EE03769B1 - 5-arüül-3-(8-asabitsüklo[3.2.1]okt-3-üül)-1,3,4-oksadiasool-2(3H)-ooni derivaadid kui 5-HT4 retseptori ligandid - Google Patents

5-arüül-3-(8-asabitsüklo[3.2.1]okt-3-üül)-1,3,4-oksadiasool-2(3H)-ooni derivaadid kui 5-HT4 retseptori ligandid

Info

Publication number
EE03769B1
EE03769B1 EEP199900487A EEP9900487A EE03769B1 EE 03769 B1 EE03769 B1 EE 03769B1 EE P199900487 A EEP199900487 A EE P199900487A EE P9900487 A EEP9900487 A EE P9900487A EE 03769 B1 EE03769 B1 EE 03769B1
Authority
EE
Estonia
Prior art keywords
oxadiazol
azabicyclo
oct
aryl
derivatives
Prior art date
Application number
EEP199900487A
Other languages
English (en)
Estonian (et)
Inventor
Jegham Samir
Lochead Alistair
Galli Fr�d�ric
Nedelec Alain
Samson Axelle
Gallet Thierry
Original Assignee
Sanofi-Synthlabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthlabo filed Critical Sanofi-Synthlabo
Publication of EE9900487A publication Critical patent/EE9900487A/xx
Publication of EE03769B1 publication Critical patent/EE03769B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EEP199900487A 1997-04-18 1998-04-15 5-arüül-3-(8-asabitsüklo[3.2.1]okt-3-üül)-1,3,4-oksadiasool-2(3H)-ooni derivaadid kui 5-HT4 retseptori ligandid EE03769B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9704802A FR2762316B1 (fr) 1997-04-18 1997-04-18 Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
PCT/FR1998/000754 WO1998047898A1 (fr) 1997-04-18 1998-04-15 Derives de 5-aryl-3-(8-azabicyclo(3.2.2)oct-3-yl)-1,3,4-oxadiazol-2(3h)-one en tant que ligands des recepteurs 5-ht4

Publications (2)

Publication Number Publication Date
EE9900487A EE9900487A (et) 2000-06-15
EE03769B1 true EE03769B1 (et) 2002-06-17

Family

ID=9506076

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900487A EE03769B1 (et) 1997-04-18 1998-04-15 5-arüül-3-(8-asabitsüklo[3.2.1]okt-3-üül)-1,3,4-oksadiasool-2(3H)-ooni derivaadid kui 5-HT4 retseptori ligandid

Country Status (32)

Country Link
US (1) US6255319B1 (de)
EP (1) EP0975631B1 (de)
JP (1) JP2001521542A (de)
KR (1) KR20010006452A (de)
CN (1) CN1260794A (de)
AR (1) AR012458A1 (de)
AT (1) ATE206424T1 (de)
AU (1) AU742666B2 (de)
BG (1) BG64053B1 (de)
BR (1) BR9808926A (de)
CA (1) CA2286106A1 (de)
CO (1) CO4750656A1 (de)
CZ (1) CZ289154B6 (de)
DE (1) DE69801905T2 (de)
DK (1) DK0975631T3 (de)
EE (1) EE03769B1 (de)
ES (1) ES2165162T3 (de)
FR (1) FR2762316B1 (de)
HU (1) HUP0002456A3 (de)
IL (1) IL132352A0 (de)
NO (1) NO995040L (de)
NZ (1) NZ500396A (de)
PL (1) PL186894B1 (de)
PT (1) PT975631E (de)
RU (1) RU2186066C2 (de)
SI (1) SI0975631T1 (de)
SK (1) SK283441B6 (de)
TR (1) TR199902600T2 (de)
TW (1) TW502005B (de)
UA (1) UA57071C2 (de)
WO (1) WO1998047898A1 (de)
ZA (1) ZA983257B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0211230D0 (en) * 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
ATE474577T1 (de) * 2003-03-26 2010-08-15 Merck Sharp & Dohme Bicyclische piperidin-derivate als melanocortin-4 rezeptor-agonisten
US7321042B2 (en) * 2003-10-16 2008-01-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for preparing N-substituted 3-β-aminonortropanes
BRPI0416691A (pt) * 2003-11-18 2007-01-30 Boehringer Ingelheim Int forma de preparação farmacêutica sólida
EA200801607A1 (ru) 2004-06-15 2008-10-30 Пфайзер Инк. Производные бензимидазолонкарбоновой кислоты
US7737163B2 (en) 2004-06-15 2010-06-15 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
FR2873693B1 (fr) * 2004-07-29 2006-09-15 Sanofi Synthelabo Derives d'amino-tropane, leur preparation et leur application en therapeutique
ATE469897T1 (de) * 2004-12-22 2010-06-15 Theravance Inc Indazolcarbonsäureamidverbindungen
SE532388C2 (sv) * 2008-03-14 2010-01-12 Tetra Laval Holdings & Finance Förpackningslaminat och -behållare med två separata gasbarriärskikt samt metod för deras framställning
ES2657989T3 (es) * 2013-03-15 2018-03-07 Monsanto Technology Llc Azoles n-, c-disustituidos para controlar plagas de nematodos
GB201814151D0 (en) * 2018-08-31 2018-10-17 Ucl Business Plc Compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055476A (en) * 1990-08-13 1991-10-08 Hoechst-Roussel Pharmaceuticals Incorporated 3-(1,2-benzisoxazol-3-yl)-4-pyridinamines and derivatives
ES2135414T3 (es) * 1991-09-12 1999-11-01 Smithkline Beecham Plc Antagonistas del receptor 5-ht4.
PH31171A (en) * 1992-02-04 1998-03-20 Esai Co Ltd Aminobenzonic acid derivatives useful for treatinggastrointestinal conditions.
CA2129112A1 (en) * 1992-02-06 1993-08-19 Francis David King Benzopyran, benzothiopyran and benzofuran derivatives as 5-ht4 antagonists
JP3235913B2 (ja) * 1993-07-30 2001-12-04 エーザイ株式会社 アミノ安息香酸誘導体
JP4263240B2 (ja) * 1995-11-09 2009-05-13 サノフィ−アベンティス ５−フェニル−３−（ピペリジン−４−イル）−１，３，４−オキサジアゾール−２（３ｈ）−オン誘導体、及びその５−ｈｔ４又はｈ３レセプターリガンドとしての用途

Also Published As

Publication number Publication date
DE69801905D1 (de) 2001-11-08
WO1998047898A1 (fr) 1998-10-29
TR199902600T2 (xx) 2000-03-21
PL186894B1 (pl) 2004-03-31
AR012458A1 (es) 2000-10-18
ATE206424T1 (de) 2001-10-15
DK0975631T3 (da) 2002-01-28
RU2186066C2 (ru) 2002-07-27
DE69801905T2 (de) 2002-07-04
BG103810A (en) 2000-06-30
SK283441B6 (sk) 2003-07-01
CA2286106A1 (en) 1998-10-29
FR2762316B1 (fr) 1999-12-17
SI0975631T1 (en) 2002-06-30
CN1260794A (zh) 2000-07-19
CO4750656A1 (es) 1999-03-31
FR2762316A1 (fr) 1998-10-23
BG64053B1 (bg) 2003-11-28
US6255319B1 (en) 2001-07-03
CZ364199A3 (cs) 2000-03-15
AU742666B2 (en) 2002-01-10
PL336315A1 (en) 2000-06-19
BR9808926A (pt) 2000-08-01
KR20010006452A (ko) 2001-01-26
AU7341598A (en) 1998-11-13
SK142699A3 (en) 2000-05-16
ZA983257B (en) 1998-10-19
EE9900487A (et) 2000-06-15
JP2001521542A (ja) 2001-11-06
CZ289154B6 (cs) 2001-11-14
NZ500396A (en) 2001-04-27
PT975631E (pt) 2002-03-28
NO995040L (no) 1999-12-16
IL132352A0 (en) 2001-03-19
NO995040D0 (no) 1999-10-15
EP0975631A1 (de) 2000-02-02
TW502005B (en) 2002-09-11
ES2165162T3 (es) 2002-03-01
HUP0002456A3 (en) 2001-03-28
EP0975631B1 (de) 2001-10-04
UA57071C2 (uk) 2003-06-16
HUP0002456A2 (hu) 2000-12-28

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

MM4A Lapsed by not paying the annual fees

Effective date: 20040415