PH27019A - Improved phase separation microencapsulation process and pharmaceutical compositions produced thereby - Google Patents

Improved phase separation microencapsulation process and pharmaceutical compositions produced thereby Download PDF

Info

Publication number: PH27019A
Authority: PH; Philippines
Prior art keywords: solvent; core material; polymer; encapsulating polymer; volatile silicone
Prior art date: 1987-05-26

Application number

PH36977A

Other languages

English (en)

Inventor

James Ronald Lawter

Michael Gerard Lanzilotti

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-26

Filing date

1988-05-26

Publication date

1993-02-01

1988-05-26 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1993-02-01 Publication of PH27019A publication Critical patent/PH27019A/en

Links

238000000034 method Methods 0.000 title claims abstract description 60
238000005191 phase separation Methods 0.000 title claims abstract description 15
239000008194 pharmaceutical composition Substances 0.000 title claims description 9
239000003094 microcapsule Substances 0.000 claims abstract description 49
239000003795 chemical substances by application Substances 0.000 claims abstract description 29
239000012530 fluid Substances 0.000 claims abstract description 24
239000000203 mixture Substances 0.000 claims abstract description 22
229920001296 polysiloxane Polymers 0.000 claims abstract description 19
238000004519 manufacturing process Methods 0.000 claims abstract description 8
239000002904 solvent Substances 0.000 claims description 55
229920000642 polymer Polymers 0.000 claims description 49
239000011162 core material Substances 0.000 claims description 43
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 36
-1 polydimethylsiloxane Polymers 0.000 claims description 31
HMMGMWAXVFQUOA-UHFFFAOYSA-N octamethylcyclotetrasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 HMMGMWAXVFQUOA-UHFFFAOYSA-N 0.000 claims description 14
239000008177 pharmaceutical agent Substances 0.000 claims description 12
239000003960 organic solvent Substances 0.000 claims description 11
229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 10
150000003839 salts Chemical class 0.000 claims description 10
239000004205 dimethyl polysiloxane Substances 0.000 claims description 9
239000002245 particle Substances 0.000 claims description 7
239000007787 solid Substances 0.000 claims description 7
239000006185 dispersion Substances 0.000 claims description 6
229940088597 hormone Drugs 0.000 claims description 6
239000005556 hormone Substances 0.000 claims description 6
238000003756 stirring Methods 0.000 claims description 6
XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims description 5
229920001577 copolymer Polymers 0.000 claims description 5
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229920002545 silicone oil Polymers 0.000 claims description 5
239000011782 vitamin Substances 0.000 claims description 5
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FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 claims description 3
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 3
229930182555 Penicillin Natural products 0.000 claims description 3
KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 3
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108090000623 proteins and genes Proteins 0.000 claims description 3
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SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims description 2
FMTDIUIBLCQGJB-UHFFFAOYSA-N Demethylchlortetracyclin Natural products C1C2C(O)C3=C(Cl)C=CC(O)=C3C(=O)C2=C(O)C2(O)C1C(N(C)C)C(O)=C(C(N)=O)C2=O FMTDIUIBLCQGJB-UHFFFAOYSA-N 0.000 claims description 2
VTUSIVBDOCDNHS-UHFFFAOYSA-N Etidocaine Chemical compound CCCN(CC)C(CC)C(=O)NC1=C(C)C=CC=C1C VTUSIVBDOCDNHS-UHFFFAOYSA-N 0.000 claims description 2
NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 2
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FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 2
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IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 claims description 2
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GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims description 2
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JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 4
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 2
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XIYOPDCBBDCGOE-IWVLMIASSA-N (4s,4ar,5s,5ar,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methylidene-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C=C1C2=CC=CC(O)=C2C(O)=C2[C@@H]1[C@H](O)[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O XIYOPDCBBDCGOE-IWVLMIASSA-N 0.000 claims 1
OAPVUSSHCBRCOL-KBHRXELFSA-N (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide;hydrochloride Chemical compound Cl.C1([C@H]2O)=C(Cl)C=CC(O)=C1C(O)=C1[C@@H]2C[C@H]2[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]2(O)C1=O OAPVUSSHCBRCOL-KBHRXELFSA-N 0.000 claims 1
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NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
229960001278 teniposide Drugs 0.000 description 1
229960003604 testosterone Drugs 0.000 description 1
229940040944 tetracyclines Drugs 0.000 description 1
RGYLYUZOGHTBRF-BIHRQFPBSA-N tetragastrin Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C2=CC=CC=C2NC=1)CCSC)C(N)=O)C1=CC=CC=C1 RGYLYUZOGHTBRF-BIHRQFPBSA-N 0.000 description 1
229960002784 thioridazine Drugs 0.000 description 1
WYWHKKSPHMUBEB-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 description 1
229960005013 tiotixene Drugs 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
229960000707 tobramycin Drugs 0.000 description 1
NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 description 1
ZEWQUBUPAILYHI-UHFFFAOYSA-N trifluoperazine Chemical compound C1CN(C)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 ZEWQUBUPAILYHI-UHFFFAOYSA-N 0.000 description 1
229960002324 trifluoperazine Drugs 0.000 description 1
229960003904 triflupromazine Drugs 0.000 description 1
XSCGXQMFQXDFCW-UHFFFAOYSA-N triflupromazine Chemical compound C1=C(C(F)(F)F)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 XSCGXQMFQXDFCW-UHFFFAOYSA-N 0.000 description 1
YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 description 1
102000003390 tumor necrosis factor Human genes 0.000 description 1
238000001291 vacuum drying Methods 0.000 description 1
229960003726 vasopressin Drugs 0.000 description 1
229960003048 vinblastine Drugs 0.000 description 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
229960004528 vincristine Drugs 0.000 description 1
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
229960000641 zorubicin Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/20—After-treatment of capsule walls, e.g. hardening

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Dispersion Chemistry (AREA)
Medicinal Preparation (AREA)
Manufacturing Of Micro-Capsules (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)
Packages (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Materials For Medical Uses (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Glass Compositions (AREA)
Sampling And Sample Adjustment (AREA)
Physical Or Chemical Processes And Apparatus (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Polymerisation Methods In General (AREA)

PH36977A 1987-05-26 1988-05-26 Improved phase separation microencapsulation process and pharmaceutical compositions produced thereby PH27019A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/054,372 US5000886A (en)	1987-05-26	1987-05-26	Silicone-hardened pharmaceutical microcapsules and process of making the same

Publications (1)

Publication Number	Publication Date
PH27019A true PH27019A (en)	1993-02-01

Family

ID=21990585

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH36977A PH27019A (en)	1987-05-26	1988-05-26	Improved phase separation microencapsulation process and pharmaceutical compositions produced thereby

Country Status (19)

Country	Link
US (1)	US5000886A (de)
EP (1)	EP0292710B1 (de)
JP (1)	JP2712101B2 (de)
KR (1)	KR970001209B1 (de)
AT (1)	ATE70992T1 (de)
AU (1)	AU618000B2 (de)
BR (1)	BR1100810A (de)
CA (1)	CA1330533C (de)
DE (1)	DE3867313D1 (de)
DK (1)	DK169119B1 (de)
ES (1)	ES2038236T3 (de)
GR (1)	GR3004186T3 (de)
HK (1)	HK116493A (de)
IE (1)	IE61338B1 (de)
IL (1)	IL86274A (de)
NO (1)	NO177984C (de)
NZ (1)	NZ224722A (de)
PH (1)	PH27019A (de)
ZA (1)	ZA883737B (de)

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1987
- 1987-05-26 US US07/054,372 patent/US5000886A/en not_active Expired - Lifetime
1988
- 1988-05-04 IL IL86274A patent/IL86274A/xx not_active IP Right Cessation
- 1988-05-18 AT AT88106617T patent/ATE70992T1/de not_active IP Right Cessation
- 1988-05-18 EP EP88106617A patent/EP0292710B1/de not_active Expired - Lifetime
- 1988-05-18 DE DE8888106617T patent/DE3867313D1/de not_active Expired - Lifetime
- 1988-05-18 ES ES198888106617T patent/ES2038236T3/es not_active Expired - Lifetime
- 1988-05-20 NZ NZ224722A patent/NZ224722A/en unknown
- 1988-05-24 CA CA000567503A patent/CA1330533C/en not_active Expired - Lifetime
- 1988-05-25 NO NO882277A patent/NO177984C/no not_active IP Right Cessation
- 1988-05-25 JP JP63126021A patent/JP2712101B2/ja not_active Expired - Lifetime
- 1988-05-25 AU AU16592/88A patent/AU618000B2/en not_active Expired
- 1988-05-25 ZA ZA883737A patent/ZA883737B/xx unknown
- 1988-05-25 IE IE156588A patent/IE61338B1/en not_active IP Right Cessation
- 1988-05-25 DK DK285088A patent/DK169119B1/da not_active IP Right Cessation
- 1988-05-26 KR KR1019880006203A patent/KR970001209B1/ko not_active Expired - Lifetime
- 1988-05-26 PH PH36977A patent/PH27019A/en unknown
1992
- 1992-03-31 GR GR910401088T patent/GR3004186T3/el unknown
1993
- 1993-10-28 HK HK1164/93A patent/HK116493A/en not_active IP Right Cessation
1997
- 1997-05-12 BR BR1100810-5A patent/BR1100810A/pt active IP Right Grant

Also Published As

Publication number	Publication date
BR1100810A (pt)	1999-10-13
NO177984B (no)	1995-09-25
NO177984C (no)	1996-01-03
HK116493A (en)	1993-11-05
IE881565L (en)	1988-11-26
EP0292710B1 (de)	1992-01-02
IL86274A (en)	1992-03-29
AU618000B2 (en)	1991-12-12
AU1659288A (en)	1988-12-01
US5000886A (en)	1991-03-19
NO882277L (no)	1988-11-28
IE61338B1 (en)	1994-11-02
DK169119B1 (da)	1994-08-22
NZ224722A (en)	1990-04-26
JPS63307813A (ja)	1988-12-15
KR880013553A (ko)	1988-12-21
EP0292710A2 (de)	1988-11-30
GR3004186T3 (de)	1993-03-31
KR970001209B1 (ko)	1997-02-04
NO882277D0 (no)	1988-05-25
DK285088A (da)	1988-11-27
IL86274A0 (en)	1988-11-15
ES2038236T3 (es)	1993-07-16
JP2712101B2 (ja)	1998-02-10
CA1330533C (en)	1994-07-05
ATE70992T1 (de)	1992-01-15
DE3867313D1 (de)	1992-02-13
DK285088D0 (da)	1988-05-25
ZA883737B (en)	1989-02-22
EP0292710A3 (en)	1989-03-22

Publication	Publication Date	Title
EP0292710B1 (de)	1992-01-02	Härtungsmittel für Phasentrennungsmikroverkapselung
US5143661A (en)	1992-09-01	Silicone-hardened pharmaceutical microcapsules
EP0052510B2 (de)	1994-10-19	Mikroverkapslung wasserlöslicher Polypeptide
DK175849B1 (da)	2005-03-29	Fremgangsmåde til fremstilling af mikropartikler omfattende et lægemiddelstof, formulering med forlænget afgivelse, octreotidpamoat og fremgangsmåde til fremstilling heraf
US5500228A (en)	1996-03-19	Phase separation-microencapsulated pharmaceuticals compositions useful for alleviating dental disease
CA2382577C (en)	2008-01-22	Injectable buprenorphine microparticle compositions and their use
US5503851A (en)	1996-04-02	Microencapsulation of water-soluble medicaments
US4675189A (en)	1987-06-23	Microencapsulation of water soluble active polypeptides
CA2126685C (en)	2002-07-23	Process for the production of microcapsules
EP0535937B1 (de)	1997-06-11	Mikropartikeln-Zusammenfassung zur verlängerten Freigabe und Herstellung derselbe
WO1989003678A1 (en)	1989-05-05	Low residual solvent microspheres and microencapsulation process
EP0374532B1 (de)	1994-09-21	Durch Phasentrennung microinkapsulierte Arzneimittelzusammensetzung zur Verminderung der Zahnkrankheit
JP2002234833A (ja)	2002-08-23	徐放型マイクロカプセルの製造法
EP1555023A2 (de)	2005-07-20	Injizierbare Buprenorphin-Mikropartikelformulierung und ihre Verwendung
Lao	1993	Formulation of sustained release microparticles of a bacterial nutrient and an antihistamine
HK1000314B (en)	1998-02-27	Improved phase separation-microencapsulated pharmaceutical compositions useful for alleviating dental disease
CY1844A (en)	1996-03-08	Sustained release formulations of water soluble peptides