078089B1 (de) 2006-10-31 2016-05-04 E. I. du Pont de Nemours and Company Sojabohnensorte dp-305423-1 sowie zusammensetzungen und verfahren zu ihrer identifikation und/oder erkennung
CA2668457C (en) * 2006-11-02 2016-10-04 Veridex, Llc Imaging of activated vascular endothelium using immunomagnetic mri contrast agents
US8338109B2 (en) 2006-11-02 2012-12-25 Mayo Foundation For Medical Education And Research Predicting cancer outcome
US8148067B2 (en) 2006-11-09 2012-04-03 Xdx, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
WO2008067552A2 (en) * 2006-11-30 2008-06-05 Fluidigm Corporation Method and apparatus for biological sample analysis
US20080131878A1 (en) * 2006-12-05 2008-06-05 Asuragen, Inc. Compositions and Methods for the Detection of Small RNA
WO2008073919A2 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Mir-20 regulated genes and pathways as targets for therapeutic intervention
WO2008073920A2 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Mir-21 regulated genes and pathways as targets for therapeutic intervention
CN101622348A (zh) * 2006-12-08 2010-01-06 奥斯瑞根公司 作为治疗性干预靶标的miR-20调节的基因和途径
CA2671299A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Functions and targets of let-7 micro rnas
CN102851369B (zh) 2006-12-13 2015-01-21 卢米耐克斯公司 用于实时pcr多重分析的系统和方法
US9938641B2 (en) * 2006-12-18 2018-04-10 Fluidigm Corporation Selection of aptamers based on geometry
EP2479273A3 (de) 2006-12-18 2012-10-10 Wako Pure Chemical Industries, Ltd. Primer und Sonde zur Erkennung von Mykobakterium Avium und Verfahren zur Erkennung von Mykobakterium Avium damit
CA2672951A1 (en) 2006-12-20 2008-07-03 Bayer Healthcare Llc Hydroxy methyl phenyl pyrazolyl urea compound useful in the treatment of cancer
JP2010514450A (ja) * 2006-12-29 2010-05-06 アプライド バイオシステムズ インコーポレイテッド 核酸検出方法及びシステム
US20080241838A1 (en) * 2006-12-29 2008-10-02 Applera Corporation, Applied Biosystems Group Methods and systems for detecting nucleic acids
US20090175827A1 (en) * 2006-12-29 2009-07-09 Byrom Mike W miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
WO2008092002A2 (en) 2007-01-24 2008-07-31 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
CA2674907C (en) 2007-01-31 2017-04-04 Celera Corporation A molecular prognostic signature for predicting breast cancer distant metastasis, and uses thereof
US20100129792A1 (en) * 2007-02-06 2010-05-27 Gerassimos Makrigiorgos Direct monitoring and pcr amplification of the dosage and dosage difference between target genetic regions
GB0703997D0 (en) * 2007-03-01 2007-04-11 Oxitec Ltd Methods for detecting nucleic sequences
GB0703996D0 (en) * 2007-03-01 2007-04-11 Oxitec Ltd Nucleic acid detection
US20110189663A1 (en) 2007-03-05 2011-08-04 Cancer Care Ontario Assessment of risk for colorectal cancer
DK2574681T3 (en) 2007-03-28 2016-07-04 Signal Diagnostics System and method for high-resolution analysis of nucleic acids to detect sequence variations
JP5191041B2 (ja) * 2007-04-05 2013-04-24 エフ.ホフマン−ラ ロシュ アーゲー 急速ワンステップrt−pcr
WO2008128198A2 (en) * 2007-04-12 2008-10-23 Usc Stevens - University Of Southern California Dna methylation analysis by digital bisulfite genomic sequencing and digital methylight
US20080274458A1 (en) * 2007-05-01 2008-11-06 Latham Gary J Nucleic acid quantitation methods
US20110091377A1 (en) 2007-05-11 2011-04-21 The Johns Hopkins University Biomarkers for melanoma
US20090232893A1 (en) * 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
EP2527472B1 (de) 2007-05-31 2016-09-28 Yale University Mit Krebs assoziierte genetische Läsion
BRPI0811271A2 (pt) * 2007-05-31 2015-01-20 Monsanto Technology Llc Polimorfismos da soja e processos de genotipagem
CA2689974A1 (en) * 2007-06-08 2008-12-18 Asuragen, Inc. Mir-34 regulated genes and pathways as targets for therapeutic intervention
EP2016821A1 (de) 2007-06-13 2009-01-21 Syngeta Participations AG Neues Hybridsystem für Brassica napus (Raps)
DE102007029772B4 (de) 2007-06-22 2011-12-08 Aj Innuscreen Gmbh Verfahren und Schnelltest zum Nachweis spezifischer Nukleinsäuresequenzen
US8008010B1 (en) * 2007-06-27 2011-08-30 Applied Biosystems, Llc Chimeric oligonucleotides for ligation-enhanced nucleic acid detection, methods and compositions therefor
US10745701B2 (en) 2007-06-28 2020-08-18 The Trustees Of Princeton University Methods of identifying and treating poor-prognosis cancers
US20090324596A1 (en) * 2008-06-30 2009-12-31 The Trustees Of Princeton University Methods of identifying and treating poor-prognosis cancers
HRP20151261T1 (hr) 2007-07-02 2016-01-01 Oncomed Pharmaceuticals, Inc. Sastavi i postupci za lijeäśenje i dijagnosticiranje raka
IL184478A (en) * 2007-07-08 2017-07-31 Hadasit Medical Res Services & Development Ltd Preparations, methods and kits for identifying carriers of mutations in genes 1brca and 2brca and for the early detection of cancers associated with mutations in these genes
WO2009029771A2 (en) 2007-08-29 2009-03-05 Monsanto Technology Llc Methods and compositions for breeding for preferred traits
JP5707132B2 (ja) 2007-09-07 2015-04-22 フルイダイム コーポレイション コピー数変動の決定、方法およびシステム
US20100173294A1 (en) * 2007-09-11 2010-07-08 Roche Molecular Systems, Inc. Diagnostic test for susceptibility to b-raf kinase inhibitors
EP2198050A1 (de) 2007-09-14 2010-06-23 Asuragen, INC. Mikrornas mit unterschiedlicher expression bei zervikalkarzinom und verwendungen davon
WO2009052386A1 (en) * 2007-10-18 2009-04-23 Asuragen, Inc. Micrornas differentially expressed in lung diseases and uses thereof
US8039212B2 (en) 2007-11-05 2011-10-18 Celera Corporation Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
AU2008321063B2 (en) 2007-11-16 2015-04-23 E. I. Du Pont De Nemours And Company Method for detection and/or analysis of yeast and mold in filterable liquids
WO2009070805A2 (en) 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
WO2009086156A2 (en) * 2007-12-21 2009-07-09 Asuragen, Inc. Mir-10 regulated genes and pathways as targets for therapeutic intervention
WO2009091556A2 (en) * 2008-01-17 2009-07-23 The General Hospital Corporation Diagnostic methods and kits using fibroblast growth factor-23
WO2009092564A2 (en) * 2008-01-23 2009-07-30 Roche Diagnostics Gmbh Integrated instrument performing synthesis and amplification
US20090203022A1 (en) * 2008-02-07 2009-08-13 Arizona Board Of Regents For And On Behalf Of Arizona State University Analysis
JPWO2009099037A1 (ja) 2008-02-08 2011-05-26 和光純薬工業株式会社 クラミドフィラ・キャビエ検出用プライマー及びプローブ、並びにこれを用いたクラミドフィラ・キャビエの検出方法
US9157116B2 (en) 2008-02-08 2015-10-13 Fluidigm Corporation Combinatorial amplification and detection of nucleic acids
WO2009100430A2 (en) * 2008-02-08 2009-08-13 Asuragen, Inc miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS
EP2252702B1 (de) 2008-02-08 2014-01-29 Mayo Foundation for Medical Education and Research Nachweis von clostridium difficile
US20090221620A1 (en) 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
KR101419980B1 (ko) * 2008-03-15 2014-07-15 홀로직, 인크. 증폭 반응 도중에 핵산 분자를 분석하기 위한 조성물 및 방법
WO2009154835A2 (en) * 2008-03-26 2009-12-23 Asuragen, Inc. Compositions and methods related to mir-16 and therapy of prostate cancer
MX2010010881A (es) * 2008-04-01 2011-03-04 Biosearch Tech Inc Sondas oscuras apagadoras de fluoroforo de acido nucleico estabilizado.
US20090253121A1 (en) * 2008-04-04 2009-10-08 Micah Halpern Method for amt-rflp dna fingerprinting
WO2009126726A1 (en) * 2008-04-08 2009-10-15 Asuragen, Inc Methods and compositions for diagnosing and modulating human papillomavirus (hpv)
GB0806676D0 (en) 2008-04-12 2008-05-14 Environment Agency The Environmental monitoring
CN104388568B (zh) 2008-04-24 2017-04-12 孟山都技术有限公司 鉴定大豆中亚洲大豆锈病抗性数量性状基因座的方法和其组合物
US8258111B2 (en) * 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
WO2009140374A2 (en) 2008-05-13 2009-11-19 Gen-Probe Incorporated Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
CA2725978A1 (en) 2008-05-28 2009-12-03 Genomedx Biosciences, Inc. Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer
WO2009145181A1 (ja) 2008-05-28 2009-12-03 和光純薬工業株式会社 マイコバクテリウム・イントラセルラー検出用プライマー及びプローブ、並びにこれを用いたマイコバクテリウム・イントラセルラーの検出方法
US10407731B2 (en) 2008-05-30 2019-09-10 Mayo Foundation For Medical Education And Research Biomarker panels for predicting prostate cancer outcomes
US20090305251A1 (en) * 2008-06-09 2009-12-10 University Of Miami Brca1/brca2 screening panel
EP2878680B1 (de) 2008-07-09 2016-06-08 Celera Corporation Mit kardiovaskulären Krankheiten assoziierte, genetische Polymorphismen, Verfahren zum Nachweis und Verwendungen davon
US20100092960A1 (en) * 2008-07-25 2010-04-15 Pacific Biosciences Of California, Inc. Helicase-assisted sequencing with molecular beacons
EP2148187A1 (de) 2008-07-25 2010-01-27 Roche Diagnostics GmbH Anregungs- und Abbildungsoptik für die Fluoreszenzdetektion
WO2010012464A1 (en) * 2008-08-01 2010-02-04 Roche Diagnostics Gmbh Improved lysis and reverse transcription for mrna quantification
US9182406B2 (en) * 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
PL3663411T3 (pl) 2008-08-12 2022-02-07 Stokes Bio Limited Sposoby do cyfrowego pcr
WO2010021936A1 (en) * 2008-08-16 2010-02-25 The Board Of Trustees Of The Leland Stanford Junior University Digital pcr calibration for high throughput sequencing
WO2010028014A1 (en) * 2008-09-03 2010-03-11 Abbott Laboratories Assays and kits for determining hiv-1 tropism
US8583380B2 (en) 2008-09-05 2013-11-12 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
US9250249B2 (en) 2008-09-08 2016-02-02 Enzo Biochem, Inc. Autophagy and phospholipidosis pathway assays
US9334281B2 (en) * 2008-09-08 2016-05-10 Enzo Life Sciences, Inc. Fluorochromes for organelle tracing and multi-color imaging
EP2353008A2 (de) 2008-09-22 2011-08-10 Oregon Health and Science University Verfahren zum nachweis einer infektion mit mycobacterium tuberculosis
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
CA2738578C (en) 2008-09-23 2021-05-04 Quantalife, Inc. Droplet-based assay system
US12162008B2 (en) 2008-09-23 2024-12-10 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US9598725B2 (en) 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US12090480B2 (en) 2008-09-23 2024-09-17 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
TWI506037B (zh) 2008-09-26 2015-11-01 Oncomed Pharm Inc 捲曲結合劑類及彼等之用途
CA2682439A1 (en) 2008-10-17 2010-04-17 F. Hoffmann-La Roche Ag Cell monitoring and molecular analysis
EP2687609B1 (de) 2008-11-10 2017-01-04 The United States of America, as represented by The Secretary, Department of Health and Human Services Behandlung von soliden Tumoren
EP3153862A1 (de) 2008-11-11 2017-04-12 The Regents of the University of Michigan Anti-cxcr1-zusammensetzungen und verfahren
US20100179213A1 (en) * 2008-11-11 2010-07-15 Mirna Therapeutics, Inc. Methods and Compositions Involving miRNAs In Cancer Stem Cells
CA2743211A1 (en) 2008-11-12 2010-05-20 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Methods and systems of using exosomes for determining phenotypes
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
US10669574B2 (en) 2008-11-18 2020-06-02 XCR Diagnostics, Inc. DNA amplification technology
WO2010068473A1 (en) * 2008-11-25 2010-06-17 Gen-Probe Incorporated Compositions and methods for detecting small rnas, and uses thereof
US20100150949A1 (en) * 2008-12-16 2010-06-17 Oncopharmacologics, Inc. Methods and compositions for modulating proline levels
EP2376659B1 (de) * 2008-12-17 2015-12-02 Life Technologies Corporation Verfahren, zusammensetzungen und kits für den nachweis von allelen varianten
US8362318B2 (en) 2008-12-18 2013-01-29 Board Of Trustees Of Michigan State University Enzyme directed oil biosynthesis in microalgae
WO2010071431A1 (en) 2008-12-19 2010-06-24 Monsanto Invest N.V. Method of breeding cysdv-resistant cucumber plants
CA2688174C (en) * 2008-12-19 2018-08-07 F. Hoffmann-La Roche Ag Dry composition of reaction compounds with stabilized polymerase
US20100159452A1 (en) * 2008-12-22 2010-06-24 Roche Molecular Systems, Inc. Method For Detecting a Target Nucleic Acid in a Sample
WO2010083250A2 (en) 2009-01-13 2010-07-22 Fluidigm Corporation Single-cell nucleic acid analysis
DK2381965T3 (da) 2009-01-14 2020-07-27 Univ Drexel Modulation af præ-mrna under anvendelse af splejsningsmodulerende oligonukleotider som terapeutiske midler til behandling af sygdom
AU2010221721A1 (en) 2009-02-06 2011-08-18 Yale University A SNP marker of breast and ovarian cancer risk
US8640555B2 (en) * 2009-02-09 2014-02-04 Bioaccel Performance
WO2010093872A2 (en) 2009-02-13 2010-08-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Molecular-based method of cancer diagnosis and prognosis
WO2010096713A2 (en) 2009-02-20 2010-08-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method for the diagnosis of age-associated vascular disorders
US9074258B2 (en) 2009-03-04 2015-07-07 Genomedx Biosciences Inc. Compositions and methods for classifying thyroid nodule disease
US8039215B2 (en) 2009-03-10 2011-10-18 Roche Molecular Systems, Inc. Multiplex quantitative nucleic acid amplification and melting assay
US9598739B1 (en) 2009-03-13 2017-03-21 Grifols Therapeutics Inc. Human erythrovirus
US8481698B2 (en) * 2009-03-19 2013-07-09 The President And Fellows Of Harvard College Parallel proximity ligation event analysis
EP3249053A1 (de) 2009-03-27 2017-11-29 Life Technologies Corporation Verfahren, zusammensetzungen und kits für den nachweis von allelen varianten
DK2414547T3 (da) 2009-04-02 2014-06-16 Fluidigm Corp Multiprimer-amplifikationsmetode til stregkodning af målnukleinsyrer
CN202830041U (zh) * 2009-04-03 2013-03-27 Illumina公司 用于加热生物样本的设备
US20100272824A1 (en) * 2009-04-16 2010-10-28 The Texas A&M University System Compositions and methods for preventing and monitoring disease
US20110091931A1 (en) * 2009-04-24 2011-04-21 Colby Pharmaceutical Company Methods and Kits for Determining Oxygen Free Radical (OFR) Levels in Animal and Human Tissues as a Prognostic Marker for Cancer and Other Pathophysiologies
US9206482B2 (en) 2009-04-29 2015-12-08 Genomedx Biosciences Inc. Systems and methods for expression-based classification of thyroid tissue
EP2256215A1 (de) * 2009-04-30 2010-12-01 Steffen Mergemeier Testsystem unter Verwendung einer Nukleaseaktivität einer Nukleinsäurepolymerase
US8669057B2 (en) 2009-05-07 2014-03-11 Veracyte, Inc. Methods and compositions for diagnosis of thyroid conditions
US20100299773A1 (en) * 2009-05-20 2010-11-25 Monsanto Technology Llc Methods and compositions for selecting an improved plant
WO2010135692A2 (en) 2009-05-22 2010-11-25 Asuragen, Inc. Mirna biomarkers of prostate disease
WO2010138908A1 (en) 2009-05-29 2010-12-02 Ventana Medical Systems, Inc. Igfir gene copy number as a prognostic marker in a non-small cell lung cancer
JP2012528569A (ja) 2009-05-29 2012-11-15 ヴェンタナ メディカル システムズ, インク. インサイツハイブリダイゼーションを使用した生物学試料の遺伝子コピー数のスコアリング法
JP2012531210A (ja) 2009-06-25 2012-12-10 イェール ユニバ−シティ− Brca1における一塩基多型および癌のリスク
CA2767616A1 (en) 2009-07-09 2011-01-13 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
CA2781595C (en) 2009-07-10 2016-07-05 The Regents Of The University Of Michigan Compositions and methods for diagnosing and treating macular degeneration
CA2805033A1 (en) 2009-07-14 2011-01-20 Beth Israel Deaconess Medical Center, Inc. Methods of increasing liver proliferation
AU2010276352B2 (en) 2009-07-22 2016-05-19 Qualicon Diagnostics, Llc Sequences and their use for detection and characterization of E. coli O157:H7
EP2462515A4 (de) * 2009-08-05 2015-08-12 Life Technologies Corp Verfahren zur analyse von näherungsbindenden assay-daten
WO2011022589A2 (en) * 2009-08-20 2011-02-24 Mayo Foundation For Medical Education And Research Detection of enterovirus
CN102725632A (zh) 2009-08-28 2012-10-10 奥斯瑞根公司 肺病的miRNA生物标志物
US9056114B2 (en) 2009-08-28 2015-06-16 Jeffrey P. Erickson Chemical induction of lactation
CA2767056C (en) 2009-09-02 2018-12-04 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
GB0915664D0 (en) 2009-09-08 2009-10-07 Enigma Diagnostics Ltd Reaction method
CN201837588U (zh) * 2009-09-09 2011-05-18 海利克斯公司 用于多个反应的光学系统
US20110070590A1 (en) 2009-09-22 2011-03-24 Jan Rohozinski Primers and Methods for Determining RhD Zygosity
US8815515B1 (en) 2009-09-24 2014-08-26 University Of Utah Research Foundation Methods, compositions, and kits for rare allele detection
EP2483425B1 (de) 2009-09-28 2016-08-24 Igor Kutyavin Verfahren und zusammensetzung zur nukleinsäureerkennung auf basis stabilisierter oligonukleotidsondenkomplexe
US8975019B2 (en) * 2009-10-19 2015-03-10 University Of Massachusetts Deducing exon connectivity by RNA-templated DNA ligation/sequencing
EP2494073B1 (de) 2009-10-26 2017-11-29 AGCT GmbH Konjugate von nukleotiden und methoden zu deren anwendung
WO2011059686A2 (en) 2009-10-29 2011-05-19 Wisconsin Alumni Research Foundation Detection of b-cell activating factor as a biomaker for antibody mediated rejection in transplant recipients
US8524450B2 (en) 2009-10-30 2013-09-03 Illumina, Inc. Microvessels, microparticles, and methods of manufacturing and using the same
US20110117546A1 (en) * 2009-11-18 2011-05-19 Microfluidic Systems, Inc. Increase of signal sensitivity using dual probes in pcr reactions
EP3360566B1 (de) 2009-11-20 2019-12-25 Oregon Health&Science University Verfahren zum erkennen einer infektion mit dem mycobakterium tuberculosis
US8916349B2 (en) 2009-11-23 2014-12-23 Becton, Dickinson And Company Assay method for target nucleic acid by signal amplification using probe hybridization and restriction
US9133343B2 (en) 2009-11-30 2015-09-15 Enzo Biochem, Inc. Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications
US20130203061A1 (en) 2009-11-30 2013-08-08 Michael KLASS Methods and systems for isolating, storing, and analyzing vesicles
EP4276190A3 (de) 2009-12-03 2023-12-27 Quest Diagnostics Investments Incorporated Verfahren zur diagnose bakterieller vaginose
CN102317454A (zh) * 2009-12-07 2012-01-11 爱科来株式会社 疾病相关基因的多态性检测用探针及其用途
US10446272B2 (en) 2009-12-09 2019-10-15 Veracyte, Inc. Methods and compositions for classification of samples
US8614071B2 (en) 2009-12-11 2013-12-24 Roche Molecular Systems, Inc. Preferential amplification of mRNA over DNA using chemically modified primers
US9845492B2 (en) 2009-12-21 2017-12-19 Seegene, Inc. TSG primer target detection
US8877437B1 (en) 2009-12-23 2014-11-04 Biotium, Inc. Methods of using dyes in association with nucleic acid staining or detection
WO2011082253A2 (en) 2009-12-30 2011-07-07 Board Of Trustees Of Michigan State University A method to produce acetyldiacylglycerols (ac-tags) by expression ofan acetyltransferase gene isolated from euonymus alatus (burning bush)
ES3027507T3 (en) 2010-01-11 2025-06-16 Genomic Health Inc Method to use gene expression to determine likelihood of clinical outcome of renal cancer
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Wnt拮抗劑及治療和篩選方法
AU2011205230A1 (en) 2010-01-13 2012-08-02 Caris Life Sciences Switzerland Holdings Gmbh Detection of gastrointestinal disorders
US8574832B2 (en) 2010-02-03 2013-11-05 Massachusetts Institute Of Technology Methods for preparing sequencing libraries
TWI518325B (zh) 2010-02-04 2016-01-21 自治醫科大學 對alk抑制劑具有先抗性或後抗性癌症的識別、判斷和治療
WO2011097519A2 (en) * 2010-02-05 2011-08-11 The Translational Genomics Research Institute Methods and kits used in classifying adrenocortical carcinoma
US8940487B2 (en) * 2010-02-09 2015-01-27 UmiTaq Bio Methods and compositions for universal detection of nucleic acids
US8658397B2 (en) 2010-02-16 2014-02-25 Becton, Dickinson And Company Assay for detecting closely-related serotypes of human papillomavirus (HPV)
US9128101B2 (en) 2010-03-01 2015-09-08 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
CN102918155B (zh) 2010-03-23 2015-12-16 和光纯药工业株式会社 沙眼衣原体检测用引物和探针、以及使用该引物和探针的沙眼衣原体的检测方法
EP2556170A4 (de) 2010-03-25 2014-01-01 Quantalife Inc Tröpfchentransport- und erkennungssystem
CA2767182C (en) 2010-03-25 2020-03-24 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
CA2767113A1 (en) 2010-03-25 2011-09-29 Bio-Rad Laboratories, Inc. Detection system for droplet-based assays
EP2553123B1 (de) 2010-03-26 2016-08-24 Integrated DNA Technologies, Inc. Verfahren zur verstärkung einer nukleinsäurehybridisierung
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
WO2011123785A2 (en) 2010-04-01 2011-10-06 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
WO2011127219A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
KR20130048217A (ko) 2010-04-06 2013-05-09 메사추세츠 인스티튜트 오브 테크놀로지 적은 수의 전사체 측정치를 이용한 유전자 발현 프로파일링
US9125931B2 (en) 2010-04-06 2015-09-08 Massachusetts Institute Of Technology Post-transcriptional regulation of RNA-related processes using encoded protein-binding RNA aptamers
DE102010003782B4 (de) 2010-04-08 2023-09-28 Ist Innuscreen Gmbh Vorrichtung zum Nachweis von Nukleinsäuren
DE102010003781B4 (de) 2010-04-08 2012-08-16 Aj Innuscreen Gmbh Verfahren zum Nachweis spezifischer Nukleinsäuresequenzen
WO2011130184A2 (en) 2010-04-11 2011-10-20 Life Technologies Corporation SYSTEMS AND METHODS FOR MODEL-BASED qPCR
US20110250598A1 (en) 2010-04-12 2011-10-13 Ulrike Fischer Detergent free polymerases
WO2011130728A1 (en) 2010-04-17 2011-10-20 Bayer Healthcare Llc Synthetic metabolites of fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention diseases and conditions
US20110269735A1 (en) 2010-04-19 2011-11-03 Celera Corporation Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
WO2011139721A1 (en) 2010-04-27 2011-11-10 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
US9309565B2 (en) 2010-05-14 2016-04-12 Life Technologies Corporation Karyotyping assay
WO2011150277A2 (en) 2010-05-28 2011-12-01 Life Technologies Corporation Synthesis of 2', 3'-dideoxynucleosides for automated dna synthesis and pyrophosphorolysis activated polymerization
US9410194B2 (en) 2010-06-21 2016-08-09 Life Technologies Corporation Compositions, kits and methods for synthesis and/or detection of nucleic acids
ES2908415T3 (es) 2010-06-21 2022-04-29 Life Technologies Corp Composición y método para la síntesis y amplificación de ácidos nucleicos mediante el uso de RT
US9650629B2 (en) 2010-07-07 2017-05-16 Roche Molecular Systems, Inc. Clonal pre-amplification in emulsion
EP3305920B1 (de) 2010-07-12 2020-02-12 Gen-Probe Incorporated Zusammensetzungen und assays zur erkennung von saisonaler h3-influenza a-virus-nukleinsäure
EP2407242A1 (de) 2010-07-13 2012-01-18 Dublin City University Direkte Klonanalyse und Auswahltechnologie
EP2752247A3 (de) 2010-07-23 2016-08-31 Beckman Coulter, Inc. System oder Verfahren zur Aufnahme analytischer Einheiten
US9046507B2 (en) 2010-07-29 2015-06-02 Gen-Probe Incorporated Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure
DE102010033107A1 (de) 2010-08-02 2012-02-02 Aj Innuscreen Gmbh Nachweis spezifischer Nukleinsäuresequenzen mittels Fluoreszenzlöschung
WO2012016936A1 (de) 2010-07-31 2012-02-09 Aj Innuscreen Gmbh Nachweis spezifischer nukleinsäuresequenzen mittels fluoreszenz - quenching
CN103210079B (zh) 2010-08-02 2015-07-22 B·L·韦特 用于聚合酶链式反应的可增压筒
US9370589B2 (en) * 2010-08-23 2016-06-21 Shimadzu Corporation Switching fluorescent nanoparticle probe and fluorescent particle imaging method using same
US8557532B2 (en) 2010-08-30 2013-10-15 The University Of Utah Research Foundation Diagnosis and treatment of drug-resistant Ewing'S sarcoma
WO2012030856A2 (en) 2010-08-30 2012-03-08 Gen-Probe Incorporated Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus
EP2614149B1 (de) 2010-09-07 2015-04-08 Integrated Dna Technologies, Inc. Modifizierungen für antisense-verbindungen
US9051606B2 (en) 2010-09-10 2015-06-09 Qiagen Gaithersburg, Inc. Methods and compositions for nucleic acid detection
WO2012038049A2 (en) 2010-09-22 2012-03-29 Roche Diagnostics Gmbh Amplification of distant nucleic acid targets using engineered primers
RU2565550C2 (ru) 2010-09-24 2015-10-20 Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити Прямой захват, амплификация и секвенирование днк-мишени с использованием иммобилизированных праймеров
EP2622097B1 (de) 2010-09-29 2017-03-15 Mor Research Applications Ltd. Prognoseverfahren, zusammensetzungen und kits zur vorhersage eines rezidivs bei akuter lymphoblastischer leukämie (all)
ES2533732T3 (es) 2010-10-04 2015-04-14 F. Hoffmann-La Roche Ag Método para lisis celular en un tampón de reacción de RT-PCR
CN103124797B (zh) 2010-10-04 2015-04-22 霍夫曼-拉罗奇有限公司 用于在相同反应容器内的细胞裂解和pcr的方法
WO2012045670A1 (en) 2010-10-04 2012-04-12 Roche Diagnostics Gmbh Method for cell lysis in a pcr reaction buffer
US10093981B2 (en) 2010-10-19 2018-10-09 Northwestern University Compositions and methods for identifying depressive disorders
US10233501B2 (en) 2010-10-19 2019-03-19 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US20150218639A1 (en) 2014-01-17 2015-08-06 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US20150225792A1 (en) 2014-01-17 2015-08-13 Northwestern University Compositions and methods for identifying depressive disorders
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
CA2815085C (en) 2010-10-22 2022-06-21 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
KR20120042100A (ko) 2010-10-22 2012-05-03 주식회사 씨젠 이중표지 고정화 프로브를 이용한 고상에서의 타겟 핵산서열 검출
SG190074A1 (en) 2010-11-01 2013-06-28 Bio Rad Laboratories System for forming emulsions
US20120108651A1 (en) 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
WO2012068106A2 (en) 2010-11-15 2012-05-24 Exelixis, Inc. Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture
EP2640366A2 (de) 2010-11-15 2013-09-25 Exelixis, Inc. Benzoxazepine als pi3k/mtor-hemmer sowie verfahren zur ihrer verwendung und herstellung
EP2641201B1 (de) 2010-11-16 2018-12-26 Life Technologies Corporation Systeme und verfahren zur analyse von näherungsbindenden testdaten
US20130267443A1 (en) 2010-11-19 2013-10-10 The Regents Of The University Of Michigan ncRNA AND USES THEREOF
DE102010052524A1 (de) 2010-11-22 2012-05-24 Aj Innuscreen Gmbh Verfahren zum qualitativen und quantitativen Nachweis von spezifischen Nukleinsäuresequenzen in Echtzeit
UA122558C2 (uk) 2010-11-24 2020-12-10 Піонер Хай-Бред Інтернешнл, Інк. Рослина brassica, яка є стійкою до гліфосату, та спосіб її одержання
US20140378436A9 (en) 2010-11-24 2014-12-25 Exelixis, Inc. Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their use and Manufacture
CA2759290A1 (en) 2010-11-24 2012-05-24 Alina Cywinska Qualitative/quantitative detection of fungal species
WO2012071039A1 (en) 2010-11-24 2012-05-31 Pioner Hi-Bred International, Inc. Brassica gat event dp-061061-7 and compositions and methods for the identification and/or detection thereof
EP2646569A1 (de) 2010-11-30 2013-10-09 Diagon Kft. Verfahren für nukleinsäurebasierte molekulardiagnostische bestimmung von keimzählungen und kit hierfür
CA2858526C (en) 2010-12-07 2020-06-30 Northwestern University Molecular targets for als and related disorders
JP6096672B2 (ja) * 2010-12-07 2017-03-15 ヌビオ,インコーポレイテッド 検出体、プローブ、および阻害剤を用いた核酸標的検出
TWI667347B (zh) 2010-12-15 2019-08-01 瑞士商先正達合夥公司 大豆品種syht0h2及偵測其之組合物及方法
EP2659002B1 (de) 2010-12-27 2017-02-01 Abbott Molecular Inc. Quantifizierung von proben mit hohem titer mittels digitaler pcr
CN107326073A (zh) 2010-12-29 2017-11-07 生命技术公司 作为荧光参考标准品的 ddao 化合物
US20120174246A1 (en) 2010-12-30 2012-07-05 Chaky Julian M Methods of identifying aphid resistant soybeans
MX340258B (es) 2011-01-11 2016-07-01 Seegene Inc Detección de secuencias de ácido nucleico objetivo mediante ensayo de escisión y extensión del pto.
US20120208189A1 (en) 2011-01-14 2012-08-16 Life Technologies Corporation Methods for isolation, identification, and quantification of mirnas
ES2632768T3 (es) 2011-01-17 2017-09-15 Life Technologies Corporation Flujo de trabajo para la detección de ligandos empleando ácidos nucleicos
BR112013018924A2 (en) 2011-01-25 2018-05-08 Almac Diagnostics Limited Colon cancer gene expression signatures and methods of use
WO2012106288A2 (en) * 2011-01-31 2012-08-09 Primeradx, Inc. Methods of nucleic acid quantification and detection using anomalous migration
WO2012112883A1 (en) 2011-02-18 2012-08-23 Yale University The kras-variant and endometriosis
US12097495B2 (en) 2011-02-18 2024-09-24 Bio-Rad Laboratories, Inc. Methods and compositions for detecting genetic material
AU2012222178B2 (en) 2011-02-24 2014-12-18 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
PH12013501802B1 (en) 2011-03-02 2018-06-27 Berg Llc Interrogatory cell-based assays and uses thereof
AU2012231098B2 (en) 2011-03-18 2016-09-29 Bio-Rad Laboratories, Inc. Multiplexed digital assays with combinatorial use of signals
WO2012129352A1 (en) 2011-03-21 2012-09-27 Yale University The kras variant and tumor biology
WO2012129347A1 (en) 2011-03-21 2012-09-27 Biodesy, Llc Classification of kinase inhibitors using nonlinear optical techniques
EP2691543B1 (de) 2011-03-29 2017-11-01 Seegene, Inc. Erkennung von zielnukleinsäuresequenzen durch pto-spaltung und verlängerungsabhängige spaltung
US20120328567A1 (en) 2011-04-08 2012-12-27 Steven Bushnell Biomarkers predictive of therapeutic responsiveness to ifnb and uses thereof
EP2697657B8 (de) 2011-04-15 2017-08-16 Becton, Dickinson and Company Mikrofluidischer abtastender echtzeit-thermocycler und verfahren zur optischen detektion mittels synchronisierter thermozyklierung und abtastung
WO2012142003A2 (en) 2011-04-15 2012-10-18 Life Technologies Corporation Chemical ligation
WO2012149042A2 (en) 2011-04-25 2012-11-01 Bio-Rad Laboratories, Inc. Methods and compositions for nucleic acid analysis
DE102012008375A1 (de) 2011-04-27 2012-10-31 Genovoxx Gmbh Methoden und Komponenten zur Detektion von Nukleinsäureketten
WO2012149193A2 (en) 2011-04-29 2012-11-01 Monsanto Technology Llc Diagnostic molecular markers for seed lot purity traits in soybeans
EP2704554B1 (de) 2011-05-02 2019-04-10 The Board of Regents of the University of Nebraska Pflanzen mit nutzeigenschaften und zugehörige verfahren
MX342067B (es) 2011-05-04 2016-09-09 Seegene Inc Detección de secuencias de ácido nucleico objetivo por desdoblamiento e hibridización de oligonucleótido de sonda.
CA2834788C (en) 2011-05-05 2020-11-17 Coordinated Program Development, Llc Cochleate compositions and methods of making and using same
EP2707496A1 (de) 2011-05-11 2014-03-19 Diagon Kft. Verfahren zur schnellen bestimmung von viren mittels nukleinsäurebasierter molekulardiagnostik und kit hierfür
WO2012170907A2 (en) 2011-06-08 2012-12-13 Life Technologies Corporation Polymerization of nucleic acids using proteins having low isoelectric points
DK2718260T3 (en) 2011-06-08 2018-11-19 Life Technologies Corp DESIGN AND DEVELOPMENT OF NEW DETERGENTS FOR USE IN PCR SYSTEMS
US20140186845A1 (en) 2011-06-14 2014-07-03 Universite Paul Sabatier - Toulouse Iii Methods for determining the expression level of a gene of interest including correction of rt-qpcr data for genomic dna-derived signals
US8815509B2 (en) * 2011-06-14 2014-08-26 University Of Southern California Fluorescence-based assay for the rapid detection and quantification of deoxyribonucleoside triphosphates
JP6154809B2 (ja) 2011-06-27 2017-06-28 エーザイ・アール・アンド・ディー・マネジメント株式会社 アルツハイマー病を示すマイクロrnaバイオマーカー
US9487824B2 (en) 2011-06-28 2016-11-08 Igor Kutyavin Methods and compositions for enrichment of nucleic acids in mixtures of highly homologous sequences
US9040244B2 (en) 2011-07-05 2015-05-26 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention HIV-1 genotyping assay for global surveillance of HIV-1 drug resistance
WO2013019751A1 (en) 2011-07-29 2013-02-07 Bio-Rad Laboratories, Inc., Library characterization by digital assay
US9758837B2 (en) 2011-08-02 2017-09-12 The United States Of America, As Represented By The Secretary Of Agriculture Sensitive and rapid method for Candidatus Liberibacter species detection
US8759618B2 (en) 2011-08-17 2014-06-24 Stine Seed Farm, Inc. Maize event HCEM485, compositions and methods for detecting and use thereof
KR20140057343A (ko) 2011-08-18 2014-05-12 네스텍 소시에테아노님 대립형질 변이 검출을 위한 조성물 및 방법
ES2704126T3 (es) 2011-08-23 2019-03-14 Found Medicine Inc Moléculas de fusión KIF5B-RET y usos de las mismas
HUE059863T2 (hu) 2011-08-31 2023-01-28 Seminis Vegetable Seeds Inc Eljárás és készítmények görögdinnye keménységhez
WO2013030841A1 (en) 2011-09-04 2013-03-07 Yissum Research Development Company Of The Hebrew Universitiy Of Jerusalem Ltd. Prognostic methods and compositions for predicting interferon treatment eficacy in a subject
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
WO2013040491A2 (en) 2011-09-15 2013-03-21 Shafer David A Probe: antiprobe compositions for high specificity dna or rna detection
SI2709613T2 (sl) 2011-09-16 2020-12-31 Gilead Pharmasset LLC c/o Gilead Sciences, Inc. Postopki za zdravljenje HCV
WO2013041577A1 (en) 2011-09-20 2013-03-28 Vib Vzw Methods for the diagnosis of amyotrophic lateral sclerosis and frontotemporal lobar degeneration
US12595500B2 (en) 2011-09-26 2026-04-07 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
CN103945931B (zh) 2011-09-26 2017-03-22 基因技术股份公司 高效的小体积核酸合成
WO2013049489A1 (en) 2011-09-28 2013-04-04 E.I. Dupont De Nemours And Company Sequences and their use for detection and characterization of stec bacteria
CN108192952A (zh) 2011-09-29 2018-06-22 露美内克丝公司 水解探针
US9416153B2 (en) 2011-10-11 2016-08-16 Enzo Life Sciences, Inc. Fluorescent dyes
WO2013056178A2 (en) 2011-10-14 2013-04-18 Foundation Medicine, Inc. Novel estrogen receptor mutations and uses thereof
WO2013059740A1 (en) 2011-10-21 2013-04-25 Foundation Medicine, Inc. Novel alk and ntrk1 fusion molecules and uses thereof
EP2773892B1 (de) 2011-11-04 2020-10-07 Handylab, Inc. Vorrichtung zur vorbereitung von polynukleotidproben
JP6165755B2 (ja) 2011-11-07 2017-07-19 ベックマン コールター, インコーポレイテッド ロボットアーム
US9046506B2 (en) 2011-11-07 2015-06-02 Beckman Coulter, Inc. Specimen container detection
JP6320926B2 (ja) 2011-11-07 2018-05-09 ベックマン コールター, インコーポレイテッド 遠心分離機システムおよびワークフロー
JP6190380B2 (ja) 2011-11-07 2017-08-30 ベックマン コールター, インコーポレイテッド 等分機システムおよびワークフロー
KR20140092378A (ko) 2011-11-07 2014-07-23 베크만 컬터, 인코포레이티드 샘플을 처리하기 위한 시스템 및 방법
BR112014011044A2 (pt) 2011-11-07 2017-04-25 Beckman Coulter Inc amortecimento magnético para sistema de transporte de espécime
TWI485253B (zh) * 2011-11-08 2015-05-21 國立成功大學 用以偵測循環性癌幹細胞的方法與套組
EP2776576B1 (de) 2011-11-09 2018-03-21 Qualicon Diagnostics LLC Sequenzen und ihre verwendung für den nachweis von salmonella
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
US20130179086A1 (en) 2011-11-29 2013-07-11 Life Technologies Corporation Systems and methods for the determination of a copy number of a genomic sequence
US8663924B2 (en) 2011-11-30 2014-03-04 Agilent Technologies, Inc. Quantitative PCR-based method to predict the efficiency of target enrichment for next-generation sequencing using repetitive DNA elements (lines/sines) as negative controls
US10513737B2 (en) 2011-12-13 2019-12-24 Decipher Biosciences, Inc. Cancer diagnostics using non-coding transcripts
ES2645418T3 (es) 2011-12-22 2017-12-05 Ibis Biosciences, Inc. Amplificación de una secuencia de un ácido ribonucleico
WO2013101750A1 (en) 2011-12-29 2013-07-04 Pioneer Hi-Bred International, Inc. Methods of improving aphid resistance in soybeans
WO2013101741A1 (en) 2011-12-30 2013-07-04 Abbott Molecular, Inc. Channels with cross-sectional thermal gradients
US20150126438A1 (en) 2012-01-24 2015-05-07 Beth Israel Deaconess Medical Center, Inc. Novel ChREBP Isoforms and Methods Using the Same
KR20130101952A (ko) 2012-02-02 2013-09-16 주식회사 씨젠 Pto 절단과 연장-의존적 혼성화를 이용한 타겟 핵산서열의 검출
CN107326085B (zh) 2012-02-03 2022-05-03 加州理工学院 多路生化测定中信号的编码和解码
US11098375B2 (en) 2012-02-24 2021-08-24 Gen-Probe Prodesse, Inc. Detection of Shiga toxin genes in bacteria
US9045803B2 (en) 2012-02-29 2015-06-02 Abbott Molecular Inc. Hepatitis B virus typing and resistance assay
CA2864523C (en) 2012-03-05 2019-02-05 Seegene, Inc. Detection of nucleotide variation on target nucleic acid sequence by pto cleavage and extension assay
WO2013139860A1 (en) 2012-03-21 2013-09-26 Roche Diagnostics Gmbh Methods for assessing rna quality
US9133509B2 (en) 2012-03-22 2015-09-15 Lgc Genomics Limited Polymerase chain reaction detection system
WO2013149258A2 (en) 2012-03-30 2013-10-03 Charles Drew University of Medicine and Science Compositions and methods for treating or preventing metabolic syndrome disorders
AU2012376214B2 (en) 2012-04-02 2019-02-14 Berg Llc Interrogatory cell-based assays and uses thereof
CN104379563B (zh) 2012-04-10 2018-12-21 加利福尼亚大学董事会 用于治疗癌症的组合物和方法
WO2013155531A2 (en) 2012-04-13 2013-10-17 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
US20150119447A1 (en) 2012-05-09 2015-04-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Clustered single nucleotide polymorphisms in the human acetylcholinesterase gene and uses thereof in diagnosis and therapy
CN104640856B (zh) 2012-05-11 2017-09-15 复位治疗公司 作为隐花色素调节剂的含有咔唑的磺酰胺类
US9840732B2 (en) 2012-05-21 2017-12-12 Fluidigm Corporation Single-particle analysis of particle populations
KR20210072137A (ko) 2012-06-14 2021-06-16 라이프 테크놀로지스 코포레이션 폴리머라제 연쇄 반응 (pcr)을 위한 신규 조성물, 방법 및 키트
US9347105B2 (en) 2012-06-15 2016-05-24 Pioneer Hi Bred International Inc Genetic loci associated with resistance of soybean to cyst nematode and methods of use
US9758829B2 (en) 2012-06-22 2017-09-12 Htg Molecular Diagnostics, Inc. Molecular malignancy in melanocytic lesions
US9657290B2 (en) 2012-07-03 2017-05-23 The Board Of Trustees Of The Leland Stanford Junior University Scalable bio-element analysis
IN2015DN01609A (de) 2012-08-03 2015-07-03 California Inst Of Techn
ES3015226T3 (en) 2012-08-16 2025-04-30 Veracyte Sd Inc Prostate cancer prognosis using biomarkers
AU2013315800A1 (en) 2012-09-11 2015-03-12 Theranos Ip Company, Llc Information management systems and methods using a biological signature
CA2886334C (en) 2012-09-28 2021-12-21 Bna Inc. Bna clamp method
MY167603A (en) 2012-10-04 2018-09-20 The Board Of Trustees Of Leland Stanford Junior Univ Method and reagents for detection, quantitation, and serotyping of dengue viruses
EP2909341A2 (de) 2012-10-18 2015-08-26 Oslo Universitetssykehus HF Biomarker für gebärmutterhalskrebs
EP2911691B1 (de) 2012-10-23 2018-10-10 OncoMed Pharmaceuticals, Inc. Verfahren zur behandlung von neuroendokrinen tumoren mit wnt-pad-bindemitteln
PL3260558T3 (pl) 2012-11-02 2020-08-10 Life Technologies Corporation Nowe kompozycje i sposoby poprawy specyficzności pcr
AU2013337277B2 (en) 2012-11-05 2018-03-08 Foundation Medicine, Inc. Novel NTRK1 fusion molecules and uses thereof
WO2014071419A2 (en) 2012-11-05 2014-05-08 Foundation Medicine, Inc. Novel fusion molecules and uses thereof
US10314253B2 (en) 2012-12-04 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and compositions for watermelon sex expression
JP6574703B2 (ja) 2012-12-05 2019-09-11 アムプリディアグ オイAmplidiag Oy 糞便サンプル中のヘリコバクターピロリdnaを検出するための方法
AU2013205090B2 (en) 2012-12-07 2016-07-28 Gen-Probe Incorporated Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid
RU2620958C2 (ru) 2012-12-27 2017-05-30 Сиджен, Инк. Детекция нуклеиновокислотной последовательности-мишени в анализе с отсутствием гибридизации, зависящим от расщепления и удлинения зондирующего и метящего олигонуклеотида (рто)
WO2014113540A1 (en) 2013-01-16 2014-07-24 Iowa State University Research Foundation, Inc. A deep intronic target for splicing correction on spinal muscular atrophy gene
WO2014113729A2 (en) 2013-01-18 2014-07-24 Foundation Mecicine, Inc. Methods of treating cholangiocarcinoma
NZ729172A (en) 2013-01-31 2018-06-29 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
JP2016510411A (ja) 2013-02-04 2016-04-07 オンコメッド ファーマシューティカルズ インコーポレイテッド Wnt経路インヒビターによる処置の方法およびモニタリング
EP2959012B1 (de) 2013-02-21 2018-02-14 Qualicon Diagnostics LLC Sequenzen und deren verwendung für den nachweis und die charakterisierung von e.coli o157:h7
EP2770065B1 (de) 2013-02-25 2017-12-13 Seegene, Inc. Detektion einer Nukleotidvariation auf Nukleinsäurezielsequenz
US9914979B2 (en) 2013-03-04 2018-03-13 Fry Laboratories, LLC Method and kit for characterizing microorganisms
US11254977B2 (en) 2013-03-12 2022-02-22 Life Technologies Corporation Universal reporter-based genotyping methods and materials
EP2971115B1 (de) 2013-03-13 2022-07-27 Seegene, Inc. Quantifizierung von zielnukleinsäuren unter verwendung von schmelzspitzenwertanalyse
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
US10563240B2 (en) 2013-03-14 2020-02-18 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
US10294489B2 (en) 2013-03-15 2019-05-21 Board Of Trustees Of Southern Illinois University Soybean resistant to cyst nematodes
US11976329B2 (en) 2013-03-15 2024-05-07 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
AU2014227883B9 (en) 2013-03-15 2020-09-10 Life Technologies Corporation Classification and actionability indices for lung cancer
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
CN105324492A (zh) 2013-03-26 2016-02-10 健能泰格技术公司 用于dna和rna检测的双探针:反探针组合物
EP2981621B1 (de) 2013-04-05 2019-05-22 Life Technologies Corporation Genfusionen
WO2014176259A1 (en) 2013-04-22 2014-10-30 Icahn School Of Medicine At Mount Sinai Mutations in pdgfrb and notch3 as causes of autosomal dominant infantile myofibromatosis
US9896717B2 (en) 2013-05-09 2018-02-20 Bio-Rad Laboratories, Inc. Magnetic immuno digital PCR assay
CA2912312C (en) 2013-05-20 2023-01-24 Board Of Trustees Of The University Of Arkansas Gep5 model for multiple myeloma
WO2014190230A1 (en) 2013-05-23 2014-11-27 Iphenotype Llc Phenotypic integrated social search database and method
US10059999B2 (en) 2013-06-10 2018-08-28 Monsanto Technology Llc Molecular markers associated with soybean tolerance to low iron growth conditions
US20140378327A1 (en) 2013-06-19 2014-12-25 Luminex Corporation Real-time multiplexed hydrolysis probe assay using spectrally identifiable microspheres
WO2015008985A1 (en) 2013-07-15 2015-01-22 Seegene, Inc. Detection of target nucleic acid sequence by pto cleavage and extension-dependent immobilized oligonucleotide hybridization
US10392670B2 (en) 2013-07-25 2019-08-27 Dch Molecular Diagnostics, Inc. Methods and compositions for detecting bacterial contamination
EP3715470B1 (de) 2013-08-09 2023-10-11 Luminex Corporation Sonden für verbesserte schmelzunterscheidung und multiplexierung in nukleinsäuretests
AU2014309047A1 (en) 2013-08-20 2016-02-11 Qualicon Diagnostics, Llc Sequences and their use for detection of Salmonella enteritidis and/or Salmonella typhimurium
SG10201908167YA (en) 2013-09-04 2019-10-30 Fluidigm Corp Proximity assays for detecting nucleic acids and proteins in a single cell
CN105722996A (zh) 2013-09-13 2016-06-29 生命科技公司 癌症的分类和可行性指数
US10767188B2 (en) 2013-09-25 2020-09-08 Nutech Ventures Methods and compositions for obtaining useful plant traits
NZ630628A (en) 2013-10-08 2015-04-24 Seminis Vegetable Seeds Inc Methods and compositions for peronospora resistance in spinach
RU2016117929A (ru) 2013-10-09 2017-11-15 Флюоресентрик, Инк. Мультиплексные зонды
WO2015054451A1 (en) 2013-10-09 2015-04-16 The United States Of America As Represented By The Secretary Department Of Health And Human Services Detection of hepatitis delta virus (hdv) for the diagnosis and treatment of sjögren's syndrome and lymphoma
JO3805B1 (ar) 2013-10-10 2021-01-31 Araxes Pharma Llc مثبطات كراس جي12سي
EP3058105B1 (de) 2013-10-18 2019-05-22 Seegene, Inc. Nachweis einer zielnukleinsäuresequenz in fester phase durch pto-spaltung und extension mit einem hcto-test
CN106458885B (zh) 2013-10-25 2019-12-10 生命技术公司 用于聚合酶链式反应系统的新颖化合物及其应用
CA2923296A1 (en) 2013-10-25 2015-04-30 Pioneer Hi-Bred International, Inc. Stem canker tolerant soybeans and methods of use
CN111443069A (zh) 2013-10-28 2020-07-24 多茨技术公司 过敏原检测
EP3063297A1 (de) 2013-11-01 2016-09-07 Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. Diagnoseverfahren und kits zur bestimmung eines individuellen behandlungsplans für eine person mit einer pathologischen störung
US10072288B2 (en) 2013-11-11 2018-09-11 Roche Molecular Systems, Inc. Detecting single nucleotide polymorphism using overlapped primer and melting probe
WO2015073709A2 (en) 2013-11-14 2015-05-21 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Detection of atherosclerotic cardiovascular disease risk and heart failure risk
NZ767892A (en) 2013-11-27 2022-07-01 Seminis Vegetable Seeds Inc Disease resistance loci in onion
ES2964927T3 (es) 2013-12-04 2024-04-10 Newleaf Symbiotics Inc Composiciones para el tratamiento de plantas
WO2015089438A1 (en) 2013-12-13 2015-06-18 Northwestern University Biomarkers for post-traumatic stress states
CN122038564A (zh) 2014-01-05 2026-05-15 G·索兹 使用mirna比率确定肺癌
US10398772B2 (en) 2014-01-08 2019-09-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Ras pathways as markers of protection against HIV and methods to improve vaccine efficacy
US10392629B2 (en) 2014-01-17 2019-08-27 Board Of Trustees Of Michigan State University Increased caloric and nutritional content of plant biomass
US10619210B2 (en) 2014-02-07 2020-04-14 The Johns Hopkins University Predicting response to epigenetic drug therapy
US10619219B2 (en) * 2014-02-07 2020-04-14 University Of Iowa Research Foundation Oligonucleotide-based probes and methods for detection of microbes
CN105531408B (zh) 2014-02-13 2019-09-10 生物辐射实验室股份有限公司 染色体构象划分产物捕获
GB201403076D0 (en) * 2014-02-21 2014-04-09 ALERE TECHNOLOGIES GmbH Methods for detecting multiple nucleic acids in a sample
PT3632202T (pt) 2014-02-21 2022-10-03 Syngenta Participations Ag Locais genéticos associados a fertilidade acrescida em milho
EP3110976B1 (de) 2014-02-27 2020-05-13 Biogen MA Inc. Verfahren zur beurteilung eines pml-risikos
NZ630710A (en) 2014-02-27 2016-03-31 Seminis Vegetable Seeds Inc Compositions and methods for peronospora resistance in spinach
ES2788631T3 (es) 2014-03-17 2020-10-22 Newleaf Symbiotics Inc Composiciones y métodos de mejora de la producción de tomate
EP3122901B1 (de) 2014-03-27 2018-08-15 Life Technologies Corporation Mit krebs assoziierte genfusionen und genvarianten
WO2015147370A1 (en) 2014-03-28 2015-10-01 Seegene, Inc. Detection of target nucleic acid sequences using different detection temperatures
US10844436B2 (en) 2014-04-01 2020-11-24 Cornell University Use of double-stranded DNA in exosomes: a novel biomarker in cancer detection
TWI690521B (zh) 2014-04-07 2020-04-11 美商同步製藥公司 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
CA2887840C (en) 2014-04-18 2020-04-14 Schweitzer Biotech Company Ltd. Methods for detecting pathogen in coldwater fish
WO2015172083A1 (en) 2014-05-08 2015-11-12 Biogen Ma Inc. Dimethylfumarate and prodrugs for treatment of multiple sclerosis
EP2942401A1 (de) 2014-05-09 2015-11-11 Lifecodexx AG Nachweis von aus einem spezifischen Zelltyp stammender DNA
US10801067B2 (en) 2014-05-09 2020-10-13 Eurofins Lifecodexx Gmbh Detection of DNA that originates from a specific cell-type and related methods
EP2942400A1 (de) 2014-05-09 2015-11-11 Lifecodexx AG Multiplex-Nachweis von DNA, die aus einem spezifischen Zelltyp herrührt
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
EP3146077A4 (de) 2014-05-22 2018-05-02 The Scripps Research Institute Molekulare gewebesignaturen von nierentransplantatabstossungen
WO2015179771A2 (en) 2014-05-22 2015-11-26 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
EP3146076A4 (de) 2014-05-22 2018-05-09 The Scripps Research Institute Mit subklinischer nierentransplantatabstossung assoziierte genexpressionsprofile
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
WO2015200833A2 (en) 2014-06-27 2015-12-30 Abbott Laboratories COMPOSITIONS AND METHODS FOR DETECTING HUMAN PEGIVIRUS 2 (HPgV-2)
US10316369B2 (en) 2014-06-27 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and assays for male sterile watermelon
RU2017103505A (ru) 2014-07-10 2018-08-15 Флюоресентрик, Инк. Технология амплификации днк
US12297505B2 (en) 2014-07-14 2025-05-13 Veracyte, Inc. Algorithms for disease diagnostics
EP3175244A4 (de) 2014-07-30 2018-06-13 Mor Research Applications Ltd. Zusammensetzungen zur behandlung von akuter lymphoblastischer leukämie und verfahren zur verwendung davon
EP4613872A3 (de) 2014-08-11 2025-11-12 Luminex Corporation Sonden zur verbesserten schmelzunterscheidung und multiplexierung in nukleinsäuretests
ES2832748T3 (es) 2014-08-19 2021-06-11 Hoffmann La Roche Procedimientos y composiciones para la detección de ácidos nucleicos
WO2016027168A2 (en) 2014-08-20 2016-02-25 Lifesplice Pharma Llc Splice modulating oligonucleotides and methods of use thereof
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
JP2017528498A (ja) 2014-09-25 2017-09-28 アラクセス ファーマ エルエルシー Kras g12c変異体タンパク質のインヒビター
WO2016049568A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Methods and compositions for inhibition of ras
CN113016623A (zh) 2014-09-26 2021-06-25 谱赛科美国股份有限公司 用于甜菊的单核苷酸多态性(snp)标志物
GB201417500D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417497D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417499D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
EP3005862A1 (de) 2014-10-10 2016-04-13 Seminis Vegetable Seeds, Inc. Melonenpflanzen mit verbesserter krankheitstoleranz
EP3207156A1 (de) 2014-10-13 2017-08-23 Life Technologies Corporation Verfahren, kits und zusammensetzungen zur bestimmung der genkopienzahl
EP3207472B1 (de) 2014-10-16 2024-11-27 Cepheid Biosicherheitsscreeningsystem und -verfahren
CA2962956C (en) 2014-10-20 2023-09-05 Gen-Probe Incorporated Red blood cell lysis solution
CN114606309A (zh) 2014-11-05 2022-06-10 威拉赛特公司 使用机器学习和高维转录数据的诊断系统和方法
US11543411B2 (en) 2014-12-05 2023-01-03 Prelude Corporation DCIS recurrence and invasive breast cancer
WO2016094330A2 (en) 2014-12-08 2016-06-16 20/20 Genesystems, Inc Methods and machine learning systems for predicting the liklihood or risk of having cancer
EP3230314B1 (de) 2014-12-08 2023-05-03 Berg LLC Verwendung von markern einschliesslich filamin a bei der diagnose und behandlung von prostatakrebs
KR102084405B1 (ko) 2014-12-09 2020-03-04 주식회사 씨젠 타겟 핵산 서열에 대한 시그널의 구별
CA3147259A1 (en) 2014-12-09 2016-06-16 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
WO2016092045A1 (en) 2014-12-11 2016-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for predicting medically refractory acute severe colitis
EP3230467A1 (de) 2014-12-12 2017-10-18 ELITechGroup B.V. Verfahren und zusammensetzungen zum nachweis von antibiotikaresistenten bakterien
EP3230468B1 (de) 2014-12-12 2020-09-16 ELITechGroup, Inc. Verfahren und kits zum nachweis von antibiotikaresistenten bakterien
EP3037545A1 (de) 2014-12-23 2016-06-29 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin DNS-Methylierungstest auf Prostatakrebs
EP3237906B8 (de) 2014-12-23 2020-10-28 Bluelight Therapeutics, Inc. Befestigung von proteinen an schnittstellen zur verwendung in nicht-linearer optischer detektion
WO2016118766A2 (en) 2015-01-21 2016-07-28 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of tick-borne pathogens
CN114277081A (zh) 2015-02-22 2022-04-05 里兰斯坦福初级大学理事会 微筛选装置、方法和产品
WO2016149547A1 (en) 2015-03-17 2016-09-22 Bio-Rad Laboratories, Inc. Detection of genome editing
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US9957393B2 (en) 2015-03-30 2018-05-01 Enzo Biochem, Inc. Monoazo dyes with cyclic amine as fluorescence quenchers
MX382355B (es) 2015-04-10 2025-03-13 Araxes Pharma Llc Compuestos de quinazolina sustituidos y métodos de uso de los mismos.
EP3283462B1 (de) 2015-04-15 2020-12-02 Araxes Pharma LLC Kondensierte tricyclische inhibitoren von kras und anwendungsverfahren dafür
CN104845967B (zh) 2015-04-15 2020-12-11 苏州新海生物科技股份有限公司 寡聚核苷酸片段及使用其的选择性扩增目标核酸序列变异体的方法及应用
ES2961374T3 (es) 2015-04-24 2024-03-11 Atila Biosystems Incorporated Amplificación con cebadores de composición de nucleótidos limitada
CA3285074A1 (en) 2015-04-28 2026-03-02 Monsanto Technology Llc Methods and compositions for producing brachytic corn plants
UA126326C2 (uk) 2015-04-30 2022-09-21 Монсанто Текнолоджі Елелсі Спосіб відбору рослини каноли, стійкої до кили капустяних
EP3292214A1 (de) 2015-05-04 2018-03-14 Academisch Medisch Centrum Verfahren zur quantifizierung von mirnas mittels normalisierung
US11278029B2 (en) 2015-06-10 2022-03-22 Newleaf Symbiotics, Inc. Antifungal Methylobacterium compositions and methods of use
CN107922941A (zh) 2015-06-15 2018-04-17 塞弗德公司 在自动化反应盒中DNA甲基化的整合的纯化和测量以及突变和/或mRNA表达水平的共同测量
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
BR112018000541B1 (pt) 2015-08-18 2023-11-28 Monsanto Technology Llc Métodos para selecionar uma população de plantas ou sementes de algodão staygreen (stg), para selecionar uma planta ou semente de algodão e para avaliar uma coleção de germoplasma de algodão
US10448595B2 (en) 2015-09-03 2019-10-22 Seminis Vegetable Seeds, Inc. Downy mildew resistant lettuce plants
WO2017044651A2 (en) 2015-09-10 2017-03-16 Beckman Coulter, Inc. Short oligonucleotide quenchers for reduction of taqman probe baseline fluorescence
US10858709B2 (en) 2015-09-10 2020-12-08 Monsanto Technology Llc Methods for producing corn plants with downy mildew resistance and compositions thereof
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
EP3356347A1 (de) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitoren von kras-g12c-mutanten proteinen
US10689356B2 (en) 2015-09-28 2020-06-23 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
EP3356354A1 (de) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitoren von kras-g12c-mutanten proteinen
WO2017058728A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
WO2017058792A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
EP3356351A1 (de) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitoren von kras-g12c-mutanten proteinen
EP3356349A1 (de) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitoren von kras-g12c-mutanten proteinen
EP3355914B1 (de) 2015-09-29 2024-03-06 The General Hospital Corporation Eine bcg-haltige zusammensetzung zur cholesterolsenkung.
EP3359689B1 (de) 2015-10-08 2021-04-14 Decipher Biosciences, Inc. Diagnostische verwendung eines einer genetischen signatur zur bewertung von behandlungsstrategien für prostatakrebs
CN115418401A (zh) 2015-10-08 2022-12-02 会聚基因学有限公司 用于膀胱癌的尿监测的诊断测定
EP3359690A4 (de) 2015-10-09 2019-06-26 Genefron Ltd. Verfahren und kits zur vorhersage und diagnose der kongenitalen übertragung des humanen cytomegalovirus (hcmv)
WO2017070256A2 (en) 2015-10-19 2017-04-27 Araxes Pharma Llc Method for screening inhibitors of ras
WO2017070244A1 (en) 2015-10-20 2017-04-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Biodosimetry analysis
EP3371211B1 (de) 2015-11-04 2025-01-01 Icahn School of Medicine at Mount Sinai Rho-assoziierte proteinkinasehemmer zur behandlung von tumoren und krebs sowie identifizierung von kandidatenpatienten für solch eine behandlung
HUE050491T2 (hu) 2015-11-10 2020-12-28 Eurofins Lifecodexx Gmbh Magzati kromoszomális aneuploidiák kimutatása olyan DNS régiókat alkalmazva, amelyek különbözõképpen vannak metilezve a magzat és a terhes nõstény között
EP3377481A1 (de) 2015-11-16 2018-09-26 Araxes Pharma LLC 2-substituierte chinazolinverbindungen mit einer substituierten heterocyclischen gruppe und verfahren zur verwendung davon
IL259466B (en) 2015-11-20 2022-09-01 Seegene Inc Method for calibrating a data set of a target analyte
WO2017100546A1 (en) 2015-12-09 2017-06-15 Araxes Pharma Llc Methods for preparation of quinazoline derivatives
US11485998B2 (en) 2015-12-15 2022-11-01 Seegene, Inc. Signal extraction for a target nucleic acid sequence
WO2017106731A1 (en) 2015-12-18 2017-06-22 Monsanto Technology Llc Methods for producing corn plants with northern leaf blight resistance and compositions thereof
US11319599B2 (en) 2015-12-18 2022-05-03 Pioneer Hi-Bred International, Inc. Genetic loci associated with reproductive growth phenotypes in soybean and methods of use
JP2019503176A (ja) 2016-01-12 2019-02-07 インターロイキン ジェネティクス, インコーポレイテッド 処置に対する応答を予測するための方法
US20190032104A1 (en) 2016-01-21 2019-01-31 T2 Biosystems, Inc. Rapid antimicrobial susceptibility testing using high-sensitivity direct detection methods
US11268124B2 (en) 2016-01-25 2022-03-08 Bio-Rad Europe Gmbh Digital microbiology
JP6685138B2 (ja) 2016-01-27 2020-04-22 シスメックス株式会社 核酸増幅の精度管理方法、精度管理用試薬およびその試薬キット
CA3004914A1 (en) 2016-02-05 2017-08-10 Pioneer Hi-Bred International, Inc. Genetic loci associated with brown stem rot resistance in soybean and methods of use
US10978173B2 (en) 2016-02-05 2021-04-13 Seegene, Inc. Method for reducing noise level of data set for a target analyte
US11306362B2 (en) 2016-02-08 2022-04-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Gene signature predictive of hepatocellular carcinoma response to transcatheter arterial chemoembolization (TACE)
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
US10822312B2 (en) 2016-03-30 2020-11-03 Araxes Pharma Llc Substituted quinazoline compounds and methods of use
EP4219519A3 (de) 2016-04-01 2023-09-13 Chromacode, Inc. Kompetitive sonden zur erzeugung von techniksignalen
EP3440221B1 (de) 2016-04-06 2025-08-27 Life Technologies Corporation Verfahren zur synthese und zum nachweis von nukleinsäuren
WO2017180745A1 (en) 2016-04-14 2017-10-19 T2 Biosystems, Inc. Methods and systems for amplification in complex samples
WO2017189730A1 (en) 2016-04-26 2017-11-02 Icahn School Of Medicine At Mount Sinai Treatment of hippo pathway mutant tumors and methods of identifying subjects as candidates for treatment
EP3449015A1 (de) 2016-04-27 2019-03-06 Mira DX, Inc. Immunbasierte behandlung von patienten mit krebs der kras-variante
EP3448998B1 (de) 2016-04-27 2020-06-03 Gen-Probe Incorporated Reagens für blutzelllyse
CA3022377A1 (en) 2016-04-29 2017-11-02 Board Of Regents, The University Of Texas System Targeted measure of transcriptional activity related to hormone receptors
US12033724B2 (en) 2016-05-12 2024-07-09 Pioneer Hi-Bred International, Inc. Methods for simultaneous pooled genotyping
US11118233B2 (en) 2016-05-18 2021-09-14 The University Of Chicago BTK mutation and ibrutinib resistance
US11066704B2 (en) 2016-06-10 2021-07-20 Seegene, Inc. Methods for preparing tagging oligonucleotides
US11946107B2 (en) 2016-06-16 2024-04-02 Bio-Rad Europe Gmbh Method of detecting Salmonella typhimurium
US20170362640A1 (en) 2016-06-16 2017-12-21 Life Technologies Corporation Novel compositions, methods and kits for microorganism detection
US10066263B2 (en) 2016-06-17 2018-09-04 California Institute Of Technology Nucleic acid reactions and related methods and compositions
US11602752B2 (en) 2016-06-30 2023-03-14 Seegene, Inc. Apparatus for amplificating nucleic acid and fluorescence-detecting device
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
CA3031994A1 (en) 2016-07-29 2018-02-01 Juno Therapeutics, Inc. Methods for assessing the presence or absence of replication competent virus
EP3496528A4 (de) 2016-08-11 2020-03-18 Monsanto Technology LLC Verfahren und zusammensetzungen zur erzeugung von maispflanzen mit resistenz gegen spätes verwelken
US11414708B2 (en) 2016-08-24 2022-08-16 Decipher Biosciences, Inc. Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy
CN118207299A (zh) 2016-08-26 2024-06-18 生命技术公司 核酸提取和扩增对照及其使用方法
WO2018045162A1 (en) 2016-09-01 2018-03-08 Biogen Ma Inc. Biomarkers predictive of primary progressive multiple sclerosis and uses thereof
KR102468633B1 (ko) 2016-09-15 2022-11-18 에프. 호프만-라 로슈 아게 멀티플렉스 실시간 pcr 수행 방법
EP3519402A1 (de) 2016-09-29 2019-08-07 Araxes Pharma LLC Inhibitoren von kras-g12c-mutanten proteinen
AU2017232187B2 (en) 2016-09-30 2023-11-09 Seminis Vegetable Seeds, Inc. Xanthomonas resistant brassica oleracea plants
WO2018066950A1 (en) 2016-10-06 2018-04-12 Seegene, Inc. . Methods for preparing oligonucleotides for detecting target nucleic acid molecules in samples
US10377743B2 (en) 2016-10-07 2019-08-13 Araxes Pharma Llc Inhibitors of RAS and methods of use thereof
CN115254210A (zh) 2016-11-14 2022-11-01 浩康生物系统公司 用于分选目标颗粒的方法和装置
US20180163270A1 (en) 2016-12-12 2018-06-14 Cepheid Integrated immuno-pcr and nucleic acid analysis in an automated reaction cartridge
CA3046636A1 (en) 2016-12-12 2018-06-21 Cepheid Integrated purification and measurement of dna methylation and co-measurement of mutations and/or mrna expression levels in an automated reaction cartridge
EP3555077B1 (de) 2016-12-15 2023-04-19 The Regents of The University of California Zusammensetzungen und verfahren zur behandlung von krebs
US10427162B2 (en) 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics
ES2903538T3 (es) 2016-12-29 2022-04-04 Seegene Inc Procedimiento para reducir la formación de dímeros de cebadores y aumentar la eficacia de la amplificación
US10337070B2 (en) 2017-01-12 2019-07-02 Cardioforecast Ltd. Methods and kits for treating cardiovascular disease
AU2018210695B2 (en) 2017-01-20 2024-07-18 The University Of British Columbia Molecular subtyping, prognosis, and treatment of bladder cancer
US11136308B2 (en) 2017-01-26 2021-10-05 Araxes Pharma Llc Substituted quinazoline and quinazolinone compounds and methods of use thereof
US11358959B2 (en) 2017-01-26 2022-06-14 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
WO2018140513A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
CN110382482A (zh) 2017-01-26 2019-10-25 亚瑞克西斯制药公司 稠合的杂-杂二环化合物及其使用方法
EP3573954A1 (de) 2017-01-26 2019-12-04 Araxes Pharma LLC Fusionierte bicyclische benzoheteroaromatische verbindungen und verfahren zur verwendung davon
WO2018162516A1 (en) 2017-03-08 2018-09-13 Etablissement Francais Du Sang Rhd gene allele associated with a weak d phenotype and its uses
WO2018165600A1 (en) 2017-03-09 2018-09-13 Genomedx Biosciences, Inc. Subtyping prostate cancer to predict response to hormone therapy
US20180265887A1 (en) 2017-03-16 2018-09-20 Jacobs Farm Del Cabo Basil Plants With High Tolerance to Downy Mildew
EP4219771A3 (de) 2017-03-24 2023-08-16 Gen-Probe Incorporated Zusammensetzungen und verfahren für den multiplexnachweis viraler krankheitserreger in proben
KR102270849B1 (ko) 2017-03-28 2021-06-29 주식회사 씨젠 타겟 핵산 서열의 존재를 결정하기 위한 분석 시그널
US11078542B2 (en) 2017-05-12 2021-08-03 Decipher Biosciences, Inc. Genetic signatures to predict prostate cancer metastasis and identify tumor aggressiveness
CN110831933A (zh) 2017-05-25 2020-02-21 亚瑞克西斯制药公司 喹唑啉衍生物作为突变kras、hras或nras的调节剂
JP2020521741A (ja) 2017-05-25 2020-07-27 アラクセス ファーマ エルエルシー がんの処置のための化合物およびその使用の方法
US20190093155A1 (en) 2017-05-25 2019-03-28 Roche Molecular Systems, Inc. Multiplex Nucleic Acid Amplification Assay
CN110869358A (zh) 2017-05-25 2020-03-06 亚瑞克西斯制药公司 Kras的共价抑制剂
US11217329B1 (en) 2017-06-23 2022-01-04 Veracyte, Inc. Methods and systems for determining biological sample integrity
EP3644721A1 (de) 2017-06-29 2020-05-06 Juno Therapeutics, Inc. Mausmodell zur auswertung von toxizitäten im zusammenhang mit immunotherapien
CN111032209A (zh) 2017-07-10 2020-04-17 简·探针公司 分析系统和方法
KR20200064060A (ko) 2017-07-29 2020-06-05 주노 쎄러퓨티크스 인코퍼레이티드 재조합 수용체를 발현하는 세포 증폭용 시약
AU2018310987A1 (en) 2017-08-04 2020-02-27 Decipher Biosciences, Inc. Use of immune cell-specific gene expression for prognosis of prostate cancer and prediction of responsiveness to radiation therapy
KR102380264B1 (ko) 2017-08-31 2022-03-29 주식회사 씨젠 다이머-형성 프라이머 쌍을 이용한 구성요소의 성능 평가
US20210071258A1 (en) 2017-09-01 2021-03-11 Juno Therapeutics, Inc. Gene expression and assessment of risk of developing toxicity following cell therapy
EP4513499A3 (de) 2017-09-28 2025-04-16 Seegene, Inc. Verfahren und vorrichtung zur analyse eines zielanalyten in einer probe
WO2019066461A2 (en) 2017-09-29 2019-04-04 Seegene, Inc. DETECTION OF TARGET NUCLEIC ACID SEQUENCES BY CLEAVAGE ANALYSIS AND EXTENSION OF PTO
EP3688181A4 (de) 2017-09-29 2021-06-16 University of Iowa Research Foundation Zusammensetzungen und verfahren zur detektion von digitalen nukleasen
US11060133B2 (en) 2017-10-26 2021-07-13 Arizona Board Of Regents On Behalf Of Arizona State University Methods for detection and quantification of infectious carbapenem resistant Enterobacteriaceae (CRE)
MA50859A (fr) 2017-11-01 2020-09-09 Celgene Corp Procédé pour la production d'une composition de lymphocytes t
JP2021502825A (ja) 2017-11-13 2021-02-04 ライフ テクノロジーズ コーポレイション 尿路微生物検出のための組成物、方法、およびキット
US10815484B2 (en) 2017-11-22 2020-10-27 The Regents Of The University Of Michigan Compositions and methods for treating cancer
EP3735476B1 (de) 2018-01-05 2023-08-23 Seegene, Inc. Verfahren zur bestimmung der anwesenheit oder abwesenheit von m. tuberculosis, m. bovis und m. bovis bcg in einer probe
EP3746225B1 (de) 2018-01-29 2024-10-30 Gen-Probe Incorporated Analytische systeme und verfahren
WO2019152747A1 (en) 2018-01-31 2019-08-08 Juno Therapeutics, Inc. Methods and reagents for assessing the presence or absence of replication competent virus
CN112119151B (zh) 2018-03-02 2025-08-29 量子细胞公司 从组织中分离和表达分析感兴趣的区域的方法、组成和装置
CA3091687A1 (en) 2018-03-16 2019-09-19 BASF Agricultural Solutions Seed US LLC Brassica plant resistant to plasmodiophora brassicae (clubroot)
CN112424377A (zh) 2018-04-17 2021-02-26 克罗玛科德公司 用于多重分析的方法和系统
EP3781708B1 (de) 2018-04-20 2025-01-15 Seegene, Inc. Verfahren zur detektion einer vielzahl von zielnukleinsäuresequenzen in einer probe
US12235273B2 (en) 2018-05-04 2025-02-25 Abbott Laboratories HBV diagnostic, prognostic, and therapeutic methods and products
US11268102B2 (en) 2018-05-16 2022-03-08 University Of Florida Research Foundation, Incorporated Compositions and methods for identifying and selecting brachytic locus in solanaceae
US12203129B2 (en) 2018-07-03 2025-01-21 ChromaCode, Inc. Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays
JP7470095B2 (ja) 2018-07-10 2024-04-17 ジェン-プローブ・インコーポレーテッド 核酸を検出および定量するための方法およびシステム
EP3820610A1 (de) 2018-07-12 2021-05-19 Luminex Corporation Systeme und verfahren zur durchführung variabler probenvorbereitung und analyseverfahren
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same
BR112021001709A2 (pt) 2018-08-01 2021-05-04 Araxes Pharma Llc compostos espiro heterocíclicos e métodos de uso dos mesmos para o tratamento de câncer
BR112021002507A2 (pt) 2018-08-10 2021-07-27 Life Technologies Corporation corantes de rodamina substituída por silício e conjugados de corante
CN112602153A (zh) 2018-08-30 2021-04-02 生命科技股份有限公司 用于对pcr测定进行基因分型的机器学习系统
US11836614B2 (en) 2018-08-31 2023-12-05 Life Technologies Corporation Image driven quality control for array-based PCR
WO2020051301A1 (en) 2018-09-06 2020-03-12 Hygiena, Llc Sequences and their use for detection and characterization of escherichia coli serotype o157:h7
WO2020056338A1 (en) 2018-09-14 2020-03-19 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
WO2020072409A1 (en) 2018-10-01 2020-04-09 Gen-Probe Incorporated Compositions and methods for amplifying or detecting varicella-zoster virus
WO2020069656A1 (zh) 2018-10-05 2020-04-09 福又达生物科技股份有限公司 鱼病原体检测方法
JP7604366B2 (ja) 2018-11-06 2024-12-23 ジュノー セラピューティクス インコーポレイテッド 遺伝子操作されたt細胞を作製するための方法
US12139764B2 (en) 2018-11-14 2024-11-12 Arizona Board Of Regents On Behalf Of The University Of Arizona Systems and methods for characterizing and treating breast cancer
US20220025449A1 (en) 2018-12-14 2022-01-27 Seegene, Inc. Method for detecting a target analyte in a sample using an s-shaped function for a slope data set
EP3899035B1 (de) 2018-12-20 2025-04-16 F. Hoffmann-La Roche AG Nachweis einer zielnukleinsäure durch festphasenmolografie
LU101073B1 (en) * 2018-12-21 2020-06-24 Luxembourg Inst Science & Tech List Dna aptamers specific of adenovirus types
AU2020208190B2 (en) 2019-01-15 2022-07-28 Seminis Vegetable Seeds, Inc. Green bean plants with improved disease resistance
KR102097721B1 (ko) 2019-01-24 2020-04-06 주식회사 시선바이오머티리얼스 태그서열 snp를 이용한 단일 검출 프로브 기반 다중 표적 검출방법
JP7687957B2 (ja) 2019-03-14 2025-06-03 インシリクサ, インコーポレイテッド 時間ゲート蛍光ベースの検出のための方法およびシステム
US11634782B2 (en) 2019-03-20 2023-04-25 Hygiena, Llc Quantification of microorganisms in samples and methods of determining quantification conditions thereof
US12582726B1 (en) 2019-04-05 2026-03-24 Earli Inc. Synthetic cancer-specific promoters
CA3132338A1 (en) 2019-04-05 2020-10-08 David Suhy Improved methods and compositions for synthetic biomarkers
WO2020205491A1 (en) 2019-04-05 2020-10-08 Hygiena, Llc Sequences and their use for detection and characterization of genus cronobacter
EP3719144A1 (de) 2019-04-05 2020-10-07 Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) Mir-151a-3p als universelle endogene steuerung zur exosomenladungsnormalisierung
KR20220035032A (ko) 2019-04-17 2022-03-21 알파인 이뮨 사이언시즈, 인코포레이티드 변이체 icos 리간드(icosl) 융합 단백질의 방법 및 용도
US12210028B2 (en) 2019-05-03 2025-01-28 Gen-Probe Incorporated Receptacle delivery system
CA3142662A1 (en) 2019-06-06 2020-12-10 Sitokine Limited Compositions and methods for treating lung, colorectal and breast cancer
US20220249637A1 (en) 2019-06-12 2022-08-11 Juno Therapeutics, Inc. Combination therapy of a cell-mediated cytotoxic therapy and an inhibitor of a prosurvival bcl2 family protein
WO2020251306A1 (en) 2019-06-14 2020-12-17 Seegene, Inc. Computer-implemented method for collaborative development of reagents for detection of target nucleic acids
RU2723390C1 (ru) * 2019-07-04 2020-06-11 Объединенный Институт Ядерных Исследований (Оияи) СПОСОБ ПРОГНОЗИРОВАНИЯ РИСКА РАЗВИТИЯ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С УРОВНЕМ ИММУНОГЛОБУЛИНА E(IgE) В СЫВОРОТКЕ КРОВИ ЧЕЛОВЕКА
WO2021016090A1 (en) 2019-07-19 2021-01-28 The Regents Of The University Of Michigan Compositions and methods for individualized characterization of non-ige mediated food allergies
US20220267857A1 (en) 2019-07-19 2022-08-25 Fundación Para La Investigación Biomédikca Del Hospital Universitario La Paz (Fibhulp) Method for determining the response to treatment of a patient affected by non-small cell lung carcinoma (nsclc)
US12496305B2 (en) 2019-07-30 2025-12-16 The Cleveland Clinic Foundation Detection for determining corticosteroid responsiveness
US20220290246A1 (en) 2019-08-07 2022-09-15 Arizona Board Of Regents On Behalf Of The University Of Arizona Single nucleotide polymorphisms and uses thereof
WO2021028469A1 (en) 2019-08-12 2021-02-18 Sitokine Limited Compositions and methods for treating cytokine release syndrome and neurotoxicity
CN114555112A (zh) 2019-08-22 2022-05-27 朱诺治疗学股份有限公司 T细胞疗法和zeste增强子同源物2(ezh2)抑制剂的组合疗法及相关方法
US11542513B2 (en) 2019-09-26 2023-01-03 Seminis Vegetable Seeds, Inc. Lettuce plants having resistance to Nasonovia ribisnigri biotype Nr:1
WO2021140173A1 (en) 2020-01-10 2021-07-15 Biouniversa S.R.L. Methods and uses for treating fibrotic solid tumors with bags inhibitors
CN119432744A (zh) 2020-01-13 2025-02-14 艾斯本神经科学公司 使神经细胞分化的方法及相关组合物和使用方法
FI130554B (en) 2020-01-20 2023-11-16 Oy Arctic Partners Ab Luminescence hybridisation assay method
CN116113714A (zh) 2020-02-18 2023-05-12 生命技术公司 用于检测病毒序列的组合物、试剂盒和方法
WO2021205013A1 (en) 2020-04-09 2021-10-14 Sitokine Limited Compositions and methods for treating covid-19
KR20230022868A (ko) 2020-05-13 2023-02-16 주노 쎄러퓨티크스 인코퍼레이티드 재조합 수용체를 발현하는 공여자-배치 세포의 제조 방법
WO2021236651A1 (en) * 2020-05-19 2021-11-25 The Regents Of The University Of California Compositions and methods of a nuclease chain reaction for nucleic acid detection
KR20230007464A (ko) 2020-06-05 2023-01-12 주식회사 씨젠 호흡기 병원체 검출을 위한 검체수송 키트 및 이를 이용한 호흡기 병원체 검출방법
WO2021260186A1 (en) 2020-06-26 2021-12-30 Juno Therapeutics Gmbh Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods
AU2021204717A1 (en) 2020-07-15 2022-02-03 Seminis Vegetable Seeds, Inc. Green Bean Plants with Improved Disease Resistance
CA3186955A1 (en) 2020-07-23 2022-01-27 Scott Benson Energy transfer dye conjugates for use in biological assays
US20230304932A1 (en) 2020-07-23 2023-09-28 Life Technologies Corporation Compositions, systems and methods for biological analysis involving energy transfer dye conjugates and analytes comprising the same
US12116637B2 (en) 2020-07-24 2024-10-15 The Regents Of The University Of Michigan Compositions and methods for detecting and treating high grade subtypes of uterine cancer
RU2741838C1 (ru) * 2020-08-19 2021-01-29 Объединенный Институт Ядерных Исследований (Оияи) Способ определения наличия генетической предрасположенности к долголетию человека
US11649441B2 (en) 2020-10-07 2023-05-16 Abclonal Science, Inc. Taq DNA polymerase mutants for probe qPCR
CA3177256A1 (en) 2020-10-21 2022-04-28 Gen-Probe Incorporated Fluid container management system
CA3199114A1 (en) 2020-11-20 2022-05-27 Edward Matthew SCHAEFFER Methods and genomic classifiers for identifying homologous recombination deficiency prostate cancer
WO2022115705A2 (en) 2020-11-30 2022-06-02 Enigma Biointelligence, Inc. Non-invasive assessment of alzheimer's disease
JP7209980B2 (ja) 2020-12-11 2023-01-23 東洋紡株式会社 Dnaポリメラーゼの5’→3’エキソヌクレアーゼ活性ドメインに特異的に結合する抗体
CA3201992A1 (en) 2020-12-21 2022-06-30 Thi Ninh Thuan NGUYEN Brassica napus plants comprising an improved fertility restorer
WO2022136477A1 (en) 2020-12-22 2022-06-30 F. Hoffmann-La Roche Ag Methods for performing multiplexed real-time pcr with the use of large stokes shift fluorescent dyes
US20250270619A1 (en) 2021-01-18 2025-08-28 Life Technologies Corporation Compositions, kits and methods for direct amplification from crude biological samples
WO2022159874A1 (en) 2021-01-25 2022-07-28 Life Technologies Corporation Compositions, kits and methods for detection of viral variant sequences
WO2022178216A2 (en) 2021-02-22 2022-08-25 Cotropia Joseph Corona virus antigens and epitopes and proteins that bind thereto
EP4301880A4 (de) 2021-03-05 2025-06-18 Seegene, Inc. Verfahren zum nachweis von sars-cov-2-mutationen
WO2022197882A1 (en) 2021-03-18 2022-09-22 Cotropia Joseph Human immunodeficiency virus (hiv) antigens and epitopes and proteins that bind thereto
US20250333806A1 (en) 2021-03-23 2025-10-30 Life Technologies Corporation Compositions, kits, and methods for variant-resistant detection of target viral sequences
CA3214833A1 (en) 2021-04-06 2022-10-13 Bpgbio, Inc. Protein markers for the prognosis of breast cancer progression
CA3214819A1 (en) 2021-04-06 2022-10-13 Guisong WANG Protein markers for estrogen receptor (er)-positive luminal a(la)-like and luminal b1 (lb1)-like breast cancer
EP4320441A1 (de) 2021-04-06 2024-02-14 BPGbio, Inc. Proteinmarker für östrogenrezeptor (er)-positiv- und östrogenrezeptor (er)-negativ-ähnlichen brustkrebs
CA3217862A1 (en) 2021-05-05 2022-11-10 Radius Pharmaceuticals, Inc. Animal model having homologous recombination of mouse pth1 receptor
EP4359561A1 (de) 2021-06-25 2024-05-01 F. Hoffmann-La Roche AG Verfahren zur durchführung von temperaturmultiplex-pcr mit erhöhter empfindlichkeit
US20250084250A1 (en) 2021-07-21 2025-03-13 Life Technologies Corporation Azaindole cyanine dyes, uses, and methods of preparation
WO2023004400A1 (en) 2021-07-21 2023-01-26 Life Technologies Corporation Dibenzoxanthene quenchers, uses, and methods of preparation
WO2023004371A1 (en) 2021-07-21 2023-01-26 Aspen Neuroscience, Inc. Methods of differentiating neural cells and predicting engraftment thereof and related compositions
AU2022313321B2 (en) 2021-07-23 2026-05-07 BASF Agricultural Solutions Seed US LLC Blackleg resistant plants and methods for the identification of blackleg resistant plants
WO2023006642A1 (en) 2021-07-26 2023-02-02 Glaxosmithkline Intellectual Property Development Limited Assay methods for titration of retrovirus and retroviral vectors
FR3125824B1 (fr) 2021-07-30 2025-07-11 Bforcure Dispositif et procédé de détection multiplexée de séquences d’acides nucléiques
WO2023014729A1 (en) 2021-08-02 2023-02-09 Life Technologies Corporation Compositions, kits, and methods for detection of nucleic acid sequence loads
IL311066A (en) 2021-08-30 2024-04-01 Galderma Holding SA Treatments for atopic dermatitis
US20240376534A1 (en) 2021-09-10 2024-11-14 Life Technologies Corporation Master mix compositions, kits, and methods
KR20240058112A (ko) 2021-09-17 2024-05-03 주식회사 씨젠 합성 비자연 염기를 포함하는 태그 올리고뉴클레오타이드를 이용한 타겟 핵산 서열의 검출
WO2023054848A1 (ko) 2021-09-30 2023-04-06 주식회사 씨젠 분자진단 시스템의 샘플 처리 및 분석 방법
EP4419712A1 (de) 2021-10-20 2024-08-28 Life Technologies Corporation Zusammensetzungen, kits und verfahren zur quantifizierung von nukleinsäuresequenzen unter verwendung eines internen quantitativen standards
US20240418649A1 (en) 2021-10-21 2024-12-19 Seegene, Inc. Device and method for reading positive/negative with respect to target assay substance in sample
US20250019739A1 (en) 2021-10-26 2025-01-16 Caribou Biosciences, Inc. Exonuclease-coupled real-time endonuclease activity assay
US20240398393A1 (en) 2021-10-29 2024-12-05 Seegene, Inc. Sample collecting swab tool and method for detection of respiratory pathogen
US20250019752A1 (en) 2021-11-02 2025-01-16 Life Technologies Corporation Compositions and methods for reducing master mix contamination
WO2023102459A1 (en) 2021-12-03 2023-06-08 Medicinal Genomics Corporation Psilocybe assay
US20230193310A1 (en) 2021-12-10 2023-06-22 Seminis Vegetabe Seeds, Inc. Lettuce plants having resistance to downy mildew
US20250145989A1 (en) 2022-01-26 2025-05-08 Seegene, Inc. Method for detecting target nucleic acids in sample
KR20250007548A (ko) 2022-04-15 2025-01-14 아스펜 뉴로사이언스 인코포레이티드 세포의 분화 상태를 분류하는 방법 및 관련 분화된 세포 조성물
EP4520433A4 (de) 2022-05-06 2026-03-04 Seegene Inc Nukleinsäurenachweiskassette
EP4532695A1 (de) 2022-05-25 2025-04-09 Celgene Corporation Verfahren zur herstellung von t-zelltherapien
EP4542552A1 (de) 2022-06-15 2025-04-23 Seegene, Inc. Verfahren und vorrichtung zum erstellen einer technischen konstruktionsdatei
US20230404003A1 (en) 2022-06-21 2023-12-21 Seminis Vegetable Seeds, Inc. Novel qtls conferring resistance to cucumber mosaic virus
EP4547757A2 (de) 2022-06-28 2025-05-07 F. Hoffmann-La Roche AG Fluoreszierende farbstoffe mit grosser stokes-verschiebung
WO2024006924A1 (en) 2022-06-29 2024-01-04 Life Technologies Corporation Systems and methods for analyte detection from multiplexed assays
CN119768474A (zh) 2022-06-29 2025-04-04 生命科技股份有限公司 多重染料化合物
WO2024010351A1 (ko) 2022-07-05 2024-01-11 주식회사 씨젠 복수의 표적 분석물 각각에 대한 근사 신호의 획득 방법 및 이를 수행하는 컴퓨터 장치
EP4564355A1 (de) 2022-07-29 2025-06-04 Seegene, Inc. Vorrichtung und verfahren zur bereitstellung einer schnittstelle zur einstellung des schwellenwerts eines parameters
EP4577672A1 (de) 2022-08-26 2025-07-02 The General Hospital Corporation Verfahren und zusammensetzungen zur prognose und behandlung von dilatierter kardiomyopathie und herzinsuffizienz
WO2024054925A1 (en) 2022-09-09 2024-03-14 Life Technologies Corporation Compositions, kits and methods for detection of viral variant sequences
EP4587594A1 (de) 2022-09-13 2025-07-23 Medicinal Genomics Corporation <smallcapsilocybe-assay
KR20250086619A (ko) 2022-10-14 2025-06-13 주식회사 씨젠 상이한 tm 값을 가지는 2개의 프로브를 이용하여 샘플 내 타겟 핵산을 검출하는 방법
IL320357A (en) 2022-10-20 2025-06-01 Seegene Inc Method of guiding multiple detailed performance experiments required for developing reagent for detecting target nucleic acid molecule, and organizing experiment result record sheets
WO2024102839A1 (en) 2022-11-10 2024-05-16 Life Technologies Corporation Compositions, kits, and methods for detection of viral sequences
WO2024106890A1 (ko) 2022-11-16 2024-05-23 주식회사 씨젠 퀀칭-pto 절단 및 연장(quenching-pto cleavage and extension; q-ptoce) 어세이에 의한 타겟 핵산의 검출
IL321497A (en) 2022-12-15 2025-08-01 Seegene Inc Device and method for displaying performance comparison results with respect to a fluorescence data analysis algorithm
EP4389911A1 (de) 2022-12-21 2024-06-26 Mobidiag Oy Verfahren und systeme zur isolierung eines analyten
EP4389887A1 (de) 2022-12-21 2024-06-26 Mobidiag Oy Isolierung und lyse von zellen
WO2024148013A1 (en) 2023-01-02 2024-07-11 Life Technologies Corporation Compositions, kits and methods for detection of viral sequences
US20240254568A1 (en) 2023-01-27 2024-08-01 Life Technologies Corporation Compositions, kits, and methods for detecting sti pathogen sequences
WO2024161179A1 (en) 2023-01-31 2024-08-08 Mobidiag Oy Compositions and methods for detecting stx nucleic acids
MX2024004405A (es) 2023-04-14 2024-11-08 Seminis Vegetable Seeds Inc Métodos y composiciones de resistencia a peronospora en la espinaca
EP4455304A1 (de) 2023-04-28 2024-10-30 Mobidiag Oy Kontrollen für nukleinsäureamplifikationsverfahren
EP4455303A1 (de) 2023-04-28 2024-10-30 Mobidiag Oy Kontrollen für nukleinsäureamplifikationsverfahren
EP4454758A1 (de) 2023-04-28 2024-10-30 Mobidiag Oy Kontrollen für nukleinsäureamplifikationsverfahren
CN121335987A (zh) 2023-05-12 2026-01-13 生命科技股份有限公司 用于多重聚合酶链式反应过程和数据分析的系统和方法
FI20235652A1 (en) 2023-06-12 2024-12-13 Mobidiag Oy Methods for isolating microbial analyte
WO2025007089A1 (en) 2023-06-30 2025-01-02 Life Technologies Corporation Compositions, methods and kits for nucleic acids synthesis and amplification
WO2025151807A1 (en) 2024-01-11 2025-07-17 Life Technologies Corporation Crude lysate sample extraction for digital pcr
WO2025175243A1 (en) 2024-02-15 2025-08-21 Life Technologies Corporation Amplification and data collection protocol for rapid genotyping
WO2025175212A1 (en) 2024-02-15 2025-08-21 Life Technologies Corporation Methods for rapid extraction-free genotyping
WO2025184318A1 (en) 2024-02-28 2025-09-04 The General Hospital Corporation Methods and compositions for prognosis and treatment of peripartum cardiomyopathy
WO2025184324A1 (en) 2024-02-28 2025-09-04 The General Hospital Corporation Methods and compositions for prognosis and treatment of cancer therapy-related cardiac dysfunction
WO2025188713A1 (en) 2024-03-05 2025-09-12 Cotropia Joseph Feline leukemia virus antigens and epitopes and proteins that bind thereto
WO2025245399A1 (en) 2024-05-23 2025-11-27 Indapta Therapeutics, Inc. Method of treating cancer with natural killer cells
WO2026024677A1 (en) 2024-07-22 2026-01-29 Abbott Laboratories Method for determining the plasma volume of a blood sample and method for determining the dilution of plasma
WO2026024668A1 (en) 2024-07-22 2026-01-29 Abbott Laboratories Method of determining a volume of a liquid in a sample
WO2026024666A1 (en) 2024-07-22 2026-01-29 Abbott Laboratories Systems and methods for digital detection assays
WO2026044153A1 (en) 2024-08-21 2026-02-26 Bpgbio, Inc. Use of biomarkers in the diagnosis of pancreatic cancer
WO2026050087A1 (en) 2024-08-27 2026-03-05 Caribou Biosciences, Inc. Real-time crispr endonuclease activity assay
WO2026052826A1 (en) 2024-09-09 2026-03-12 Roche Diagnostics Gmbh Methods for producing fluorescent dyes
US20260071285A1 (en) 2024-09-11 2026-03-12 Seminis Vegetable Seeds, Inc. Novel qtls conferring resistance to cucurbit aphid-borne yellow virus

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4220450A (en) * 1978-04-05 1980-09-02 Syva Company Chemically induced fluorescence immunoassay
JPS613063A (ja) * 1984-06-18 1986-01-09 Fujirebio Inc 発光物質を利用したポリヌクレオチドの測定方法
CA1273552A (en) * 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
US4996143A (en) 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
EP0232967B1 (de) * 1986-01-10 1993-04-28 Amoco Corporation Kompetitiver homogener Test
EP0343955A3 (de) * 1988-05-27 1990-04-18 Bioventures, Inc. Verfahren zur Bindung von Komplexen beabsichtigter Molekularspezies
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
AU6309690A (en) 1989-09-28 1991-04-11 Abbott Laboratories Stabilization of monoclonal antibody for use in fluorescent polarization techniques
DE69126915T2 (de) 1990-05-16 1998-02-19 Abbott Lab Test für Barbiturate, Tracer, Immunogene, Antikörper und Testsatz dafür
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
DE4123540A1 (de) * 1991-07-16 1993-01-21 Boehringer Mannheim Gmbh Immobilisierung von nukleinsaeuren
JP3085756B2 (ja) * 1991-10-30 2000-09-11 株式会社日立製作所 核酸の検出方法
US5747244A (en) * 1991-12-23 1998-05-05 Chiron Corporation Nucleic acid probes immobilized on polystyrene surfaces
US5332659A (en) * 1992-04-09 1994-07-26 The United States Of America As Represented By The Secretary Of The Navy Light emission-or absorbance-based binding assays for polynucleic acids
EP0601889A2 (de) * 1992-12-10 1994-06-15 Maine Medical Center Research Institute Nukleinsäure-Sonden
US6482655B1 (en) * 1993-07-23 2002-11-19 University Of Utah Research Foundation Immunoassay procedure utilizing fluorogenic tracer antigens
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
DE4442011C2 (de) * 1993-11-29 1997-09-11 Gerhard Ing Grad Hiesl Verfahren und Vorrichtung zum Füllen der Ausnehmungen eines Gegenstandes mit einem in der Wärme flüssigen Material, insbesondere der Ausnehmungen von Gleitlagerbuchsen mit Wachs
US5654419A (en) 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
US5565554A (en) 1994-07-29 1996-10-15 The Regents Of The University Of California Dimeric fluorescent energy transfer dyes comprising asymmetric cyanine azole-indolenine chromophores
US5491063A (en) * 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5741657A (en) 1995-03-20 1998-04-21 The Regents Of The University Of California Fluorogenic substrates for β-lactamase and methods of use
US6008373A (en) 1995-06-07 1999-12-28 Carnegie Mellon University Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer

Also Published As

Publication number Publication date
EP0792374B1 (de) 2001-01-17
US5723591A (en) 1998-03-03
CA2201756C (en) 2005-02-08
DE69519940D1 (de) 2001-02-22
WO1996015270A1 (en) 1996-05-23
US5876930A (en) 1999-03-02
JPH10510982A (ja) 1998-10-27
AU695561B2 (en) 1998-08-13
US5538848A (en) 1996-07-23
AU4283696A (en) 1996-06-06
DE69519940T2 (de) 2001-05-23
CA2201756A1 (en) 1996-05-23
EP0972848A3 (de) 2000-10-04
JP4131749B2 (ja) 2008-08-13
US6030787A (en) 2000-02-29
EP0792374A1 (de) 1997-09-03
US6258569B1 (en) 2001-07-10
EP0972848A2 (de) 2000-01-19
JP2003144198A (ja) 2003-05-20
JP2005176858A (ja) 2005-07-07

Similar Documents

Publication Publication Date Title
DE69519940D1 (de) Selbst dämpfende fluorescenz probe und verfahren
US6287781B1 (en) Method for detection of target nucleic acids using PCR
US6833257B2 (en) Fluorimetric detection system of a nucleic acid
US6103476A (en) Detectably labeled, dual conformation oligonucleotide probes, assays and kits
JP5385973B2 (ja) 反応における複数の核酸配列の同時検出
JP4457001B2 (ja) ドナー/アクセプター部分が相補鎖上となる標的核酸検出のmet/fretに基づく方法
JP2001510681A5 (de)
JP2004506431A5 (de)
CA2308599A1 (en) Dna polymorphism identity determination using flow cytometry
US20020197611A1 (en) Method for real-time detection and quantification of nucleic acid sequences using fluorescent primers
CA2295333A1 (en) Assaying nucleotides in solution using a fluorescent intensity quenching effect
US20060188902A1 (en) Primer for nucleic acid detection
US20030017465A1 (en) Use of fluorescent molecular beacons in the detection of methylated nucleic acids
CA2902920C (en) Polymerase chain reaction detection system
JP7391321B2 (ja) アクネ菌のdnaタイプの判別用オリゴヌクレオチドセット、キット及びアクネ菌のdnaタイプの判別方法
DE60017750T2 (de) Amplifizierungsverfahren zum Nachweis von zu bestimmenden Nucleinsäuren und Anwendung von Flourszenzenergieübertragung
CN116121241A (zh) 探针、检测试剂盒及靶核酸甲基化的检测方法
JP7697691B2 (ja) Strジェノタイピングのためのプローブおよび方法
JP2003506068A5 (de)
RU2675378C1 (ru) Способ детекции последовательностей нуклеотидов методом полимеразной цепной реакции в реальном времени с универсальным зондом
Kota Non-gel based techniques for plant genotyping.
KR970703430A (ko) 표적 핵산의 검출방법
AU2648000A (en) Use of fluorescent molecular beacons in the detection of methylated nucleic acids