CA2004532C - Derives de peptides - Google Patents

Derives de peptides Download PDF

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Publication number
CA2004532C
CA2004532C CA002004532A CA2004532A CA2004532C CA 2004532 C CA2004532 C CA 2004532C CA 002004532 A CA002004532 A CA 002004532A CA 2004532 A CA2004532 A CA 2004532A CA 2004532 C CA2004532 C CA 2004532C
Authority
CA
Canada
Prior art keywords
group
somatostatin peptide
hydrogen
modified
peptide according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002004532A
Other languages
English (en)
Other versions
CA2004532A1 (fr
Inventor
Rainer Albert
Eric P. Krenning
Steven W.J. Lamberts
Janos Pless
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888828364A external-priority patent/GB8828364D0/en
Priority claimed from GB898916115A external-priority patent/GB8916115D0/en
Priority claimed from GB898916761A external-priority patent/GB8916761D0/en
Application filed by Novartis AG filed Critical Novartis AG
Publication of CA2004532A1 publication Critical patent/CA2004532A1/fr
Application granted granted Critical
Publication of CA2004532C publication Critical patent/CA2004532C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002004532A 1988-12-05 1989-12-04 Derives de peptides Expired - Lifetime CA2004532C (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB8828364 1988-12-05
GB888828364A GB8828364D0 (en) 1988-12-05 1988-12-05 Improvements in/relating to organic compounds
GB8916115 1989-07-13
GB898916115A GB8916115D0 (en) 1989-07-13 1989-07-13 Improvements in or relating to organic compounds
GB898916761A GB8916761D0 (en) 1989-07-21 1989-07-21 Improvements in or relating to organic compounds
GB8916761 1989-07-21

Publications (2)

Publication Number Publication Date
CA2004532A1 CA2004532A1 (fr) 1990-06-05
CA2004532C true CA2004532C (fr) 2000-02-22

Family

ID=27264222

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002004532A Expired - Lifetime CA2004532C (fr) 1988-12-05 1989-12-04 Derives de peptides

Country Status (24)

Country Link
JP (2) JP2726320B2 (fr)
KR (1) KR0156541B1 (fr)
AT (1) AT403476B (fr)
AU (1) AU633859B2 (fr)
BE (1) BE1002296A5 (fr)
CA (1) CA2004532C (fr)
CH (1) CH678329A5 (fr)
DE (1) DE3991505B4 (fr)
DK (1) DK175338B1 (fr)
ES (1) ES2023533A6 (fr)
FI (1) FI102540B1 (fr)
FR (1) FR2639947B1 (fr)
GB (1) GB2225579B (fr)
HK (1) HK189995A (fr)
HU (2) HUT53375A (fr)
IE (1) IE62091B1 (fr)
IL (1) IL92534A (fr)
LU (1) LU87633A1 (fr)
MY (1) MY106120A (fr)
NL (1) NL194828C (fr)
PT (1) PT92487B (fr)
SA (1) SA96160495B1 (fr)
SE (1) SE508799C2 (fr)
WO (1) WO1990006949A2 (fr)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU639371B2 (en) * 1987-07-10 1993-07-22 Novartis Ag Method of treating breast cancer
DE3845000C2 (de) * 1987-07-10 1998-11-19 Novartis Ag Anwendung von Octreotid zur Behandlung von Brustkrebs
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
JPH05506254A (ja) * 1991-02-08 1993-09-16 バイオメジャー，インコーポレイテッド 良性および悪性増殖性皮膚病の治療方法
WO1992021383A1 (fr) * 1991-06-03 1992-12-10 Mallinckrodt Medical, Inc. Derives de somatostatine radiomarques, leur preparation et utilisation
DK0600992T3 (da) * 1991-08-29 2000-10-09 Mallinckrodt Medical Inc Anvendelse af gentissyre eller gentisylalkohol til stabilisering af radiomærkede peptider og proteiner
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
DE69231586T2 (de) * 1992-01-03 2001-07-19 Rhomed, Inc. Pharmazeutische anwendungen auf der basis von peptid-metall-ionen
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
JPH08504166A (ja) * 1992-02-05 1996-05-07 マリンクロッド・メディカル・インコーポレイテッド 放射標識ペプチド化合物
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
WO1993018797A1 (fr) * 1992-03-25 1993-09-30 Mallinckrodt Medical, Inc. Procede pour detecter et localiser de façon peroperatoire des tissus tumoraux
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
NZ250653A (en) * 1993-01-12 1995-12-21 Sandoz Ltd Somatostatin derivatives and pharmaceutical or diagnostic imaging compositions
CA2154667A1 (fr) * 1993-02-02 1994-08-18 Linda M. Gustavson Biodistribution dirigee de petites molecules
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
ATE337338T1 (de) * 1993-06-23 2006-09-15 Diatide Inc Radioaktiv-markierte peptidderivate des somatostatins zur bildformenden und therapeutischen verwendung
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
CA2190727C (fr) * 1994-05-19 2006-07-18 Sudhakar Kasina Ligands d'atomes donneurs d'azote et de soufre pontes et substitues par amines aromatiques, utilises en imagerie
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
GB9417873D0 (en) * 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
GB9708265D0 (en) 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
FI965181A7 (fi) * 1996-12-20 1998-06-21 Map Medical Tech Oy Polyalkoholi-peptidijohdannaiset
US6630570B1 (en) 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
HU228811B1 (hu) * 2001-04-23 2013-05-28 Mallinckrodt Llc Technéciummal és réniummal radioaktívan jelölt, glikozilált oktreotidszármazékok
US7968080B2 (en) 2003-08-20 2011-06-28 The Regents Of The University Of California Somatostatin analogs with inhibitory activity to growth hormone release
WO2005027981A1 (fr) * 2003-09-17 2005-03-31 Board Of Regents, The University Of Texas System Imagerie de cellules beta cibles du pancreas fondee sur un mecanisme, et therapie associee
EP2067786A1 (fr) 2007-12-07 2009-06-10 ITALFARMACO S.p.A. Nouveaux analogues non sélectifs de somatostatine
EP2922578B1 (fr) 2012-11-21 2018-12-12 Serene, Llc Composés de liaison de récepteur somatostatine comprenant l'isotope de l'etain 117m
CN119708199A (zh) 2023-09-27 2025-03-28 钱杭江医药科技(嘉兴)有限公司 生长抑素肽类类似物、螯合物及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1222691A (fr) * 1981-12-29 1987-06-09 Wilhelmus T. Goedemans Methode de preparation de proteines marquees par un radionucleide, notamment des anticorps ou des fragments d'anticorps
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
DE3511206A1 (de) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Neue polypeptidderivate, ihre herstellung und pharmazeutische praeparate, welche diese polypeptidderivate enthalten
DE3522638A1 (de) * 1985-06-25 1987-01-08 Diamalt Ag Neue somatostatin-derivate
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
CA1266344A (fr) * 1986-02-14 1990-02-27 Miki Kurami Composes extra-moleculaires a groupes d'amines, et leur emploi
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
NL194729C (nl) * 1986-10-13 2003-01-07 Novartis Ag Werkwijze voor de bereiding van peptidealcoholen via vaste fase.
CH679045A5 (fr) * 1987-06-29 1991-12-13 Sandoz Ag
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
BE1003762A3 (fr) * 1988-11-11 1992-06-09 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives.

Also Published As

Publication number Publication date
PT92487B (pt) 1996-01-31
IE893866L (en) 1990-06-05
GB2225579A (en) 1990-06-06
SE508799C2 (sv) 1998-11-09
KR0156541B1 (ko) 1998-10-15
IE62091B1 (en) 1994-12-14
DK175338B1 (da) 2004-08-30
FI102540B (fi) 1998-12-31
JPH1095737A (ja) 1998-04-14
FI102540B1 (fi) 1998-12-31
ATA901789A (de) 1997-07-15
JPH02184698A (ja) 1990-07-19
AU633859B2 (en) 1993-02-11
DK612689D0 (da) 1989-12-05
FR2639947B1 (fr) 1995-04-21
FI895809A0 (fi) 1989-12-04
MY106120A (en) 1995-03-31
SE8904087D0 (sv) 1989-12-04
HK189995A (en) 1995-12-29
KR900009697A (ko) 1990-07-05
GB2225579B (en) 1993-03-17
ES2023533A6 (es) 1992-01-16
WO1990006949A2 (fr) 1990-06-28
BE1002296A5 (fr) 1990-11-20
FR2639947A1 (fr) 1990-06-08
CH678329A5 (fr) 1991-08-30
AT403476B (de) 1998-02-25
DE3991505B4 (de) 2006-04-20
GB8927255D0 (en) 1990-01-31
JP3686503B2 (ja) 2005-08-24
DK612689A (da) 1990-06-06
HUT53375A (en) 1990-10-28
SA96160495B1 (ar) 2006-08-23
HU211468A9 (en) 1995-11-28
PT92487A (pt) 1990-06-29
IL92534A (en) 1994-06-24
NL194828B (nl) 2002-12-02
CA2004532A1 (fr) 1990-06-05
LU87633A1 (fr) 1991-09-18
JP2726320B2 (ja) 1998-03-11
NL194828C (nl) 2003-04-03
NL8902981A (nl) 1990-07-02
SE8904087L (sv) 1991-06-05
WO1990006949A3 (fr) 1990-07-26
AU4587189A (en) 1990-06-14
HU896359D0 (en) 1990-02-28

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry