BE1002296A5 - Derives peptidiques. - Google Patents

Derives peptidiques. Download PDF

Info

Publication number
BE1002296A5
BE1002296A5 BE8901294A BE8901294A BE1002296A5 BE 1002296 A5 BE1002296 A5 BE 1002296A5 BE 8901294 A BE8901294 A BE 8901294A BE 8901294 A BE8901294 A BE 8901294A BE 1002296 A5 BE1002296 A5 BE 1002296A5
Authority
BE
Belgium
Prior art keywords
somatostatin
receptors
peptide derivatives
amino group
detectable element
Prior art date
Application number
BE8901294A
Other languages
English (en)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888828364A external-priority patent/GB8828364D0/en
Priority claimed from GB898916115A external-priority patent/GB8916115D0/en
Priority claimed from GB898916761A external-priority patent/GB8916761D0/en
Application filed by Sandoz Sa filed Critical Sandoz Sa
Application granted granted Critical
Publication of BE1002296A5 publication Critical patent/BE1002296A5/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention a pour objet des peptides somatostatines portant au moins un groupe chélateur pour un élément détectable, ledit groupe chélateur étant lié à un groupe amino dudit peptide, et ledit groupe amino n'ayant pas d'affinité de liaison significative pour les récepteurs de la somatostatine, sous forme libre ou sous forme de sel, complexés avec un élément détectable. Ces composés sont, ent tant que tels, utiles comme spécialités pharmaceutiques, par exemple comme spécialité pharmaceutiques, pour l'imagerie in vivo des tumeurs positives aux récepteurs de somatostatine, ou pour le traitement.
BE8901294A 1988-12-05 1989-12-05 Derives peptidiques. BE1002296A5 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888828364A GB8828364D0 (en) 1988-12-05 1988-12-05 Improvements in/relating to organic compounds
GB898916115A GB8916115D0 (en) 1989-07-13 1989-07-13 Improvements in or relating to organic compounds
GB898916761A GB8916761D0 (en) 1989-07-21 1989-07-21 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
BE1002296A5 true BE1002296A5 (fr) 1990-11-20

Family

ID=27264222

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8901294A BE1002296A5 (fr) 1988-12-05 1989-12-05 Derives peptidiques.

Country Status (24)

Country Link
JP (2) JP2726320B2 (fr)
KR (1) KR0156541B1 (fr)
AT (1) AT403476B (fr)
AU (1) AU633859B2 (fr)
BE (1) BE1002296A5 (fr)
CA (1) CA2004532C (fr)
CH (1) CH678329A5 (fr)
DE (1) DE3991505B4 (fr)
DK (1) DK175338B1 (fr)
ES (1) ES2023533A6 (fr)
FI (1) FI102540B1 (fr)
FR (1) FR2639947B1 (fr)
GB (1) GB2225579B (fr)
HK (1) HK189995A (fr)
HU (2) HUT53375A (fr)
IE (1) IE62091B1 (fr)
IL (1) IL92534A (fr)
LU (1) LU87633A1 (fr)
MY (1) MY106120A (fr)
NL (1) NL194828C (fr)
PT (1) PT92487B (fr)
SA (1) SA96160495B1 (fr)
SE (1) SE508799C2 (fr)
WO (1) WO1990006949A2 (fr)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3822557C2 (de) * 1987-07-10 1998-07-02 Ciba Geigy Ag Arzneimittel, enthaltend Somatostatine
AU639371B2 (en) * 1987-07-10 1993-07-22 Novartis Ag Method of treating breast cancer
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
CA2079896A1 (fr) * 1991-02-08 1992-08-09 Arthur E. Bogden Methode de traitement d'affections cutanees benignes ou malignes caracterisees par une proliferation cellulaire
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
EP0588905A1 (fr) * 1991-06-03 1994-03-30 Mallinckrodt Medical, Inc. Derives de somatostatine radiomarques, leur preparation et utilisation
DE69231469T2 (de) * 1991-08-29 2001-01-25 Mallinckrodt Medical, Inc. Verwendung von gentisinsäure oder gentisylalkohol zur stabilisierung von radio-markierten peptiden und proteinen
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en) 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
WO1993012819A1 (fr) * 1992-01-03 1993-07-08 Rhomed Incorporated Applications pharmaceutiques a base d'ions metalliques-proteines et peptides
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
CA2129033A1 (fr) * 1992-02-05 1993-08-19 Leon Lyle Composes peptidiques marques par des radio-isotopes
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
JPH07505621A (ja) * 1992-03-25 1995-06-22 マリンクロッド・インコーポレイテッド 外科手術中における腫瘍組織の検出および探知法
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
NO940080L (no) * 1993-01-12 1994-07-13 Sandoz Ag Polypeptider , fremgangsmåte for deres fremstilling og farmasöytiske preparater derav
WO1994017829A1 (fr) * 1993-02-02 1994-08-18 Neorx Corporation Biodistribution dirigee des petites molecules
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
DE69426673T2 (de) * 1993-06-23 2001-09-20 Diatide, Inc. Radiomarkierte somatostatin derivate zur abbildung und zur therapeutischen verwendung
CA2190727C (fr) * 1994-05-19 2006-07-18 Sudhakar Kasina Ligands d'atomes donneurs d'azote et de soufre pontes et substitues par amines aromatiques, utilises en imagerie
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
GB9417873D0 (en) 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
GB9708265D0 (en) 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
FI965181L (fi) 1996-12-20 1998-06-21 Map Medical Technologies Oy Polyalkoholi-peptidijohdannaiset
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US6630570B1 (en) 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
JP5398945B2 (ja) * 2001-04-23 2014-01-29 マリンクロッド エルエルシー ＴｃおよびＲｅ標識放射活性グリコシル化オクトレオチド誘導体
CN100475271C (zh) 2003-08-20 2009-04-08 加利福尼亚大学董事会 具有抑制生长激素释放活性的促生长素抑制素类似物
BRPI0414512B8 (pt) * 2003-09-17 2021-05-25 Board Of Regentes The Univ Of Texas System composição para reproduzir imagens de um pâncreas e uso desta
EP2067786A1 (fr) 2007-12-07 2009-06-10 ITALFARMACO S.p.A. Nouveaux analogues non sélectifs de somatostatine
EP2922578B1 (fr) 2012-11-21 2018-12-12 Serene, Llc Composés de liaison de récepteur somatostatine comprenant l'isotope de l'etain 117m
CN119708199A (zh) 2023-09-27 2025-03-28 钱杭江医药科技(嘉兴)有限公司 生长抑素肽类类似物、螯合物及其应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150844A2 (fr) * 1984-01-30 1985-08-07 Enzo Biochem, Inc. Méthode pour le marquage radioactif d'agents diagnostiques et thérapeutiques contenant un groupe de chélation
DE3511206A1 (de) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Neue polypeptidderivate, ihre herstellung und pharmazeutische praeparate, welche diese polypeptidderivate enthalten
EP0233619A1 (fr) * 1986-02-14 1987-08-26 Nihon Medi-Physics Co., Ltd. Composés aminés de haut poids moléculaire et leur utilisation
EP0247866A1 (fr) * 1986-05-29 1987-12-02 Mallinckrodt, Inc. (a Delaware corporation) Agents de couplage pour la préparation de protéines marquées par la radioactivité
EP0248506A1 (fr) * 1986-03-05 1987-12-09 Mallinckrodt, Inc. (a Delaware corporation) Marquage de molécules de support par les ions métalliques
WO1989004666A1 (fr) * 1987-11-18 1989-06-01 The Administrators Of The Tulane Educational Fund Traitement du cancer avec de la somatostatine et avec des analogues de celle-ci

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1222691A (fr) * 1981-12-29 1987-06-09 Wilhelmus T. Goedemans Methode de preparation de proteines marquees par un radionucleide, notamment des anticorps ou des fragments d'anticorps
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
DE3522638A1 (de) * 1985-06-25 1987-01-08 Diamalt Ag Neue somatostatin-derivate
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
HU206890B (en) * 1986-10-13 1993-01-28 Sandoz Ag Process for producing sugar-modified somatostatin peptide derivatives and pharmaceutical compositions containing them as active components
CH679045A5 (fr) * 1987-06-29 1991-12-13 Sandoz Ag
BE1003762A3 (fr) * 1988-11-11 1992-06-09 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150844A2 (fr) * 1984-01-30 1985-08-07 Enzo Biochem, Inc. Méthode pour le marquage radioactif d'agents diagnostiques et thérapeutiques contenant un groupe de chélation
DE3511206A1 (de) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Neue polypeptidderivate, ihre herstellung und pharmazeutische praeparate, welche diese polypeptidderivate enthalten
EP0233619A1 (fr) * 1986-02-14 1987-08-26 Nihon Medi-Physics Co., Ltd. Composés aminés de haut poids moléculaire et leur utilisation
EP0248506A1 (fr) * 1986-03-05 1987-12-09 Mallinckrodt, Inc. (a Delaware corporation) Marquage de molécules de support par les ions métalliques
EP0247866A1 (fr) * 1986-05-29 1987-12-02 Mallinckrodt, Inc. (a Delaware corporation) Agents de couplage pour la préparation de protéines marquées par la radioactivité
WO1989004666A1 (fr) * 1987-11-18 1989-06-01 The Administrators Of The Tulane Educational Fund Traitement du cancer avec de la somatostatine et avec des analogues de celle-ci

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LIFE SCIENCES, vol. 43, no. 5, 1988, Pergamon Press plc, US; J.E. TAYLOR et al.: "High affinity binding of [125l-Tyr 11Üsomatostatin-14 to human small cell lung carcinoma (NCI-H69)", pages 421-427 *

Also Published As

Publication number Publication date
FI102540B (fi) 1998-12-31
HU896359D0 (en) 1990-02-28
IL92534A (en) 1994-06-24
NL194828B (nl) 2002-12-02
DK612689A (da) 1990-06-06
LU87633A1 (fr) 1991-09-18
ATA901789A (de) 1997-07-15
PT92487A (pt) 1990-06-29
HUT53375A (en) 1990-10-28
CA2004532C (fr) 2000-02-22
JP2726320B2 (ja) 1998-03-11
JPH02184698A (ja) 1990-07-19
FR2639947B1 (fr) 1995-04-21
ES2023533A6 (es) 1992-01-16
FI895809A0 (fi) 1989-12-04
AU633859B2 (en) 1993-02-11
AT403476B (de) 1998-02-25
SE8904087D0 (sv) 1989-12-04
HU211468A9 (en) 1995-11-28
SA96160495B1 (ar) 2006-08-23
PT92487B (pt) 1996-01-31
SE8904087L (sv) 1991-06-05
JPH1095737A (ja) 1998-04-14
DK612689D0 (da) 1989-12-05
KR900009697A (ko) 1990-07-05
NL194828C (nl) 2003-04-03
GB2225579B (en) 1993-03-17
WO1990006949A2 (fr) 1990-06-28
KR0156541B1 (ko) 1998-10-15
IE62091B1 (en) 1994-12-14
WO1990006949A3 (fr) 1990-07-26
GB8927255D0 (en) 1990-01-31
DE3991505B4 (de) 2006-04-20
CA2004532A1 (fr) 1990-06-05
FR2639947A1 (fr) 1990-06-08
GB2225579A (en) 1990-06-06
SE508799C2 (sv) 1998-11-09
IE893866L (en) 1990-06-05
JP3686503B2 (ja) 2005-08-24
NL8902981A (nl) 1990-07-02
HK189995A (en) 1995-12-29
DK175338B1 (da) 2004-08-30
AU4587189A (en) 1990-06-14
FI102540B1 (fi) 1998-12-31
MY106120A (en) 1995-03-31
CH678329A5 (fr) 1991-08-30

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RE20 Patent expired

Owner name: *NOVARTIS A.G.

Effective date: 20091205