UA57071C2 - ПОХІДНІ 5-АРИЛ-3-(8-АЗАБІЦИКЛО[3.2.1]ОКТ-3-ІЛ)-1,3,4-ОКСАДІАЗОЛ-2(3Н)-ОНУ ЯК ЛІГАНДИ РЕЦЕПТОРА 5-HT4, СПОСІБ ЇХ ОДЕРЖАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА ЛІКАРСЬКИЙ ЗАСІБ НА ЇХ ОСНОВІ - Google Patents

ПОХІДНІ 5-АРИЛ-3-(8-АЗАБІЦИКЛО[3.2.1]ОКТ-3-ІЛ)-1,3,4-ОКСАДІАЗОЛ-2(3Н)-ОНУ ЯК ЛІГАНДИ РЕЦЕПТОРА 5-HT4, СПОСІБ ЇХ ОДЕРЖАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА ЛІКАРСЬКИЙ ЗАСІБ НА ЇХ ОСНОВІ Download PDF

Info

Publication number: UA57071C2
Authority: UA; Ukraine
Prior art keywords: general formula; group; compound; chloro; mixture
Prior art date: 1997-04-18

Application number

UA99105665A

Other languages

English (en)

Russian (ru)

Ukrainian (uk)

Inventor

Самір Жегам

Алістер Локхед

Фредерік Галлі

Фредерик Галли

Ален Неделек

Аксель САМСОН

Т'єррі Галле

Original Assignee

Санофі-Сентелябо

Санофи-Сентелябо

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-18

Filing date

1998-04-15

Publication date

2003-06-16

1998-04-15 Application filed by Санофі-Сентелябо, Санофи-Сентелябо filed Critical Санофі-Сентелябо

2003-06-16 Publication of UA57071C2 publication Critical patent/UA57071C2/uk

Links

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239000001257 hydrogen Substances 0.000 claims abstract description 6
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229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000000126 substance Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
230000002537 thrombolytic effect Effects 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
238000001665 trituration Methods 0.000 description 1
235000012431 wafers Nutrition 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

UA99105665A 1997-04-18 1998-04-15 ПОХІДНІ 5-АРИЛ-3-(8-АЗАБІЦИКЛО[3.2.1]ОКТ-3-ІЛ)-1,3,4-ОКСАДІАЗОЛ-2(3Н)-ОНУ ЯК ЛІГАНДИ РЕЦЕПТОРА 5-HT4, СПОСІБ ЇХ ОДЕРЖАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА ЛІКАРСЬКИЙ ЗАСІБ НА ЇХ ОСНОВІ UA57071C2 (uk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9704802A FR2762316B1 (fr)	1997-04-18	1997-04-18	Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
PCT/FR1998/000754 WO1998047898A1 (fr)	1997-04-18	1998-04-15	Derives de 5-aryl-3-(8-azabicyclo(3.2.2)oct-3-yl)-1,3,4-oxadiazol-2(3h)-one en tant que ligands des recepteurs 5-ht4

Publications (1)

Publication Number	Publication Date
UA57071C2 true UA57071C2 (uk)	2003-06-16

Family

ID=9506076

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA99105665A UA57071C2 (uk)	1997-04-18	1998-04-15	ПОХІДНІ 5-АРИЛ-3-(8-АЗАБІЦИКЛО[3.2.1]ОКТ-3-ІЛ)-1,3,4-ОКСАДІАЗОЛ-2(3Н)-ОНУ ЯК ЛІГАНДИ РЕЦЕПТОРА 5-HT<sub>4</sub>, СПОСІБ ЇХ ОДЕРЖАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА ЛІКАРСЬКИЙ ЗАСІБ НА ЇХ ОСНОВІ

Country Status (32)

Country	Link
US (1)	US6255319B1 (de)
EP (1)	EP0975631B1 (de)
JP (1)	JP2001521542A (de)
KR (1)	KR20010006452A (de)
CN (1)	CN1260794A (de)
AR (1)	AR012458A1 (de)
AT (1)	ATE206424T1 (de)
AU (1)	AU742666B2 (de)
BG (1)	BG64053B1 (de)
BR (1)	BR9808926A (de)
CA (1)	CA2286106A1 (de)
CO (1)	CO4750656A1 (de)
CZ (1)	CZ289154B6 (de)
DE (1)	DE69801905T2 (de)
DK (1)	DK0975631T3 (de)
EE (1)	EE03769B1 (de)
ES (1)	ES2165162T3 (de)
FR (1)	FR2762316B1 (de)
HU (1)	HUP0002456A3 (de)
IL (1)	IL132352A0 (de)
NO (1)	NO995040L (de)
NZ (1)	NZ500396A (de)
PL (1)	PL186894B1 (de)
PT (1)	PT975631E (de)
RU (1)	RU2186066C2 (de)
SI (1)	SI0975631T1 (de)
SK (1)	SK283441B6 (de)
TR (1)	TR199902600T2 (de)
TW (1)	TW502005B (de)
UA (1)	UA57071C2 (de)
WO (1)	WO1998047898A1 (de)
ZA (1)	ZA983257B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0211230D0 (en) *	2002-05-16	2002-06-26	Medinnova Sf	Treatment of heart failure
ATE474577T1 (de) *	2003-03-26	2010-08-15	Merck Sharp & Dohme	Bicyclische piperidin-derivate als melanocortin-4 rezeptor-agonisten
US7321042B2 (en) *	2003-10-16	2008-01-22	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Process for preparing N-substituted 3-β-aminonortropanes
BRPI0416691A (pt) *	2003-11-18	2007-01-30	Boehringer Ingelheim Int	forma de preparação farmacêutica sólida
EA200801607A1 (ru)	2004-06-15	2008-10-30	Пфайзер Инк.	Производные бензимидазолонкарбоновой кислоты
US7737163B2 (en)	2004-06-15	2010-06-15	Pfizer Inc.	Benzimidazolone carboxylic acid derivatives
FR2873693B1 (fr) *	2004-07-29	2006-09-15	Sanofi Synthelabo	Derives d'amino-tropane, leur preparation et leur application en therapeutique
ATE469897T1 (de) *	2004-12-22	2010-06-15	Theravance Inc	Indazolcarbonsäureamidverbindungen
SE532388C2 (sv) *	2008-03-14	2010-01-12	Tetra Laval Holdings & Finance	Förpackningslaminat och -behållare med två separata gasbarriärskikt samt metod för deras framställning
ES2657989T3 (es) *	2013-03-15	2018-03-07	Monsanto Technology Llc	Azoles n-, c-disustituidos para controlar plagas de nematodos
GB201814151D0 (en) *	2018-08-31	2018-10-17	Ucl Business Plc	Compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5055476A (en) *	1990-08-13	1991-10-08	Hoechst-Roussel Pharmaceuticals Incorporated	3-(1,2-benzisoxazol-3-yl)-4-pyridinamines and derivatives
ES2135414T3 (es) *	1991-09-12	1999-11-01	Smithkline Beecham Plc	Antagonistas del receptor 5-ht4.
PH31171A (en) *	1992-02-04	1998-03-20	Esai Co Ltd	Aminobenzonic acid derivatives useful for treatinggastrointestinal conditions.
CA2129112A1 (en) *	1992-02-06	1993-08-19	Francis David King	Benzopyran, benzothiopyran and benzofuran derivatives as 5-ht4 antagonists
JP3235913B2 (ja) *	1993-07-30	2001-12-04	エーザイ株式会社	アミノ安息香酸誘導体
JP4263240B2 (ja) *	1995-11-09	2009-05-13	サノフィ−アベンティス	５−フェニル−３−（ピペリジン−４−イル）−１，３，４−オキサジアゾール−２（３ｈ）−オン誘導体、及びその５−ｈｔ４又はｈ３レセプターリガンドとしての用途

1997
- 1997-04-18 FR FR9704802A patent/FR2762316B1/fr not_active Expired - Fee Related
1998
- 1998-04-15 DE DE69801905T patent/DE69801905T2/de not_active Expired - Fee Related
- 1998-04-15 IL IL13235298A patent/IL132352A0/xx unknown
- 1998-04-15 EP EP98920622A patent/EP0975631B1/de not_active Expired - Lifetime
- 1998-04-15 DK DK98920622T patent/DK0975631T3/da active
- 1998-04-15 ES ES98920622T patent/ES2165162T3/es not_active Expired - Lifetime
- 1998-04-15 HU HU0002456A patent/HUP0002456A3/hu unknown
- 1998-04-15 US US09/403,003 patent/US6255319B1/en not_active Expired - Fee Related
- 1998-04-15 NZ NZ500396A patent/NZ500396A/en unknown
- 1998-04-15 PL PL98336315A patent/PL186894B1/pl not_active IP Right Cessation
- 1998-04-15 SK SK1426-99A patent/SK283441B6/sk unknown
- 1998-04-15 EE EEP199900487A patent/EE03769B1/xx not_active IP Right Cessation
- 1998-04-15 TR TR1999/02600T patent/TR199902600T2/xx unknown
- 1998-04-15 KR KR1019997009542A patent/KR20010006452A/ko not_active Ceased
- 1998-04-15 BR BR9808926-9A patent/BR9808926A/pt not_active IP Right Cessation
- 1998-04-15 CZ CZ19993641A patent/CZ289154B6/cs not_active IP Right Cessation
- 1998-04-15 SI SI9830088T patent/SI0975631T1/xx unknown
- 1998-04-15 RU RU99123933/04A patent/RU2186066C2/ru not_active IP Right Cessation
- 1998-04-15 JP JP54514298A patent/JP2001521542A/ja active Pending
- 1998-04-15 WO PCT/FR1998/000754 patent/WO1998047898A1/fr not_active Ceased
- 1998-04-15 PT PT98920622T patent/PT975631E/pt unknown
- 1998-04-15 CA CA002286106A patent/CA2286106A1/en not_active Abandoned
- 1998-04-15 UA UA99105665A patent/UA57071C2/uk unknown
- 1998-04-15 AU AU73415/98A patent/AU742666B2/en not_active Ceased
- 1998-04-15 CN CN98806195A patent/CN1260794A/zh active Pending
- 1998-04-15 AT AT98920622T patent/ATE206424T1/de not_active IP Right Cessation
- 1998-04-17 CO CO98021244A patent/CO4750656A1/es unknown
- 1998-04-17 ZA ZA983257A patent/ZA983257B/xx unknown
- 1998-04-17 TW TW087105892A patent/TW502005B/zh not_active IP Right Cessation
- 1998-04-17 AR ARP980101772A patent/AR012458A1/es not_active Application Discontinuation
1999
- 1999-10-15 NO NO995040A patent/NO995040L/no not_active Application Discontinuation
- 1999-10-15 BG BG103810A patent/BG64053B1/bg unknown

Also Published As

Publication number	Publication date
DE69801905D1 (de)	2001-11-08
WO1998047898A1 (fr)	1998-10-29
TR199902600T2 (xx)	2000-03-21
PL186894B1 (pl)	2004-03-31
AR012458A1 (es)	2000-10-18
ATE206424T1 (de)	2001-10-15
DK0975631T3 (da)	2002-01-28
RU2186066C2 (ru)	2002-07-27
DE69801905T2 (de)	2002-07-04
BG103810A (en)	2000-06-30
SK283441B6 (sk)	2003-07-01
CA2286106A1 (en)	1998-10-29
FR2762316B1 (fr)	1999-12-17
SI0975631T1 (en)	2002-06-30
CN1260794A (zh)	2000-07-19
CO4750656A1 (es)	1999-03-31
FR2762316A1 (fr)	1998-10-23
BG64053B1 (bg)	2003-11-28
US6255319B1 (en)	2001-07-03
CZ364199A3 (cs)	2000-03-15
AU742666B2 (en)	2002-01-10
PL336315A1 (en)	2000-06-19
BR9808926A (pt)	2000-08-01
KR20010006452A (ko)	2001-01-26
AU7341598A (en)	1998-11-13
SK142699A3 (en)	2000-05-16
ZA983257B (en)	1998-10-19
EE9900487A (et)	2000-06-15
JP2001521542A (ja)	2001-11-06
CZ289154B6 (cs)	2001-11-14
NZ500396A (en)	2001-04-27
PT975631E (pt)	2002-03-28
NO995040L (no)	1999-12-16
IL132352A0 (en)	2001-03-19
NO995040D0 (no)	1999-10-15
EP0975631A1 (de)	2000-02-02
TW502005B (en)	2002-09-11
EE03769B1 (et)	2002-06-17
ES2165162T3 (es)	2002-03-01
HUP0002456A3 (en)	2001-03-28
EP0975631B1 (de)	2001-10-04
HUP0002456A2 (hu)	2000-12-28

Publication	Publication Date	Title
US5929089A (en)	1999-07-27	5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one derivatives for use as 5-Ht4 or H3 receptor ligands
AU639487B2 (en)	1993-07-29	Substituted urea compounds and their preparation and use
JPH0662607B2 (ja)	1994-08-17	新規三環式化合物
EP1562945A1 (de)	2005-08-17	1,4-dizabicyclo(3,2,2)nonane derivative, verfahren zur ihre herstellung und therapeutical verwendung
RU2186066C2 (ru)	2002-07-27	Производные 5-арил-3-(8-азабицикло[3.2.1]окт-3-ил)-1,3,4-оксадиазол-2(3h)-она, способ их получения, лекарственное средство и фармацевтическая композиция
US20040127491A1 (en)	2004-07-01	Novel diazabicyclic biaryl derivatives
JPH06157518A (ja)	1994-06-03	新規なオキサジアゾール誘導体又はその塩
KR100474454B1 (ko)	2006-03-23	5-ht₄또는h₃수용체리간드로서사용하기위한5-페닐-3-(피페리딘-4-일)-1,3,4-옥사디아졸-2(3h)-온유도체
EP0980370A1 (de)	2000-02-23	5-phenyl-2(3h)-1,3,4-oxadiazolonderivate und ihre verwendung als 5-ht4 liganden
MXPA99009506A (en)	2000-06-01	5-aryl-3-(8-azabicyclo(3.2.2)oct-3-yl)-1,3,4-oxadiazol-2(3h)-one derivatives as 5-ht4 receptor ligands
HK1016165B (en)	2000-09-22	5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h)-one derivatives for use as 5-ht4 or h3 receptor ligands