ATE461940T1 - Bindungsmoleküle abgeleitet aus immunglobulinen, die die komplementvermittelte lyse nicht veranlassen - Google Patents

Bindungsmoleküle abgeleitet aus immunglobulinen, die die komplementvermittelte lyse nicht veranlassen

Info

Publication number
ATE461940T1
ATE461940T1 AT99920998T AT99920998T ATE461940T1 AT E461940 T1 ATE461940 T1 AT E461940T1 AT 99920998 T AT99920998 T AT 99920998T AT 99920998 T AT99920998 T AT 99920998T AT E461940 T1 ATE461940 T1 AT E461940T1
Authority
AT
Austria
Prior art keywords
binding
disclosed
molecule
domains
domain
Prior art date
Application number
AT99920998T
Other languages
English (en)
Inventor
Kathryn Armour
Michael Clark
Lorna Williamson
Original Assignee
Cambridge Entpr Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Entpr Ltd filed Critical Cambridge Entpr Ltd
Application granted granted Critical
Publication of ATE461940T1 publication Critical patent/ATE461940T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2893—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/34—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT99920998T 1998-05-08 1999-05-07 Bindungsmoleküle abgeleitet aus immunglobulinen, die die komplementvermittelte lyse nicht veranlassen ATE461940T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9809951.8A GB9809951D0 (en) 1998-05-08 1998-05-08 Binding molecules
PCT/GB1999/001441 WO1999058572A1 (en) 1998-05-08 1999-05-07 Binding molecules derived from immunoglobulins which do not trigger complement mediated lysis

Publications (1)

Publication Number Publication Date
ATE461940T1 true ATE461940T1 (de) 2010-04-15

Family

ID=10831753

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99920998T ATE461940T1 (de) 1998-05-08 1999-05-07 Bindungsmoleküle abgeleitet aus immunglobulinen, die die komplementvermittelte lyse nicht veranlassen

Country Status (21)

Country Link
US (1) US7597889B1 (de)
EP (1) EP1075496B1 (de)
JP (1) JP4511035B2 (de)
KR (1) KR100634853B1 (de)
CN (1) CN1250570C (de)
AT (1) ATE461940T1 (de)
AU (1) AU752185C (de)
BR (1) BR9910281A (de)
CA (1) CA2326501C (de)
DE (1) DE69942178D1 (de)
EE (1) EE200000643A (de)
ES (1) ES2342238T3 (de)
GB (1) GB9809951D0 (de)
HU (1) HUP0101915A3 (de)
NO (1) NO328687B1 (de)
NZ (1) NZ507694A (de)
PL (1) PL343931A1 (de)
RU (1) RU2226196C2 (de)
TR (1) TR200003292T2 (de)
WO (1) WO1999058572A1 (de)
ZA (1) ZA200005870B (de)

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GB9809951D0 (en) 1998-07-08
EP1075496A1 (de) 2001-02-14
NO328687B1 (no) 2010-04-26
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RU2226196C2 (ru) 2004-03-27
ZA200005870B (en) 2002-10-25
WO1999058572A1 (en) 1999-11-18
DE69942178D1 (de) 2010-05-06
BR9910281A (pt) 2001-01-02
NZ507694A (en) 2003-07-25
HUP0101915A2 (hu) 2001-09-28
TR200003292T2 (tr) 2001-03-21
CA2326501A1 (en) 1999-11-18
JP2002514406A (ja) 2002-05-21
JP4511035B2 (ja) 2010-07-28
ES2342238T3 (es) 2010-07-02
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CA2326501C (en) 2010-10-26
US7597889B1 (en) 2009-10-06
HK1039624A1 (en) 2002-05-03
PL343931A1 (en) 2001-09-10
EP1075496B1 (de) 2010-03-24
AU752185B2 (en) 2002-09-12
KR100634853B1 (ko) 2006-10-17
KR20010034847A (ko) 2001-04-25
AU752185C (en) 2003-09-18
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NO20005612D0 (no) 2000-11-07
CN1308637A (zh) 2001-08-15
AU3837399A (en) 1999-11-29

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