ATE487722T1 - Verfahren zur verminderung von alpha, beta- ungesättigten ketonen in opioidzusammensetzungen - Google Patents

Verfahren zur verminderung von alpha, beta- ungesättigten ketonen in opioidzusammensetzungen

Info

Publication number
ATE487722T1
ATE487722T1 AT09158939T AT09158939T ATE487722T1 AT E487722 T1 ATE487722 T1 AT E487722T1 AT 09158939 T AT09158939 T AT 09158939T AT 09158939 T AT09158939 T AT 09158939T AT E487722 T1 ATE487722 T1 AT E487722T1
Authority
AT
Austria
Prior art keywords
beta
unsaturated ketones
reducing alpha
opioid compositions
reducing
Prior art date
Application number
AT09158939T
Other languages
English (en)
Inventor
Robert Joe Kupper
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of ATE487722T1 publication Critical patent/ATE487722T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT09158939T 2005-03-04 2006-02-27 Verfahren zur verminderung von alpha, beta- ungesättigten ketonen in opioidzusammensetzungen ATE487722T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65879105P 2005-03-04 2005-03-04

Publications (1)

Publication Number Publication Date
ATE487722T1 true ATE487722T1 (de) 2010-11-15

Family

ID=36301669

Family Applications (2)

Application Number Title Priority Date Filing Date
AT09158939T ATE487722T1 (de) 2005-03-04 2006-02-27 Verfahren zur verminderung von alpha, beta- ungesättigten ketonen in opioidzusammensetzungen
AT06707309T ATE430153T1 (de) 2005-03-04 2006-02-27 Verfahren zur verminderung von alpha, beta- ungesättigten ketonen in opioidzusammensetzungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT06707309T ATE430153T1 (de) 2005-03-04 2006-02-27 Verfahren zur verminderung von alpha, beta- ungesättigten ketonen in opioidzusammensetzungen

Country Status (18)

Country Link
US (1) US7939543B2 (de)
EP (2) EP1861405B1 (de)
JP (1) JP5314894B2 (de)
KR (1) KR100941761B1 (de)
CN (1) CN101133062B (de)
AT (2) ATE487722T1 (de)
CA (1) CA2598774C (de)
CY (2) CY1109262T1 (de)
DE (2) DE602006006558D1 (de)
DK (2) DK2112153T3 (de)
ES (2) ES2355870T3 (de)
HR (2) HRP20090387T1 (de)
ME (2) ME01594B (de)
PL (2) PL2112153T3 (de)
PT (2) PT1861405E (de)
RS (2) RS51131B (de)
SI (2) SI2112153T1 (de)
WO (1) WO2006094672A1 (de)

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ES2428938T3 (es) 2009-07-22 2013-11-12 Grünenthal GmbH Forma de dosificación resistente a la manipulación y estabilizada frente a la oxidación
BR112012001547A2 (pt) * 2009-07-22 2016-03-08 Gruenenthal Gmbh forma de dosagem farmacêutica extrusada por fusão a quente
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US9198861B2 (en) 2009-12-22 2015-12-01 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
US8597681B2 (en) 2009-12-22 2013-12-03 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
EP2377866B1 (de) * 2010-03-23 2014-02-26 Siegfried AG Herstellung von opiaten hoher reinheit in einem durchflussreaktor
EP2580201B1 (de) 2010-06-11 2017-08-02 Rhodes Technologies Übergangsmetallkatalysierte verfahren zur herstellung von n-allyl-verbindungen und ihre verwendung
TWI471289B (zh) 2010-06-11 2015-02-01 Rhodes Technologies 使三級胺進行ｎ－脫烷反應之方法
CN103179954A (zh) 2010-09-02 2013-06-26 格吕伦塔尔有限公司 包含阴离子聚合物的抗破碎剂型
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US9050335B1 (en) 2011-05-17 2015-06-09 Mallinckrodt Llc Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia
US8858963B1 (en) 2011-05-17 2014-10-14 Mallinckrodt Llc Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia
US8741885B1 (en) 2011-05-17 2014-06-03 Mallinckrodt Llc Gastric retentive extended release pharmaceutical compositions
CA2839123A1 (en) 2011-07-29 2013-02-07 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
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MX356421B (es) 2012-02-28 2018-05-29 Gruenenthal Gmbh Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico.
PL2838512T3 (pl) 2012-04-18 2018-12-31 Grünenthal GmbH Farmaceutyczna postać dawkowania odporna na niewłaściwe użycie i odporna na uderzeniowe uwalnianie dawki
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US10624862B2 (en) 2013-07-12 2020-04-21 Grünenthal GmbH Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
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MA40332A (fr) 2014-07-09 2021-04-28 Rhodes Tech Réduction des niveaux de cétone alpha, beta-insaturée dans des compositions de dérivés de morphinane
BR112017021475A2 (pt) 2015-04-24 2018-07-10 Gruenenthal Gmbh forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente
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Also Published As

Publication number Publication date
US7939543B2 (en) 2011-05-10
JP5314894B2 (ja) 2013-10-16
CY1111241T1 (el) 2015-06-11
WO2006094672A1 (en) 2006-09-14
JP2008531626A (ja) 2008-08-14
EP2112153A1 (de) 2009-10-28
RS51131B (sr) 2010-10-31
CA2598774C (en) 2010-12-21
SI1861405T1 (sl) 2009-10-31
ES2326491T3 (es) 2009-10-13
DK1861405T3 (da) 2009-07-20
PT1861405E (pt) 2009-07-27
RS51568B (sr) 2011-08-31
ME01594B (me) 2014-09-20
SI2112153T1 (sl) 2011-02-28
CY1109262T1 (el) 2014-07-02
CN101133062A (zh) 2008-02-27
HRP20110078T1 (hr) 2011-03-31
PT2112153E (pt) 2010-12-17
PL1861405T3 (pl) 2009-10-30
ME01184B (me) 2013-03-20
US20080132702A1 (en) 2008-06-05
HRP20090387T1 (hr) 2009-08-31
EP2112153B1 (de) 2010-11-10
PL2112153T3 (pl) 2011-04-29
EP1861405A1 (de) 2007-12-05
DK2112153T3 (da) 2011-02-14
ES2355870T3 (es) 2011-03-31
HK1111695A1 (en) 2008-08-15
CN101133062B (zh) 2014-08-06
DE602006018208D1 (de) 2010-12-23
HK1135107A1 (en) 2010-05-28
EP1861405B1 (de) 2009-04-29
CA2598774A1 (en) 2006-09-14
KR100941761B1 (ko) 2010-02-11
ATE430153T1 (de) 2009-05-15
KR20070108931A (ko) 2007-11-13
DE602006006558D1 (de) 2009-06-10

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