CA2774643A1 - Silk nanospheres and microspheres and methods of making same - Google Patents
Silk nanospheres and microspheres and methods of making same Download PDFInfo
- Publication number
- CA2774643A1 CA2774643A1 CA2774643A CA2774643A CA2774643A1 CA 2774643 A1 CA2774643 A1 CA 2774643A1 CA 2774643 A CA2774643 A CA 2774643A CA 2774643 A CA2774643 A CA 2774643A CA 2774643 A1 CA2774643 A1 CA 2774643A1
- Authority
- CA
- Canada
- Prior art keywords
- silk
- pva
- solution
- spheres
- blend
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24667609P | 2009-09-29 | 2009-09-29 | |
| US61/246,676 | 2009-09-29 | ||
| PCT/US2010/050698 WO2011041395A2 (en) | 2009-09-29 | 2010-09-29 | Silk nanospheres and microspheres and methods of making same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2774643A1 true CA2774643A1 (en) | 2011-04-07 |
Family
ID=43826861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2774643A Abandoned CA2774643A1 (en) | 2009-09-29 | 2010-09-29 | Silk nanospheres and microspheres and methods of making same |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8715740B2 (2) |
| EP (1) | EP2483199B1 (2) |
| JP (1) | JP5730317B2 (2) |
| CA (1) | CA2774643A1 (2) |
| IL (1) | IL218654A (2) |
| IN (1) | IN2012DN02358A (2) |
| WO (1) | WO2011041395A2 (2) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6092337A (ja) * | 1983-10-26 | 1985-05-23 | Sekisui Plastics Co Ltd | 発泡フエノ−ル樹脂成形物の製造方法 |
| KR101260981B1 (ko) | 2004-06-04 | 2013-05-10 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 인쇄가능한 반도체소자들의 제조 및 조립방법과 장치 |
| CA2704768A1 (en) | 2006-11-03 | 2008-10-23 | Trustees Of Tufts College | Biopolymer sensor and method of manufacturing the same |
| WO2008127403A2 (en) | 2006-11-03 | 2008-10-23 | Trustees Of Tufts College | Biopolymer optofluidic device and method of manufacturing the same |
| US9969134B2 (en) | 2006-11-03 | 2018-05-15 | Trustees Of Tufts College | Nanopatterned biopolymer optical device and method of manufacturing the same |
| US8886334B2 (en) | 2008-10-07 | 2014-11-11 | Mc10, Inc. | Systems, methods, and devices using stretchable or flexible electronics for medical applications |
| US8389862B2 (en) | 2008-10-07 | 2013-03-05 | Mc10, Inc. | Extremely stretchable electronics |
| JP5646492B2 (ja) | 2008-10-07 | 2014-12-24 | エムシー１０ インコーポレイテッドＭｃ１０，Ｉｎｃ． | 伸縮可能な集積回路およびセンサアレイを有する装置 |
| EP2483460B1 (en) | 2009-09-28 | 2015-09-02 | Trustees Of Tufts College | Method to prepare drawn silk egel fibers |
| IN2012DN02358A (2) | 2009-09-29 | 2015-08-21 | Tufts College | |
| WO2011041727A1 (en) | 2009-10-01 | 2011-04-07 | Mc10, Inc. | Protective cases with integrated electronics |
| US9936574B2 (en) | 2009-12-16 | 2018-04-03 | The Board Of Trustees Of The University Of Illinois | Waterproof stretchable optoelectronics |
| EP2513953B1 (en) | 2009-12-16 | 2017-10-18 | The Board of Trustees of the University of Illionis | Electrophysiology using conformal electronics |
| US10441185B2 (en) | 2009-12-16 | 2019-10-15 | The Board Of Trustees Of The University Of Illinois | Flexible and stretchable electronic systems for epidermal electronics |
| WO2011115643A1 (en) | 2010-03-17 | 2011-09-22 | The Board Of Trustees Of The University Of Illinois | Implantable biomedical devices on bioresorbable substrates |
| WO2012031282A2 (en) | 2010-09-03 | 2012-03-08 | Tufts University/Trustees Of Tufts College | Plasmonic nanoparticle-doped silk materials |
| BR112013027057A2 (pt) * | 2011-04-21 | 2020-08-11 | Trustees Of Tufts College | composições e métodos para a estabilização de agentes ativos |
| US9765934B2 (en) | 2011-05-16 | 2017-09-19 | The Board Of Trustees Of The University Of Illinois | Thermally managed LED arrays assembled by printing |
| KR102000302B1 (ko) | 2011-05-27 | 2019-07-15 | 엠씨10, 인크 | 전자, 광학, 및/또는 기계 장치 및 시스템, 그리고 이를 제조하기 위한 방법 |
| US8934965B2 (en) | 2011-06-03 | 2015-01-13 | The Board Of Trustees Of The University Of Illinois | Conformable actively multiplexed high-density surface electrode array for brain interfacing |
| CN102344686A (zh) * | 2011-08-02 | 2012-02-08 | 北京汇亨创管理咨询有限公司 | 一种以聚乙烯醇为稳定剂的丝素蛋白纳米颗粒的制备方法 |
| WO2013089867A2 (en) | 2011-12-01 | 2013-06-20 | The Board Of Trustees Of The University Of Illinois | Transient devices designed to undergo programmable transformations |
| EP3884931A3 (en) | 2012-02-06 | 2021-12-01 | Children's Medical Center, Corp. | Multi-layer biomaterial for tissue regeneration and wound healing |
| JP2015510818A (ja) | 2012-03-20 | 2015-04-13 | トラスティーズ オブ タフツ カレッジ | 薬物送達のための絹リザーバー |
| US9554484B2 (en) | 2012-03-30 | 2017-01-24 | The Board Of Trustees Of The University Of Illinois | Appendage mountable electronic devices conformable to surfaces |
| WO2013152265A1 (en) | 2012-04-06 | 2013-10-10 | Trustees Of Tufts College | Methods of producing and using silk microfibers |
| JP2015512944A (ja) * | 2012-04-13 | 2015-04-30 | トラスティーズ・オブ・タフツ・カレッジＴｒｕｓｔｅｅｓ Ｏｆ Ｔｕｆｔｓ Ｃｏｌｌｅｇｅ | 絹マイクロスフェアを調製するための方法および組成物 |
| WO2014021954A2 (en) * | 2012-04-13 | 2014-02-06 | Trustees Of Tufts College | Magneto-sensitive silk fibroin-based materials |
| HK1207977A1 (en) | 2012-04-25 | 2016-02-19 | Trustees Of Tufts College | Silk microspheres and methods for surface lubrication |
| WO2014012105A1 (en) * | 2012-07-13 | 2014-01-16 | Tufts University | Encapsulation of immiscible phases in silk fibroin biomaterials |
| WO2014012101A1 (en) | 2012-07-13 | 2014-01-16 | Trustees Of Tufts College | Silk powder compaction for production of constructs with high mechanical strength and stiffness |
| US9171794B2 (en) | 2012-10-09 | 2015-10-27 | Mc10, Inc. | Embedding thin chips in polymer |
| AU2014233480B2 (en) | 2013-03-15 | 2018-08-09 | Trustees Of Tufts College | Low molecular weight silk compositions and stabilizing silk compositions |
| US11376329B2 (en) | 2013-03-15 | 2022-07-05 | Trustees Of Tufts College | Low molecular weight silk compositions and stabilizing silk compositions |
| WO2014176458A2 (en) | 2013-04-24 | 2014-10-30 | Trustees Of Tufts College | Bioresorbable biopolymer anastomosis devices |
| US20160166701A1 (en) * | 2013-07-05 | 2016-06-16 | Therakine Biodelivery Gmbh | Delivery composition for topical applications and injections and ophthalmic formulations, methods for manufacturing thereof, and methods for delivery of a drug-delivery composition |
| US10080644B2 (en) * | 2013-07-19 | 2018-09-25 | National University Of Singapore | Tissue interface augmentation device for ligament/tendon reconstruction |
| EP3049068A1 (en) * | 2013-09-27 | 2016-08-03 | Tufts University | Synthesis of silk fibroin micro- and submicron spheres using a co-flow method |
| WO2015048527A1 (en) * | 2013-09-27 | 2015-04-02 | Tufts University | Optically transparent silk hydrogels |
| SG10201907426UA (en) | 2013-09-30 | 2019-09-27 | Evolved By Nature Inc | Silk protein fragment compositions and articles manufactured therefrom |
| JP6135486B2 (ja) * | 2013-12-06 | 2017-05-31 | 豊田合成株式会社 | 樹脂成形体 |
| PE20171791A1 (es) | 2014-12-02 | 2017-12-28 | Silk Therapeutics Inc | Prendas de vestir de seda y productos de alto rendimiento y metodos para elaborarla |
| US11260012B2 (en) | 2015-01-12 | 2022-03-01 | Evolved By Nature, Inc. | Preserved silk protein fragment compositions and articles manufactured therefrom |
| BR112017025609A2 (pt) | 2015-06-01 | 2018-08-07 | The Board Of Trustees Of The University Of Illinois | sistemas eletrônicos miniaturizados com potência sem fio e capacidades de comunicação de campo próximo |
| BR112017025616A2 (en) | 2015-06-01 | 2018-08-07 | The Board Of Trustees Of The University Of Illinois | alternative approach to uv capture |
| AU2016294611B2 (en) | 2015-07-14 | 2022-08-11 | Evolved By Nature, Inc. | Silk performance apparel and products and methods of preparing the same |
| US10925543B2 (en) | 2015-11-11 | 2021-02-23 | The Board Of Trustees Of The University Of Illinois | Bioresorbable silicon electronics for transient implants |
| CN105297289B (zh) * | 2015-12-07 | 2017-10-31 | 清华大学深圳研究生院 | 一种丝素蛋白储能调温纤维膜制备方法 |
| CN105963275B (zh) * | 2016-05-31 | 2019-05-17 | 中国医学科学院生物医学工程研究所 | 壳层可控的丝素蛋白微囊及制备方法 |
| US11413319B2 (en) | 2016-06-23 | 2022-08-16 | Phagelux (Canada) Inc. | Microencapsulation of bacteriophages and related products |
| CN109789218A (zh) | 2016-06-23 | 2019-05-21 | 菲吉乐科(加拿大)有限公司 | 噬菌体的微囊化和相关产品 |
| US12611435B2 (en) | 2016-06-23 | 2026-04-28 | Precisio Biotix Therapeutics, Inc. | Microencapsulation of bacteriophages and related products |
| US11248313B2 (en) | 2016-08-01 | 2022-02-15 | Trustees Of Tufts College | Biomimetic mechanical tension driven fabrication of nanofibrillar architecture |
| US10857262B2 (en) | 2016-10-31 | 2020-12-08 | Sofregen Medical, Inc. | Compositions comprising low molecular weight silk fibroin fragments and plasticizers |
| KR101957013B1 (ko) * | 2017-04-04 | 2019-03-11 | 서울대학교산학협력단 | 골 형성 단백질을 포함하는 약물 전달체 및 그 제조 방법 |
| WO2019067745A1 (en) | 2017-09-27 | 2019-04-04 | Silk, Inc. | SILK-COATED FABRICS, PRODUCTS AND PREPARATION METHODS THEREFOR |
| US11794161B1 (en) | 2018-11-21 | 2023-10-24 | Trucapsol, Llc | Reduced permeability microcapsules |
| US11571674B1 (en) | 2019-03-28 | 2023-02-07 | Trucapsol Llc | Environmentally biodegradable microcapsules |
| US11542392B1 (en) | 2019-04-18 | 2023-01-03 | Trucapsol Llc | Multifunctional particle additive for enhancement of toughness and degradation in biodegradable polymers |
| CN110327307B (zh) * | 2019-06-26 | 2020-06-23 | 浙江大学 | 一种丝素载药纳米微囊的制备方法及产品 |
| CN110483830B (zh) * | 2019-07-31 | 2021-08-17 | 武汉纺织大学 | 超轻高弹丝素微纳米纤维气凝胶及其制备方法与应用 |
| US11738174B2 (en) | 2019-10-15 | 2023-08-29 | Sofregen Medical, Inc. | Delivery devices for delivering and methods of delivering compositions |
| US11547978B2 (en) | 2020-01-30 | 2023-01-10 | Trucapsol Llc | Environmentally biodegradable microcapsules |
| CN111454468B (zh) * | 2020-03-27 | 2021-04-20 | 西安交通大学 | 一种形状可控的智能响应微球及其制备方法 |
| WO2022026495A1 (en) * | 2020-07-28 | 2022-02-03 | University Of Georgia Research Foundation, Inc. | Antimicrobial silk nanoparticles and methods for making and using the same |
| US12302933B2 (en) | 2021-06-25 | 2025-05-20 | Trucapsol Llc | Flavor delivery system |
| US12187829B2 (en) | 2021-08-12 | 2025-01-07 | Trucapsol Llc | Environmentally biodegradable microcapsules |
| US11878280B2 (en) | 2022-04-19 | 2024-01-23 | Trucapsol Llc | Microcapsules comprising natural materials |
| CN115414533B (zh) * | 2022-09-20 | 2024-02-23 | 中国人民解放军总医院第一医学中心 | 一种模拟膀胱壁生理结构的组织工程支架及其制备方法 |
| US11904288B1 (en) | 2023-02-13 | 2024-02-20 | Trucapsol Llc | Environmentally biodegradable microcapsules |
| US11969491B1 (en) | 2023-02-22 | 2024-04-30 | Trucapsol Llc | pH triggered release particle |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE374905A (2) | 1929-12-23 | |||
| US3424164A (en) | 1966-05-20 | 1969-01-28 | Ethicon Inc | Silk suture |
| JPS5838449B2 (ja) | 1979-04-17 | 1983-08-23 | カネボウ株式会社 | 微粉末状絹フィプロインの製造法 |
| JPS56166235A (en) | 1980-05-24 | 1981-12-21 | Kanebo Ltd | Hydrophilic porous body and its preparation |
| JPS5838449A (ja) | 1981-08-31 | 1983-03-05 | Matsushita Electronics Corp | 高圧ナトリウムランプ装置 |
| JPS60142259A (ja) | 1983-12-29 | 1985-07-27 | Kanebo Ltd | 固定化抗体 |
| JPS60259677A (ja) | 1984-05-31 | 1985-12-21 | 水島 繁三郎 | 動物蛋白吸着再生繊維からなる原糸、織物、編物及びその製造方法 |
| CA1340581C (en) | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices |
| JPS63190604A (ja) | 1987-02-03 | 1988-08-08 | Agency Of Ind Science & Technol | 新規の水−アルコ−ル分離膜 |
| US5606019A (en) | 1987-10-29 | 1997-02-25 | Protien Polymer Technologies, Inc. | Synthetic protein as implantables |
| JPH0694518B2 (ja) | 1987-11-02 | 1994-11-24 | 工業技術院長 | 絹フィブロイン多孔質体の製造方法 |
| GB8800078D0 (en) | 1988-01-05 | 1988-02-10 | Ciba Geigy Ag | Novel antibodies |
| JPH0669485B2 (ja) * | 1988-10-19 | 1994-09-07 | 住江織物株式会社 | シルクフィブロイン含有成形物 |
| US5290494A (en) | 1990-03-05 | 1994-03-01 | Board Of Regents, The University Of Texas System | Process of making a resorbable implantation device |
| US5989894A (en) | 1990-04-20 | 1999-11-23 | University Of Wyoming | Isolated DNA coding for spider silk protein, a replicable vector and a transformed cell containing the DNA |
| JPH04263611A (ja) | 1991-02-16 | 1992-09-18 | Pola Chem Ind Inc | 水不溶性固形フィブロイン成形物及びその製造法 |
| JPH06346314A (ja) | 1993-06-02 | 1994-12-20 | Toyobo Co Ltd | 再生絹フィブロイン繊維およびその製造方法 |
| JPH08295697A (ja) | 1995-04-26 | 1996-11-12 | Kanebo Ltd | 高濃度絹フィブロイン水溶液の製造方法 |
| JPH1036676A (ja) | 1996-07-26 | 1998-02-10 | Kanebo Ltd | タンパク質水溶液の濃縮方法 |
| WO1998057676A1 (en) | 1997-06-18 | 1998-12-23 | Japan As Represented By Director General Of National Institute Of Sericultural And Entomological Science Ministry Of Agriculture, Forestry And Fisheries | Wound covering material containing silk fibroin and silk sericin as the main components and process for producing the same |
| WO1999001089A1 (en) | 1997-07-01 | 1999-01-14 | Brown University Research Foundation | Implantable prosthetic devices coated with bioactive molecules |
| US6123819A (en) | 1997-11-12 | 2000-09-26 | Protiveris, Inc. | Nanoelectrode arrays |
| US5994099A (en) | 1997-12-31 | 1999-11-30 | The University Of Wyoming | Extremely elastic spider silk protein and DNA coding therefor |
| US6110590A (en) | 1998-04-15 | 2000-08-29 | The University Of Akron | Synthetically spun silk nanofibers and a process for making the same |
| US6196358B1 (en) | 1998-07-08 | 2001-03-06 | Shimano Inc. | Detachable fluid cooling system for bicycle disc brake |
| US7662409B2 (en) | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
| US20030007991A1 (en) | 1998-09-25 | 2003-01-09 | Masters David B. | Devices including protein matrix materials and methods of making and using thereof |
| US6592623B1 (en) | 1999-08-31 | 2003-07-15 | Virginia Commonwealth University Intellectual Property Foundation | Engineered muscle |
| JP3151665B2 (ja) | 1999-03-23 | 2001-04-03 | 農林水産省蚕糸・昆虫農業技術研究所長 | 生体高分子／ポリアリルアミン複合体およびその製造方法 |
| AU1412201A (en) | 1999-11-15 | 2001-05-30 | Akira Hachimori | Molecularly composite polymeric material of fibroin/cellulose and process for producing the same |
| WO2001056626A1 (en) | 2000-02-03 | 2001-08-09 | Nexia Biotechnologies, Inc. | Surgical sutures containing spider silk |
| IT1316885B1 (it) | 2000-10-02 | 2003-05-13 | Consorzio Per Gli Studi Uni | Procedimento per la preparazione di un tessuto non tessuto in fibroinadi seta. |
| JP2002128691A (ja) | 2000-10-24 | 2002-05-09 | National Institute Of Agrobiological Sciences | セリシン含有素材、その製造方法およびその使用方法 |
| JPWO2002072931A1 (ja) | 2001-03-14 | 2004-07-02 | 東京農工大学長 | 絹及び絹様材料の繊維及びフィルムの製造方法 |
| ITVR20010098A1 (it) | 2001-09-11 | 2003-03-11 | Consorzio Per Gli Studi Uni | Procedimento per l'ottenimento di idrogeli di fibroina di seta. |
| JP4570363B2 (ja) | 2001-10-02 | 2010-10-27 | ノースウエスタン ユニヴァーシティ | タンパク質およびペプチドのナノアレイ |
| GB0126118D0 (en) | 2001-10-31 | 2002-01-02 | Vollrath Friedrich W L | Precursor feedstock for forming filaments |
| US6902932B2 (en) | 2001-11-16 | 2005-06-07 | Tissue Regeneration, Inc. | Helically organized silk fibroin fiber bundles for matrices in tissue engineering |
| JP4263611B2 (ja) | 2001-12-07 | 2009-05-13 | フィリップス ルミレッズ ライティング カンパニー リミテッド ライアビリティ カンパニー | 小型の照明システム及びディスプレイ装置 |
| JP3803962B2 (ja) | 2001-12-28 | 2006-08-02 | 独立行政法人科学技術振興機構 | 絹タンパク質フィルムとその製造方法 |
| US7057023B2 (en) | 2002-01-11 | 2006-06-06 | Nexia Biotechnologies Inc. | Methods and apparatus for spinning spider silk protein |
| JP3772207B2 (ja) | 2002-06-19 | 2006-05-10 | 独立行政法人農業生物資源研究所 | 生分解性生体高分子材料、その製造方法、およびこの高分子材料からなる機能性素材 |
| AU2003249366A1 (en) | 2002-06-24 | 2004-01-06 | Tufts University | Silk biomaterials and methods of use thereof |
| CA2504327C (en) | 2002-11-01 | 2012-01-03 | Trustees Of Tufts College | Templated native silk smectic gels |
| WO2004062697A2 (en) | 2003-01-07 | 2004-07-29 | Tufts University | Silk fibroin materials and use thereof |
| EP1613796B1 (en) | 2003-04-10 | 2017-03-22 | Tufts University | Concentrated aqueous silk fibroin solution and use thereof |
| WO2005000483A1 (en) | 2003-06-06 | 2005-01-06 | Tufts University | Method for forming inorganic coatings |
| CA2608862C (en) | 2004-06-11 | 2020-05-05 | Trustees Of Tufts College | Silk-based drug delivery system |
| US7960509B2 (en) | 2005-01-14 | 2011-06-14 | Trustees Of Tufts College | Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials |
| US9290579B2 (en) | 2005-04-20 | 2016-03-22 | Trustees Of Tufts College | Covalently immobilized protein gradients in three-dimensional porous scaffolds |
| ATE526378T1 (de) | 2005-08-02 | 2011-10-15 | Tufts College | Verfahren zur stufenweisen ablagerung von seidenfibroinbeschichtungen |
| GB0516846D0 (en) | 2005-08-17 | 2005-09-21 | Knight David P | Meniscal repair device |
| DE102005043609A1 (de) | 2005-09-13 | 2007-03-22 | Technische Universität München | Verfahren und Vorrichtung zur Herstellung eines Fadens aus Seidenproteinen |
| US20100028451A1 (en) | 2006-09-26 | 2010-02-04 | Trustees Of Tufts College | Silk microspheres for encapsulation and controlled release |
| US20110121485A1 (en) | 2006-10-30 | 2011-05-26 | Spintec Engineering Gmbh | Method and apparatus for the manufacture of a fiber |
| US20100068740A1 (en) | 2006-11-03 | 2010-03-18 | Trustees Of Tufts College | Microfluidic device with a cylindrical microchannel and a method for fabricating same |
| WO2008127403A2 (en) | 2006-11-03 | 2008-10-23 | Trustees Of Tufts College | Biopolymer optofluidic device and method of manufacturing the same |
| CA2704768A1 (en) | 2006-11-03 | 2008-10-23 | Trustees Of Tufts College | Biopolymer sensor and method of manufacturing the same |
| WO2008118211A2 (en) | 2006-11-03 | 2008-10-02 | Trustees Of Tufts College | Biopolymer photonic crystals and method of manufacturing the same |
| US9969134B2 (en) | 2006-11-03 | 2018-05-15 | Trustees Of Tufts College | Nanopatterned biopolymer optical device and method of manufacturing the same |
| US9102916B2 (en) | 2007-02-27 | 2015-08-11 | Trustees Of Tufts College | Tissue-engineered silk organs |
| US8187616B2 (en) | 2007-05-29 | 2012-05-29 | Trustees Of Tufts College | Method for silk fibroin gelation using sonication |
| WO2009023615A1 (en) | 2007-08-10 | 2009-02-19 | Trustees Of Tufts College | Tubular silk compositions and methods of use thereof |
| WO2009061823A1 (en) | 2007-11-05 | 2009-05-14 | Trustees Of Tufts College | Fabrication of silk fibroin photonic structures by nanocontact imprinting |
| WO2009100280A2 (en) | 2008-02-07 | 2009-08-13 | Trustees Of Tufts College | 3-dimensional silk hydroxyapatite compositions |
| US8206774B2 (en) | 2008-03-13 | 2012-06-26 | Trustees Of Tufts College | Diazonium salt modification of silk polymer |
| WO2009126689A2 (en) | 2008-04-08 | 2009-10-15 | Trustees Of Tufts College | System and method for making biomaterial structures |
| WO2009140588A1 (en) | 2008-05-15 | 2009-11-19 | Trustees Of Tufts College | Silk polymer-based adenosine release: therapeutic potential for epilepsy |
| US20090297588A1 (en) | 2008-05-28 | 2009-12-03 | Spin'tec Engineering Gmbh | Antibiotic dressing for the treatment of infected wounds |
| US20110135697A1 (en) | 2008-06-18 | 2011-06-09 | Trustees Of Tufts College | Edible holographic silk products |
| GB2461125A (en) | 2008-06-25 | 2009-12-30 | Spintec Engineering Gmbh | A silk membrane for bone graft material |
| US8501172B2 (en) | 2008-09-26 | 2013-08-06 | Trustees Of Tufts College | pH-induced silk gels and uses thereof |
| GB2464348A (en) | 2008-10-17 | 2010-04-21 | Spintec Engineering Gmbh | Applying a liquid protein onto a permeable surface, and silk mono-filament having specific properties |
| EP2253336A1 (en) | 2009-05-15 | 2010-11-24 | Spintec Engineering GmbH | A silk medical device with antimicrobial properties and a method of manufacture thereof |
| CA2805403A1 (en) | 2009-07-10 | 2011-01-13 | Trustees Of Tufts College | Bioengineered silk protein-based nucleic acid delivery systems |
| IN2012DN02358A (2) | 2009-09-29 | 2015-08-21 | Tufts College |
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| EP2483199A2 (en) | 2012-08-08 |
| JP2013506007A (ja) | 2013-02-21 |
| IL218654A0 (en) | 2012-05-31 |
| WO2011041395A2 (en) | 2011-04-07 |
| IL218654A (en) | 2015-08-31 |
| US20120187591A1 (en) | 2012-07-26 |
| US9381164B2 (en) | 2016-07-05 |
| EP2483199A4 (en) | 2013-10-16 |
| US8715740B2 (en) | 2014-05-06 |
| JP5730317B2 (ja) | 2015-06-10 |
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