ATE206424T1 - 5-aryl-3-(8-azabicyclo(3.2.1)oct-3-yl)-1,3,4- oxadiazol-2(3h)-one derivate als 5-ht4 rezeptor liganden - Google Patents

5-aryl-3-(8-azabicyclo(3.2.1)oct-3-yl)-1,3,4- oxadiazol-2(3h)-one derivate als 5-ht4 rezeptor liganden

Info

Publication number
ATE206424T1
ATE206424T1 AT98920622T AT98920622T ATE206424T1 AT E206424 T1 ATE206424 T1 AT E206424T1 AT 98920622 T AT98920622 T AT 98920622T AT 98920622 T AT98920622 T AT 98920622T AT E206424 T1 ATE206424 T1 AT E206424T1
Authority
AT
Austria
Prior art keywords
azabicyclo
oxadiazole
oct
aryl
derivatives
Prior art date
Application number
AT98920622T
Other languages
English (en)
Inventor
Samir Jegham
Alistair Lochead
Frederic Galli
Alain Nedelec
Axelle Samson
Thierry Gallet
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Application granted granted Critical
Publication of ATE206424T1 publication Critical patent/ATE206424T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT98920622T 1997-04-18 1998-04-15 5-aryl-3-(8-azabicyclo(3.2.1)oct-3-yl)-1,3,4- oxadiazol-2(3h)-one derivate als 5-ht4 rezeptor liganden ATE206424T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9704802A FR2762316B1 (fr) 1997-04-18 1997-04-18 Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
PCT/FR1998/000754 WO1998047898A1 (fr) 1997-04-18 1998-04-15 Derives de 5-aryl-3-(8-azabicyclo(3.2.2)oct-3-yl)-1,3,4-oxadiazol-2(3h)-one en tant que ligands des recepteurs 5-ht4

Publications (1)

Publication Number Publication Date
ATE206424T1 true ATE206424T1 (de) 2001-10-15

Family

ID=9506076

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98920622T ATE206424T1 (de) 1997-04-18 1998-04-15 5-aryl-3-(8-azabicyclo(3.2.1)oct-3-yl)-1,3,4- oxadiazol-2(3h)-one derivate als 5-ht4 rezeptor liganden

Country Status (32)

Country Link
US (1) US6255319B1 (de)
EP (1) EP0975631B1 (de)
JP (1) JP2001521542A (de)
KR (1) KR20010006452A (de)
CN (1) CN1260794A (de)
AR (1) AR012458A1 (de)
AT (1) ATE206424T1 (de)
AU (1) AU742666B2 (de)
BG (1) BG64053B1 (de)
BR (1) BR9808926A (de)
CA (1) CA2286106A1 (de)
CO (1) CO4750656A1 (de)
CZ (1) CZ289154B6 (de)
DE (1) DE69801905T2 (de)
DK (1) DK0975631T3 (de)
EE (1) EE03769B1 (de)
ES (1) ES2165162T3 (de)
FR (1) FR2762316B1 (de)
HU (1) HUP0002456A3 (de)
IL (1) IL132352A0 (de)
NO (1) NO995040L (de)
NZ (1) NZ500396A (de)
PL (1) PL186894B1 (de)
PT (1) PT975631E (de)
RU (1) RU2186066C2 (de)
SI (1) SI0975631T1 (de)
SK (1) SK283441B6 (de)
TR (1) TR199902600T2 (de)
TW (1) TW502005B (de)
UA (1) UA57071C2 (de)
WO (1) WO1998047898A1 (de)
ZA (1) ZA983257B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0211230D0 (en) * 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
EP1610789B1 (de) * 2003-03-26 2010-07-21 Merck Sharp & Dohme Corp. Bicyclische piperidin-derivate als melanocortin-4 rezeptor-agonisten
US7321042B2 (en) * 2003-10-16 2008-01-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for preparing N-substituted 3-β-aminonortropanes
EP1686965A2 (de) * 2003-11-18 2006-08-09 Boehringer Ingelheim International GmbH Feste pharmazeutische zubereitungsform
BRPI0512046A (pt) 2004-06-15 2008-02-06 Pfizer derivados de ácido benzimidazolona carboxìlico
US7737163B2 (en) 2004-06-15 2010-06-15 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
FR2873693B1 (fr) * 2004-07-29 2006-09-15 Sanofi Synthelabo Derives d'amino-tropane, leur preparation et leur application en therapeutique
CA2588037A1 (en) * 2004-12-22 2006-06-29 Theravance, Inc. Indazole-carboxamide compounds
SE532388C2 (sv) * 2008-03-14 2010-01-12 Tetra Laval Holdings & Finance Förpackningslaminat och -behållare med två separata gasbarriärskikt samt metod för deras framställning
ES2657989T3 (es) * 2013-03-15 2018-03-07 Monsanto Technology Llc Azoles n-, c-disustituidos para controlar plagas de nematodos
GB201814151D0 (en) 2018-08-31 2018-10-17 Ucl Business Plc Compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055476A (en) * 1990-08-13 1991-10-08 Hoechst-Roussel Pharmaceuticals Incorporated 3-(1,2-benzisoxazol-3-yl)-4-pyridinamines and derivatives
JP3294611B2 (ja) * 1991-09-12 2002-06-24 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ４レセプター・アンタゴニスト
DE69319939T2 (de) * 1992-02-04 1999-02-18 Eisai Co., Ltd., Tokio/Tokyo Aminobenzoesäure Derivate
JPH07503480A (ja) * 1992-02-06 1995-04-13 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ４拮抗薬としてのベンゾピラン，ベンゾチオピランおよびベンゾフラン誘導体
JP3235913B2 (ja) * 1993-07-30 2001-12-04 エーザイ株式会社 アミノ安息香酸誘導体
RU2167160C2 (ru) * 1995-11-09 2001-05-20 Санофи-Синтелябо Производные 5-фенил-3-(пиперидин-4-ил)-1,3,4-оксадиазол-2(3н)-она, способ их получения, фармацевтическая композиция на их основе и лекарственное средство

Also Published As

Publication number Publication date
CA2286106A1 (en) 1998-10-29
NO995040D0 (no) 1999-10-15
TR199902600T2 (xx) 2000-03-21
SK142699A3 (en) 2000-05-16
BG103810A (en) 2000-06-30
PL336315A1 (en) 2000-06-19
SK283441B6 (sk) 2003-07-01
RU2186066C2 (ru) 2002-07-27
ES2165162T3 (es) 2002-03-01
DE69801905D1 (de) 2001-11-08
AU742666B2 (en) 2002-01-10
KR20010006452A (ko) 2001-01-26
PL186894B1 (pl) 2004-03-31
JP2001521542A (ja) 2001-11-06
ZA983257B (en) 1998-10-19
DE69801905T2 (de) 2002-07-04
US6255319B1 (en) 2001-07-03
AR012458A1 (es) 2000-10-18
EE9900487A (et) 2000-06-15
SI0975631T1 (en) 2002-06-30
DK0975631T3 (da) 2002-01-28
FR2762316B1 (fr) 1999-12-17
PT975631E (pt) 2002-03-28
CZ364199A3 (cs) 2000-03-15
HUP0002456A3 (en) 2001-03-28
FR2762316A1 (fr) 1998-10-23
BG64053B1 (bg) 2003-11-28
NO995040L (no) 1999-12-16
UA57071C2 (uk) 2003-06-16
AU7341598A (en) 1998-11-13
TW502005B (en) 2002-09-11
CZ289154B6 (cs) 2001-11-14
CN1260794A (zh) 2000-07-19
CO4750656A1 (es) 1999-03-31
IL132352A0 (en) 2001-03-19
EP0975631B1 (de) 2001-10-04
EE03769B1 (et) 2002-06-17
HUP0002456A2 (hu) 2000-12-28
NZ500396A (en) 2001-04-27
BR9808926A (pt) 2000-08-01
EP0975631A1 (de) 2000-02-02
WO1998047898A1 (fr) 1998-10-29

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