CH417852A - Procédé de préparation d'un antigène staphylococcique - Google Patents

Procédé de préparation d'un antigène staphylococcique

Info

Publication number: CH417852A
Authority: CH; Switzerland
Prior art keywords: polysaccharide; water; strain; insoluble; aqueous
Prior art date: 1961-05-15

Application number

CH576762A

Other languages

English (en)

French (fr)

Inventor

Blessing Devlin Henry

Herbert Haskell Theodore

Wolf Fisher Myron

Original Assignee

Parke Davis & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1961-05-15

Filing date

1962-05-14

Publication date

1966-07-31

1962-05-14 Application filed by Parke Davis & Co filed Critical Parke Davis & Co

1966-07-31 Publication of CH417852A publication Critical patent/CH417852A/fr

Links

239000000427 antigen Substances 0.000 title claims description 3
108091007433 antigens Proteins 0.000 title claims description 3
102000036639 antigens Human genes 0.000 title claims description 3
238000004519 manufacturing process Methods 0.000 title description 4
150000004676 glycans Chemical class 0.000 claims description 72
229920001282 polysaccharide Polymers 0.000 claims description 72
239000005017 polysaccharide Substances 0.000 claims description 72
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 70
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 57
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 49
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 25
241000191967 Staphylococcus aureus Species 0.000 claims description 22
239000007864 aqueous solution Substances 0.000 claims description 20
238000000034 method Methods 0.000 claims description 20
150000003839 salts Chemical class 0.000 claims description 18
230000002163 immunogen Effects 0.000 claims description 17
239000007787 solid Substances 0.000 claims description 16
239000000463 material Substances 0.000 claims description 12
238000006243 chemical reaction Methods 0.000 claims description 8
239000012535 impurity Substances 0.000 claims description 8
102220504040 ATP-binding cassette sub-family G member 8_K93M_mutation Human genes 0.000 claims description 7
239000011260 aqueous acid Substances 0.000 claims description 7
238000002360 preparation method Methods 0.000 claims description 7
238000004587 chromatography analysis Methods 0.000 claims description 6
238000000605 extraction Methods 0.000 claims description 6
230000015572 biosynthetic process Effects 0.000 claims description 5
239000003125 aqueous solvent Substances 0.000 claims description 4
239000001963 growth medium Substances 0.000 claims description 4
238000001556 precipitation Methods 0.000 claims description 4
125000001453 quaternary ammonium group Chemical group 0.000 claims description 4
238000010438 heat treatment Methods 0.000 claims description 3
229920001817 Agar Polymers 0.000 claims description 2
239000008272 agar Substances 0.000 claims description 2
235000004252 protein component Nutrition 0.000 claims description 2
210000002966 serum Anatomy 0.000 claims description 2
239000011343 solid material Substances 0.000 claims 3
239000000243 solution Substances 0.000 description 38
239000000047 product Substances 0.000 description 34
239000002253 acid Substances 0.000 description 26
238000005119 centrifugation Methods 0.000 description 22
239000000725 suspension Substances 0.000 description 17
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 16
235000020075 ouzo Nutrition 0.000 description 13
230000001681 protective effect Effects 0.000 description 13
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
239000000203 mixture Substances 0.000 description 12
239000002244 precipitate Substances 0.000 description 12
241000699666 Mus <mouse, genus> Species 0.000 description 11
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 11
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 11
238000010521 absorption reaction Methods 0.000 description 11
239000012153 distilled water Substances 0.000 description 11
239000007788 liquid Substances 0.000 description 11
239000011575 calcium Substances 0.000 description 10
159000000007 calcium salts Chemical class 0.000 description 10
IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 10
239000005909 Kieselgur Substances 0.000 description 9
239000000126 substance Substances 0.000 description 9
239000000706 filtrate Substances 0.000 description 8
239000011734 sodium Substances 0.000 description 8
239000007858 starting material Substances 0.000 description 8
238000011282 treatment Methods 0.000 description 8
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 7
229910052791 calcium Inorganic materials 0.000 description 7
238000003756 stirring Methods 0.000 description 7
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
238000007398 colorimetric assay Methods 0.000 description 6
229910052708 sodium Inorganic materials 0.000 description 6
239000011780 sodium chloride Substances 0.000 description 6
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 5
239000008367 deionised water Substances 0.000 description 5
229910021641 deionized water Inorganic materials 0.000 description 5
238000001914 filtration Methods 0.000 description 5
239000000843 powder Substances 0.000 description 5
238000000746 purification Methods 0.000 description 5
159000000000 sodium salts Chemical class 0.000 description 5
229960005486 vaccine Drugs 0.000 description 5
238000004458 analytical method Methods 0.000 description 4
229910052799 carbon Inorganic materials 0.000 description 4
229960001927 cetylpyridinium chloride Drugs 0.000 description 4
YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 4
238000000502 dialysis Methods 0.000 description 4
238000001035 drying Methods 0.000 description 4
238000004108 freeze drying Methods 0.000 description 4
238000005259 measurement Methods 0.000 description 4
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 4
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 3
241000295644 Staphylococcaceae Species 0.000 description 3
238000000862 absorption spectrum Methods 0.000 description 3
150000007513 acids Chemical class 0.000 description 3
239000003513 alkali Substances 0.000 description 3
230000000694 effects Effects 0.000 description 3
239000002609 medium Substances 0.000 description 3
150000007523 nucleic acids Chemical class 0.000 description 3
102000039446 nucleic acids Human genes 0.000 description 3
108020004707 nucleic acids Proteins 0.000 description 3
230000003287 optical effect Effects 0.000 description 3
239000008188 pellet Substances 0.000 description 3
239000007974 sodium acetate buffer Substances 0.000 description 3
229910052938 sodium sulfate Inorganic materials 0.000 description 3
235000011152 sodium sulphate Nutrition 0.000 description 3
239000012265 solid product Substances 0.000 description 3
239000006228 supernatant Substances 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
241000699670 Mus sp. Species 0.000 description 2
239000002585 base Substances 0.000 description 2
230000004071 biological effect Effects 0.000 description 2
150000001720 carbohydrates Chemical group 0.000 description 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
239000006285 cell suspension Substances 0.000 description 2
230000029087 digestion Effects 0.000 description 2
239000012634 fragment Substances 0.000 description 2
230000007062 hydrolysis Effects 0.000 description 2
238000006460 hydrolysis reaction Methods 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
238000002955 isolation Methods 0.000 description 2
238000002156 mixing Methods 0.000 description 2
229910052760 oxygen Inorganic materials 0.000 description 2
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
238000011218 seed culture Methods 0.000 description 2
230000004936 stimulating effect Effects 0.000 description 2
239000008399 tap water Substances 0.000 description 2
235000020679 tap water Nutrition 0.000 description 2
238000003809 water extraction Methods 0.000 description 2
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
108010076119 Caseins Proteins 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
241000364057 Peoria Species 0.000 description 1
239000001888 Peptone Substances 0.000 description 1
108010080698 Peptones Proteins 0.000 description 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
238000010306 acid treatment Methods 0.000 description 1
230000016571 aggressive behavior Effects 0.000 description 1
-1 amine salts Chemical class 0.000 description 1
230000000890 antigenic effect Effects 0.000 description 1
239000006286 aqueous extract Substances 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
229960001950 benzethonium chloride Drugs 0.000 description 1
UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 description 1
238000004166 bioassay Methods 0.000 description 1
OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 1
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
239000000920 calcium hydroxide Substances 0.000 description 1
229910001861 calcium hydroxide Inorganic materials 0.000 description 1
150000001721 carbon Chemical class 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
238000005341 cation exchange Methods 0.000 description 1
239000003729 cation exchange resin Substances 0.000 description 1
230000007253 cellular alteration Effects 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
239000003610 charcoal Substances 0.000 description 1
230000007012 clinical effect Effects 0.000 description 1
230000001427 coherent effect Effects 0.000 description 1
239000000470 constituent Substances 0.000 description 1
238000012937 correction Methods 0.000 description 1
238000010908 decantation Methods 0.000 description 1
ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
235000019797 dipotassium phosphate Nutrition 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
239000000284 extract Substances 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
239000008103 glucose Substances 0.000 description 1
WHWDWIHXSPCOKZ-UHFFFAOYSA-N hexahydrofarnesyl acetone Natural products CC(C)CCCC(C)CCCC(C)CCCC(C)=O WHWDWIHXSPCOKZ-UHFFFAOYSA-N 0.000 description 1
235000011167 hydrochloric acid Nutrition 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
150000002431 hydrogen Chemical class 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
230000036039 immunity Effects 0.000 description 1
238000003018 immunoassay Methods 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
239000002198 insoluble material Substances 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
231100000636 lethal dose Toxicity 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
238000004452 microanalysis Methods 0.000 description 1
239000011707 mineral Substances 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
230000000877 morphologic effect Effects 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
235000019319 peptone Nutrition 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
238000000053 physical method Methods 0.000 description 1
238000006116 polymerization reaction Methods 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
238000003918 potentiometric titration Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
238000002731 protein assay Methods 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
238000010992 reflux Methods 0.000 description 1
238000012827 research and development Methods 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
238000012289 standard assay Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
238000012360 testing method Methods 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
238000004448 titration Methods 0.000 description 1
238000012546 transfer Methods 0.000 description 1
108010050327 trypticase-soy broth Proteins 0.000 description 1
238000000870 ultraviolet spectroscopy Methods 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
Mycology (AREA)
Wood Science & Technology (AREA)
Polymers & Plastics (AREA)
Materials Engineering (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Zoology (AREA)
Biotechnology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

CH576762A 1961-05-15 1962-05-14 Procédé de préparation d'un antigène staphylococcique CH417852A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10997861A	1961-05-15	1961-05-15

Publications (1)

Publication Number	Publication Date
CH417852A true CH417852A (fr)	1966-07-31

Family

ID=22330610

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH576762A CH417852A (fr)	1961-05-15	1962-05-14	Procédé de préparation d'un antigène staphylococcique

Country Status (6)

Country	Link
CH (1)	CH417852A (da)
DE (1)	DE1185335B (da)
DK (1)	DK105490C (da)
FI (1)	FI40107C (da)
FR (1)	FR2679M (da)
GB (1)	GB992132A (da)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2468372A1 (fr) *	1977-09-30	1981-05-08	Yoshida Kosaku	Nouveau vaccin contre les maladies infectieuses chez les bovins et son procede de production
EP0259324A4 (en) *	1985-05-13	1988-02-18	Commw Scient Ind Res Org	Mastitis vaccine.

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1298539B1 (it) *	1998-02-03	2000-01-12	Bracco Spa	Metodo per la determinazione di infezioni da protesi
HUE034251T2 (en)	2009-10-30	2018-02-28	Glaxosmithkline Biologicals Sa	Purification of staphylococcus aureus type 5 and type 8 capsular saccharides
CN112694541B (zh) *	2020-12-26	2023-03-21	成都大学	一种黄蜀葵花多糖的温和脱色方法

1962
- 1962-05-14 CH CH576762A patent/CH417852A/fr unknown
- 1962-05-14 DK DK217262AA patent/DK105490C/da active
- 1962-05-14 GB GB18470/62A patent/GB992132A/en not_active Expired
- 1962-05-14 FI FI97262A patent/FI40107C/fi active
- 1962-05-14 DE DEP29409A patent/DE1185335B/de active Pending
- 1962-08-13 FR FR906872A patent/FR2679M/fr active Active

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2468372A1 (fr) *	1977-09-30	1981-05-08	Yoshida Kosaku	Nouveau vaccin contre les maladies infectieuses chez les bovins et son procede de production
EP0259324A4 (en) *	1985-05-13	1988-02-18	Commw Scient Ind Res Org	Mastitis vaccine.

Also Published As

Publication number	Publication date
DK105490C (da)	1966-10-03
DE1185335B (de)	1965-01-14
GB992132A (en)	1965-05-19
FI40107B (da)	1968-06-28
FR2679M (fr)	1964-07-27
FI40107C (fi)	1968-10-10

Publication	Publication Date	Title
JPS6033474B2 (ja)	1985-08-02	新規なヒアルロニダ−ゼｂｍｐ−８２３１およびその製造法
JPS608117B2 (ja)	1985-02-28	新生理活性物質エステラスチンおよびその製造法
EP0037522B1 (fr)	1983-10-19	Dérivés de l'entérotoxine thermostable de Escherichia Coli et leur préparation
EP0001945B1 (fr)	1981-03-25	Nouveaux polysaccharides extraits de corps microbiens d'Haemophilus Influenzae, leur procédé de préparation et les compositions pharmaceutiques les renfermant
CH417852A (fr)	1966-07-31	Procédé de préparation d'un antigène staphylococcique
FR2465742A1 (fr)	1981-03-27	Nouvel antibiotique utile comme agent d'inhibition de l'activite enzymatique de la glucosidase, procede pour sa production et utilisations
CH620691A5 (da)	1980-12-15
FR2502155A1 (fr)	1982-09-24	Nouveaux antibiotiques macrolides semi-synthetiques, procede microbiologique pour leur preparation et micro-organisme s'y rapportant, nouveaux produits intermediaires pour leur preparation et compositions pharmaceutiques les contenant
FR2591600A1 (fr)	1987-06-19	Derives de la glucosylmoranoline et leur preparation
BE1003486A5 (fr)	1992-04-07	Procede d'obtention de l'inhibiteur de la neuraminidase du virus de la grippe.
CA1122526A (fr)	1982-04-27	Substance biologiquement active, sa preparation et les medicaments qui la contiennent
FR2497809A1 (fr)	1982-07-16	Polysaccharide mps-80 de haute masse moleculaire et sa preparation
FR2499855A1 (fr)	1982-08-20	Nouvelles substances a action carcinostatique et immuno-stimulante, procede pour les preparer a partir de bacteries du genre fusobacterium, et agent carcinostatique contenant de telles substances
FR2531863A1 (fr)	1984-02-24	Procede de preparation d'une substance ayant une activite carcinostatique et immunostimulante, a partir de micro-organismes du genre fusobacterium
CH423098A (fr)	1966-10-31	Procédé de préparation d'un vaccin staphylococcique
FR2654623A1 (fr)	1991-05-24	Procede d'obtention de l'inhibiteur de la neuraminidase du virus de la grippe.
BE881595A (fr)	1980-08-07	Inducteur d'interferon et son procede de fabrication
FR2463619A1 (fr)	1981-02-27	Nouvelles substances produites par des bacteries du genre fusobacterium, leur procede de preparation et leur application en therapeutique
BE482061A (da)
BE569746A (da)
BE846035A (fr)	1976-12-31	Nouvelles procidines utiles comme inhibiteurs de proteasses
CH332663A (fr)	1958-09-15	Procédé de préparation d'un nouveau dérivé de la sérine, l'O-carbamyl-D-sérine
BE883444A (fr)	1980-11-24	Glucanne, son procede de preparation et son application en therapeutique
CH343349A (fr)	1959-12-31	Procédé de préparation d'une enzyme protéolytique
CH321334A (fr)	1957-04-30	Procédé de préparation d'un nouvel antibiotique

CH417852A - Procédé de préparation d'un antigène staphylococcique - Google Patents

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