ATE482710T1 - Antibakterielle medizinische zusammensetzung mit erhöhtem oralem absorptionsvermögen - Google Patents
Antibakterielle medizinische zusammensetzung mit erhöhtem oralem absorptionsvermögenInfo
- Publication number
- ATE482710T1 ATE482710T1 AT03719236T AT03719236T ATE482710T1 AT E482710 T1 ATE482710 T1 AT E482710T1 AT 03719236 T AT03719236 T AT 03719236T AT 03719236 T AT03719236 T AT 03719236T AT E482710 T1 ATE482710 T1 AT E482710T1
- Authority
- AT
- Austria
- Prior art keywords
- cefditoren pivoxil
- amorphous
- absorption capacity
- medical composition
- oral absorption
- Prior art date
Links
- 238000010521 absorption reaction Methods 0.000 title 1
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 229960002142 cefditoren pivoxil Drugs 0.000 abstract 5
- AFZFFLVORLEPPO-UVYJNCLZSA-N cefditoren pivoxil Chemical compound S([C@@H]1[C@@H](C(N1C=1C(=O)OCOC(=O)C(C)(C)C)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1\C=C/C=1SC=NC=1C AFZFFLVORLEPPO-UVYJNCLZSA-N 0.000 abstract 5
- 239000002245 particle Substances 0.000 abstract 3
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- -1 ester fatty acid Chemical class 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002290367 | 2002-10-02 | ||
| PCT/JP2003/005461 WO2004030673A1 (ja) | 2002-10-02 | 2003-04-28 | 経口吸収性が改善された抗菌性医薬組成物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE482710T1 true ATE482710T1 (de) | 2010-10-15 |
Family
ID=32063766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03719236T ATE482710T1 (de) | 2002-10-02 | 2003-04-28 | Antibakterielle medizinische zusammensetzung mit erhöhtem oralem absorptionsvermögen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8648065B2 (de) |
| EP (1) | EP1555024B1 (de) |
| KR (1) | KR101019769B1 (de) |
| CN (1) | CN1311831C (de) |
| AT (1) | ATE482710T1 (de) |
| AU (1) | AU2003235962A1 (de) |
| BR (1) | BRPI0314932B8 (de) |
| CA (1) | CA2500712C (de) |
| DE (1) | DE60334391D1 (de) |
| ES (1) | ES2358470T3 (de) |
| MX (1) | MXPA05003357A (de) |
| PT (1) | PT1555024E (de) |
| WO (1) | WO2004030673A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101178657B1 (ko) * | 2003-10-08 | 2012-08-30 | 메이지 세이카 파루마 가부시키가이샤 | 세프디토렌 피복실을 함유하는 비결정질 항균 조성물 |
| US20080069879A1 (en) * | 2006-05-02 | 2008-03-20 | Ravishekhar Bhiwgade | Stable solid dosage form containing amorphous cefditoren pivoxil and process for preparation thereof |
| US20130143857A1 (en) * | 2010-07-23 | 2013-06-06 | Lupin Limited | Pharmaceutical compositions of cefditoren pivoxil |
| CN101940575B (zh) * | 2010-10-25 | 2012-05-30 | 石药集团欧意药业有限公司 | 一种头孢妥仑匹酯固体制剂及其制备方法 |
| DK2806859T3 (da) | 2012-01-25 | 2019-08-05 | Vertex Pharma | Formuleringer af 3-(6-(1-(2.2-difluorbenzo[d][1,3]dioxol-5-yl) cyclopropancarboxamido)-3-methylpyridin-2-yl)benzoesyre |
| EP3177272A1 (de) * | 2014-08-04 | 2017-06-14 | Sandoz AG | Wassergranulierungsverfahren für amorphe, schwer wasserlösliche arzneimittel |
| WO2016114727A1 (en) | 2015-01-16 | 2016-07-21 | Öğün Yusuf Toktamiş | Cefditoren pivoxil compositions with improved stability and production methods thereof |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4470980A (en) * | 1980-03-07 | 1984-09-11 | Interx Research Corp. | Method of increasing oral absorption of β-lactam antibiotics |
| JPS60126230A (ja) | 1983-12-13 | 1985-07-05 | Asahi Chem Ind Co Ltd | 経口用β−ラクタム剤組成物 |
| JPS60132918A (ja) | 1983-12-22 | 1985-07-16 | Asahi Chem Ind Co Ltd | 経口用セフアロスポリン組成物 |
| JPS60188230A (ja) | 1984-03-08 | 1985-09-25 | Fujita Kikai:Kk | 積層板の積み込み方法 |
| JPS60188320A (ja) | 1984-03-08 | 1985-09-25 | Asahi Chem Ind Co Ltd | セフアロスポリン組成物 |
| JPS62265226A (ja) | 1986-05-12 | 1987-11-18 | Fujisawa Pharmaceut Co Ltd | 経口投与用製剤 |
| JPH01128926A (ja) * | 1987-11-12 | 1989-05-22 | Fujisawa Pharmaceut Co Ltd | 経口投与用製剤 |
| JPH0678234B2 (ja) | 1988-04-19 | 1994-10-05 | 明治製菓株式会社 | 経口投与用抗菌組成物 |
| JPH0287588A (ja) | 1988-09-24 | 1990-03-28 | Murata Mfg Co Ltd | 厚膜配線基板の抵抗体形成方法 |
| JPH0364503A (ja) | 1989-07-28 | 1991-03-19 | Teijin Ltd | 無塵衣 |
| JPH0678234A (ja) | 1992-08-07 | 1994-03-18 | Sony Corp | Ｆｍ復調器 |
| JPH0717866A (ja) | 1993-06-16 | 1995-01-20 | Meiji Seika Kaisha Ltd | 医薬組成物 |
| AU4314196A (en) | 1994-12-21 | 1996-07-10 | Yamanouchi Pharmaceutical Co., Ltd. | Solid composition with improved solubility and absorbability |
| DK0801559T3 (da) * | 1995-02-08 | 2002-06-17 | Yamanouchi Europ Bv | Fremgangsmåde til fremstilling af orale doseringsformer indeholdende et beta-lactam antibiotikum |
| JP2831135B2 (ja) | 1995-10-13 | 1998-12-02 | 明治製菓株式会社 | 経口投与用の抗菌性組成物 |
| AR004014A1 (es) | 1995-10-13 | 1998-09-30 | Meiji Seika Kaisha | Una composicion antibacteriana de cefditoren pivoxilo para administracion oral y metodo para obtener dicha composicion |
| BR9712072A (pt) * | 1996-09-20 | 1999-08-24 | Meiji Seika Kaisha | Subst-ncia cristalina de defditoren pivoxil e a produ-Æo da mesma |
| JPH1192780A (ja) | 1997-09-18 | 1999-04-06 | Mitsubishi Chemical Corp | カカオ油脂の結晶転移抑制剤 |
| EP1051978B1 (de) * | 1998-01-07 | 2012-08-22 | Meiji Seika Pharma Co., Ltd. | Kristallographisch stabile amorphe cephalosporin zusammensetzungen und verfahren zu ihrer herstellung |
| JP3290970B2 (ja) | 1998-07-22 | 2002-06-10 | 山之内製薬株式会社 | 難溶性ＮＳＡＩＤｓ含有固形製剤 |
| DE69942777D1 (de) * | 1998-07-28 | 2010-10-28 | Takeda Pharmaceutical | Leicht zerfallende feste Zubereitung |
| JP2001131071A (ja) * | 1999-10-29 | 2001-05-15 | Meiji Seika Kaisha Ltd | 非晶質および非晶質を含有する医薬組成物 |
| US20020015730A1 (en) * | 2000-03-09 | 2002-02-07 | Torsten Hoffmann | Pharmaceutical formulations and method for making |
| AU2002253642B2 (en) | 2001-04-26 | 2007-05-24 | Meiji Seika Kaisha, Ltd. | Amorphous cefditoren pivoxil composition and process for producing the same |
| JP5051865B2 (ja) | 2001-05-29 | 2012-10-17 | タケダ ファーマシューティカルズ ユー．エス．エー． インコーポレイティド | レシチンでのプロドラッグエステル非乳化調合物の経口バイオアベイラビリティの向上 |
| WO2009098963A1 (ja) | 2008-02-08 | 2009-08-13 | Fuji Oil Company, Limited | 油脂の結晶化促進剤 |
-
2003
- 2003-04-28 EP EP03719236A patent/EP1555024B1/de not_active Expired - Lifetime
- 2003-04-28 US US10/530,046 patent/US8648065B2/en not_active Expired - Fee Related
- 2003-04-28 PT PT03719236T patent/PT1555024E/pt unknown
- 2003-04-28 WO PCT/JP2003/005461 patent/WO2004030673A1/ja not_active Ceased
- 2003-04-28 CN CNB038246589A patent/CN1311831C/zh not_active Expired - Lifetime
- 2003-04-28 KR KR1020057005753A patent/KR101019769B1/ko not_active Expired - Lifetime
- 2003-04-28 CA CA2500712A patent/CA2500712C/en not_active Expired - Lifetime
- 2003-04-28 AT AT03719236T patent/ATE482710T1/de not_active IP Right Cessation
- 2003-04-28 BR BRPI0314932A patent/BRPI0314932B8/pt not_active IP Right Cessation
- 2003-04-28 AU AU2003235962A patent/AU2003235962A1/en not_active Abandoned
- 2003-04-28 MX MXPA05003357A patent/MXPA05003357A/es active IP Right Grant
- 2003-04-28 DE DE60334391T patent/DE60334391D1/de not_active Expired - Lifetime
- 2003-04-28 ES ES03719236T patent/ES2358470T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1555024A4 (de) | 2007-07-11 |
| KR20050054993A (ko) | 2005-06-10 |
| US8648065B2 (en) | 2014-02-11 |
| ES2358470T3 (es) | 2011-05-11 |
| EP1555024A1 (de) | 2005-07-20 |
| DE60334391D1 (de) | 2010-11-11 |
| US20060051411A1 (en) | 2006-03-09 |
| PT1555024E (pt) | 2010-11-18 |
| KR101019769B1 (ko) | 2011-03-04 |
| CN1694709A (zh) | 2005-11-09 |
| WO2004030673A1 (ja) | 2004-04-15 |
| CA2500712A1 (en) | 2004-04-15 |
| CN1311831C (zh) | 2007-04-25 |
| CA2500712C (en) | 2011-08-09 |
| BRPI0314932B1 (pt) | 2019-03-06 |
| AU2003235962A1 (en) | 2004-04-23 |
| MXPA05003357A (es) | 2005-06-22 |
| BRPI0314932B8 (pt) | 2021-05-25 |
| EP1555024B1 (de) | 2010-09-29 |
| BR0314932A (pt) | 2005-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |