BE1002296A5 - Derives peptidiques. - Google Patents

Derives peptidiques. Download PDF

Info

Publication number: BE1002296A5
Authority: BE; Belgium
Prior art keywords: somatostatin; receptors; peptide derivatives; amino group; detectable element
Prior art date: 1988-12-05

Application number

BE8901294A

Other languages

English (en)

French (fr)

Original Assignee

Sandoz Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-05

Filing date

1989-12-05

Publication date

1990-11-20

1988-12-05 Priority claimed from GB888828364A external-priority patent/GB8828364D0/en

1989-07-13 Priority claimed from GB898916115A external-priority patent/GB8916115D0/en

1989-07-21 Priority claimed from GB898916761A external-priority patent/GB8916761D0/en

1989-12-05 Application filed by Sandoz Sa filed Critical Sandoz Sa

1990-11-20 Application granted granted Critical

1990-11-20 Publication of BE1002296A5 publication Critical patent/BE1002296A5/fr

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
102000005157 Somatostatin Human genes 0.000 abstract 2
108010056088 Somatostatin Proteins 0.000 abstract 2
125000003277 amino group Chemical group 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
108050001286 Somatostatin Receptor Proteins 0.000 abstract 1
102000011096 Somatostatin receptor Human genes 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000011503 in vivo imaging Methods 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
150000003839 salts Chemical group 0.000 abstract 1
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 abstract 1
229960000553 somatostatin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BE8901294A 1988-12-05 1989-12-05 Derives peptidiques. BE1002296A5 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB888828364A GB8828364D0 (en)	1988-12-05	1988-12-05	Improvements in/relating to organic compounds
GB898916115A GB8916115D0 (en)	1989-07-13	1989-07-13	Improvements in or relating to organic compounds
GB898916761A GB8916761D0 (en)	1989-07-21	1989-07-21	Improvements in or relating to organic compounds

Publications (1)

Publication Number	Publication Date
BE1002296A5 true BE1002296A5 (fr)	1990-11-20

Family

ID=27264222

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE8901294A BE1002296A5 (fr)	1988-12-05	1989-12-05	Derives peptidiques.

Country Status (24)

Country	Link
JP (2)	JP2726320B2 (da)
KR (1)	KR0156541B1 (da)
AT (1)	AT403476B (da)
AU (1)	AU633859B2 (da)
BE (1)	BE1002296A5 (da)
CA (1)	CA2004532C (da)
CH (1)	CH678329A5 (da)
DE (1)	DE3991505B4 (da)
DK (1)	DK175338B1 (da)
ES (1)	ES2023533A6 (da)
FI (1)	FI102540B1 (da)
FR (1)	FR2639947B1 (da)
GB (1)	GB2225579B (da)
HK (1)	HK189995A (da)
HU (2)	HUT53375A (da)
IE (1)	IE62091B1 (da)
IL (1)	IL92534A (da)
LU (1)	LU87633A1 (da)
MY (1)	MY106120A (da)
NL (1)	NL194828C (da)
PT (1)	PT92487B (da)
SA (1)	SA96160495B1 (da)
SE (1)	SE508799C2 (da)
WO (1)	WO1990006949A2 (da)

Families Citing this family (52)

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DE3822557C2 (de) *	1987-07-10	1998-07-02	Ciba Geigy Ag	Arzneimittel, enthaltend Somatostatine
AU639371B2 (en) *	1987-07-10	1993-07-22	Novartis Ag	Method of treating breast cancer
GB9111199D0 (en) *	1991-05-23	1991-07-17	Sandoz Ltd	Improvements in or relating to organic compounds
US5460785A (en) *	1989-08-09	1995-10-24	Rhomed Incorporated	Direct labeling of antibodies and other protein with metal ions
US5700444A (en) *	1992-02-20	1997-12-23	Rhomed Incorporated	Chemotactic peptide pharmaceutical applications
US5443816A (en) *	1990-08-08	1995-08-22	Rhomed Incorporated	Peptide-metal ion pharmaceutical preparation and method
US5985240A (en) *	1989-08-09	1999-11-16	Rhomed Incorporated	Peptide radiopharmaceutical applications
GB9004017D0 (en) *	1990-02-22	1990-04-18	Krenning Eric P	Improvements in or relating to organic compounds
US5382654A (en) *	1992-02-05	1995-01-17	Mallinckrodt Medical, Inc.	Radiolabelled peptide compounds
US7238340B1 (en)	1991-11-27	2007-07-03	Cis Bio International	Monoamine, diamide, thiol-containing metal chelating agents
ES2134798T3 (es) *	1991-02-08	1999-10-16	Biomeasure Inc	Uso de analogos de somatostatina para el tratamiento de melanomas.
US5849261A (en) *	1991-02-08	1998-12-15	Diatide, Inc.	Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5443815A (en) *	1991-11-27	1995-08-22	Diatech, Inc.	Technetium-99m labeled peptides for imaging
WO1992021383A1 (en) *	1991-06-03	1992-12-10	Mallinckrodt Medical, Inc.	Radiolabelled somatostatin derivatives, their preparation and use
DK0600992T3 (da) *	1991-08-29	2000-10-09	Mallinckrodt Medical Inc	Anvendelse af gentissyre eller gentisylalkohol til stabilisering af radiomærkede peptider og proteiner
US5225180A (en) *	1991-09-10	1993-07-06	Diatech, Inc.	Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en)	1991-11-27	1998-07-21	Diatide, Inc.	Peptide-metal chelate conjugates
CA2127284C (en) *	1992-01-03	2002-02-05	Buck A. Rhodes	Protein- and peptide-metal ion pharmaceutical applications
US5556609A (en) *	1992-02-20	1996-09-17	Rhomed Incorporated	YIGSR peptide radiopharmaceutical applications
US5738838A (en) *	1992-02-20	1998-04-14	Rhomed Incorporated	IKVAV peptide radiopharmaceutical applications
DK0720621T3 (da) *	1992-01-14	2001-08-06	Diatide Inc	Radiomærkede somatostation-afledte peptider til billeddannende og terapeutiske anvendelser
WO1993015770A1 (en) *	1992-02-05	1993-08-19	Mallinckrodt Medical, Inc.	Radiolabelled peptide compounds
US5371184A (en) *	1992-02-05	1994-12-06	Mallinckrodt Medical, Inc.	Radiolabelled peptide compounds
US5643549A (en) *	1992-02-20	1997-07-01	Rhomed Incorporated	Leukostimulatory agent for in vivo leukocyte tagging
CA2131315A1 (en) *	1992-03-25	1993-09-30	Geert J. Ensing	Method of intraoperatively detecting and locating tumoral tissues
US5716596A (en) *	1992-06-23	1998-02-10	Diatide, Inc.	Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5871711A (en) *	1992-06-23	1999-02-16	Diatide, Inc.	Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US6017512A (en) *	1992-06-23	2000-01-25	Diatide, Inc.	Radiolabeled peptides
US5620675A (en)	1992-06-23	1997-04-15	Diatech, Inc.	Radioactive peptides
NO940080L (no) *	1993-01-12	1994-07-13	Sandoz Ag	Polypeptider , fremgangsmåte for deres fremstilling og farmasöytiske preparater derav
US5650134A (en) *	1993-01-12	1997-07-22	Novartis Ag (Formerly Sandoz Ltd.)	Peptides
CA2154667A1 (en) *	1993-02-02	1994-08-18	Linda M. Gustavson	Directed biodistribution of small molecules
US5879657A (en) *	1993-03-30	1999-03-09	The Dupont Merck Pharmaceutical Company	Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US5932189A (en) *	1994-07-29	1999-08-03	Diatech, Inc.	Cyclic peptide somatostatin analogs
CA2190727C (en) *	1994-05-19	2006-07-18	Sudhakar Kasina	Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
US6051206A (en) *	1994-06-03	2000-04-18	Diatide, Inc	Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
GB9417873D0 (en)	1994-09-06	1994-10-26	Sandoz Ltd	Organic compounds
US5556939A (en) *	1994-10-13	1996-09-17	Merck Frosst Canada, Inc.	TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5632969A (en) *	1994-10-13	1997-05-27	Merck & Co., Inc.	N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5830431A (en) *	1995-06-07	1998-11-03	Mallinckrodt Medical, Inc.	Radiolabeled peptide compositions for site-specific targeting
GB9708265D0 (en)	1997-04-24	1997-06-18	Nycomed Imaging As	Contrast agents
FI965181A7 (fi)	1996-12-20	1998-06-21	Map Medical Tech Oy	Polyalkoholi-peptidijohdannaiset
US7175953B2 (en)	1999-04-09	2007-02-13	Institute Fuer Diagnostik Forschung	Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US6630570B1 (en)	1999-04-09	2003-10-07	Insitut für Diagnostikforschung GmbH	Short-chain peptide-dye conjugates as contrast media for optical diagnosis
DE19917713A1 (de) *	1999-04-09	2000-10-19	Diagnostikforschung Inst	Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
US6685914B1 (en)	1999-09-13	2004-02-03	Bristol-Myers Squibb Pharma Company	Macrocyclic chelants for metallopharmaceuticals
DE60231801D1 (de)	2001-04-23	2009-05-14	Mallinckrodt Inc	Tc und re markierte radioaktive glycosylierte octreotid-derivate
US7968080B2 (en)	2003-08-20	2011-06-28	The Regents Of The University Of California	Somatostatin analogs with inhibitory activity to growth hormone release
BRPI0414512B8 (pt) *	2003-09-17	2021-05-25	Board Of Regentes The Univ Of Texas System	composição para reproduzir imagens de um pâncreas e uso desta
EP2067786A1 (en)	2007-12-07	2009-06-10	ITALFARMACO S.p.A.	Novel non selective analogs of somatostatin
US9480759B2 (en)	2012-11-21	2016-11-01	Serene, Llc	Tin-117m somatostatin receptor binding compounds and methods
CN119708199A (zh)	2023-09-27	2025-03-28	钱杭江医药科技(嘉兴)有限公司	生长抑素肽类类似物、螯合物及其应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0150844A2 (en) *	1984-01-30	1985-08-07	Enzo Biochem, Inc.	Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
DE3511206A1 (de) *	1985-03-28	1986-10-09	Sandoz-Patent-GmbH, 7850 Lörrach	Neue polypeptidderivate, ihre herstellung und pharmazeutische praeparate, welche diese polypeptidderivate enthalten
EP0233619A1 (en) *	1986-02-14	1987-08-26	Nihon Medi-Physics Co., Ltd.	High molecular compounds having amino groups, and their utilization
EP0247866A1 (en) *	1986-05-29	1987-12-02	Mallinckrodt, Inc. (a Delaware corporation)	Coupling agents for radiolabeling proteins
EP0248506A1 (en) *	1986-03-05	1987-12-09	Mallinckrodt, Inc. (a Delaware corporation)	Metal ion labeling of carrier molecules
WO1989004666A1 (en) *	1987-11-18	1989-06-01	The Administrators Of The Tulane Educational Fund	Treatment of cancer with somatostatin and analogs thereof

Family Cites Families (8)

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CA1222691A (en) *	1981-12-29	1987-06-09	Wilhelmus T. Goedemans	Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments
US4652519A (en) *	1983-02-03	1987-03-24	Yeda Research And Development Company Limited	Bifunctional chelating agents and process for their production
HUT42101A (en) *	1985-01-07	1987-06-29	Sandoz Ag	Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
DE3522638A1 (de) *	1985-06-25	1987-01-08	Diamalt Ag	Neue somatostatin-derivate
US4678667A (en) *	1985-07-02	1987-07-07	501 Regents of the University of California	Macrocyclic bifunctional chelating agents
NL194729C (nl) *	1986-10-13	2003-01-07	Novartis Ag	Werkwijze voor de bereiding van peptidealcoholen via vaste fase.
CH679045A5 (da) *	1987-06-29	1991-12-13	Sandoz Ag
FR2638968B1 (fr) *	1988-11-11	1994-10-07	Sandoz Sa	Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives

1989
- 1989-11-29 MY MYPI89001655A patent/MY106120A/en unknown
- 1989-11-30 DE DE3991505A patent/DE3991505B4/de not_active Expired - Lifetime
- 1989-11-30 CH CH2578/90A patent/CH678329A5/de not_active IP Right Cessation
- 1989-11-30 AT AT0901789A patent/AT403476B/de active
- 1989-11-30 WO PCT/EP1989/001448 patent/WO1990006949A2/en not_active Ceased
- 1989-12-01 GB GB8927255A patent/GB2225579B/en not_active Expired - Lifetime
- 1989-12-04 KR KR1019890018033A patent/KR0156541B1/ko not_active Expired - Lifetime
- 1989-12-04 JP JP1315124A patent/JP2726320B2/ja not_active Expired - Lifetime
- 1989-12-04 IE IE386689A patent/IE62091B1/en not_active IP Right Cessation
- 1989-12-04 HU HU896359A patent/HUT53375A/hu unknown
- 1989-12-04 FR FR8915993A patent/FR2639947B1/fr not_active Expired - Lifetime
- 1989-12-04 IL IL9253489A patent/IL92534A/en not_active IP Right Cessation
- 1989-12-04 SE SE8904087A patent/SE508799C2/sv unknown
- 1989-12-04 CA CA002004532A patent/CA2004532C/en not_active Expired - Lifetime
- 1989-12-04 PT PT92487A patent/PT92487B/pt active IP Right Grant
- 1989-12-04 AU AU45871/89A patent/AU633859B2/en not_active Expired
- 1989-12-04 NL NL8902981A patent/NL194828C/nl not_active IP Right Cessation
- 1989-12-04 FI FI895809A patent/FI102540B1/fi active IP Right Grant
- 1989-12-05 LU LU87633A patent/LU87633A1/fr unknown
- 1989-12-05 BE BE8901294A patent/BE1002296A5/fr not_active IP Right Cessation
- 1989-12-05 DK DK198906126A patent/DK175338B1/da not_active IP Right Cessation
- 1989-12-05 ES ES8904151A patent/ES2023533A6/es not_active Expired - Lifetime
1995
- 1995-06-15 HU HU95P/P00214P patent/HU211468A9/hu unknown
- 1995-12-21 HK HK189995A patent/HK189995A/xx not_active IP Right Cessation
1996
- 1996-01-01 SA SA96160495A patent/SA96160495B1/ar unknown
1997
- 1997-08-04 JP JP20891597A patent/JP3686503B2/ja not_active Expired - Lifetime

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0150844A2 (en) *	1984-01-30	1985-08-07	Enzo Biochem, Inc.	Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
DE3511206A1 (de) *	1985-03-28	1986-10-09	Sandoz-Patent-GmbH, 7850 Lörrach	Neue polypeptidderivate, ihre herstellung und pharmazeutische praeparate, welche diese polypeptidderivate enthalten
EP0233619A1 (en) *	1986-02-14	1987-08-26	Nihon Medi-Physics Co., Ltd.	High molecular compounds having amino groups, and their utilization
EP0248506A1 (en) *	1986-03-05	1987-12-09	Mallinckrodt, Inc. (a Delaware corporation)	Metal ion labeling of carrier molecules
EP0247866A1 (en) *	1986-05-29	1987-12-02	Mallinckrodt, Inc. (a Delaware corporation)	Coupling agents for radiolabeling proteins
WO1989004666A1 (en) *	1987-11-18	1989-06-01	The Administrators Of The Tulane Educational Fund	Treatment of cancer with somatostatin and analogs thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LIFE SCIENCES, vol. 43, no. 5, 1988, Pergamon Press plc, US; J.E. TAYLOR et al.: "High affinity binding of [125l-Tyr 11Üsomatostatin-14 to human small cell lung carcinoma (NCI-H69)", pages 421-427 *

Also Published As

Publication number	Publication date
WO1990006949A3 (en)	1990-07-26
AU4587189A (en)	1990-06-14
HU211468A9 (en)	1995-11-28
FI895809A0 (fi)	1989-12-04
DK612689A (da)	1990-06-06
DK612689D0 (da)	1989-12-05
CH678329A5 (da)	1991-08-30
PT92487B (pt)	1996-01-31
NL8902981A (nl)	1990-07-02
SE8904087D0 (sv)	1989-12-04
FI102540B (fi)	1998-12-31
JPH1095737A (ja)	1998-04-14
GB2225579B (en)	1993-03-17
GB8927255D0 (en)	1990-01-31
FR2639947A1 (fr)	1990-06-08
SE8904087L (sv)	1991-06-05
LU87633A1 (fr)	1991-09-18
DE3991505B4 (de)	2006-04-20
JPH02184698A (ja)	1990-07-19
IE893866L (en)	1990-06-05
AT403476B (de)	1998-02-25
WO1990006949A2 (en)	1990-06-28
CA2004532C (en)	2000-02-22
HU896359D0 (en)	1990-02-28
JP2726320B2 (ja)	1998-03-11
FI102540B1 (fi)	1998-12-31
SA96160495B1 (ar)	2006-08-23
HUT53375A (en)	1990-10-28
IL92534A (en)	1994-06-24
MY106120A (en)	1995-03-31
DK175338B1 (da)	2004-08-30
AU633859B2 (en)	1993-02-11
PT92487A (pt)	1990-06-29
KR900009697A (ko)	1990-07-05
JP3686503B2 (ja)	2005-08-24
FR2639947B1 (fr)	1995-04-21
KR0156541B1 (ko)	1998-10-15
NL194828C (nl)	2003-04-03
GB2225579A (en)	1990-06-06
HK189995A (en)	1995-12-29
CA2004532A1 (en)	1990-06-05
ES2023533A6 (es)	1992-01-16
IE62091B1 (en)	1994-12-14
ATA901789A (de)	1997-07-15
SE508799C2 (sv)	1998-11-09
NL194828B (nl)	2002-12-02

Legal Events

Date

Code

Title

Description

2009-12-31

RE20

Patent expired

Owner name: *NOVARTIS A.G.

Effective date: 20091205

Publication	Publication Date	Title
BE1002296A5 (fr)	1990-11-20	Derives peptidiques.
AU1943388A (en)	1989-01-04	3-indolepyruvic acid derivatives and pharmaceutical use thereof
ATE120374T1 (de)	1995-04-15	Markierte polypeptidderivate.
DE69807679D1 (de)	2002-10-10	Zusammensetzungen aus konjugaten des stabilen, aktiven, menschlichen ob proteins mit der fc kette von immunoglobulinen und damit zusammenhängende verfahren
FR2434622A1 (fr)	1980-03-28	Solutions d'acides amines destinees a l'alimentation de patients atteints de cancer
GB2268492B (en)	1996-04-17	Protein based delivery system
HUP0001293A1 (hu)	2000-08-28	Heterociklusos vegyületek és ezeket tartalmazó gyógyászati készítmények béta-amiloid-peptidek gátlására
DE69326064D1 (de)	1999-09-23	Peptide des menschlichen Proteins P53 zum Gebrauch in menschlichen-zytotoxischen-T-Zell-Antwort-induzierenden Kompositionen sowie menschliche P53-Protein-spezifische T-Lymphocyten
BR9811744A (pt)	2002-01-02	Conjugados contendo o homeodomìnio de antenapédia
NO974270D0 (no)	1997-09-16	Insulinderivater
CA2156455A1 (en)	1996-02-20	Glycinamide Derivatives, Processes for Their Preparation and Medicines Containing Them
RU92016463A (ru)	1995-09-10	Применение производных цистина для изготовления лекарственных препаратов с иммуномоделирующим действием, фармацевтические композиции на их основе
ATE100714T1 (de)	1994-02-15	Arzneimittel (calcitoningen verwandte peptide) zur behandlung erektiler dysfunktionen.
ATE125453T1 (de)	1995-08-15	Vorrichtung zum verbinden von flüssigkeitsleitungen für medizinische zwecke.
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