ATE199561T1 - Chelatbildende gruppen enthaltende somastotatin- analoge und deren radiomarkiertezusammensetzungen - Google Patents

Chelatbildende gruppen enthaltende somastotatin- analoge und deren radiomarkiertezusammensetzungen

Info

Publication number
ATE199561T1
ATE199561T1 AT95810545T AT95810545T ATE199561T1 AT E199561 T1 ATE199561 T1 AT E199561T1 AT 95810545 T AT95810545 T AT 95810545T AT 95810545 T AT95810545 T AT 95810545T AT E199561 T1 ATE199561 T1 AT E199561T1
Authority
AT
Austria
Prior art keywords
somastotatin
radiom
forming groups
analogues containing
containing chelate
Prior art date
Application number
AT95810545T
Other languages
English (en)
Inventor
Rainer Albert
Christian Bruns
Peter Smith-Jones
Barbara Stolz
Gisbert Weckbecker
Original Assignee
Novartis Erfind Verwalt Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Erfind Verwalt Gmbh filed Critical Novartis Erfind Verwalt Gmbh
Application granted granted Critical
Publication of ATE199561T1 publication Critical patent/ATE199561T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT95810545T 1994-09-06 1995-09-04 Chelatbildende gruppen enthaltende somastotatin- analoge und deren radiomarkiertezusammensetzungen ATE199561T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9417873A GB9417873D0 (en) 1994-09-06 1994-09-06 Organic compounds

Publications (1)

Publication Number Publication Date
ATE199561T1 true ATE199561T1 (de) 2001-03-15

Family

ID=10760870

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95810545T ATE199561T1 (de) 1994-09-06 1995-09-04 Chelatbildende gruppen enthaltende somastotatin- analoge und deren radiomarkiertezusammensetzungen

Country Status (31)

Country Link
US (2) US6183721B1 (de)
EP (1) EP0714911B1 (de)
JP (1) JP3054346B2 (de)
KR (1) KR100364111B1 (de)
CN (1) CN1185252C (de)
AT (1) ATE199561T1 (de)
AU (1) AU703057B2 (de)
BR (1) BR9503936A (de)
CA (1) CA2157530C (de)
CO (1) CO4410344A1 (de)
CZ (1) CZ287012B6 (de)
DE (1) DE69520256T2 (de)
DK (1) DK0714911T3 (de)
ES (1) ES2157309T3 (de)
FI (1) FI117424B (de)
GB (1) GB9417873D0 (de)
GR (1) GR3035997T3 (de)
HU (1) HU218284B (de)
IL (1) IL115154A (de)
NO (1) NO316569B1 (de)
NZ (1) NZ272919A (de)
PE (1) PE41496A1 (de)
PL (1) PL182434B1 (de)
PT (1) PT714911E (de)
RU (1) RU2156774C2 (de)
SG (1) SG50356A1 (de)
SI (1) SI0714911T1 (de)
SK (1) SK283774B6 (de)
TR (1) TR199501094A2 (de)
TW (1) TW387898B (de)
ZA (1) ZA957475B (de)

Families Citing this family (27)

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Publication number Priority date Publication date Assignee Title
GB9417873D0 (en) * 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
AT405906B (de) * 1997-03-14 1999-12-27 Irene Dr Virgolini Radiomarkierte somatostatin rezeptor-liganden zur diagnose und therapie
US6358491B1 (en) 1999-08-27 2002-03-19 Berlex Laboratories, Inc. Somatostatin analogs
EP3342411B1 (de) 2001-02-19 2019-08-21 Novartis Pharma AG Rapamycin-derivat zur behandlung von bauchspeicheldrüsenkrebs
MXPA03007595A (es) * 2001-02-26 2003-12-04 Bristol Myers Squibb Pharma Co Analogos de acido ascorbico para metalorradiofarmaceuticos.
CN101481405A (zh) * 2001-06-08 2009-07-15 研究及应用科学协会股份有限公司 生长激素释放抑制因子-多巴胺嵌合类似物
ITMI20011708A1 (it) * 2001-08-03 2003-02-03 Bracco Imaging Spa Coniugati di peptidi, loro derivati con complessi metallici e utilizzo per i'indagine diagnostica tramite imaging per risonanza magnetica(m
MXPA05000778A (es) 2002-07-18 2005-08-29 Helix Biopharma Corp Uso de ureasa para inhibir el crecimiento de celulas cancerosas.
AU2004220104A1 (en) * 2003-03-10 2004-09-23 Biogen Idec Inc. Thiol-mediated drug attachment to targeting peptides
KR101699142B1 (ko) 2004-06-18 2017-01-23 암브룩스, 인코포레이티드 신규 항원-결합 폴리펩티드 및 이의 용도
JP2008520616A (ja) * 2004-11-24 2008-06-19 アプラーゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング 固相ペプチド合成および精製方法
EP2192922A4 (de) 2007-09-17 2010-09-29 Univ California Auf prostatazellen in situ abzielende internalisierende humane monoklonale antikörper
CN105388287A (zh) 2011-03-11 2016-03-09 内布拉斯加大学董事委员会 冠状动脉疾病的生物标志物
EP2922578B1 (de) 2012-11-21 2018-12-12 Serene, Llc Tin-117m-somatostatinrezeptor-bindende verbindungen
CN103275189B (zh) * 2013-06-06 2014-08-06 深圳翰宇药业股份有限公司 一种用于肽树脂的裂解液及其在固相裂解合成生长抑素中的应用
GEP20237479B (en) * 2013-10-18 2023-03-27 Deutsches Krebsforsch Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
US10946106B2 (en) 2015-11-30 2021-03-16 The Regents Of The University Of California Tumor-specific payload delivery and immune activation using a human antibody targeting a highly specific tumor cell surface antigen
EP4529966A3 (de) 2016-08-29 2025-06-18 Fred Hutchinson Cancer Center Chelatbildende plattform zur abgabe von radionukliden
EP3538551A4 (de) 2016-11-10 2020-11-11 Fortis Therapeutics, Inc. Cd46-specifische effektorzellen und verwendungen davon
DK3568205T3 (da) 2017-01-12 2023-10-09 Radiomedix Inc Behandling af cancerceller, der overeksprimerer somatostatinreceptorer ved at anvende radioisotop-chelaterede ocreotid-derivater
TW202547563A (zh) * 2018-06-21 2025-12-16 德商愛利穆治療有限公司 用於放射性醫藥之含有體抑素類似物之組成物
TW202015744A (zh) * 2018-06-21 2020-05-01 法商艾普森藥品公司 用於放射性醫藥之含有體抑素類似物之組成物
TW202517302A (zh) 2018-07-25 2025-05-01 法商高級催化劑應用品有限公司 穩定的、濃縮的放射性核種錯合物溶液
US10596278B2 (en) 2018-07-25 2020-03-24 Advanced Accelerator Applications (Italy) S.R.L. Stable, concentrated radionuclide complex solutions
US10596276B2 (en) 2018-07-25 2020-03-24 Advanced Accelerator Applications (Italy) S.R.L. Stable, concentrated radionuclide complex solutions
US12473265B2 (en) 2019-05-20 2025-11-18 Endocyte, Inc. Methods for preparing PSMA conjugates
US11484604B2 (en) 2020-08-07 2022-11-01 Fortis Therapeutics, Inc. Immunoconjugates targeting CD46 and methods of use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US5006643A (en) 1987-06-24 1991-04-09 The Dow Chemical Company Process for preparing isothiocyanato functionalized metal complexes
DE3728600A1 (de) 1987-08-27 1989-03-09 Hoechst Ag Verfahren zur markierung von substanzen mit technetium oder rhenium
EP0416033B1 (de) * 1988-05-25 1996-03-06 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Makrocyclische chelate und verwendungsverfahren
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
CA2066031C (en) 1989-09-29 2001-02-27 Mary A. Gray Methods for reducing non-target retention of immunoconjugates and metabolites thereof
EP0636032A1 (de) * 1992-03-25 1995-02-01 Mallinckrodt Medical, Inc. Methode zur Feststellung und Lokalisierung von Tumorgeweben während einerOperation
FI940109A7 (fi) * 1993-01-12 1994-10-11 Novartis Ag Peptidejä
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
CA2179990A1 (en) * 1994-01-12 1995-07-20 Gary Robert Bower Biological targeting agents
GB9417873D0 (en) * 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds

Also Published As

Publication number Publication date
PE41496A1 (es) 1996-10-14
JP3054346B2 (ja) 2000-06-19
DE69520256T2 (de) 2001-08-09
RU2156774C2 (ru) 2000-09-27
ES2157309T3 (es) 2001-08-16
JPH0881498A (ja) 1996-03-26
CA2157530A1 (en) 1996-03-07
SI0714911T1 (en) 2001-08-31
GR3035997T3 (en) 2001-09-28
CN1185252C (zh) 2005-01-19
DK0714911T3 (da) 2001-07-09
SK108895A3 (en) 1996-06-05
NO316569B1 (no) 2004-02-23
US6277356B1 (en) 2001-08-21
ZA957475B (en) 1997-03-06
AU703057B2 (en) 1999-03-11
CO4410344A1 (es) 1997-01-09
HUT72895A (en) 1996-06-28
TW387898B (en) 2000-04-21
PL182434B1 (pl) 2002-01-31
EP0714911A3 (de) 1996-08-21
NZ272919A (en) 1996-12-20
IL115154A0 (en) 1995-12-31
KR960010683A (ko) 1996-04-20
SK283774B6 (sk) 2004-01-08
TR199501094A2 (tr) 1996-06-21
FI117424B (fi) 2006-10-13
KR100364111B1 (ko) 2003-02-05
NO953457L (no) 1996-03-07
SG50356A1 (en) 2000-11-21
PT714911E (pt) 2001-08-30
PL310274A1 (en) 1996-03-18
NO953457D0 (no) 1995-09-04
CZ226395A3 (en) 1996-03-13
HU218284B (en) 2000-07-28
EP0714911B1 (de) 2001-03-07
US6183721B1 (en) 2001-02-06
DE69520256D1 (de) 2001-04-12
FI954147A0 (fi) 1995-09-04
BR9503936A (pt) 1996-09-24
EP0714911A2 (de) 1996-06-05
IL115154A (en) 2000-08-13
AU3041495A (en) 1996-03-21
GB9417873D0 (en) 1994-10-26
HU9502577D0 (en) 1995-11-28
FI954147L (fi) 1996-03-07
CZ287012B6 (en) 2000-08-16
CA2157530C (en) 2007-04-03
CN1127259A (zh) 1996-07-24

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