BRPI0713436A2 - método para a produção de alérgeno hidrolisado - Google Patents
método para a produção de alérgeno hidrolisado Download PDFInfo
- Publication number
- BRPI0713436A2 BRPI0713436A2 BRPI0713436-3A BRPI0713436A BRPI0713436A2 BR PI0713436 A2 BRPI0713436 A2 BR PI0713436A2 BR PI0713436 A BRPI0713436 A BR PI0713436A BR PI0713436 A2 BRPI0713436 A2 BR PI0713436A2
- Authority
- BR
- Brazil
- Prior art keywords
- extract
- purified
- weight
- proteins
- allergen
- Prior art date
Links
- 239000013566 allergen Substances 0.000 title abstract 8
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 7
- 108090000623 proteins and genes Proteins 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000002009 allergenic effect Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Botany (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
MéTODO PARA A PRODUçãO DE ALéRGENO HIDROLISADO. A presente invenção refere-se a um método para a produção de um extrato purificado de alérgenos naturais compreendendo as etapas de a) extração de uma fonte natural de alérgenos compreendendo proteínas alergênicas para formar um extrato, b) purificação do referido extrato para remover os componentes de não-proteína para formar um extrato purificado, c) desnaturação do referido extrato purificado para formar um extrato desnaturado purificado, o referido extrato desnaturado purificado compreendendo proteínas, em que as proteínas mais abundantes (peso/peso), formando junto pelo menos 60% (peso/peso) de todas as proteínas, são pelo menos duas proteínas e todas as proteínas presentes representam pelo menos 60% (peso/peso) do peso seco do extrato desnaturado purificado e um método para a produção de um extrato purificado de alérgenos naturais compreendendo as etapas de a) hidrólise de um alérgeno desnaturado para formar um hidrolisato de alérgeno, b) purificação do referido hidrolisato de alérgeno para remover peptídeos com um peso molecular acima de 10.000 Da e abaixo de 1.000 Da de modo a obter um hidrolisato purificado onde 70%, mais preferivelmente 80% dos peptídeos estão entre 10.000 Da e 1.000 Da.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06116322.6 | 2006-06-29 | ||
| EP06116322A EP1872792A1 (en) | 2006-06-29 | 2006-06-29 | A method for the production of hydrolyzed allergen |
| US84248506P | 2006-09-06 | 2006-09-06 | |
| US60/842,485 | 2006-09-06 | ||
| PCT/EP2007/056454 WO2008000783A1 (en) | 2006-06-29 | 2007-06-28 | A method for the production of hydrolyzed allergen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0713436A2 true BRPI0713436A2 (pt) | 2012-03-13 |
| BRPI0713436B1 BRPI0713436B1 (pt) | 2018-06-12 |
Family
ID=37526991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0713436-3A BRPI0713436B1 (pt) | 2006-06-29 | 2007-06-28 | Método para a produção de um extrato purificado de alérgenos naturais, composição farmacêutica e seus usos |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20090324650A1 (pt) |
| EP (3) | EP1872792A1 (pt) |
| JP (2) | JP6029803B2 (pt) |
| CN (2) | CN101478986B (pt) |
| BR (1) | BRPI0713436B1 (pt) |
| DK (1) | DK2043684T3 (pt) |
| ES (1) | ES2657625T3 (pt) |
| PL (1) | PL2043684T3 (pt) |
| WO (1) | WO2008000783A1 (pt) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2224953A1 (en) * | 2008-01-02 | 2010-09-08 | Biotech Tools S.A. | Pharmaceutical formulation for allergen preparation |
| AU2012269031B2 (en) * | 2011-06-15 | 2016-10-06 | Biotech Tools S.A. | A method for the production of hydrolyzed allergens |
| US20140255449A1 (en) | 2011-07-21 | 2014-09-11 | Biotech Tools S.A. | Dosage of dnak |
| US20140086849A1 (en) * | 2012-09-21 | 2014-03-27 | Elizabeth McKenna | Naturally-Occurring CpG Oligonucleotide Compositions and Therapeutic Applications Thereof |
| SG10202013014RA (en) | 2012-01-16 | 2021-02-25 | Mckenna Elizabeth | Compositions and Methods for the Treatment of Hepatic Diseases and Disorders |
| US12268718B2 (en) | 2012-01-16 | 2025-04-08 | Labyrinth Holdings Llc | Control of cellular redox levels |
| WO2013179663A1 (ja) * | 2012-05-29 | 2013-12-05 | 日本ハム株式会社 | 食品成分抽出液および抽出方法 |
| JP6419775B2 (ja) * | 2013-03-19 | 2018-11-07 | バイオテック ツールズ エスエー | アレルゲン調製物 |
| EP3129001B1 (en) * | 2014-04-10 | 2019-10-02 | ASIT BioTech s.a. | Hsp-free allergen preparation |
| CN104447943A (zh) * | 2014-11-21 | 2015-03-25 | 浙江我武生物科技股份有限公司 | 一种提取狗毛皮屑变应原的方法 |
| KR101721944B1 (ko) * | 2015-01-30 | 2017-04-04 | (주)청룡수산 | 연산호의 효소적 가수분해물을 포함하는 화장품 조성물 |
| US10143742B2 (en) | 2015-02-20 | 2018-12-04 | The Board Of Trustees Of The Leland Stanford Junior University | Mixed allergen compositions and methods for using the same |
| US11452774B2 (en) | 2015-02-20 | 2022-09-27 | The Board Of Trustees Of The Leland Stanford Junior University | Mixed allergen compositions and methods for using the same |
| US10166286B2 (en) | 2015-02-20 | 2019-01-01 | The Board Of Trustees Of The Leland Stanford Junior University | Mixed allergen compositions and methods for using the same |
| US10149904B2 (en) | 2015-02-20 | 2018-12-11 | The Board Of Trusteees Of The Leland Stanford Junior University | Mixed allergen compositions and methods for using the same |
| WO2016134291A2 (en) | 2015-02-20 | 2016-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Mixed allergen compositions and methods for using the same |
| GB201602850D0 (en) * | 2016-02-18 | 2016-04-06 | Bial Ind Farmaceutica S A | Fusion proteins |
| EP3503746B8 (en) | 2016-08-25 | 2023-04-05 | Usgreentech, L.L.C. | Treated walnut shell infill for artificial turf and manufacturing process |
| ES2868631T3 (es) * | 2016-10-05 | 2021-10-21 | Asit Biotech S A | Prevención de la alergia |
| CN111465328A (zh) | 2017-07-18 | 2020-07-28 | 前品牌股份有限公司 | 制备混合型变应原组合物的方法 |
| WO2019166544A1 (en) | 2018-02-28 | 2019-09-06 | Asit Biotech Sa | Detection of blocking antibodies |
| US20210123905A1 (en) * | 2018-04-30 | 2021-04-29 | Asit Biotech Sa | Evaluation of hydrolyzed allergen preparations |
| US11766477B2 (en) | 2019-01-23 | 2023-09-26 | Societe Des Produits Nestle S.A. | Methods for making mixed allergen compositions |
| CN110872357B (zh) * | 2019-11-06 | 2021-04-30 | 中国石油天然气股份有限公司 | 一种多肽表面活性剂及其制备及应用 |
| US20240285688A1 (en) | 2019-11-07 | 2024-08-29 | N.V. Nutricia | Extensive whey protein hydrolysate with tolerogenic peptides |
| CN111471730A (zh) * | 2020-04-02 | 2020-07-31 | 珠海良仆食品有限公司 | 一种澳洲坚果多肽超声辅助提取工艺 |
| JP7583410B2 (ja) * | 2021-04-16 | 2024-11-14 | 住友ゴム工業株式会社 | 膜タンパク質複合体由来タンパク質を精製する方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1247614A (en) | 1969-06-20 | 1971-09-29 | Miles Lab | Improved therapeutic and diagnostic allergenic extract and process for preparing same |
| US4822611A (en) | 1986-12-09 | 1989-04-18 | Immunotec, Inc. | Oral hyposensitization in the treatment of allergies |
| JPH06507494A (ja) * | 1991-04-26 | 1994-08-25 | カレノフ，エマニユエル | 細菌性アレルゲンにより惹起される疾患の検出及び治療方法 |
| US6555116B1 (en) * | 1991-10-12 | 2003-04-29 | Regents Of The University Of California | Alleviation of the allergenic potential of airborne and contact allergens by thioredoxin |
| WO1994006821A1 (en) * | 1992-09-21 | 1994-03-31 | Laboratorios Leti S.A. | A process for the purification of aqueous extracts containing allergenically active proteins, extracts obtainable according to this process as well as their use |
| ES2098543T3 (es) * | 1992-09-21 | 1997-05-01 | Leti Lab | Un proceso para la purificacion de extractos acuosos que contienen proteinas alergenicamente activas, extractos obtenibles de acuerdo con este proceso, asi como su uso. |
| WO1998009990A1 (en) * | 1996-09-04 | 1998-03-12 | Takara Shuzo Co., Ltd. | Fungal antigens and process for producing the same |
| JPH10234379A (ja) * | 1997-02-27 | 1998-09-08 | Takara Shuzo Co Ltd | 真菌抗原及びその製造方法 |
| PL187544B1 (pl) * | 1997-10-30 | 2004-07-30 | C B F Leti Sa | Wywołujące tolerancję fragmenty naturalnych alergenów |
| JP2869531B2 (ja) * | 1998-01-05 | 1999-03-10 | フマキラー株式会社 | 精製ダニアレルゲン |
| EP1082340A1 (en) | 1999-03-30 | 2001-03-14 | Idexx Laboratories, Inc. | Peptide vaccine for canine allergy |
| DE19939982A1 (de) * | 1999-08-24 | 2001-03-01 | Merck Patent Gmbh | Verfahren zur Isolierung und Aufreinigung von Gräserpollenallergenen |
| JP2001231563A (ja) * | 2000-02-18 | 2001-08-28 | Asahi Breweries Ltd | 改変したダニアレルゲン（システイン変異体）及びその製造方法 |
| CU22983A1 (es) * | 2002-05-08 | 2004-09-09 | Inst Finlay | Composición vacunal contra las alergias y método para su obtención y empleo en el tratamiento de las mismas |
| WO2004047793A1 (en) * | 2002-11-26 | 2004-06-10 | Alk-Abelló A/S | Pharmaceutical allergen product |
| WO2004112833A1 (en) * | 2003-06-23 | 2004-12-29 | Biotech Tools Sa | Epitope composition for sublingual, buccal or enteric administration prepared by hydrolysis of antigenic structures with chymotrypsin |
| ATE396200T1 (de) * | 2004-07-15 | 2008-06-15 | Biomay Ag | Reagenzien zur diagnose und behandlung von latexallergie und verfahren zu ihrer herstellung |
| AT501101B1 (de) * | 2004-12-02 | 2008-01-15 | Biomay Ag | Protein-allergen-derivat |
| US20070003579A1 (en) * | 2005-06-30 | 2007-01-04 | Mannkind Corporation | Allergen-specific immunotherapy |
-
2006
- 2006-06-29 EP EP06116322A patent/EP1872792A1/en not_active Withdrawn
-
2007
- 2007-06-28 US US12/308,859 patent/US20090324650A1/en not_active Abandoned
- 2007-06-28 WO PCT/EP2007/056454 patent/WO2008000783A1/en not_active Ceased
- 2007-06-28 CN CN200780023913.3A patent/CN101478986B/zh not_active Expired - Fee Related
- 2007-06-28 BR BRPI0713436-3A patent/BRPI0713436B1/pt not_active IP Right Cessation
- 2007-06-28 EP EP07730314.7A patent/EP2043684B1/en not_active Not-in-force
- 2007-06-28 CN CN201610191809.6A patent/CN105854012A/zh active Pending
- 2007-06-28 PL PL07730314T patent/PL2043684T3/pl unknown
- 2007-06-28 JP JP2009517199A patent/JP6029803B2/ja not_active Expired - Fee Related
- 2007-06-28 EP EP17198661.5A patent/EP3308799A1/en not_active Withdrawn
- 2007-06-28 DK DK07730314.7T patent/DK2043684T3/en active
- 2007-06-28 ES ES07730314.7T patent/ES2657625T3/es active Active
-
2014
- 2014-10-09 JP JP2014208256A patent/JP6014100B2/ja not_active Expired - Fee Related
-
2018
- 2018-05-09 US US15/974,916 patent/US20180256708A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DK2043684T3 (en) | 2018-02-05 |
| EP2043684A1 (en) | 2009-04-08 |
| EP2043684B1 (en) | 2017-11-01 |
| EP3308799A1 (en) | 2018-04-18 |
| WO2008000783A1 (en) | 2008-01-03 |
| JP2015051979A (ja) | 2015-03-19 |
| US20180256708A1 (en) | 2018-09-13 |
| BRPI0713436B1 (pt) | 2018-06-12 |
| ES2657625T3 (es) | 2018-03-06 |
| CN101478986B (zh) | 2016-05-04 |
| CN105854012A (zh) | 2016-08-17 |
| PL2043684T3 (pl) | 2018-04-30 |
| JP2010504278A (ja) | 2010-02-12 |
| US20090324650A1 (en) | 2009-12-31 |
| EP1872792A1 (en) | 2008-01-02 |
| JP6029803B2 (ja) | 2016-11-24 |
| JP6014100B2 (ja) | 2016-10-25 |
| CN101478986A (zh) | 2009-07-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] | ||
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 14A ANUIDADE. |
|
| B24D | Patent annual fee: restoration after fee payment | ||
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 15A ANUIDADE. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2676 DE 19-04-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |