BRPI0309142B8 - suspensão de microcápsulas em uma fase líquida aquosa, que permite a liberação modificada de pelo menos um princípio ativo com exclusão da amoxicilina e que é destinada a ser administrada por via oral - Google Patents

suspensão de microcápsulas em uma fase líquida aquosa, que permite a liberação modificada de pelo menos um princípio ativo com exclusão da amoxicilina e que é destinada a ser administrada por via oral

Info

Publication number
BRPI0309142B8
BRPI0309142B8 BRPI0309142A BR0309142A BRPI0309142B8 BR PI0309142 B8 BRPI0309142 B8 BR PI0309142B8 BR PI0309142 A BRPI0309142 A BR PI0309142A BR 0309142 A BR0309142 A BR 0309142A BR PI0309142 B8 BRPI0309142 B8 BR PI0309142B8
Authority
BR
Brazil
Prior art keywords
microcapsules
modified release
active ingredient
suspension
liquid phase
Prior art date
Application number
BRPI0309142A
Other languages
English (en)
Other versions
BR0309142A (pt
BRPI0309142B1 (pt
BRPI0309142C1 (pt
Inventor
Catherine Castan
Florence Guimberteau
Rémi Meyrueix
Original Assignee
Flamel Ireland Ltd
Flamel Tech Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0210847A external-priority patent/FR2843881B1/fr
Application filed by Flamel Ireland Ltd, Flamel Tech Sa filed Critical Flamel Ireland Ltd
Publication of BR0309142A publication Critical patent/BR0309142A/pt
Publication of BRPI0309142B1 publication Critical patent/BRPI0309142B1/pt
Publication of BRPI0309142B8 publication Critical patent/BRPI0309142B8/pt
Publication of BRPI0309142C1 publication Critical patent/BRPI0309142C1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"formulação farmacêutica oral sob a forma de suspensão aquosa de microcápsulas que permitem a liberação modificada de princípio(s) ativo(s)". a presente invenção refere-se a formulações farmacêuticas líquidas, administráveis oralmente, com liberação modificada de princípio(s) ativo(s) com exclusão da amoxicilina e constituídas por suspensões de partículas de princípios ativos revestidas (microcápsulas). as microcápsulas que constituem a fase dispersa da suspensão são projetadas, de acordo com a invenção, para permitir a liberação modificada do (ou dos) princípio(s) ativo(s), de acordo com um perfil que não evolui no decorrer da estocagem da suspensão líquida. para fazer isso, os inventores propõem selecionar uma composição de revestimento específica para as microcápsulas, constituída por pelo menos quatro componentes que permitem conservar essas microcápsulas na água sem modificar suas propriedades de liberação modificada do princípio ativo, essa fase líquida sendo por outro lado saturada em princípio(s) ativo(s).
BRPI0309142A 2002-04-09 2003-04-07 suspensão de microcápsulas em uma fase líquida aquosa, que permite a liberação modificada de pelo menos um princípio ativo com exclusão da amoxicilina e que é destinada a ser administrada por via oral BRPI0309142C1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0204409 2002-04-09
FR0210847A FR2843881B1 (fr) 2002-09-02 2002-09-02 Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s)
PCT/FR2003/001096 WO2003084518A2 (fr) 2002-04-09 2003-04-07 Suspension orale de microcapsules de principes actifs

Publications (4)

Publication Number Publication Date
BR0309142A BR0309142A (pt) 2005-02-01
BRPI0309142B1 BRPI0309142B1 (pt) 2015-09-22
BRPI0309142B8 true BRPI0309142B8 (pt) 2016-09-13
BRPI0309142C1 BRPI0309142C1 (pt) 2021-05-25

Family

ID=28793279

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0309142A BRPI0309142C1 (pt) 2002-04-09 2003-04-07 suspensão de microcápsulas em uma fase líquida aquosa, que permite a liberação modificada de pelo menos um princípio ativo com exclusão da amoxicilina e que é destinada a ser administrada por via oral

Country Status (15)

Country Link
US (5) US7906145B2 (pt)
EP (1) EP1492511B3 (pt)
JP (1) JP4732696B2 (pt)
KR (1) KR101061351B1 (pt)
CN (1) CN100553625C (pt)
AT (1) ATE419840T1 (pt)
AU (1) AU2003246792B2 (pt)
BR (1) BRPI0309142C1 (pt)
CA (1) CA2480826C (pt)
DE (1) DE60325709D1 (pt)
ES (1) ES2320438T7 (pt)
IL (2) IL164222A0 (pt)
MX (1) MXPA04009968A (pt)
PT (1) PT1492511E (pt)
WO (1) WO2003084518A2 (pt)

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HK1079448A1 (zh) 2006-04-07
DE60325709D1 (de) 2009-02-26
AU2003246792B2 (en) 2008-08-28
US9814684B2 (en) 2017-11-14
BR0309142A (pt) 2005-02-01
WO2003084518A3 (fr) 2004-04-01
US20150374635A1 (en) 2015-12-31
ES2320438T3 (es) 2009-05-22
CN100553625C (zh) 2009-10-28
CA2480826C (fr) 2012-02-07
US7906145B2 (en) 2011-03-15
KR20050005438A (ko) 2005-01-13
IL164222A0 (en) 2005-12-18
KR101061351B1 (ko) 2011-08-31
US10004693B2 (en) 2018-06-26
JP4732696B2 (ja) 2011-07-27
ES2320438T7 (es) 2013-02-14
AU2003246792A1 (en) 2003-10-20
EP1492511A2 (fr) 2005-01-05
US20150374636A1 (en) 2015-12-31
BRPI0309142B1 (pt) 2015-09-22
JP2005527573A (ja) 2005-09-15
EP1492511B3 (fr) 2012-05-02
CA2480826A1 (fr) 2003-10-16
US20170281558A1 (en) 2017-10-05
WO2003084518A2 (fr) 2003-10-16
PT1492511E (pt) 2009-04-09
CN1652755A (zh) 2005-08-10
EP1492511B1 (fr) 2009-01-07
ATE419840T1 (de) 2009-01-15
IL164222A (en) 2011-07-31
US20110117205A1 (en) 2011-05-19
US20060165807A1 (en) 2006-07-27
BRPI0309142C1 (pt) 2021-05-25
MXPA04009968A (es) 2004-12-13

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