ATE295851T1 - Nicht-aromatische estrogenische steroide mit einem 11-hydrocarbyl substituent - Google Patents

Nicht-aromatische estrogenische steroide mit einem 11-hydrocarbyl substituent

Info

Publication number: ATE295851T1
Authority: AT; Austria
Prior art keywords: alkyl; alkynyl; alkenyl; alpha; hydrocarbyl substituent
Prior art date: 1999-09-06

Application number

AT00964053T

Other languages

English (en)

Inventor

Hubert Jan Jozef Loozen

Gerrit Herman Veeneman

Wilhelmus Gerardus Ed Schoonen

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-06

Filing date

2000-08-28

Publication date

2005-06-15

2000-08-28 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

2005-06-15 Application granted granted Critical

2005-06-15 Publication of ATE295851T1 publication Critical patent/ATE295851T1/de

Links

230000001076 estrogenic effect Effects 0.000 title 1
150000003431 steroids Chemical class 0.000 title 1
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000006729 (C2-C5) alkenyl group Chemical group 0.000 abstract 2
125000006730 (C2-C5) alkynyl group Chemical group 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
229940011871 estrogen Drugs 0.000 abstract 2
239000000262 estrogen Substances 0.000 abstract 2
125000002345 steroid group Chemical group 0.000 abstract 2
125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
125000004399 C1-C4 alkenyl group Chemical group 0.000 abstract 1
125000001118 alkylidene group Chemical group 0.000 abstract 1
HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001721 carbon Chemical group 0.000 abstract 1
125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT00964053T 1999-09-06 2000-08-28 Nicht-aromatische estrogenische steroide mit einem 11-hydrocarbyl substituent ATE295851T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP99202900		1999-09-06
PCT/EP2000/008406 WO2001018027A1 (en)	1999-09-06	2000-08-28	Non-aromatic estrogenic steroids with a hydrocarbon substituent in position 11

Publications (1)

Publication Number	Publication Date
ATE295851T1 true ATE295851T1 (de)	2005-06-15

Family

ID=8240610

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00964053T ATE295851T1 (de)	1999-09-06	2000-08-28	Nicht-aromatische estrogenische steroide mit einem 11-hydrocarbyl substituent

Country Status (24)

Country	Link
US (1)	US6677329B1 (de)
EP (1)	EP1224204B1 (de)
JP (1)	JP2003508541A (de)
KR (1)	KR20020092907A (de)
CN (2)	CN100354299C (de)
AT (1)	ATE295851T1 (de)
AU (1)	AU770331B2 (de)
BR (1)	BR0013769A (de)
CA (1)	CA2382489C (de)
CZ (1)	CZ2002831A3 (de)
DE (1)	DE60020260T2 (de)
EC (1)	ECSP013947A (de)
ES (1)	ES2241657T3 (de)
HU (1)	HUP0202595A3 (de)
IL (2)	IL148116A0 (de)
MX (1)	MXPA02001831A (de)
NO (1)	NO20021079L (de)
NZ (1)	NZ517281A (de)
PL (1)	PL353826A1 (de)
RU (1)	RU2245886C2 (de)
SK (1)	SK3282002A3 (de)
TR (1)	TR200200575T2 (de)
WO (1)	WO2001018027A1 (de)
ZA (1)	ZA200201250B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2204613T3 (es) *	1999-04-06	2004-05-01	Akzo Nobel N.V.	Androgenos 7-alfa alquilo oralmente activos.
NZ517281A (en) *	1999-09-06	2003-09-26	Akzo Nobel Nv	Non-aromatic estrogenic steroids with a hydrocarbon substituent in position 11
US8173628B2 (en) *	2000-06-22	2012-05-08	Northeastern University	Steroidal antiestrogens and antiandrogens and uses thereof
WO2001098322A1 (en) *	2000-06-22	2001-12-27	Northeastern University	Novel steroidal antiestrogens and antiandrogens and uses thereof
US7696190B2 (en) *	2000-07-28	2010-04-13	N.V. Organon	16Alpha-methyl or ethyl substituted estrogens
UA89964C2 (ru)	2004-09-08	2010-03-25	Н.В. Органон	15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ
HUE071989T2 (hu) *	2016-03-03	2025-10-28	Curia Spain S A U	Új intermedierek 11-metilén-szteroidok elõállítására
CN114249789B (zh) *	2020-09-23	2023-06-02	湖南普尔生物医药有限公司	一种7α-甲基-3,3-二甲氧基-5(10)-雄烯-17-酮的制备方法
CN114409717B (zh) *	2021-12-17	2023-03-17	湖南科益新生物医药有限公司	替勃龙中间体醚化物和替勃龙的制备方法
CN114230627B (zh) *	2021-12-31	2023-09-15	湖南新合新生物医药有限公司	一种倍他米松环氧水解物中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3092645A (en)	1961-12-28	1963-06-04	Searle & Co	Esters of 17alpha-alkynylester-5(10)-ene-3beta, 17beta-diols
GB1110792A (en)	1964-04-07	1968-04-24	Res Inst Medicine Chem	Novel 5(10)-dehydro-steroids
US3465010A (en) *	1966-11-22	1969-09-02	Searle & Co	17 - (unsaturated hydrocarbon - substituted) 11,13beta - dialkylgon -4 - ene - 3,17beta-diols and esters thereof
US3377366A (en)	1966-12-02	1968-04-09	Searle & Co	17alpha-alkynyl/alkenyl-11, 13beta-dialkylgon-5(10)-en-3-ones and esters thereof
US3652606A (en) *	1970-08-07	1972-03-28	Searle & Co	3-oxygenated 11beta-methylestr-4-en-17beta-ol and esters thereof
AU572589B2 (en) *	1983-12-14	1988-05-12	Upjohn Company, The	11(alpha)-difluoromethyl and (e)-and (z)-11-fluoromethylene steroids
ZA94715B (en) *	1993-02-08	1994-10-24	Akzo Nv	Steroids for treating menopausal complaints
EP0613687B1 (de)	1993-03-05	1999-06-02	Akzo Nobel N.V.	Verwendung von Pregnanderivaten zur Behandlung von Tumoren
CA2319765A1 (en)	1998-03-09	1999-09-16	Akzo Nobel Nv	New contraceptive kit
NZ517281A (en) *	1999-09-06	2003-09-26	Akzo Nobel Nv	Non-aromatic estrogenic steroids with a hydrocarbon substituent in position 11

2000
- 2000-08-28 NZ NZ517281A patent/NZ517281A/en unknown
- 2000-08-28 HU HU0202595A patent/HUP0202595A3/hu unknown
- 2000-08-28 US US10/070,262 patent/US6677329B1/en not_active Expired - Fee Related
- 2000-08-28 IL IL14811600A patent/IL148116A0/xx active IP Right Grant
- 2000-08-28 AU AU75117/00A patent/AU770331B2/en not_active Ceased
- 2000-08-28 EP EP00964053A patent/EP1224204B1/de not_active Expired - Lifetime
- 2000-08-28 TR TR2002/00575T patent/TR200200575T2/xx unknown
- 2000-08-28 KR KR1020027002929A patent/KR20020092907A/ko not_active Withdrawn
- 2000-08-28 AT AT00964053T patent/ATE295851T1/de not_active IP Right Cessation
- 2000-08-28 CN CNB2004100946128A patent/CN100354299C/zh not_active Expired - Fee Related
- 2000-08-28 SK SK328-2002A patent/SK3282002A3/sk unknown
- 2000-08-28 RU RU2002108723/04A patent/RU2245886C2/ru not_active IP Right Cessation
- 2000-08-28 MX MXPA02001831A patent/MXPA02001831A/es active IP Right Grant
- 2000-08-28 JP JP2001522250A patent/JP2003508541A/ja not_active Withdrawn
- 2000-08-28 BR BR0013769-3A patent/BR0013769A/pt not_active IP Right Cessation
- 2000-08-28 ES ES00964053T patent/ES2241657T3/es not_active Expired - Lifetime
- 2000-08-28 CA CA002382489A patent/CA2382489C/en not_active Expired - Fee Related
- 2000-08-28 CZ CZ2002831A patent/CZ2002831A3/cs unknown
- 2000-08-28 CN CNB008125155A patent/CN1185249C/zh not_active Expired - Fee Related
- 2000-08-28 WO PCT/EP2000/008406 patent/WO2001018027A1/en not_active Ceased
- 2000-08-28 PL PL00353826A patent/PL353826A1/xx not_active Application Discontinuation
- 2000-08-28 DE DE60020260T patent/DE60020260T2/de not_active Expired - Lifetime
2001
- 2001-02-22 EC EC2001003947A patent/ECSP013947A/es unknown
2002
- 2002-02-12 IL IL148116A patent/IL148116A/en not_active IP Right Cessation
- 2002-02-13 ZA ZA200201250A patent/ZA200201250B/xx unknown
- 2002-03-05 NO NO20021079A patent/NO20021079L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2241657T3 (es)	2005-11-01
CZ2002831A3 (cs)	2002-05-15
SK3282002A3 (en)	2002-06-04
BR0013769A (pt)	2002-04-30
DE60020260D1 (de)	2005-06-23
AU7511700A (en)	2001-04-10
RU2245886C2 (ru)	2005-02-10
EP1224204B1 (de)	2005-05-18
NO20021079L (no)	2002-04-29
AU770331B2 (en)	2004-02-19
CA2382489C (en)	2008-03-11
HUP0202595A3 (en)	2004-06-28
DE60020260T2 (de)	2006-01-19
WO2001018027A1 (en)	2001-03-15
HUP0202595A2 (hu)	2002-12-28
MXPA02001831A (es)	2002-10-23
TR200200575T2 (tr)	2002-06-21
IL148116A (en)	2006-10-31
ZA200201250B (en)	2003-07-30
CN100354299C (zh)	2007-12-12
ECSP013947A (es)	2002-09-27
EP1224204A1 (de)	2002-07-24
CN1372565A (zh)	2002-10-02
PL353826A1 (en)	2003-12-01
CN1637016A (zh)	2005-07-13
JP2003508541A (ja)	2003-03-04
IL148116A0 (en)	2002-09-12
KR20020092907A (ko)	2002-12-12
NZ517281A (en)	2003-09-26
CA2382489A1 (en)	2001-03-15
CN1185249C (zh)	2005-01-19
NO20021079D0 (no)	2002-03-05
US6677329B1 (en)	2004-01-13

Legal Events

Date	Code	Title	Description
2005-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60020260D1 (de)	2005-06-23	Nicht-aromatische estrogenische steroide mit einem 11-hydrocarbyl substituent
ATE284895T1 (de)	2005-01-15	Neuroaktive steroide der androstan- und pregnanreihe
ES2121570T3 (es)	1998-12-01	Derivados de androgenos para uso en la inhibicion de la actividad de los esteroides sexuales.
ATE186913T1 (de)	1999-12-15	17-substituierte steroide, verwendbar bei behandlung von krebs
ATE410171T1 (de)	2008-10-15	Graduierte östrogen-kontrazeptiva
FI961792L (fi)	1996-04-26	Steroidi-C17-20-lyaasiestäjinä käyttökelpoiset delta16-tyydyttymättömät heterosykliset C17-steroidit
NO20013632D0 (no)	2001-07-24	Steroide sulfataseinhibitorer og fremgangsmåter for å fremstille og anvende disse
AU1967300A (en)	2000-06-13	Estrogenic estra-1,3,5(10)-trienes with differential effects on the alpha and beta estrogen receptors, having a linear hydrocarbon chain of from 5-9 carbon atoms in position 11
DK1051177T3 (da)	2006-07-24	Steroide 3-O-Sulfamatderivater som inhibitorer af östronsulfatase
DK0469548T3 (da)	1996-06-24	4-Amino-delta4-steroider og deres anvendelse som inhibitorer af 5alfa-reduktase
RU2002108723A (ru)	2003-11-20	Неароматические эстрогенные стероиды с углеводородным заместителем в положении 11
ZA805249B (en)	1981-09-30	New amino-14 steriod derivatives and process for preparataion of the same
EP0515264A3 (en)	1993-01-13	New steroid derivatives of pregna-4,9(11),17(20)-trien-3-on, their preparation, their use in the preparation of derivatives of pregna-4,9(11),16-trien-3,20-dione and intermediates therefor
ATE154606T1 (de)	1997-07-15	2beta,19-methylenamin überbrückte steroide als aromatasehemmer
NO20020260L (no)	2002-03-14	11<beta>-aryl-17,17-spirotiolansubstituerte steroider
ZA924665B (en)	1993-06-24	Substituted 16-methyl steroid derivatives of pregna-1, 4-dien-3,20-doine, their preparation, their use in the preparation of 16-methylene steroids and intermediates.
FI946189A0 (fi)	1994-12-30	5-alfa-reduktaasi-inhibiittoreina käyttökelpoiset 17-alkyyliketonisteroidit
DK352086A (da)	1987-02-02	Steroide aromatase-inhibitorer
MXPA03000845A (es)	2004-04-05	Estrogenos substituidos por 16alfa-metilo o etilo.
CO5251432A1 (es)	2003-02-28	Derivados de 3-metileno esteroides
MXPA03005224A (es)	2004-03-26	Esteroides de metileno como androgenos novedosos.
ES505051A0 (es)	1983-03-01	Procedimiento para preparar 18-sustituidas pregn-4-ene-3,20-dionas
RU2000116237A (ru)	2002-05-10	Ингибиторы стероидсульфатазы