BE1002296A5 - Derives peptidiques. - Google Patents

Derives peptidiques. Download PDF

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Publication number
BE1002296A5
BE1002296A5 BE8901294A BE8901294A BE1002296A5 BE 1002296 A5 BE1002296 A5 BE 1002296A5 BE 8901294 A BE8901294 A BE 8901294A BE 8901294 A BE8901294 A BE 8901294A BE 1002296 A5 BE1002296 A5 BE 1002296A5
Authority
BE
Belgium
Prior art keywords
somatostatin
receptors
peptide derivatives
amino group
detectable element
Prior art date
Application number
BE8901294A
Other languages
English (en)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888828364A external-priority patent/GB8828364D0/en
Priority claimed from GB898916115A external-priority patent/GB8916115D0/en
Priority claimed from GB898916761A external-priority patent/GB8916761D0/en
Application filed by Sandoz Sa filed Critical Sandoz Sa
Application granted granted Critical
Publication of BE1002296A5 publication Critical patent/BE1002296A5/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention a pour objet des peptides somatostatines portant au moins un groupe chélateur pour un élément détectable, ledit groupe chélateur étant lié à un groupe amino dudit peptide, et ledit groupe amino n'ayant pas d'affinité de liaison significative pour les récepteurs de la somatostatine, sous forme libre ou sous forme de sel, complexés avec un élément détectable. Ces composés sont, ent tant que tels, utiles comme spécialités pharmaceutiques, par exemple comme spécialité pharmaceutiques, pour l'imagerie in vivo des tumeurs positives aux récepteurs de somatostatine, ou pour le traitement.
BE8901294A 1988-12-05 1989-12-05 Derives peptidiques. BE1002296A5 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888828364A GB8828364D0 (en) 1988-12-05 1988-12-05 Improvements in/relating to organic compounds
GB898916115A GB8916115D0 (en) 1989-07-13 1989-07-13 Improvements in or relating to organic compounds
GB898916761A GB8916761D0 (en) 1989-07-21 1989-07-21 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
BE1002296A5 true BE1002296A5 (fr) 1990-11-20

Family

ID=27264222

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8901294A BE1002296A5 (fr) 1988-12-05 1989-12-05 Derives peptidiques.

Country Status (24)

Country Link
JP (2) JP2726320B2 (fr)
KR (1) KR0156541B1 (fr)
AT (1) AT403476B (fr)
AU (1) AU633859B2 (fr)
BE (1) BE1002296A5 (fr)
CA (1) CA2004532C (fr)
CH (1) CH678329A5 (fr)
DE (1) DE3991505B4 (fr)
DK (1) DK175338B1 (fr)
ES (1) ES2023533A6 (fr)
FI (1) FI102540B1 (fr)
FR (1) FR2639947B1 (fr)
GB (1) GB2225579B (fr)
HK (1) HK189995A (fr)
HU (2) HUT53375A (fr)
IE (1) IE62091B1 (fr)
IL (1) IL92534A (fr)
LU (1) LU87633A1 (fr)
MY (1) MY106120A (fr)
NL (1) NL194828C (fr)
PT (1) PT92487B (fr)
SA (1) SA96160495B1 (fr)
SE (1) SE508799C2 (fr)
WO (1) WO1990006949A2 (fr)

Families Citing this family (52)

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DE3822557C2 (de) * 1987-07-10 1998-07-02 Ciba Geigy Ag Arzneimittel, enthaltend Somatostatine
AU639371B2 (en) * 1987-07-10 1993-07-22 Novartis Ag Method of treating breast cancer
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
ES2134798T3 (es) * 1991-02-08 1999-10-16 Biomeasure Inc Uso de analogos de somatostatina para el tratamiento de melanomas.
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
WO1992021383A1 (fr) * 1991-06-03 1992-12-10 Mallinckrodt Medical, Inc. Derives de somatostatine radiomarques, leur preparation et utilisation
DK0600992T3 (da) * 1991-08-29 2000-10-09 Mallinckrodt Medical Inc Anvendelse af gentissyre eller gentisylalkohol til stabilisering af radiomærkede peptider og proteiner
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en) 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
CA2127284C (fr) * 1992-01-03 2002-02-05 Buck A. Rhodes Applications pharmaceutiques a base de proteines et de peptides comportant un ion metallique
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
DK0720621T3 (da) * 1992-01-14 2001-08-06 Diatide Inc Radiomærkede somatostation-afledte peptider til billeddannende og terapeutiske anvendelser
WO1993015770A1 (fr) * 1992-02-05 1993-08-19 Mallinckrodt Medical, Inc. Composes de peptides radiomarques
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
CA2131315A1 (fr) * 1992-03-25 1993-09-30 Geert J. Ensing Methode peroperatoire de detection et de localisation des tissus tumoraux
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
NO940080L (no) * 1993-01-12 1994-07-13 Sandoz Ag Polypeptider , fremgangsmåte for deres fremstilling og farmasöytiske preparater derav
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
CA2154667A1 (fr) * 1993-02-02 1994-08-18 Linda M. Gustavson Biodistribution dirigee de petites molecules
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
CA2190727C (fr) * 1994-05-19 2006-07-18 Sudhakar Kasina Ligands d'atomes donneurs d'azote et de soufre pontes et substitues par amines aromatiques, utilises en imagerie
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
GB9417873D0 (en) 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
GB9708265D0 (en) 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
FI965181A7 (fi) 1996-12-20 1998-06-21 Map Medical Tech Oy Polyalkoholi-peptidijohdannaiset
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US6630570B1 (en) 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
DE60231801D1 (de) 2001-04-23 2009-05-14 Mallinckrodt Inc Tc und re markierte radioaktive glycosylierte octreotid-derivate
US7968080B2 (en) 2003-08-20 2011-06-28 The Regents Of The University Of California Somatostatin analogs with inhibitory activity to growth hormone release
BRPI0414512B8 (pt) * 2003-09-17 2021-05-25 Board Of Regentes The Univ Of Texas System composição para reproduzir imagens de um pâncreas e uso desta
EP2067786A1 (fr) 2007-12-07 2009-06-10 ITALFARMACO S.p.A. Nouveaux analogues non sélectifs de somatostatine
US9480759B2 (en) 2012-11-21 2016-11-01 Serene, Llc Tin-117m somatostatin receptor binding compounds and methods
CN119708199A (zh) 2023-09-27 2025-03-28 钱杭江医药科技(嘉兴)有限公司 生长抑素肽类类似物、螯合物及其应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150844A2 (fr) * 1984-01-30 1985-08-07 Enzo Biochem, Inc. Méthode pour le marquage radioactif d'agents diagnostiques et thérapeutiques contenant un groupe de chélation
DE3511206A1 (de) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Neue polypeptidderivate, ihre herstellung und pharmazeutische praeparate, welche diese polypeptidderivate enthalten
EP0233619A1 (fr) * 1986-02-14 1987-08-26 Nihon Medi-Physics Co., Ltd. Composés aminés de haut poids moléculaire et leur utilisation
EP0247866A1 (fr) * 1986-05-29 1987-12-02 Mallinckrodt, Inc. (a Delaware corporation) Agents de couplage pour la préparation de protéines marquées par la radioactivité
EP0248506A1 (fr) * 1986-03-05 1987-12-09 Mallinckrodt, Inc. (a Delaware corporation) Marquage de molécules de support par les ions métalliques
WO1989004666A1 (fr) * 1987-11-18 1989-06-01 The Administrators Of The Tulane Educational Fund Traitement du cancer avec de la somatostatine et avec des analogues de celle-ci

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CA1222691A (fr) * 1981-12-29 1987-06-09 Wilhelmus T. Goedemans Methode de preparation de proteines marquees par un radionucleide, notamment des anticorps ou des fragments d'anticorps
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DE3522638A1 (de) * 1985-06-25 1987-01-08 Diamalt Ag Neue somatostatin-derivate
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
NL194729C (nl) * 1986-10-13 2003-01-07 Novartis Ag Werkwijze voor de bereiding van peptidealcoholen via vaste fase.
CH679045A5 (fr) * 1987-06-29 1991-12-13 Sandoz Ag
FR2638968B1 (fr) * 1988-11-11 1994-10-07 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150844A2 (fr) * 1984-01-30 1985-08-07 Enzo Biochem, Inc. Méthode pour le marquage radioactif d'agents diagnostiques et thérapeutiques contenant un groupe de chélation
DE3511206A1 (de) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Neue polypeptidderivate, ihre herstellung und pharmazeutische praeparate, welche diese polypeptidderivate enthalten
EP0233619A1 (fr) * 1986-02-14 1987-08-26 Nihon Medi-Physics Co., Ltd. Composés aminés de haut poids moléculaire et leur utilisation
EP0248506A1 (fr) * 1986-03-05 1987-12-09 Mallinckrodt, Inc. (a Delaware corporation) Marquage de molécules de support par les ions métalliques
EP0247866A1 (fr) * 1986-05-29 1987-12-02 Mallinckrodt, Inc. (a Delaware corporation) Agents de couplage pour la préparation de protéines marquées par la radioactivité
WO1989004666A1 (fr) * 1987-11-18 1989-06-01 The Administrators Of The Tulane Educational Fund Traitement du cancer avec de la somatostatine et avec des analogues de celle-ci

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LIFE SCIENCES, vol. 43, no. 5, 1988, Pergamon Press plc, US; J.E. TAYLOR et al.: "High affinity binding of [125l-Tyr 11Üsomatostatin-14 to human small cell lung carcinoma (NCI-H69)", pages 421-427 *

Also Published As

Publication number Publication date
WO1990006949A3 (fr) 1990-07-26
AU4587189A (en) 1990-06-14
HU211468A9 (en) 1995-11-28
FI895809A0 (fi) 1989-12-04
DK612689A (da) 1990-06-06
DK612689D0 (da) 1989-12-05
CH678329A5 (fr) 1991-08-30
PT92487B (pt) 1996-01-31
NL8902981A (nl) 1990-07-02
SE8904087D0 (sv) 1989-12-04
FI102540B (fi) 1998-12-31
JPH1095737A (ja) 1998-04-14
GB2225579B (en) 1993-03-17
GB8927255D0 (en) 1990-01-31
FR2639947A1 (fr) 1990-06-08
SE8904087L (sv) 1991-06-05
LU87633A1 (fr) 1991-09-18
DE3991505B4 (de) 2006-04-20
JPH02184698A (ja) 1990-07-19
IE893866L (en) 1990-06-05
AT403476B (de) 1998-02-25
WO1990006949A2 (fr) 1990-06-28
CA2004532C (fr) 2000-02-22
HU896359D0 (en) 1990-02-28
JP2726320B2 (ja) 1998-03-11
FI102540B1 (fi) 1998-12-31
SA96160495B1 (ar) 2006-08-23
HUT53375A (en) 1990-10-28
IL92534A (en) 1994-06-24
MY106120A (en) 1995-03-31
DK175338B1 (da) 2004-08-30
AU633859B2 (en) 1993-02-11
PT92487A (pt) 1990-06-29
KR900009697A (ko) 1990-07-05
JP3686503B2 (ja) 2005-08-24
FR2639947B1 (fr) 1995-04-21
KR0156541B1 (ko) 1998-10-15
NL194828C (nl) 2003-04-03
GB2225579A (en) 1990-06-06
HK189995A (en) 1995-12-29
CA2004532A1 (fr) 1990-06-05
ES2023533A6 (es) 1992-01-16
IE62091B1 (en) 1994-12-14
ATA901789A (de) 1997-07-15
SE508799C2 (sv) 1998-11-09
NL194828B (nl) 2002-12-02

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RE20 Patent expired

Owner name: *NOVARTIS A.G.

Effective date: 20091205