ATE468536T1 - Verfahren zur messung von adamts13-aktivität auf der blutplättchenoberfläche. - Google Patents

Verfahren zur messung von adamts13-aktivität auf der blutplättchenoberfläche.

Info

Publication number
ATE468536T1
ATE468536T1 AT04778605T AT04778605T ATE468536T1 AT E468536 T1 ATE468536 T1 AT E468536T1 AT 04778605 T AT04778605 T AT 04778605T AT 04778605 T AT04778605 T AT 04778605T AT E468536 T1 ATE468536 T1 AT E468536T1
Authority
AT
Austria
Prior art keywords
adamts13 activity
platelet surface
measuring adamts13
assays
measuring
Prior art date
Application number
AT04778605T
Other languages
English (en)
Inventor
Robert Greenfield
Safi Ranzurmal
Original Assignee
American Diagnostica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Diagnostica Inc filed Critical American Diagnostica Inc
Application granted granted Critical
Publication of ATE468536T1 publication Critical patent/ATE468536T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/222—Platelet disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/226—Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT04778605T 2004-07-19 2004-07-19 Verfahren zur messung von adamts13-aktivität auf der blutplättchenoberfläche. ATE468536T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2004/023177 WO2006019379A1 (en) 2004-07-19 2004-07-19 Methods for measuring adamts13 activity and protein on platelets and in plasma

Publications (1)

Publication Number Publication Date
ATE468536T1 true ATE468536T1 (de) 2010-06-15

Family

ID=35907688

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04778605T ATE468536T1 (de) 2004-07-19 2004-07-19 Verfahren zur messung von adamts13-aktivität auf der blutplättchenoberfläche.

Country Status (5)

Country Link
EP (1) EP1779117B1 (de)
AT (1) ATE468536T1 (de)
DE (1) DE602004027314D1 (de)
ES (1) ES2348397T3 (de)
WO (1) WO2006019379A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2897340C (en) * 2013-01-09 2022-09-06 Friedrich-Alexander-Universitat Erlangen-Nuernberg Method for in vitro detection and monitoring of a disease by measuring disease-associated protease activity in extracellular vesicles
CN105833255A (zh) * 2016-03-23 2016-08-10 兆科药业(合肥)有限公司 抗血小板溶栓素在制备治疗血栓性血小板减少性紫癜的药物中的应用
CN110139935A (zh) 2016-10-11 2019-08-16 美国控股实验室公司 用于测定adamts13酶活性的方法和系统

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
US20050153383A1 (en) * 2000-07-28 2005-07-14 Montgomery Robert R. Synthetic and recombinant substrates for the detecion of the von willebrand factor-cleaving protease
US6926894B2 (en) * 2000-11-22 2005-08-09 Baxter Aktiengesellschaft Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
WO2004019953A1 (en) * 2002-08-28 2004-03-11 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment methods
US7718763B2 (en) * 2002-10-18 2010-05-18 Japan As Represented By The President Of National Cardiovascular Center Substrate polyeptides for von Willebrand factor cleaving protease ADAMTS-13

Also Published As

Publication number Publication date
EP1779117A1 (de) 2007-05-02
EP1779117B1 (de) 2010-05-19
WO2006019379A1 (en) 2006-02-23
EP1779117A4 (de) 2008-02-20
DE602004027314D1 (de) 2010-07-01
ES2348397T3 (es) 2010-12-03

Similar Documents

Publication Publication Date Title
ATE497164T1 (de) Testverfahren zur messung der phosphorylierung
DE60142691D1 (de) Verfahren und zusammensetzungen zur isolierung von metastatischen krebszellen und anwendung zur messung des metastatischen potentials eines krebses
ATE440151T1 (de) Verfahren zur beurteilung eines krankheitzustandes mittels nachweis von partikel- und nicht partikelgebundenen nukleinsäuren in blutplasma und -serum
ATE513833T1 (de) Thienopyridinverbindungen und verfahren zu ihrer verwendung
SG171582A1 (en) Apparatus and method for electrochemical detection
DK1268847T3 (da) Ubiquitin-ligaseassay
ATE310101T1 (de) Verfahren und kit zur erkennung von kinase aktivität
BRPI0618713B8 (pt) cardiolipina modificada e seus usos
ATE441860T1 (de) Verfahren und kits zur messung von adamts13/fxi- komplexen
ATE42342T1 (de) Verfahren zur alpha-amylasebestimmung und reagenssatz.
ATE548467T1 (de) Verfahren zur identifizierung von biomarkern mit eignung bei der diagnose biologischer zustände
ATE480777T1 (de) System zur differenziellen bestimmung der menge eines proteolytischen enzyms in einer körperflüssigkeit
DE602004026888D1 (de) Kinase- und phosphatasetests
ATE368229T1 (de) Diagnostischer test zur bestimmung der konzentration einer transienten proteolytischen aktivität in zusammengesetzten biologischen medien
ATE491155T1 (de) Verfahren und kits zur erkennung und messung von adamts13/fx1-komplexen
DE60315715D1 (de) Verwendung von nicotinamide n-methyltransferase zur diagnose von kolorektalem krebs
DE602007011661D1 (de) Verfahren zur messung der konzentration transienter proteolytischer aktivität in zellen enthaltenden zusammengesetzten biologischen medien
DE602004027314D1 (de) Verfahren zur messung von adamts13-aktivität auf der blutplättchenoberfläche.
ATE544071T1 (de) Fluoreszenzpolarisationstests für die acetyltransferase-deacetylase-aktivität
ATE145672T1 (de) Neue inhibitoren für hydrolytische enzyme und substrate und bestimmungsverfahren, selbige einschliessende verfahren und testsätze
ATE347105T1 (de) Verfahren, assay und kit zur quantifizierung von hiv-proteasehemmer
ATA463976A (de) Verahren zur bestimmung von thrombin und thrombinartigen enzymen durch spaltung chromogene substrate
HRP20060118A2 (en) Method and device for the detection of very small quantities of particles
ATE280836T1 (de) Test zur gleichzeitigen messung von verschiedenen enzymatischen aktivitäten
FR2875242B1 (fr) Nouveaux substrats enzymatiques derives de phenoxazinone et leur utilisation comme revelateur dans la detection de microorganismes a activite peptidase

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties