ATE458199T1 - Diagnostische marker der akuten koronaren syndrome und ihre verwendungen - Google Patents

Diagnostische marker der akuten koronaren syndrome und ihre verwendungen

Info

Publication number
ATE458199T1
ATE458199T1 AT06002477T AT06002477T ATE458199T1 AT E458199 T1 ATE458199 T1 AT E458199T1 AT 06002477 T AT06002477 T AT 06002477T AT 06002477 T AT06002477 T AT 06002477T AT E458199 T1 ATE458199 T1 AT E458199T1
Authority
AT
Austria
Prior art keywords
immunoassay
subject
cardiac troponin
threshold level
acute coronary
Prior art date
Application number
AT06002477T
Other languages
English (en)
Inventor
Gunars E Valkirs
Jeffrey R Dahlen
Howard Kirchick
Kenneth F Buechler
Original Assignee
Biosite Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26965308&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE458199(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biosite Inc filed Critical Biosite Inc
Application granted granted Critical
Publication of ATE458199T1 publication Critical patent/ATE458199T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Brain natriuretic peptide [BNP, proBNP]; Cardionatrin; Cardiodilatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Error Detection And Correction (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
AT06002477T 2001-05-04 2002-05-04 Diagnostische marker der akuten koronaren syndrome und ihre verwendungen ATE458199T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28887101P 2001-05-04 2001-05-04
US31564201P 2001-08-28 2001-08-28

Publications (1)

Publication Number Publication Date
ATE458199T1 true ATE458199T1 (de) 2010-03-15

Family

ID=26965308

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02734211T ATE439588T1 (de) 2001-05-04 2002-05-04 Diagnostische marker für akute herzerkrankungen und verfahren des gebrauchs
AT06002477T ATE458199T1 (de) 2001-05-04 2002-05-04 Diagnostische marker der akuten koronaren syndrome und ihre verwendungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT02734211T ATE439588T1 (de) 2001-05-04 2002-05-04 Diagnostische marker für akute herzerkrankungen und verfahren des gebrauchs

Country Status (8)

Country Link
US (2) US7361473B2 (de)
EP (3) EP2261669A1 (de)
JP (3) JP3806694B2 (de)
AT (2) ATE439588T1 (de)
AU (1) AU2002305394A1 (de)
CA (1) CA2414073A1 (de)
DE (2) DE60235416D1 (de)
WO (1) WO2002089657A2 (de)

Families Citing this family (265)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627404B1 (en) * 1995-04-18 2003-09-30 Biosite, Inc. Methods for improving the recovery of troponin I and T in membranes, filters and vessels
US6991907B1 (en) * 1995-04-18 2006-01-31 Biosite, Inc. Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
DE19847690A1 (de) * 1998-10-15 2000-04-20 Brahms Diagnostica Gmbh Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen
WO2002038794A2 (en) 2000-11-09 2002-05-16 The Brigham And Women's Hospital, Inc. Cardiovascular disease diagnostic and therapeutic targets
US7635676B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaccuticals, Inc. Modified annexin proteins and methods for their use in organ transplantation
US7635680B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaceuticals, Inc. Attenuation of reperfusion injury
US7645739B2 (en) 2001-02-21 2010-01-12 Alavita Pharmaceuticals, Inc. Modified annexin compositions and methods of using same
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US7713705B2 (en) 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
US20030199000A1 (en) * 2001-08-20 2003-10-23 Valkirs Gunars E. Diagnostic markers of stroke and cerebral injury and methods of use thereof
WO2003016910A1 (en) 2001-08-20 2003-02-27 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
US7524635B2 (en) 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
US20040176914A1 (en) * 2001-04-13 2004-09-09 Biosite Incorporated Methods and compositions for measuring biologically active natriuretic peptides and for improving their therapeutic potential
US7632647B2 (en) * 2001-04-13 2009-12-15 Biosite Incorporated Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
US20040219509A1 (en) * 2001-08-20 2004-11-04 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7608406B2 (en) * 2001-08-20 2009-10-27 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US20040209307A1 (en) * 2001-08-20 2004-10-21 Biosite Incorporated Diagnostic markers of stroke and cerebral injury and methods of use thereof
US6461828B1 (en) 2001-09-04 2002-10-08 Syn X Pharma Conjunctive analysis of biological marker expression for diagnosing organ failure
PT3072978T (pt) 2002-05-09 2018-10-15 Brigham & Womens Hospital Inc 1l1rl-1 como um marcador de doença cardiovascular
MXPA03004105A (es) 2002-05-14 2004-10-15 Hoffmann La Roche Elaboracion de una prognosis en casos de enfermedad cardiaca usando una combinacion de marcadores.
US20040175754A1 (en) * 2002-10-09 2004-09-09 David Bar-Or Diagnosis and monitoring of inflammation, ischemia and appendicitis
BR0316560A (pt) * 2002-11-26 2005-10-04 Nobex Corp Conjugado de composto natriurético, formulação farmacêutica, método de tratar uma condição, método de preparação do conjugado de composto natriurético, conjugado de peptìdeo pró-polinatriurético modificado, análogo de peptìdeo natriurético, análogo de hbnp, composto, e, método de preparar um composto
GB0229747D0 (en) * 2002-12-20 2003-01-29 Axis Shield Asa Assay
EP1587955A4 (de) * 2002-12-24 2007-03-14 Biosite Inc Differenzialdiagnose-marker und verfahren zu ihrer verwendung
DK2360475T3 (da) * 2003-03-27 2020-01-06 Childrens Hospital Med Ct Fremgangsmåde og kit til detektion af tidlig indtræden af renal tubulær celleskade
DE10316583A1 (de) * 2003-04-10 2004-10-28 B.R.A.H.M.S Aktiengesellschaft Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung
WO2004094460A2 (en) 2003-04-17 2004-11-04 Ciphergen Biosystems, Inc. Polypeptides related to natriuretic peptides and methods of their identification and use
WO2004097368A2 (en) * 2003-04-28 2004-11-11 Ciphergen Biosystems, Inc. Improved immunoassays
WO2004105575A2 (en) * 2003-05-29 2004-12-09 Trustee Of Darmouth College A method for detecting cardiac ischemia via changes in b-natriuretic peptide levels
JP2007518062A (ja) * 2003-09-29 2007-07-05 バイオサイト インコーポレイテッド 敗血症を診断する方法および診断するための組成物
US20050148029A1 (en) * 2003-09-29 2005-07-07 Biosite, Inc. Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes
DE10351238A1 (de) * 2003-11-03 2005-06-02 Roche Diagnostics Gmbh Diagnosestellung von akuten myokardialen, ischämischen Erkrankungen durch Kombination von Markern
EP1530047A1 (de) * 2003-11-07 2005-05-11 Roche Diagnostics GmbH Proximale Markermoleküle der Arterienthrombose und der Entzündung zur Risikostratifizierung einer koronaren Herzkrankheit
CA2563310A1 (en) * 2003-11-07 2005-05-26 Princeton Biochemicals, Inc. Multi-dimensional electrophoresis apparatus
GB0329288D0 (en) * 2003-12-18 2004-01-21 Inverness Medical Switzerland Monitoring method and apparatus
US20050196817A1 (en) * 2004-01-20 2005-09-08 Molecular Staging Inc. Biomarkers for sepsis
US20050181451A1 (en) * 2004-02-12 2005-08-18 Bates Harold M. Detection of asymptomatic coronary artery disease using atherogenic proteins and acute phase reactants
US20080175191A1 (en) * 2004-02-23 2008-07-24 Siemens Aktiengesellschaft Method, Intermediate Station and Central Control Unit For the Packet-Switched Data Transmission in a Self-Organizing Radio Network
US20050244892A1 (en) * 2004-02-27 2005-11-03 Lazar Mitchell A Resistin as a marker and therapeutic target for cardiovascular disease
EP1755642B1 (de) * 2004-04-15 2010-01-13 Athera Biotechnologies Ab Annexin zur prävention von der ruptur des plaques
US20050272101A1 (en) * 2004-06-07 2005-12-08 Prasad Devarajan Method for the early detection of renal injury
DE102004028303A1 (de) 2004-06-11 2005-12-29 Roche Diagnostics Gmbh Verfahren und Vorrichtung zum Nachweis von Analyten
CA2567738C (en) 2004-06-15 2010-12-21 F. Hoffmann-La Roche Ag The use of cardiac hormones for diagnosing the risk of suffering from a cardiovascular complication as a consequence of cardiotoxic medication
EP1615035B1 (de) * 2004-07-07 2007-06-06 F.Hoffmann-La Roche Ag Kombinationen von Markern zum Nachweis von typ 1 und 2 Diabetes
NZ555926A (en) * 2004-12-20 2008-11-28 Antibodyshop As Determination of neutrophil gelatinase-associated lipocalin (NGAL) as a diagnostic marker for renal disorders
US20070092911A1 (en) * 2005-10-03 2007-04-26 Buechler Kenneth F Methods and compositions for diagnosis and /or prognosis in systemic inflammatory response syndromes
US20080050832A1 (en) * 2004-12-23 2008-02-28 Buechler Kenneth F Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
WO2006076471A2 (en) * 2005-01-12 2006-07-20 Nobex Corporation Bnp conjugates and methods of use
US7432107B2 (en) 2005-01-24 2008-10-07 Roche Diagnostics Operations, Inc. Cardiac hormones for assessing cardiovascular risk
JP4870686B2 (ja) * 2005-01-24 2012-02-08 エフ．ホフマン−ラ ロシュ アーゲー 抗炎症剤の投与に関連する心血管リスクを評価するための心臓ホルモンの使用
EP1691200A1 (de) * 2005-02-14 2006-08-16 F. Hoffmann-La Roche Ag Verwendung des BNP-Art und ANP-Art Peptiden für das Festsetzen der Gefahren von Herzgefäß- Komplikationen als Folge der Volumenüberlastung
DE102005003687A1 (de) * 2005-01-26 2006-07-27 Sphingo Tec Gmbh Immunoassay zur Bestimmung der Freisetzung von Neurotensin in die Zirkulation
US8900815B2 (en) 2005-02-21 2014-12-02 Saga University Platelet-derived microparticles as a novel diagnosis maker for a cardiovascular disease
US20060199280A1 (en) * 2005-03-03 2006-09-07 David Bar-Or Quantification of proteins
US20070037232A1 (en) * 2005-03-31 2007-02-15 Barasch Jonathan M Detection of NGAL in chronic renal disease
US20060240444A1 (en) * 2005-04-21 2006-10-26 Peiguo Chu Detection methods
US7300631B2 (en) * 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
CN100422742C (zh) * 2005-05-16 2008-10-01 艾博（武汉）生物技术有限公司 急性心肌梗死早期诊断三合一检测试剂板
EP1904846A4 (de) * 2005-06-29 2009-03-18 Rules Based Medicine Inc Verfahren und kits zur diagnose von akutem koronarsyndrom
ES2288358B1 (es) * 2005-07-01 2008-11-16 Proyecto De Biomedicina Cima, S.L. Marcadores de fibrosis.
JP4850001B2 (ja) * 2005-09-05 2012-01-11 プリマハム株式会社 新規ストレスバイオマーカー及びその用途
IL172297A (en) 2005-10-03 2016-03-31 Compugen Ltd Soluble vegfr-1 variants for diagnosis of preeclamsia
US20080090304A1 (en) * 2006-10-13 2008-04-17 Barasch Jonathan Matthew Diagnosis and monitoring of chronic renal disease using ngal
US7399598B2 (en) * 2005-10-14 2008-07-15 Taipei Medical University Diagnosis method of endometriosis by detecting biochemical markers and usage of these biochemical markers
US20110076255A1 (en) * 2005-11-07 2011-03-31 Pecora Andrew L Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency
JP2007131548A (ja) * 2005-11-08 2007-05-31 Hirosaki Univ プロテオグリカンの新規医薬用途
NZ568992A (en) 2005-11-17 2012-01-12 Biogen Idec Inc Platelet aggregation assays comprising platelet activiating agents and agents that cross-links the CD40L-binding moiety
JP4976412B2 (ja) * 2005-12-01 2012-07-18 ベー・エル・アー・ハー・エム・エス・ゲーエムベーハー エンドセリン、エンドセリンアゴニスト及びアドレノメジュリンアンタゴニストによる危篤患者の診断及び治療のための方法
US8906857B2 (en) * 2005-12-01 2014-12-09 B.R.A.H.M.S. Gmbh Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists
GB0601058D0 (en) * 2006-01-19 2006-03-01 Univ Southampton Mast Cell Carboxypeptidase As A Marker For Anaphylaxis And Mastocytosis
US20070172888A1 (en) * 2006-01-25 2007-07-26 Klaus Hallermayer Measuring troponin antibodies to assess cardiovascular risk
US20070224643A1 (en) * 2006-03-09 2007-09-27 Mcpherson Paul H Methods and compositions for the diagnosis of diseases of the aorta
EP1837659B1 (de) * 2006-03-24 2010-06-09 F. Hoffman-la Roche AG Vorrichtung und Verfahren zur Unterscheidung zwischen akuter und chronischer Myokardial-Nekrose bei symptomatischen Patienten
CN101432626B (zh) 2006-04-04 2013-06-19 神谷来克斯公司 用于肌钙蛋白分析的高灵敏系统和方法
AU2014200749B2 (en) * 2006-04-04 2016-04-14 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
JP6325022B2 (ja) * 2006-04-04 2018-05-16 シングレックス，インコーポレイテッド トロポニンの分析のための高感度のシステムおよび方法
US7838250B1 (en) * 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
EP1845379A1 (de) 2006-04-13 2007-10-17 F. Hoffmann-La Roche AG Mittel und Verfahren zur Differenzierung kardialer und pulmonaler Ursachen von Atemnot
DE602007007595D1 (en) * 2006-04-24 2010-08-19 Univ Wien Med Ten
ES2529618T3 (es) 2006-04-24 2015-02-23 Critical Care Diagnostics, Inc. Predicción de la mortalidad y detección de enfermedades graves
ES2566169T3 (es) * 2006-05-01 2016-04-11 Critical Care Diagnostics, Inc. Diagnóstico de enfermedad cardiovascular
HUE025058T2 (en) * 2006-05-02 2016-01-28 Critical Care Diagnostics Inc Differential diagnosis of pulmonary and cardiovascular disease
US20080118924A1 (en) * 2006-05-26 2008-05-22 Buechler Kenneth F Use of natriuretic peptides as diagnostic and prognostic indicators in vascular diseases
EP2035835B1 (de) 2006-05-30 2011-12-28 Antibodyshop A/S Verfahren zur schnellen beurteilung der schwere eines traumas
US7935498B2 (en) * 2006-07-07 2011-05-03 Siemens Healthcare Diagnostics Inc. Methods for identifying patients with increased risk of an adverse cardiovascular event
EP1882945A1 (de) 2006-07-28 2008-01-30 F.Hoffmann-La Roche Ag Vorrichtungen und Verfahren zur Differentierung zwischen herz- und lungenbedingten Ursachen für akute Atemnot
WO2008015254A2 (en) 2006-08-04 2008-02-07 Medizinische Hochschule Hannover Means and methods for assessing the risk of cardiac interventions based on gdf-15
EP2602624A1 (de) * 2006-08-07 2013-06-12 Antibodyshop A/S Diagnostischer Test zum Ausschliessen einer signifikanten Nierenverletzung
EP1890153A1 (de) 2006-08-16 2008-02-20 F. Hoffman-la Roche AG Herztroponin als Indikator für fortgeschrittene Koronararterienerkrankung
US20080050749A1 (en) * 2006-08-17 2008-02-28 Ildiko Amann-Zalan Use of bnp-type peptides for the stratification of therapy with erythropoietic stimulating agents
US8158374B1 (en) 2006-09-05 2012-04-17 Ridge Diagnostics, Inc. Quantitative diagnostic methods using multiple parameters
DE602006010705D1 (de) 2006-09-15 2010-01-07 Roche Diagnostics Gmbh Biochemische Marker für akute Lungenembolie
EP1901073A1 (de) 2006-09-18 2008-03-19 Roche Diagnostics GmbH Natriuretische Peptide zur Diagnose von Herzkomplikationen infolge von Koronarkatheterisierung
DE602006015964D1 (de) * 2006-09-20 2010-09-16 Roche Diagnostics Gmbh Natriurethische Peptide und Plazenta-Wachstumfaktor/löslicher VEGF-Rezeptor unterscheiden zwischen mit der Plazenta verbundener Herzdysfunktion und mit Herzerkrankung verbundener Herzdysfunktion
DE112007003185A5 (de) 2006-10-26 2009-10-01 Brahms Aktiengesellschaft Risikostratifizierung des akuten Koronarsyndroms mittels Fragmenten / Teilpeptiden des proVasopressins, insbesondere Copeptin oder Neurophysin II
US7842472B2 (en) 2006-11-14 2010-11-30 Alere International Methods and compositions for monitoring and risk prediction in cardiorenal syndrome
US8524462B2 (en) * 2006-11-14 2013-09-03 Alere San Diego, Inc. Methods and compositions for diagnosis and prognosis of renal artery stenosis
EP1925943A1 (de) 2006-11-21 2008-05-28 F. Hoffman-la Roche AG Vorrichtungen und Verfahren zur Optimierung von diagnostischen and therapeutischen Ansätzen für chronische Arterienerkrankungen basierend auf dem Nachweis von Troponin T und NT-proBNP.
JP5240945B2 (ja) * 2006-11-28 2013-07-17 ピクター リミテッド アッセイ膜およびその使用法
EP2498095A3 (de) * 2007-01-25 2012-11-28 Roche Diagniostics GmbH Verwendung von IGFBP-7 bei der Beurteilung von Herzversagen
ES2426069T3 (es) 2007-02-12 2013-10-21 A1M Pharma Ab Diagnóstico de preeclampsia
WO2009014787A2 (en) 2007-04-30 2009-01-29 Nanogen, Inc. Multianalyte assay
EP2145184B1 (de) * 2007-03-08 2013-10-02 Roche Diagnostics GmbH Verwendung von slim-1 bei der beurteilung von herzversagen
GB0705223D0 (en) * 2007-03-19 2007-04-25 Univ Sussex Method, apparatus and computer program for analysing medical image data
CN101680903A (zh) * 2007-03-21 2010-03-24 比奥波托诊断股份公司 肾损伤的诊断试验
US8221995B2 (en) * 2007-03-23 2012-07-17 Seok-Won Lee Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US20090004755A1 (en) * 2007-03-23 2009-01-01 Biosite, Incorporated Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
DE102007022367A1 (de) * 2007-05-07 2008-11-20 B.R.A.H.M.S Ag Verfahren zur Bestimmung von aminoterminalen pro-ANP bei übergewichtigen Patienten
ES2401741T3 (es) * 2007-05-08 2013-04-24 Abbott Laboratories Ensayo de péptido natriurético de tipo B humano que tiene una reducida reactividad cruzada con otras formas péptidicas
EP1998178A1 (de) * 2007-05-29 2008-12-03 F. Hoffman-la Roche AG H-FABP als Prädiktor für Herzinfarkt
CN101896816B (zh) * 2007-06-22 2014-08-20 B.R.A.H.M.S有限公司 用于检测分析物的方法
EP2174143B1 (de) * 2007-08-03 2011-06-22 B.R.A.H.M.S GmbH Verwendung von procalcitonin (pct) zur risikostratifikation und prognose bei patienten mit einer primären nichtinfektiösen krankheit
EP2031397A1 (de) 2007-08-30 2009-03-04 F. Hoffmann-La Roche AG Surfactantproteine B und D bei der Unterscheidung der Ursachen für Atemnot
JP2011501113A (ja) 2007-10-10 2011-01-06 エフ．ホフマン−ラ ロシュ アーゲー 急性冠症候群を有する患者での既存の心筋機能不全の評価のためのナトリウム利尿ペプチド／トロポニン比
EP2538222B1 (de) * 2007-11-05 2021-08-25 Nordic Bioscience A/S Biochemische Marker zur Bewertung des CVD-Risikos
WO2009062520A1 (en) * 2007-11-15 2009-05-22 Bioporto Diagnostics A/S Diagnostic use of individual molecular forms of a biomarker
EP2231186A4 (de) 2007-12-17 2012-08-08 Dyax Corp Zusammensetzungen und verfahren zur behandlung von osteolytischen erkrankungen mit mmp-14-bindungsproteinen
AU2009221916A1 (en) 2008-03-03 2009-09-11 Dyax Corp. Metalloproteinase 9 and metalloproteinase 2 binding proteins
EP2262529A4 (de) 2008-03-03 2013-05-08 Dyax Corp Metalloproteinase-9-bindungsproteine
US7927880B2 (en) 2008-05-21 2011-04-19 Mohan Rajapurkar Methods and kit for early detection of acute coronary syndrome and prediction of adverse cardiac events
ES2420841T3 (es) * 2008-03-05 2013-08-27 Mohan Rajapurkar Procedimientos para la detección precoz del síndrome coronario agudo y predicción de acontecimientos cardiacos adversos
US20090234202A1 (en) * 2008-03-05 2009-09-17 Goix Philippe J Method and compositions for highly sensitive detection of molecules
EP2103943A1 (de) 2008-03-20 2009-09-23 F. Hoffman-la Roche AG GDF-15 zur Beurteilung eines kardiovaskulären Risikos hinsichtlich Verabreichung von Entzündungshemmern
DK2660599T3 (en) 2008-04-18 2014-12-08 Critical Care Diagnostics Inc PREDICTION OF RISK OF MAJOR ADVERSE HEART EVENTS
JP5419968B2 (ja) 2008-05-21 2014-02-19 エフ．ホフマン−ラ ロシュ アーゲー 心臓治療を必要とする個体におけるｌ−ｆａｂｐ、ナトリウム利尿ペプチド及び心筋トロポニン
US8497078B2 (en) 2008-05-23 2013-07-30 The Johns Hopkins University Biomarkers for myocardial ischemia
EP2133696A1 (de) 2008-06-10 2009-12-16 Eberhardt Spanuth Sehr geringe Konzentrationen von Troponin I oder T zur Beurteilung eines kardiovaskulären Risikos hinsichtlich der Verabreichung von Entzündungshemmern
WO2009150253A1 (en) * 2008-06-13 2009-12-17 F. Hoffmann La-Roche Ag Assessment of complications of patients with type 1 diabetes
JP2011528798A (ja) * 2008-07-23 2011-11-24 エフ．ホフマン−ラ ロシュ アーゲー 抗血管形成療法のモニター
EP2321651B1 (de) 2008-07-23 2017-08-23 F. Hoffmann-La Roche AG Identifikation von für eine anti-angiogenese-therapie geeigneten personen
EP2148203A1 (de) * 2008-07-23 2010-01-27 BRAHMS Aktiengesellschaft Azurophili-Granulat-Proteasen als Marker bei Herzkrankheiten
WO2010017972A1 (en) 2008-08-13 2010-02-18 Roche Diagnostics Gmbh D-dimer, troponin, nt-probnp for pulmonary embolism
JP5550021B2 (ja) * 2008-08-28 2014-07-16 株式会社島津製作所 血液試料を用いて心筋虚血状態を評価する方法
CA2740736A1 (en) * 2008-10-15 2010-04-22 Ridge Diagnostics, Inc. Human biomarker hypermapping for depressive disorders
US20120083421A1 (en) * 2008-10-16 2012-04-05 The Trustees Of Columbia University In The City Of New York Use of urinary ngal to diagnose and monitor hiv-associated nephropathy (hivan)
EP2347266B9 (de) * 2008-11-11 2014-02-12 B.R.A.H.M.S GmbH Prognose und risikobeurteilung bei an herzinsuffizienz leidenden patienten durch bestimmen des adm-spiegels
EP2356453A4 (de) * 2008-11-18 2012-08-15 Ridge Diagnostics Inc Stoffwechselsyndrom- und hpa-achsen-biomarker für schwere depression
US8457724B2 (en) * 2008-12-11 2013-06-04 Siemens Medical Solutions Usa, Inc. System for heart performance characterization and abnormality detection
CN102341705B (zh) * 2009-03-05 2015-08-19 味之素株式会社 克罗恩氏病诊断试剂
CA2754741C (en) * 2009-03-11 2019-02-12 Augurex Life Sciences Corporation Compositions and methods for characterizing arthritic conditions
US20110213219A1 (en) * 2010-01-26 2011-09-01 Ridge Diagnostics, Inc. Multiple Biomarker Panels to Stratify Disease Severity and Monitor Treatment of Depression
CN102460153A (zh) * 2009-04-06 2012-05-16 里奇诊断学股份有限公司 监控神经精神疾病治疗的生物标记
JP5871791B2 (ja) 2009-04-29 2016-03-01 アカデミス・メディス・セントルム・ベイ・デ・ウニフェルジテイト・ファン・アムステルダムＡｃａｄｅｍｉｓｃｈ Ｍｅｄｉｓｃｈ Ｃｅｎｔｒｕｍ Ｂｉｊ Ｄｅ Ｕｎｉｖｅｒｓｉｔｅｉｔ Ｖａｎ Ａｍｓｔｅｒｄａｍ 心不全または心不全の危険性を中和、予防および／または決定する手段および方法
WO2010138610A2 (en) * 2009-05-26 2010-12-02 The Johns Hopkins University Novel desmin phosphorylation sites useful in diagnosis and intervention of cardiac disease
AU2010259022B2 (en) * 2009-06-08 2016-05-12 Singulex, Inc. Highly sensitive biomarker panels
WO2010143422A1 (ja) * 2009-06-10 2010-12-16 国立大学法人 新潟大学 腎疾患の検査方法
WO2011006072A2 (en) * 2009-07-10 2011-01-13 Northwestern University Cardioprotective role of hepatic cells and hepatocyte secretory factors in myocardial ischemia
BR112012006105A2 (pt) 2009-09-17 2016-06-07 Hoffmann La Roche painel de múltiplos marcadores de hipertrofia ventricular esquerda.
EP2491395B1 (de) 2009-10-21 2015-09-16 The Scripps Research Institute Verfahren zur verwendung nicht seltener zellen zur erkennung seltener zellen
US20120288481A1 (en) 2009-11-09 2012-11-15 The Brigham And Women's Hospital, Inc. Treatment of heart disease
US20120321595A1 (en) 2009-11-09 2012-12-20 The Brigham And Women's Hospital, Inc. Treatment of heart disease
EA201290311A1 (ru) * 2009-11-13 2012-12-28 БиДжи МЕДИСИН, ИНК. Факторы риска и прогнозирование инфаркта миокарда
WO2011063470A1 (en) 2009-11-27 2011-06-03 Baker Idi Heart And Diabetes Institute Holdings Limited Lipid biomarkers for stable and unstable heart disease
ES2647461T3 (es) 2009-12-18 2017-12-21 F. Hoffmann-La Roche Ag GDF-15 y/o troponina T para predecir insuficiencia renal en pacientes con cirugía cardíaca
WO2011098519A1 (en) 2010-02-12 2011-08-18 Synlab Medizinisches Versorgungszentrum Heidelberg Gmbh Homoarginine as a biomarker for the risk of mortality
AU2011231982B2 (en) * 2010-03-24 2014-02-20 Preelumina Diagnostics Ab HbF and A1M as early stage markers for preeclampsia
US20110301053A1 (en) 2010-05-06 2011-12-08 Singulex, Inc. Methods for Diagnosing, Staging, Predicting Risk for Developing and Identifying Treatment Responders for Rheumatoid Arthritis
EP2388594A1 (de) 2010-05-17 2011-11-23 Roche Diagnostics GmbH Mittel auf GDF-15-Basis sowie Verfahren zur Überlebens- und Genesungsvorhersage bei akuter Entzündung
WO2011149962A1 (en) 2010-05-24 2011-12-01 The Trustees Of Columbia University In The City Of New York Mutant ngal proteins and uses thereof
US8602996B2 (en) 2010-06-01 2013-12-10 Cardiac Pacemakers, Inc. Integrating device-based sensors and bedside biomarker assays to detect worsening heart failure
AU2011280878B2 (en) 2010-07-23 2016-06-16 Astellas Institute For Regenerative Medicine Methods for detection of rare subpopulations of cells and highly purified compositions of cells
CN101942416B (zh) * 2010-07-23 2012-03-28 中国医学科学院放射医学研究所 抗人心肌肌钙蛋白i特异性单克隆抗体及其制备方法
WO2012018535A2 (en) * 2010-07-26 2012-02-09 Wellness Indicators, Inc. Wellness panel
WO2012020045A1 (en) 2010-08-10 2012-02-16 Roche Diagnostics Gmbh Method for selecting patients with stable coronary artery disease for pci or medical treatment
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
EP2367006A1 (de) 2010-08-24 2011-09-21 Roche Diagnostics GmbH Mittel und Verfahren auf PLGF-Basis zur Diagnose kardialer Ursachen bei akuten Entzündungen
EP2609427B1 (de) 2010-08-26 2015-01-21 Roche Diagnostics GmbH Verwendung von Biomarkern bei der Beurteilung des frühen Übergangs von arteriellem Bluthochdruck zu Herzinsuffizienz
EP2439535A1 (de) 2010-10-07 2012-04-11 F. Hoffmann-La Roche AG Diagnose von Herzerkrankungen im Zusammenhang mit Diabetes und GDF-15 und Troponin als Prädiktor für die Entwicklung von Diabetes mellitus Typ 2
EP2447720A1 (de) 2010-10-26 2012-05-02 Roche Diagnostics GmbH sFlt1 und Lungenkomplikationen
US8868168B2 (en) 2010-11-11 2014-10-21 Siemens Medical Solutions Usa, Inc. System for cardiac condition characterization using electrophysiological signal data
US8818494B2 (en) 2010-11-29 2014-08-26 Siemens Medical Solutions Usa, Inc. System for ventricular function abnormality detection and characterization
EP2383579A1 (de) 2010-12-17 2011-11-02 F. Hoffmann-La Roche AG sFlt-1, Kardiotroponine und natriuretische Peptide beim Nachweis einer Therapie mit HER-2-Inhibitoren
EP2666017B1 (de) * 2011-01-20 2018-10-03 Cyrex Laboratories, LLC Verfahren und vorrichtung zum nachweis einer glutenempfindlichkeit und zu ihrer differenzierung von zöliakie
GB2490652A (en) * 2011-04-18 2012-11-14 Microtest Matrices Ltd Methods of quantifying antibodies, especially IgE antibodies in a sample
WO2012151349A1 (en) 2011-05-03 2012-11-08 Liu Shu Q Neuroprotection by hepatic cells and hepatocyte secretory factors
US8684942B2 (en) 2011-05-25 2014-04-01 Siemens Medical Solutions Usa, Inc. System for cardiac impairment detection based on signal regularity
EP2385373A1 (de) 2011-07-01 2011-11-09 F. Hoffmann-La Roche AG Natriuretische Peptide bei der Schwangerschaft
US20120258477A1 (en) * 2011-07-25 2012-10-11 Northwestern University Fecal neopterin concentration measurement as an indicator of disease activity in inflammatory bowel disease
EP2581040A1 (de) 2011-10-10 2013-04-17 Roche Diagnostics GmbH TNT-basiertes Herzhypertrophierisiko im Zusammenhang mit physiologischem Training und Führung in Athleten
CN105785053B (zh) 2011-10-17 2018-09-21 霍夫曼-拉罗奇有限公司 风险患者和中风原因的基于肌钙蛋白和bnp的诊断
US10314909B2 (en) 2011-10-21 2019-06-11 Dyax Corp. Combination therapy comprising an MMP-14 binding protein
SG11201402354YA (en) 2011-11-16 2014-06-27 Adrenomed Ag Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for regulating the fluid balance in a patient having a chronic or acute disease
EP2780717B1 (de) 2011-11-16 2016-12-21 sphingotec GmbH Adrenomedullintests und verfahren zur bestimmung von reifem adrenomedullin
PT3553084T (pt) 2011-11-16 2023-02-17 Adrenomed Ag Anticorpo anti-adrenomedulina (adm) ou fragmento de anticorpo anti-adm ou esqueleto não-ig anti-adm para prevenção ou redução de disfunção de órgãos ou insuficiência de órgãos num paciente possuindo uma doença crónica ou aguda ou condição aguda
SG11201402358RA (en) 2011-11-16 2014-06-27 Adrenomed Ag Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in therapy of an acute disease or acute condition of a patient for stabilizing the circulation
CN104094121B (zh) 2011-12-01 2016-10-26 霍夫曼-拉罗奇有限公司 用于诊断中风的nt-原anp和nt-原bnp
CN103163295B (zh) * 2011-12-08 2015-11-18 吴宗贵 一种用于急性冠脉综合征的液相芯片试剂盒以其制备方法
WO2013087887A2 (en) * 2011-12-15 2013-06-20 Pronota N.V. Biomarkers and parameters for hypertensive disorders of pregnancy
JP5814800B2 (ja) * 2011-12-28 2015-11-17 株式会社Ｌｓｉメディエンス 神経変性疾患の検出方法
EP2620773B1 (de) 2012-01-26 2015-03-18 Roche Diagniostics GmbH Verfahren zur Differenzierung eines Vor- und Rückwärtsherzversagens
US20130196870A1 (en) * 2012-01-31 2013-08-01 Medical University Of South Carolina Systems and methods using biomarker panel data
US10502747B2 (en) 2012-01-31 2019-12-10 Cardiac Pacemakers, Inc. Systems and methods using biomarker panel data
EP2650684A1 (de) 2012-04-10 2013-10-16 Roche Diagniostics GmbH Diagnose auf Pro-SP-B und NT-proBNP bei Patienten mit Lungenentzündung
US8903480B2 (en) 2012-04-11 2014-12-02 Siemens Medical Solutions Usa, Inc. System for cardiac condition detection using heart waveform area associated analysis
CN104428674A (zh) * 2012-04-24 2015-03-18 思研（Sri）国际顾问与咨询公司 前列腺癌和sar-cov的人血清生物标记物
EP2615459A1 (de) 2012-04-27 2013-07-17 Roche Diagniostics GmbH Verfahren zur Diagnose von Distalbronchoalveolargewebeschäden in Asthma durch Erkennen von proSP-B
WO2013181127A1 (en) * 2012-05-30 2013-12-05 Clarient Diagnostic Services, Inc. Multiplexed assay method for lung cancer classification
JPWO2013183725A1 (ja) * 2012-06-06 2016-02-01 国立大学法人九州大学 非ヒトモデル動物、非ヒトモデル動物の作製方法及び抗血栓薬のスクリーニング方法
EP2600155A1 (de) 2012-06-18 2013-06-05 Roche Diagniostics GmbH sFlt-1-basierte Diagnose und Überwachung von Schlaganfallpatienten
EP2597466A1 (de) 2012-06-26 2013-05-29 Roche Diagniostics GmbH Mittel und Verfahren zur proSP-B-basierten Diagnose von Alveolenbeschädigung bei Patienten mit pulmonaler Hypertonie
EP2597467A1 (de) 2012-06-26 2013-05-29 Roche Diagniostics GmbH Mittel und Verfahren zur proSP-B-basierten Diagnose von Lungenstauung bei Patienten mit akutem Koronarsyndrom
WO2014009418A1 (en) 2012-07-10 2014-01-16 Roche Diagnostics Gmbh TnT, NTproBNP, sFlt-1 for CURB65 IN PNEUMONIA
HK1212057A1 (en) 2012-08-21 2016-06-03 重症监护诊断股份有限公司 Multimarker risk stratification
ES2680149T3 (es) 2012-09-12 2018-09-04 F. Hoffmann-La Roche Ag Identificación de pacientes con fracción de acortamiento anormal
EP2904398B1 (de) * 2012-10-02 2018-04-11 SphingoTec GmbH Verfahren zur vorhersage des risikos von krebs bei einer weiblichen patientin
US20140273273A1 (en) 2012-11-01 2014-09-18 Christie Mitchell Ballantyne Biomarkers to improve prediction of heart failure risk
EP2730923A1 (de) 2012-11-09 2014-05-14 Roche Diagniostics GmbH NTproBNP- und cTnT-basierte Therapieanleitung bei Herzversagen
CN108120837B (zh) 2012-11-09 2021-06-22 霍夫曼-拉罗奇有限公司 阵发性心房纤颤的基于TnT的诊断
EP2925337B1 (de) 2012-11-21 2019-07-03 The Trustees of Columbia University in the City of New York Mutante ngal-proteine und verwendungen davon
CN113759128A (zh) 2012-12-04 2021-12-07 霍夫曼-拉罗奇有限公司 心力衰竭疗法的选择中的生物标记物
DE102012223378A1 (de) * 2012-12-17 2014-06-18 Charité - Universitätsmedizin Berlin In-vitro Verfahren und Kit zur Diagnose von akutem Koronarsyndrom
ES2676893T3 (es) * 2012-12-20 2018-07-26 National University Corporation Hokkaido University Método para detectar células basales prostáticas
US20160116472A1 (en) * 2013-02-04 2016-04-28 The General Hospital Corporation Biomarkers for stroke diagnosis
KR101494882B1 (ko) * 2013-02-21 2015-02-25 한국과학기술연구원 급성 심근 경색 진단용 조성물, 그 조성물을 포함하는 급성 심근 경색 진단용 키트 및 급성 심근 경색 진단 방법
US9020583B2 (en) 2013-03-13 2015-04-28 Siemens Medical Solutions Usa, Inc. Patient signal analysis and characterization
EP2866033A1 (de) 2013-10-23 2015-04-29 Roche Diagniostics GmbH Differenzialdiagnose von akuter Atemnot auf Basis von c-terminiertem proSP-B, KL-6 und BNP-Peptiden
US20160231334A1 (en) * 2013-10-28 2016-08-11 The Forsyth Institute Compositions and Methods for Evaluating Metabolic Syndrome and Related Diseases
AU2014343709B2 (en) 2013-11-04 2020-11-19 The Regents Of The University Of Michigan Biomarkers and methods for progression prediction for chronic kidney disease
CA2930790A1 (en) * 2013-11-15 2015-05-21 Christopher Joseph Pemberton Biomarker for cardiac disorders
EP3099821B1 (de) * 2014-01-27 2021-08-11 Epic Sciences, Inc. Diagnostika für zirkulierende tumorzellen zum nachweis von neuroendokrinem prostatakrebs (nepc)
ES2712201T3 (es) 2014-01-28 2019-05-09 Hoffmann La Roche Biomarcadores para la evaluación de riesgos y la monitorización del tratamiento en pacientes de insuficiencia cardíaca que han recibido terapia guiada por el péptido natriurético de tipo B
EA201691682A1 (ru) 2014-02-21 2017-02-28 Эпик Сайенсиз, Инк. Способы анализирования редких циркулирующих в крови клеток
EP2916134B1 (de) 2014-03-05 2017-08-16 Roche Diagnostics GmbH Verwendung von Seprase zur Differenzialdiagnose von akuter Atemnot
EP3413052B1 (de) 2014-03-26 2022-12-28 Roche Diagnostics GmbH Igfbp7 zur diagnose von diastolischer dysfunktion
KR102328327B1 (ko) 2014-09-26 2021-11-22 소마로직, 인크. 심혈관 위험 사건 예측 및 이의 용도
SG11201705444QA (en) * 2015-01-09 2017-07-28 Global Genomics Group Llc Blood based biomarkers for diagnosing atherosclerotic coronary artery disease
EP3411721A1 (de) 2016-02-04 2018-12-12 Metanomics GmbH Mittel und verfahren zur differenzierung zwischen herzinsuffizienz und lungenerkrankung bei einer person
US11226343B2 (en) * 2016-04-08 2022-01-18 Biothelis Methods and kits for diagnosing postoperative pulmonary infections in patients who underwent surgery
EP3279665B1 (de) 2016-08-04 2020-07-08 Roche Diagniostics GmbH Zirkulierende esm-1 (endocan) bei der beurteilung von vorhofflimmern
WO2018069487A1 (en) 2016-10-14 2018-04-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for predicting the risk of loss of renal function in patients with type 2 diabetes
WO2018127372A1 (en) 2016-12-13 2018-07-12 Witteman Johanna Cornelia Maria Detection of transient troponin peaks for diagnosis of subjects at high risk of cardiovascular disease
EP3360570A1 (de) 2017-02-13 2018-08-15 Roche Diagnostics GmbH Monoklonale antikörper für nt-probnp punktmutationen
US20210018507A1 (en) * 2018-03-04 2021-01-21 Mazumdar Shaw Medical Foundation Sall.ivary protein biomarkers for the diagnosis and prognosis of head and neck cancers, and precancers
JP7334910B2 (ja) * 2018-03-30 2023-08-29 栄研化学株式会社 新規大動脈瘤マーカー
EP3572813A1 (de) * 2018-05-22 2019-11-27 Centre National de la Recherche Scientifique Diagnoseverfahren von multipler sklerose
IT201800007264A1 (it) * 2018-07-17 2020-01-17 Metodo per la diagnosi in vitro di carcinoma della prostata mediante biomarcatori urinari
CN113167799B (zh) 2018-07-31 2025-01-10 豪夫迈·罗氏有限公司 循环DKK3(Dickkopf相关蛋白3)在心房颤动评定中的应用
KR20210044216A (ko) 2018-08-10 2021-04-22 에프. 호프만-라 로슈 아게 심방세동-관련 뇌졸중 평가를 위한 ces-2 (카르복실에스테라제-2)
EP3837549A1 (de) 2018-08-16 2021-06-23 Roche Diagnostics GmbH Zirkulierendes tfpi-2 (gewebefaktorpfadinhibitor 2) bei der beurteilung von vorhofflimmern und der antikoagulationstherapie
KR20210044257A (ko) 2018-08-17 2021-04-22 에프. 호프만-라 로슈 아게 심방 세동의 평가에서의 순환 bmp10 (골형성 단백질 10)
WO2020039001A1 (en) 2018-08-22 2020-02-27 Roche Diagnostics Gmbh Circulating spon-1 (spondin-1) in the assessment of atrial fibrillation
EP3841382A1 (de) 2018-08-24 2021-06-30 Roche Diagnostics GmbH Zirkulierendes fgfbp-1 (fibroblasten-wachstumsfaktor-bindendes protein 1) bei der beurteilung von vorhofflimmern und zur vorhersage von schlaganfall
WO2020064995A1 (en) 2018-09-28 2020-04-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of biomarkers representing cardiac, vascular and inflammatory pathways for the prediction of acute kidney injury in patients with type 2 diabetes
CN111192687A (zh) * 2018-11-14 2020-05-22 复旦大学附属儿科医院 一种进展期阑尾炎列线图预测模型及其用途
CN113439214A (zh) * 2019-02-21 2021-09-24 勃拉姆斯有限公司 用于诊断经历了胃肠道手术的患者的macce的方法
WO2020214166A1 (en) * 2019-04-17 2020-10-22 The Governors Of The University Of Alberta Treatment of autoimmune liver disease
GB201906199D0 (en) * 2019-05-02 2019-06-19 Belgian Volition Sprl Method for the detection of cancer
CN113939741B (zh) 2019-05-23 2025-07-22 豪夫迈·罗氏有限公司 HFpEF的IGFBP7比率
JP2022544169A (ja) * 2019-08-07 2022-10-17 エディフィス・ヘルス・インコーポレイテッド 心血管疾患の処置および予防
WO2021165465A1 (en) 2020-02-20 2021-08-26 Universiteit Maastricht Detection method of circulating bmp10 (bone morphogenetic protein 10)
CN116547537A (zh) 2020-07-29 2023-08-04 皮克托有限公司 SARS-CoV-2抗体免疫测定
EP4222499A1 (de) 2020-09-30 2023-08-09 F. Hoffmann-La Roche AG Zirkulierendes total-nt-probnp (glycosyliertes und unglycosyliertes nt-probnp) und sein verhältnis mit nt-probnp (unglycosyliertem nt-probnp) bei der beurteilung von vorhofflimmern
CN114182010B (zh) * 2022-01-11 2022-06-07 首都医科大学附属北京朝阳医院 一种血浆外泌体circRNA标志物及其应用
WO2023175152A1 (en) 2022-03-18 2023-09-21 Roche Diagnostics Gmbh Troponin marker combinations for early discrimination of type 2 versus type 1 acute myocardial infarction
CN118922721A (zh) 2022-03-18 2024-11-08 豪夫迈·罗氏有限公司 用于2型与1型急性心肌梗死的早期辨别的cMyBPC标志物组合
CN115356486A (zh) * 2022-08-19 2022-11-18 华中科技大学同济医学院附属同济医院 一种变异型心绞痛的辅助诊断试剂、试剂盒及其应用
WO2024100050A1 (en) 2022-11-07 2024-05-16 Hôpitaux Universitaires Saint-Louis-Lariboisière Rapid optimization of oral heart failure therapies helped by nt-probnp testing
EP4365598A1 (de) 2022-11-07 2024-05-08 Hôpitaux Universitaires Saint-Louis-Lariboisière Schnelle optimierung von oralen herzinsuffizienztherapien mithilfe von nt-probnp-tests
CN115902237B (zh) * 2022-11-09 2024-09-27 哈尔滨医科大学 用于判断急性心肌梗死后心源性猝死的生物标志物及其应用
WO2024160752A1 (en) 2023-01-30 2024-08-08 F. Hoffmann-La Roche Ag Effect induced by a sodium-glucose cotransporter inhibitor (SGLTi) in a subject suffering from a cardiovascular disease
JPWO2024190857A1 (de) * 2023-03-15 2024-09-19
CN121713069A (zh) 2023-08-22 2026-03-20 豪夫迈·罗氏有限公司 间质液中心血管标志物的监测及其在心力衰竭评定中的应用
CN121713064A (zh) 2023-08-23 2026-03-20 豪夫迈·罗氏有限公司 电化学免疫测定
EP4685484A1 (de) 2024-07-25 2026-01-28 Target Cells Spólka z ograniczona odpowiedzialnoscia Verfahren, assay und verwendung von saueren alpha-1 glykoprotein zur bestimmung der bindungskapazität von stammzellen

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5114923A (en) 1988-05-31 1992-05-19 California Biotechnology Inc. Recombinant techniques for production of novel natriuretic and vasodilator peptides
US5453359A (en) 1988-06-13 1995-09-26 American Biogenetic Sciences, Inc. Immunoassay and kit for in vitro detection of soluble DesAABB fibrin polymers
US5206140A (en) * 1988-06-24 1993-04-27 Research Corporation Technologies, Inc. Assay for soluble crosslinked fibrin polymers
US5422393A (en) 1988-07-11 1995-06-06 Naturon Pharmaceutical Corporation Natriuretic hormone
US5939272A (en) 1989-01-10 1999-08-17 Biosite Diagnostics Incorporated Non-competitive threshold ligand-receptor assays
US5028535A (en) 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
ATE170192T1 (de) 1989-06-23 1998-09-15 Genentech Inc Zusammensetzungen und methoden zur synthese des b-rezeptors für das natriuretische protein und verwendungsmethoden
US5922615A (en) 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
CA2072758A1 (en) 1990-09-14 1992-03-15 Kenneth Francis Buechler Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays
CA2027434C (en) * 1990-10-12 1999-01-05 George Jackowski Diagnostic kit for diagnosing and distinguishing chest pain in early onset thereof
US5955377A (en) 1991-02-11 1999-09-21 Biostar, Inc. Methods and kits for the amplification of thin film based assays
ATE177841T1 (de) 1991-04-10 1999-04-15 Biosite Diagnostics Inc ''crosstalk''- oder übersprech-inhibitoren und ihre verwendung
CA2107899A1 (en) 1991-04-10 1992-10-11 Gunars Edwin Valkirs Novel conjugates and assays for simultaneous detection of multiple ligands
US6143576A (en) 1992-05-21 2000-11-07 Biosite Diagnostics, Inc. Non-porous diagnostic devices for the controlled movement of reagents
US5885527A (en) 1992-05-21 1999-03-23 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membrances
GB9211686D0 (en) 1992-06-03 1992-07-15 Medisinsk Innovation A S Chemical compounds
US5494829A (en) 1992-07-31 1996-02-27 Biostar, Inc. Devices and methods for detection of an analyte based upon light interference
US6147688A (en) 1993-06-28 2000-11-14 Athena Design Systems, Inc. Method and apparatus for defining and selectively repeating unit image cells
US5824799A (en) 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
US5795725A (en) 1995-04-18 1998-08-18 Biosite Diagnostics Incorporated Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays
AU1981597A (en) * 1996-03-04 1997-09-22 Scios Inc. Assay and reagents for quantifying hbnp
US6028055A (en) 1996-10-22 2000-02-22 Genetech, Inc. Receptor selective BNP
US6113855A (en) 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
US6156521A (en) 1997-12-19 2000-12-05 Biosite Diagnostics, Inc. Methods for the recovery and measurement of troponin complexes
US5947124A (en) 1997-03-11 1999-09-07 Biosite Diagnostics Incorporated Diagnostic for determining the time of a heart attack
US6057098A (en) 1997-04-04 2000-05-02 Biosite Diagnostics, Inc. Polyvalent display libraries
AU728558B2 (en) 1997-04-30 2001-01-11 Maruha Nichiro Seafoods, Inc. Method for detecting or predicting ischemic diseases
US6117644A (en) 1998-06-04 2000-09-12 Ottawa Heart Institute Research Corporation Predicting and detecting cardiac allograft rejection
US6171870B1 (en) 1998-08-06 2001-01-09 Spectral Diagnostics, Inc. Analytical test device and method for use in medical diagnoses
US6309888B1 (en) * 1998-09-04 2001-10-30 Leuven Research & Development Vzw Detection and determination of the stages of coronary artery disease
AU761451B2 (en) 1998-09-29 2003-06-05 Vladimir Berezin NCAM binding compounds
CA2263063C (en) * 1999-02-26 2004-08-10 Skye Pharmatech Incorporated Method for diagnosing and distinguishing stroke and diagnostic devices for use therein
AT407580B (de) 1999-08-20 2001-04-25 Biomedica Gmbh Indikatorpeptid zur diagnose und/oder vorhersage von cardiovasculären und/oder endothelialen erkrankungen, antikörperzusammensetzung und immunoassay
AUPQ893300A0 (en) 2000-07-21 2000-08-17 Newbrain Technologies Pty Limited Method and system for utilising database information
US6670138B2 (en) 2000-11-01 2003-12-30 Agy Therapeutics, Inc. Method of diagnosing ischemic stroke via UCP-2 detection
US7632647B2 (en) 2001-04-13 2009-12-15 Biosite Incorporated Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
WO2003002530A2 (en) * 2001-06-27 2003-01-09 Smithkline Beecham Corporation Pyrrolidines as dipeptidyl peptidase inhibitors
US6627457B2 (en) 2001-07-30 2003-09-30 Quest Diagnostics Investments Incorporated Methods for detecting pregnancy
US6461828B1 (en) * 2001-09-04 2002-10-08 Syn X Pharma Conjunctive analysis of biological marker expression for diagnosing organ failure
MXPA03004105A (es) * 2002-05-14 2004-10-15 Hoffmann La Roche Elaboracion de una prognosis en casos de enfermedad cardiaca usando una combinacion de marcadores.

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JP2005121664A (ja) 2005-05-12
EP1322957B1 (de) 2009-08-12
DE60233301D1 (de) 2009-09-24
EP1666881B1 (de) 2010-02-17
US7361473B2 (en) 2008-04-22
JP2006234823A (ja) 2006-09-07
EP1666881A2 (de) 2006-06-07
CA2414073A1 (en) 2002-11-14
JP4235652B2 (ja) 2009-03-11
EP2261669A1 (de) 2010-12-15
US20060063204A1 (en) 2006-03-23
EP1666881A3 (de) 2007-09-19
EP1322957A2 (de) 2003-07-02
JP2004520598A (ja) 2004-07-08
US20030109420A1 (en) 2003-06-12
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JP3806694B2 (ja) 2006-08-09
DE60235416D1 (de) 2010-04-01
EP1322957A4 (de) 2005-11-02
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US7358055B2 (en) 2008-04-15
WO2002089657A2 (en) 2002-11-14

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