TR200200575T2 - 11 Konumunda bir hidrokarbon ikame ediciye sahip, aromatik olmayan östrojenik steroidler. - Google Patents

11 Konumunda bir hidrokarbon ikame ediciye sahip, aromatik olmayan östrojenik steroidler.

Info

Publication number
TR200200575T2
TR200200575T2 TR2002/00575T TR200200575T TR200200575T2 TR 200200575 T2 TR200200575 T2 TR 200200575T2 TR 2002/00575 T TR2002/00575 T TR 2002/00575T TR 200200575 T TR200200575 T TR 200200575T TR 200200575 T2 TR200200575 T2 TR 200200575T2
Authority
TR
Turkey
Prior art keywords
alkyl
alkynyl
alkenyl
alpha
aromatic
Prior art date
Application number
TR2002/00575T
Other languages
English (en)
Inventor
Jan Jozef Loozen Hubert
Herman Veeneman Gerrit
Gerardus Eduardus Joseph Schoonen Wilhelmus
Original Assignee
Akzo Nobel N. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N. V. filed Critical Akzo Nobel N. V.
Publication of TR200200575T2 publication Critical patent/TR200200575T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Aromatik olmayan bir A halkasina ve karbon atomu No.3' te serbest veya kapatilmis bir hidroksil grubuna sahip tipte, yeni, seçici östrojenler açiklanmistir. Östrojenler genel formül (I)' e sahiptirler; bu formülde, R1, H, (C1-C3) alkil veya (C2-C3) asildir; R2, H, alfa-(C1-C4) alkil, alfa-(C2-C4) alkenil veya alfa (C2-C4) alkinildir; R3, H veya herbiri steroid iskeletin 15 veya 16 konumunda (C1-C4) alkil, (C2-C4) alkenil veya (C2-C4) alkinildir; R4, H veya herbiri seçime bagli olarak halojenle ikame edilmis (C1-C5) alkil, (C2-C5) alkenil veya (C2-C5) alkinildir; tercih edilen etinildir; R5, H, (C1-C3) alkil veya (C2-C3) asildir; R6, herbiri seçime bagli olarak halojen veya (C1-C3) alkiloksi ile ikame edilen (C1-C5)alkil, (C2-C5)alkenil,(C2-C5)alkinil veya (C1-C5)alkilidendir; nokta nokta baglar, seçime bagli çift baglari gösterirler.
TR2002/00575T 1999-09-06 2000-08-28 11 Konumunda bir hidrokarbon ikame ediciye sahip, aromatik olmayan östrojenik steroidler. TR200200575T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99202900 1999-09-06

Publications (1)

Publication Number Publication Date
TR200200575T2 true TR200200575T2 (tr) 2002-06-21

Family

ID=8240610

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/00575T TR200200575T2 (tr) 1999-09-06 2000-08-28 11 Konumunda bir hidrokarbon ikame ediciye sahip, aromatik olmayan östrojenik steroidler.

Country Status (24)

Country Link
US (1) US6677329B1 (tr)
EP (1) EP1224204B1 (tr)
JP (1) JP2003508541A (tr)
KR (1) KR20020092907A (tr)
CN (2) CN100354299C (tr)
AT (1) ATE295851T1 (tr)
AU (1) AU770331B2 (tr)
BR (1) BR0013769A (tr)
CA (1) CA2382489C (tr)
CZ (1) CZ2002831A3 (tr)
DE (1) DE60020260T2 (tr)
EC (1) ECSP013947A (tr)
ES (1) ES2241657T3 (tr)
HU (1) HUP0202595A3 (tr)
IL (2) IL148116A0 (tr)
MX (1) MXPA02001831A (tr)
NO (1) NO20021079L (tr)
NZ (1) NZ517281A (tr)
PL (1) PL353826A1 (tr)
RU (1) RU2245886C2 (tr)
SK (1) SK3282002A3 (tr)
TR (1) TR200200575T2 (tr)
WO (1) WO2001018027A1 (tr)
ZA (1) ZA200201250B (tr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2204613T3 (es) * 1999-04-06 2004-05-01 Akzo Nobel N.V. Androgenos 7-alfa alquilo oralmente activos.
NZ517281A (en) * 1999-09-06 2003-09-26 Akzo Nobel Nv Non-aromatic estrogenic steroids with a hydrocarbon substituent in position 11
US8173628B2 (en) * 2000-06-22 2012-05-08 Northeastern University Steroidal antiestrogens and antiandrogens and uses thereof
WO2001098322A1 (en) * 2000-06-22 2001-12-27 Northeastern University Novel steroidal antiestrogens and antiandrogens and uses thereof
US7696190B2 (en) * 2000-07-28 2010-04-13 N.V. Organon 16Alpha-methyl or ethyl substituted estrogens
UA89964C2 (ru) 2004-09-08 2010-03-25 Н.В. Органон 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ
HUE071989T2 (hu) * 2016-03-03 2025-10-28 Curia Spain S A U Új intermedierek 11-metilén-szteroidok elõállítására
CN114249789B (zh) * 2020-09-23 2023-06-02 湖南普尔生物医药有限公司 一种7α-甲基-3,3-二甲氧基-5(10)-雄烯-17-酮的制备方法
CN114409717B (zh) * 2021-12-17 2023-03-17 湖南科益新生物医药有限公司 替勃龙中间体醚化物和替勃龙的制备方法
CN114230627B (zh) * 2021-12-31 2023-09-15 湖南新合新生物医药有限公司 一种倍他米松环氧水解物中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3092645A (en) 1961-12-28 1963-06-04 Searle & Co Esters of 17alpha-alkynylester-5(10)-ene-3beta, 17beta-diols
GB1110792A (en) 1964-04-07 1968-04-24 Res Inst Medicine Chem Novel 5(10)-dehydro-steroids
US3465010A (en) * 1966-11-22 1969-09-02 Searle & Co 17 - (unsaturated hydrocarbon - substituted) 11,13beta - dialkylgon -4 - ene - 3,17beta-diols and esters thereof
US3377366A (en) 1966-12-02 1968-04-09 Searle & Co 17alpha-alkynyl/alkenyl-11, 13beta-dialkylgon-5(10)-en-3-ones and esters thereof
US3652606A (en) * 1970-08-07 1972-03-28 Searle & Co 3-oxygenated 11beta-methylestr-4-en-17beta-ol and esters thereof
AU572589B2 (en) * 1983-12-14 1988-05-12 Upjohn Company, The 11(alpha)-difluoromethyl and (e)-and (z)-11-fluoromethylene steroids
ZA94715B (en) * 1993-02-08 1994-10-24 Akzo Nv Steroids for treating menopausal complaints
EP0613687B1 (en) 1993-03-05 1999-06-02 Akzo Nobel N.V. Use of a pregnane derivatives for the treatment of tumours
CA2319765A1 (en) 1998-03-09 1999-09-16 Akzo Nobel Nv New contraceptive kit
NZ517281A (en) * 1999-09-06 2003-09-26 Akzo Nobel Nv Non-aromatic estrogenic steroids with a hydrocarbon substituent in position 11

Also Published As

Publication number Publication date
ES2241657T3 (es) 2005-11-01
CZ2002831A3 (cs) 2002-05-15
SK3282002A3 (en) 2002-06-04
BR0013769A (pt) 2002-04-30
ATE295851T1 (de) 2005-06-15
DE60020260D1 (de) 2005-06-23
AU7511700A (en) 2001-04-10
RU2245886C2 (ru) 2005-02-10
EP1224204B1 (en) 2005-05-18
NO20021079L (no) 2002-04-29
AU770331B2 (en) 2004-02-19
CA2382489C (en) 2008-03-11
HUP0202595A3 (en) 2004-06-28
DE60020260T2 (de) 2006-01-19
WO2001018027A1 (en) 2001-03-15
HUP0202595A2 (hu) 2002-12-28
MXPA02001831A (es) 2002-10-23
IL148116A (en) 2006-10-31
ZA200201250B (en) 2003-07-30
CN100354299C (zh) 2007-12-12
ECSP013947A (es) 2002-09-27
EP1224204A1 (en) 2002-07-24
CN1372565A (zh) 2002-10-02
PL353826A1 (en) 2003-12-01
CN1637016A (zh) 2005-07-13
JP2003508541A (ja) 2003-03-04
IL148116A0 (en) 2002-09-12
KR20020092907A (ko) 2002-12-12
NZ517281A (en) 2003-09-26
CA2382489A1 (en) 2001-03-15
CN1185249C (zh) 2005-01-19
NO20021079D0 (no) 2002-03-05
US6677329B1 (en) 2004-01-13

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