ATE548031T1 - Inhibitoren gegen die produktion und freisetzung entzündungfördernder zytokine - Google Patents

Inhibitoren gegen die produktion und freisetzung entzündungfördernder zytokine

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Publication number
ATE548031T1
ATE548031T1 AT01271124T AT01271124T ATE548031T1 AT E548031 T1 ATE548031 T1 AT E548031T1 AT 01271124 T AT01271124 T AT 01271124T AT 01271124 T AT01271124 T AT 01271124T AT E548031 T1 ATE548031 T1 AT E548031T1
Authority
AT
Austria
Prior art keywords
pro
release
production
inflammatory cytokine
inhibitors against
Prior art date
Application number
AT01271124T
Other languages
English (en)
Inventor
Susumu Muto
Tatsuo Nagano
Tomomi Saotome
Akiko Itai
Original Assignee
Inst Med Molecular Design Inc
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Publication date
Application filed by Inst Med Molecular Design Inc filed Critical Inst Med Molecular Design Inc
Application granted granted Critical
Publication of ATE548031T1 publication Critical patent/ATE548031T1/de

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/055—Phenols the aromatic ring being substituted by halogen
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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AT01271124T 2000-12-18 2001-12-18 Inhibitoren gegen die produktion und freisetzung entzündungfördernder zytokine ATE548031T1 (de)

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EP1847263A3 (de) 2000-12-18 2009-08-26 Institute of Medicinal Molecular Design, Inc. Hemmer für die Produktion und Freisetzung entzündlicher Zytokine
US7638536B2 (en) 2002-01-18 2009-12-29 Astellas Pharma Inc. 2-Acylaminothiazole derivative or salt thereof
AR038703A1 (es) 2002-02-28 2005-01-26 Novartis Ag Derivados de 5-feniltiazol y uso como inhibidor de quinasa p i 3
EP2311818B1 (de) * 2002-02-28 2013-01-16 Novartis AG Kombination aus einem 5-phenylthiazolderivat als PI3-Kinasehemmer und eine entzündungshemmender, bronchodilatatorische oder antihistaminischen Verbindung
EA009523B1 (ru) * 2002-06-05 2008-02-28 Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. Ингибиторы в отношении активации ар-1 и nfat
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AU2002222683B9 (en) 2021-12-23
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JPWO2002049632A1 (ja) 2004-04-15
CN101125138A (zh) 2008-02-20
UA82827C2 (en) 2008-05-26
EP1844766A2 (de) 2007-10-17
JP4224566B2 (ja) 2009-02-18
US8097759B2 (en) 2012-01-17
EP1352650A1 (de) 2003-10-15
ATE553758T1 (de) 2012-05-15
CN101849953B (zh) 2012-04-25
KR101088557B1 (ko) 2011-12-05
US20080318956A1 (en) 2008-12-25
EP1844766B1 (de) 2012-04-18
EP1844766A3 (de) 2009-04-29
EP1847263A2 (de) 2007-10-24
AU2268302A (en) 2002-07-01
EP1352650A4 (de) 2005-07-20
US8263657B2 (en) 2012-09-11
CA2431083A1 (en) 2002-06-27
CA2431083C (en) 2011-08-09
AU2002222683B2 (en) 2006-09-21
EP1352650B1 (de) 2012-03-07
EP1847263A3 (de) 2009-08-26
CN101849953A (zh) 2010-10-06
EA200300695A1 (ru) 2003-12-25
WO2002049632A1 (en) 2002-06-27
KR20030070063A (ko) 2003-08-27
US20090192122A2 (en) 2009-07-30
HK1063433A1 (zh) 2004-12-31
US20100274051A1 (en) 2010-10-28
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CN1489458A (zh) 2004-04-14
EA011719B1 (ru) 2009-04-28

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