BRPI9612938B1 - método para cultivo de lawsonia intracellularis em células mccoy, bem como uso das referidas células. - Google Patents

método para cultivo de lawsonia intracellularis em células mccoy, bem como uso das referidas células.

Info

Publication number: BRPI9612938B1
Authority: BR; Brazil
Prior art keywords: bacteria; cells; infected cells; attenuated; cultivate
Prior art date: 1995-06-05

Application number

BRPI9612938-7A

Other languages

English (en)

Inventor

Jeffrey P Knittel

Michael B Roof

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-05

Filing date

1996-06-05

Publication date

2010-07-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27041284&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI9612938(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-06-05 Priority claimed from US08/465,337 external-priority patent/US5714375A/en

1996-06-05 Application filed filed Critical

2010-07-27 Publication of BRPI9612938B1 publication Critical patent/BRPI9612938B1/pt

2017-09-12 Publication of BRPI9612938B8 publication Critical patent/BRPI9612938B8/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Gram-negative bacteria
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/56922—Campylobacter
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/825—Bacterial vaccine for porcine species, e.g. swine

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
General Engineering & Computer Science (AREA)
Cell Biology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Pathology (AREA)
Food Science & Technology (AREA)
General Physics & Mathematics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Mycology (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)

BRPI9612938A 1995-06-05 1996-06-05 método para cultivo de lawsonia intracellularis em células mccoy, bem como uso das referidas células. BRPI9612938B8 (pt)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US08/465,337 US5714375A (en)	1995-06-05	1995-06-05	Ileal symbiont intracellularis propagation in suspended host cells
US08/658,194 US5885823A (en)	1995-06-05	1996-06-04	Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents
PCT/US1996/009576 WO1996039629A1 (en)	1995-06-05	1996-06-05	Lawsonia intracellularis cultivation, anti-lawsonia intracellularis vaccines and diagnostic agents
BRPI9608338-7A BR9608338B1 (pt)	1995-06-05	1996-06-05	vacina para a indução de uma resposta imune a bactérias de l-intracelularis em um animal não humano.

Publications (2)

Publication Number	Publication Date
BRPI9612938B1 true BRPI9612938B1 (pt)	2010-07-27
BRPI9612938B8 BRPI9612938B8 (pt)	2017-09-12

Family

ID=27041284

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BRPI9612938A BRPI9612938B8 (pt)	1995-06-05	1996-06-05	método para cultivo de lawsonia intracellularis em células mccoy, bem como uso das referidas células.
BRPI9608338-7A BR9608338B1 (pt)	1995-06-05	1996-06-05	vacina para a indução de uma resposta imune a bactérias de l-intracelularis em um animal não humano.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
BRPI9608338-7A BR9608338B1 (pt)	1995-06-05	1996-06-05	vacina para a indução de uma resposta imune a bactérias de l-intracelularis em um animal não humano.

Country Status (23)

Country	Link
US (1)	US5885823A (pt)
EP (5)	EP1403643B2 (pt)
JP (4)	JP3765834B2 (pt)
KR (4)	KR100513481B1 (pt)
AT (3)	ATE289069T1 (pt)
AU (1)	AU717045B2 (pt)
BG (1)	BG64292B1 (pt)
BR (2)	BRPI9612938B8 (pt)
CA (1)	CA2222643C (pt)
CZ (1)	CZ295933B6 (pt)
DE (5)	DE69638016D1 (pt)
DK (3)	DK0843818T3 (pt)
ES (3)	ES2332587T3 (pt)
FR (1)	FR07C0071I2 (pt)
HU (1)	HU230199B1 (pt)
LU (1)	LU91405I2 (pt)
NL (1)	NL300331I2 (pt)
NZ (1)	NZ319994A (pt)
PL (6)	PL189286B1 (pt)
PT (3)	PT1645567E (pt)
RO (1)	RO118885B1 (pt)
RU (2)	RU2265849C2 (pt)
WO (1)	WO1996039629A1 (pt)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2000502054A (ja)	1995-11-30	2000-02-22	アグリカルチャービクトリアサービシーズピーティーワイ．エルティーディー．	治療用および診断用の組成物
FR2772047B1 (fr) *	1997-12-05	2004-04-09	Ct Nat D Etudes Veterinaires E	Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
US7052697B1 (en) *	1999-05-13	2006-05-30	Agriculture Victoria Services Pty Ltd	Lawsonia derived gene and related OmpH polypeptides, peptides and proteins and their uses
JP2003501013A (ja) *	1999-05-13	2003-01-14	ファイザープロダクツインコーポレーティッド	ローソニア由来の遺伝子及び関連ＳｏｄＣポリペプチド、ぺプチド及びタンパク質並びにそれらの使用
EP1177213A4 (en) *	1999-05-13	2002-08-28	Pfizer Prod Inc	LAWSONIA DERIVATIVE GENE, POLYPEPTIDES, PEPTIDES AND HEMOLYSIN PROTEINS AND USES THEREOF
NZ515331A (en) *	1999-05-13	2003-07-25	Pfizer Prod Inc	Lawsonia derived gene and related FlgE polypeptides, peptides and proteins and their uses
US7029683B1 (en)	1999-05-13	2006-04-18	Pfizer Products, Inc.	Lawsonia derived gene and related hemolysin polypeptides, peptides and proteins and their uses
AU767390B2 (en) *	1999-05-13	2003-11-06	Agriculture Victoria Services Pty Ltd	(lawsonia) derived gene and related OmpH polypeptides, peptides and proteins and their uses
US6605696B1 (en) *	1999-10-22	2003-08-12	Pfizer, Inc.	Lawsonia intracellularis proteins, and related methods and materials
EP1324768A2 (en) *	2000-09-29	2003-07-09	The Arizona Board of Regents on Behalf of the University of Arizona	Vaccines for proliferative ileitis
AUPR138100A0 (en)	2000-11-10	2000-12-07	Agriculture Victoria Services Pty Ltd	Novel therapeutic compositions for treating infection by lawsonia spp
CA2399276A1 (en) *	2000-11-10	2002-05-16	Agriculture Victoria Services Pty, Ltd.	Novel therapeutic compositions for treating infection by lawsonia spp
DE60120621T2 (de) *	2000-12-20	2006-12-14	Intervet International B. V.	Lawsonia intracellularis Impfstoff
US20030087421A1 (en) *	2001-07-11	2003-05-08	Gebhart Connie J	Lawsonia intracellularis
AU2003295341A1 (en) *	2002-10-04	2004-05-04	Regents Of The University Of Minnesota	Nucleic acid and polypeptide sequences from lawsonia intracellularis and methods of using
UA87665C2 (ru) *	2003-07-25	2009-08-10	Берингер Ингельхайм Ветмедика, Инк.	Авирулентный изолят lawsonia intracellularis европейского происхождения, вакцина для иммунизации животных, применение заявленного авирулентного изолята как вакцины, способ получения вакцины, способ культивирования lawsonia intracellularis, способ диагностики пролиферативной энтеропатии свиней и способ получения антисыворотки к lawsonia intracellularis
US7662390B2 (en)	2003-09-12	2010-02-16	Intarvet International B.V.	Lawsonia intracellularis subunit vaccine
CN101124241A (zh) *	2003-12-09	2008-02-13	英特威国际有限公司	细胞内劳索尼亚菌26kD亚单位疫苗
BRPI0507017A (pt) *	2004-01-22	2007-06-05	Intervet Int Bv	ácido nucleico que codifica uma proteìna de lawsonia intracellularis, fragmento de dna, molécula de dna recombinante, carreador recombinante vivo, célula hospedeira, proteìna de lawsonia intracellularis, uso da mesma, vacina para combater as infecções por lawsonia intracellularis, método para preparação da mesma, e, teste de diagnóstico
EP1609870A1 (en) *	2004-06-24	2005-12-28	Boehringer Ingelheim Vetmedica Gmbh	Method of diagnosing lawsonia intracellularis
MY146476A (en) *	2004-06-24	2012-08-15	Boehringer Ingelheim Vetmed	Method of diagnosing lawsonia intracellularis
US20060021536A1 (en) *	2004-07-30	2006-02-02	Limin Song	Method for creating an absorbent article exhibiting a harmonic color scheme
KR100621882B1 (ko) *	2004-09-30	2006-09-19	건국대학교 산학협력단	돼지 증식성 회장염 감염돈에서 로소니아인트라셀룰라리스 균을 분리하는 방법
AU2005308583A1 (en) *	2004-11-24	2006-06-01	Pharmacia & Upjohn Company Llc	Methods for cultivating Lawsonia intracellularis
US20070212373A1 (en) *	2004-12-08	2007-09-13	Akzo Nobel N.V.	Lawsonia Intracellularis 26 Kd Subunit Vaccine
UA95602C2 (ru)	2004-12-30	2011-08-25	Берингер Ингельхейм Ветмедика, Инк.	Иммуногенная композиция цвс2 и способы приготовления такой композиции
US7700285B1 (en)	2005-12-29	2010-04-20	Boehringer Ingelheim Vetmedica, Inc.	PCV2 immunogenic compositions and methods of producing such compositions
US7833707B2 (en) *	2004-12-30	2010-11-16	Boehringer Ingelheim Vetmedica, Inc.	Methods of overexpression and recovery of porcine circovirus type 2 ORF2
US8834891B2 (en)	2005-03-14	2014-09-16	Boehringer Ingelheim Vetmedica, Inc.	Immunogenic compositions comprising Lawsonia intracellularis
US8398994B2 (en) *	2005-07-15	2013-03-19	Boehringer Ingelheim Vetmedica, Inc.	Lawsonia vaccine and methods of use thereof
MX338626B (es)	2005-12-29	2016-04-26	Boehringer Ingelheim Vetmed	Uso de una composicion inmunogenica de pcv2 para producir los sintomas clinicos en cerdos.
EP2275132B1 (en)	2005-12-29	2021-03-03	Boehringer Ingelheim Animal Health USA Inc.	Multivalent PCV2 immunogenic compositions and methods of producing them
US8470336B2 (en) *	2006-05-25	2013-06-25	Boehringer Ingelheim Vetmedica, Inc.	Vaccination of young animals against Lawsonia intracellularis infections
US20080241190A1 (en) *	2006-11-13	2008-10-02	Boehringer Ingelheim Vetmedica, Inc.	Vaccination of horses against lawsonia intracellularis
EP2859900A1 (en)	2006-12-11	2015-04-15	Boehringer Ingelheim Vetmedica, Inc.	Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
BRPI0721083A2 (pt) *	2006-12-15	2014-02-25	Boehringer Ingelheim Vetmed	Tratamento de porcos com antígeno de pcv2
EP1941903A1 (en)	2007-01-03	2008-07-09	Boehringer Ingelheim Vetmedica Gmbh	Prophylaxis and treatment of PRDC
EP1958644A1 (en)	2007-02-13	2008-08-20	Boehringer Ingelheim Vetmedica Gmbh	Prevention and treatment of sub-clinical pcvd
US7829274B2 (en)	2007-09-04	2010-11-09	Boehringer Ingelheim Vetmedica, Inc.	Reduction of concomitant infections in pigs by the use of PCV2 antigen
EP2200643B1 (en)	2007-09-17	2013-09-04	Boehringer Ingelheim Vetmedica, Inc.	A live lawsonia intracellularis vaccine administered in combination with an antibiotic for use in the treatment of lawsonia intracellularis infections in pigs
CN101874106A (zh) *	2007-10-12	2010-10-27	辉瑞大药厂	培养胞内劳森氏菌的方法
JP2011508595A (ja) *	2007-12-31	2011-03-17	ベーリンガーインゲルハイムフェトメディカインコーポレイテッド	外来性アミノ酸の挿入を含むｐｃｖ２ｏｒｆ２ウイルス様粒子
JP5613061B2 (ja) *	2008-01-23	2014-10-22	ベーリンガーインゲルハイムフェトメディカインコーポレイテッド	Ｐｃｖ２マイコプラズマ・ハイオニューモニエ免疫原性組成物および前記組成物の製造方法
US20110033495A1 (en) *	2008-02-15	2011-02-10	Boehringer Ingelheim Vetmedica, Inc.	Methods and compositions for reducing the impact of enteric diseases
TWI449533B (zh)	2008-04-18	2014-08-21	Intervet Int Bv	防備胞內勞森菌（Ｌａｗｓｏｎｉａｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）、豬肺炎黴漿菌（Ｍｙｃｏｐｌａｓｍａｈｙｏｐｎｅｕｍｏｎｉａｅ）及豬環狀病毒（Ｐｏｒｃｉｎｅｃｉｒｃｏｖｉｒｕｓ）用疫苗
TWI551295B (zh)	2008-04-18	2016-10-01	英特威特國際股份有限公司	防備胞內勞森菌（Ｌａｗｓｏｎｉａｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）用疫苗
ES2534556T3 (es) *	2008-07-22	2015-04-24	Intervet International Bv	Bacteria Lawsonia intracellularis de un nuevo serotipo, vacuna basada en esa bacteria, anticuerpos adecuados para diagnosticar el nuevo serotipo de Lawsonia intracellularis e hibridomas para producir dichos anticuerpos
US8142760B2 (en) *	2008-09-05	2012-03-27	Nathan Len Winkelman	Vaccination for Lawsonia intracellularis
WO2011006880A1 (en) *	2009-07-14	2011-01-20	Intervet International B.V.	Lawsonia intracellularis propagation
TWI627281B (zh) *	2009-09-02	2018-06-21	百靈佳殷格翰家畜藥品公司	降低ｐｃｖ－２組合物殺病毒活性之方法及具有改良免疫原性之ｐｃｖ－２組合物
EP2499233B1 (en)	2009-11-09	2016-11-02	Intervet International B.V.	Method to grow lawsonia intracellularis bacteria in persistently infected mccoy cells
DK2938747T3 (da) *	2012-12-28	2019-08-05	Boehringer Ingelheim Vetmedica Gmbh	Fremgangsmåde til fremstilling af en mycoplasma vaccine
KR102319843B1 (ko)	2013-09-25	2021-10-29	조에티스 서비시즈 엘엘씨	Pcv2b 분지형 백신 조성물 및 사용 방법
US9505808B2 (en)	2013-10-02	2016-11-29	Boehringer Ingelheim Vetmedica, Inc.	PCV2 ORF2 protein variant and virus like particles composed thereof
EP3253410B1 (en)	2015-02-04	2020-05-06	Intervet International B.V.	A vaccine for use against subclinical lawsonia infection in a pig
EP3253409B1 (en)	2015-02-04	2020-05-06	Intervet International B.V.	A vaccine for use against subclinical lawsonia infection in a pig
KR20180062468A (ko) *	2016-11-18	2018-06-11	녹십자수의약품(주)	신규한 로소니아 인트라셀룰라리스 균주 및 이의 용도
JP7139437B2 (ja) *	2018-02-28	2022-09-20	ベーリンガーインゲルハイムフェトメディカゲーエムベーハー	動物内のスカトール及び／又はインドールの低減方法
CA3185751A1 (en)	2020-07-24	2022-01-27	Edgar DIAZ	Combination porcine vaccine
WO2023073640A1 (en)	2021-11-01	2023-05-04	Boehringer Ingelheim Vetmedica Gmbh	Immunogenic gel compositions
US20260103674A1 (en)	2022-09-27	2026-04-16	Intervet Inc.	A method of culturing lawsonia intracellularis bacteria
EP4731748A1 (en) *	2023-06-23	2026-04-29	Intervet International B.V.	A method of culturing lawsonia intracellularis bacteria
CN119185351B (zh) *	2024-09-25	2025-09-16	武汉轻工大学	Li0004蛋白靶点在制备抑制劳森菌感染细胞增殖的药物中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4132597A (en) *	1976-06-09	1979-01-02	Ab Medipharm	Method for cultivation of bacteria
US4237218A (en) *	1979-02-09	1980-12-02	Bio-Rad Laboratories, Inc.	Micro-carrier cell culture
JPS5991879A (ja) *	1982-11-16	1984-05-26	Hideaki Yamada	シユ−ドモナス属細菌の培養法
DK594084A (da) *	1984-12-12	1986-06-13	Novo Industri As	Fremgangsmaade til stabilisering af extra-chromosomale elementer i bakterier under dyrkning
JPH0644865B2 (ja) *	1985-10-29	1994-06-15	三菱瓦斯化学株式会社	カンピロバクタ−属細菌の培養方法
US5338670A (en) *	1986-07-28	1994-08-16	The United States Of America As Represented By The Department Of Health And Human Services	Production of bordetella pertussis toxin with a low concentration of iron
IT1227657B (it) *	1988-12-01	1991-04-23	Mini Ricerca Scient Tecnolog	Antibiotici ab-021 e processo per la loro produzione
JPH0822221B2 (ja) *	1988-12-28	1996-03-06	日東化学工業株式会社	シュードモナス属細菌の培養法
JPH02308754A (ja) *	1989-05-24	1990-12-21	Yakult Honsha Co Ltd	乳発酵食品の製造法
US5296221A (en) *	1990-01-31	1994-03-22	Sani-Ei Sucrochemical Co., Ltd.	Lactobacillus johnsonii ferm bp-2680 lactic acid bacteria preparations using the same and a process of manufacturing the preparations
ES2150419T3 (es) *	1990-11-01	2000-12-01	Univ Iowa State Res Found Inc	Procedimiento de atenuacion bacteriana y vacuna.
SU1768637A1 (en) *	1990-12-04	1992-10-15	Inst Virusologii Im D I Ivanov	Strain of human immunodeficient virus 1-type for preparation of diagnostic preparation
AU667858B2 (en) *	1991-11-15	1996-04-18	Smithkline Beecham Corporation	Gram-negative bacterial vaccines
DE4208785A1 (de) *	1992-03-19	1993-09-23	Degussa	Verfahren zum auffinden von insertionselementen (is-elemente) oder transposonen
US5610059A (en) *	1992-11-09	1997-03-11	University Of Arizona	Etiological agent for porcine enteritis

1996
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Publication number	Publication date
DK1645567T3 (da)	2007-11-26
PL187850B1 (pl)	2004-10-29
PT1403643E (pt)	2009-10-08
RU2305707C2 (ru)	2007-09-10
BG64292B1 (bg)	2004-08-31
CZ389997A3 (cs)	1998-07-15
KR100758614B1 (ko)	2007-09-13
EP2199795B1 (en)	2016-03-30
DE69637251D1 (de)	2007-10-25
DE122007000102I1 (de)	2008-04-17
RO118885B1 (ro)	2003-12-30
PT1645567E (pt)	2007-11-19
PL189187B1 (pl)	2005-07-29
EP0843818A1 (en)	1998-05-27
ES2332587T3 (es)	2010-02-09
CZ295933B6 (cs)	2005-12-14
FR07C0071I2 (fr)	2010-12-31
EP1655607B1 (en)	2015-05-13
PL189287B1 (pl)	2005-07-29
KR100513481B1 (ko)	2006-01-27
EP1403643A1 (en)	2004-03-31
AU717045B2 (en)	2000-03-16
KR20050048651A (ko)	2005-05-24
PL187849B1 (pl)	2004-10-29
DE69634334T2 (de)	2006-04-13
JP2008266340A (ja)	2008-11-06
US5885823A (en)	1999-03-23
PL189250B1 (pl)	2005-07-29
PT843818E (pt)	2005-04-29
ES2173055T1 (es)	2002-10-16
ES2173055T3 (es)	2005-07-01
FR07C0071I1 (pt)	2008-01-02
NL300331I1 (nl)	2008-03-03
JP5078740B2 (ja)	2012-11-21
JP4263212B2 (ja)	2009-05-13
EP1645567A1 (en)	2006-04-12
BR9608338A (pt)	1999-01-05
ES2294620T3 (es)	2008-04-01
BR9608338B1 (pt)	2009-05-05
EP1403643B2 (en)	2018-10-03
JP2007151554A (ja)	2007-06-21
DK0843818T3 (da)	2005-05-09
KR19990022509A (ko)	1999-03-25
MX9709464A (es)	1998-06-30
DE69634334D1 (de)	2005-03-17
HU230199B1 (hu)	2015-10-28
ATE441863T1 (de)	2009-09-15
ATE289069T1 (de)	2005-02-15
HK1010911A1 (en)	1999-07-02
PL325872A1 (en)	1998-08-17
WO1996039629A1 (en)	1996-12-12
LU91405I2 (fr)	2008-02-21
JPH11507225A (ja)	1999-06-29
BRPI9612938B8 (pt)	2017-09-12
NL300331I2 (nl)	2008-07-01
DE69638016D1 (de)	2009-10-15
AU6262796A (en)	1996-12-24
DE843818T1 (de)	2002-11-28
EP0843818B1 (en)	2005-02-09
EP0843818B2 (en)	2018-12-19
EP2199795A3 (en)	2010-11-03
ES2294620T5 (es)	2016-03-23
EP0843818A4 (en)	2002-02-06
PL189286B1 (pl)	2005-07-29
DE69637251T3 (de)	2016-06-02
JP3920300B2 (ja)	2007-05-30
HUP9900884A3 (en)	2001-01-29
EP1403643B1 (en)	2009-09-02
RU2005114739A (ru)	2006-11-20
EP2199795A2 (en)	2010-06-23
KR100544857B1 (ko)	2006-01-24
DK1403643T3 (da)	2010-01-04
NZ319994A (en)	2000-01-28
DE69637251T2 (de)	2008-06-12
EP1645567B2 (en)	2016-01-06
RU2265849C2 (ru)	2005-12-10
JP2006061165A (ja)	2006-03-09
EP1645567B1 (en)	2007-09-12
HUP9900884A2 (hu)	1999-07-28
KR20050046741A (ko)	2005-05-18
EP1655607A1 (en)	2006-05-10
ATE373015T1 (de)	2007-09-15
DK1645567T4 (en)	2016-04-11
KR20060129549A (ko)	2006-12-15
CA2222643A1 (en)	1996-12-12
JP3765834B2 (ja)	2006-04-12
CA2222643C (en)	2013-08-13
BG102130A (bg)	1998-09-30

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Publication	Publication Date	Title
ES2294620T5 (es)	2016-03-23	Cultivo de Lawsonia intracellularis, vacunas anti-Lawsonia intracellularis y agentes de diagnóstico
ES2090297T3 (es)	1996-10-16	Produccion de proteinas que utilizan recombinacion homologa.
MY134726A (en)	2007-12-31	Lawsonia intracellularis cultivation, anti-lawsonia intracellularis vaccines and diagnostic agents
AU634148B2 (en)	1993-02-18	Use of cellulase preparations in the cultivation and use of cellulose-producing microorganisms
ES2052760T3 (es)	1994-07-16	Nuevo sistema enzimatico, su procedimiento de preparacion, y su aplicacion particularmente a la preparacion de d-parahidroxifenilglicina.
BG36046A3 (en)	1984-08-15	Method for cultivating basid
KR970064356A (ko)	1997-10-13	버섯류의 재배방법
JPS6474976A (en)	1989-03-20	Short-period 'sanpai' yeast culture using thermostable lactic acid bacteria
TH112991A (th)	2012-03-20	การเลี้ยง Lawsonia intracellularis, วัคซีนต้าน Lawsonia intracellularis และสารสำหรับใช้วินิจฉัย
JPS5743684A (en)	1982-03-11	Preparation of maltose dehydrogenase
JPS57132880A (en)	1982-08-17	Preparation of choline oxidase by fermentation method
JPS5651989A (en)	1981-05-09	Preparation of l-valine by fermentation method
KR880002995A (ko)	1988-05-13	푸럭토 올리고(Fructo-oligo)당의 제조방법
Byalebeka	1987	Effect of the host genotype on Bradyrhizobium acceptance and performance on peanuts (Arachis hypogaea L.)
KR940014768A (ko)	1994-07-19	복령재배방법
Perov et al.	1988	Improved biotechnology of dendrobacillin production.
JPS55131391A (en)	1980-10-13	Preparation of heat-resistant cellulase
JPS5786292A (en)	1982-05-29	Preparation of n-benzoyl-l-alanine acylase
GB1110710A (en)	1968-04-24	Method of cultivating leishmania
JPS56106589A (en)	1981-08-24	Preparation of glutathione reductase
JPS56160990A (en)	1981-12-11	Preparation of yeast fungal body
DK529687D0 (da)	1987-10-09	Fremgangsmaade til fremstilling af l-arginin ved fermentering
JPS57206386A (en)	1982-12-17	Preparation of ethanolamine oxidase