DK0478363T3 - Hidtil ukendte sulfonamidfibrinogenreceptorantagonister - Google Patents

Hidtil ukendte sulfonamidfibrinogenreceptorantagonister

Info

Publication number: DK0478363T3
Authority: DK; Denmark
Prior art keywords: opt; substd; alkyl; aryl; het1
Prior art date: 1990-09-27

Application number

DK91308850.6T

Other languages

Danish (da)

English (en)

Inventor

George D Hartman

Wasyl Halczenko

Melissa S Egbertson

William L Laswell

Mark E Duggan

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-27

Filing date

1991-09-27

Publication date

1997-05-12

1991-09-27 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1997-05-12 Application granted granted Critical

1997-05-12 Publication of DK0478363T3 publication Critical patent/DK0478363T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pyridine Compounds (AREA)
Materials For Medical Uses (AREA)
External Artificial Organs (AREA)

DK91308850.6T 1990-09-27 1991-09-27 Hidtil ukendte sulfonamidfibrinogenreceptorantagonister DK0478363T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US58913090A	1990-09-27	1990-09-27
US75064791A	1991-08-30	1991-08-30

Publications (1)

Publication Number	Publication Date
DK0478363T3 true DK0478363T3 (da)	1997-05-12

Family

ID=27080454

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91308850.6T DK0478363T3 (da)	1990-09-27	1991-09-27	Hidtil ukendte sulfonamidfibrinogenreceptorantagonister

Country Status (33)

Country	Link
US (5)	US5292756A (fr)
EP (2)	EP0478363B1 (fr)
JP (2)	JPH0794425B2 (fr)
KR (1)	KR100216939B1 (fr)
CN (1)	CN1038748C (fr)
AT (1)	ATE150454T1 (fr)
AU (1)	AU655436B2 (fr)
BG (1)	BG61810B1 (fr)
CA (1)	CA2052073C (fr)
CY (1)	CY2048B1 (fr)
DE (2)	DE69125235T2 (fr)
DK (1)	DK0478363T3 (fr)
ES (2)	ES2100214T3 (fr)
FI (2)	FI108295B (fr)
GR (2)	GR3023226T3 (fr)
HK (1)	HK1000509A1 (fr)
HR (1)	HRP930779B1 (fr)
IE (1)	IE913383A1 (fr)
IL (1)	IL99540A (fr)
LU (1)	LU90505I2 (fr)
LV (1)	LV12089B (fr)
NL (1)	NL990040I2 (fr)
NO (2)	NO177702C (fr)
NZ (1)	NZ239846A (fr)
PL (1)	PL172687B1 (fr)
PT (1)	PT99098B (fr)
RO (1)	RO116621B1 (fr)
RU (1)	RU2116296C1 (fr)
SI (1)	SI9210306B (fr)
SK (1)	SK281233B6 (fr)
UA (1)	UA44222C2 (fr)
WO (1)	WO1993019046A1 (fr)
YU (1)	YU48912B (fr)

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1991
- 1991-09-18 NZ NZ239846A patent/NZ239846A/en not_active IP Right Cessation
- 1991-09-20 IL IL9954091A patent/IL99540A/en active Protection Beyond IP Right Term
- 1991-09-23 CA CA002052073A patent/CA2052073C/fr not_active Expired - Lifetime
- 1991-09-26 IE IE338391A patent/IE913383A1/en not_active IP Right Cessation
- 1991-09-26 AU AU84782/91A patent/AU655436B2/en not_active Expired
- 1991-09-26 KR KR1019910016836A patent/KR100216939B1/ko not_active Expired - Lifetime
- 1991-09-26 NO NO913784A patent/NO177702C/no not_active IP Right Cessation
- 1991-09-26 FI FI914534A patent/FI108295B/fi not_active IP Right Cessation
- 1991-09-26 PT PT99098A patent/PT99098B/pt not_active IP Right Cessation
- 1991-09-27 ES ES91308850T patent/ES2100214T3/es not_active Expired - Lifetime
- 1991-09-27 JP JP3248808A patent/JPH0794425B2/ja not_active Expired - Lifetime
- 1991-09-27 EP EP91308850A patent/EP0478363B1/fr not_active Expired - Lifetime
- 1991-09-27 DE DE69125235T patent/DE69125235T2/de not_active Expired - Lifetime
- 1991-09-27 ES ES96202038T patent/ES2133892T3/es not_active Expired - Lifetime
- 1991-09-27 AT AT91308850T patent/ATE150454T1/de active
- 1991-09-27 DK DK91308850.6T patent/DK0478363T3/da active
- 1991-09-27 EP EP96202038A patent/EP0743302B1/fr not_active Expired - Lifetime
- 1991-09-27 DE DE1991625235 patent/DE19875054I2/de active Active
1992
- 1992-03-18 RU RU94041739A patent/RU2116296C1/ru active
- 1992-03-18 RO RO94-01414A patent/RO116621B1/ro unknown
- 1992-03-18 PL PL92305248A patent/PL172687B1/pl unknown
- 1992-03-18 SK SK1023-94A patent/SK281233B6/sk not_active IP Right Cessation
- 1992-03-18 WO PCT/US1992/002249 patent/WO1993019046A1/fr not_active Ceased
- 1992-03-18 UA UA94095834A patent/UA44222C2/uk unknown
- 1992-03-25 US US07/860,747 patent/US5292756A/en not_active Expired - Lifetime
- 1992-03-26 YU YU30692A patent/YU48912B/sh unknown
- 1992-03-26 SI SI9210306A patent/SI9210306B/sl unknown
- 1992-03-26 CN CN92102940A patent/CN1038748C/zh not_active Expired - Lifetime
1993
- 1993-04-02 HR HR930779A patent/HRP930779B1/xx not_active IP Right Cessation
1994
- 1994-09-01 BG BG99020A patent/BG61810B1/bg unknown
1995
- 1995-07-21 US US08/505,417 patent/US5658929A/en not_active Expired - Lifetime
1996
- 1996-07-31 JP JP8201864A patent/JP2812431B2/ja not_active Expired - Lifetime
1997
- 1997-04-22 GR GR970400888T patent/GR3023226T3/el unknown
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- 1997-11-04 HK HK97102089A patent/HK1000509A1/en not_active IP Right Cessation
1998
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- 1998-04-30 CY CY9802048A patent/CY2048B1/xx unknown
- 1998-08-06 US US09/130,334 patent/US5880136A/en not_active Expired - Lifetime
- 1998-12-28 US US09/221,044 patent/US6040317A/en not_active Expired - Lifetime
1999
- 1999-10-08 GR GR990402564T patent/GR3031473T3/el unknown
- 1999-12-01 NL NL990040C patent/NL990040I2/nl unknown
2000
- 2000-01-19 LU LU90505C patent/LU90505I2/fr unknown
- 2000-04-13 NO NO2000001C patent/NO2000001I2/no unknown
2001
- 2001-06-06 FI FI20011201A patent/FI20011201L/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0478363B1 (fr)	1997-03-19
WO1993019046A1 (fr)	1993-09-30
DE69125235D1 (de)	1997-04-24
RO116621B1 (ro)	2001-04-30
HRP930779A2 (en)	1997-02-28
FI914534A0 (fi)	1991-09-26
IL99540A (en)	1995-07-31
JPH09132558A (ja)	1997-05-20
FI108295B (fi)	2001-12-31
NO177702C (no)	1995-11-08
ES2100214T3 (es)	1997-06-16
PL172687B1 (pl)	1997-11-28
IE913383A1 (en)	1992-04-08
PT99098B (pt)	1999-02-26
FI20011201A7 (fi)	2001-06-06
RU94041739A (ru)	1996-08-10
CN1038748C (zh)	1998-06-17
JPH0794425B2 (ja)	1995-10-11
EP0743302A3 (fr)	1997-03-05
EP0743302A2 (fr)	1996-11-20
ES2133892T3 (es)	1999-09-16
LV12089B (en)	1998-11-20
US5814643A (en)	1998-09-29
EP0478363A3 (en)	1992-08-19
DE19875054I2 (de)	2007-05-24
FI914534L (fi)	1992-03-28
US5292756A (en)	1994-03-08
KR100216939B1 (ko)	1999-09-01
AU8478291A (en)	1992-04-02
EP0478363A2 (fr)	1992-04-01
US5880136A (en)	1999-03-09
GR3031473T3 (en)	2000-01-31
UA44222C2 (uk)	2002-02-15
BG99020A (bg)	1995-07-28
CY2048B1 (en)	1998-04-30
FI20011201L (fi)	2001-06-06
US6040317A (en)	2000-03-21
SI9210306A (en)	1995-08-31
CN1069971A (zh)	1993-03-17
DE69125235T2 (de)	1997-08-07
RU2116296C1 (ru)	1998-07-27
NL990040I1 (nl)	2000-02-01
US5658929A (en)	1997-08-19
HRP930779B1 (en)	2000-08-31
SK281233B6 (sk)	2001-01-18
NO913784L (no)	1992-03-30
KR920006313A (ko)	1992-04-27
NL990040I2 (nl)	2000-03-01
CA2052073A1 (fr)	1992-03-28
NO913784D0 (no)	1991-09-26
LV12089A (lv)	1998-07-20
SK102394A3 (en)	1995-04-12
IL99540A0 (en)	1992-08-18
NO177702B (no)	1995-07-31
BG61810B1 (bg)	1998-06-30
EP0743302B1 (fr)	1999-08-04
NZ239846A (en)	1994-11-25
NO2000001I2 (no)	2005-09-26
YU30692A (sh)	1995-10-24
PT99098A (pt)	1992-08-31
JPH04288051A (ja)	1992-10-13
GR3023226T3 (en)	1997-07-30
LU90505I2 (fr)	2000-03-20
YU48912B (sh)	2002-11-15
JP2812431B2 (ja)	1998-10-22
ATE150454T1 (de)	1997-04-15
CA2052073C (fr)	1998-04-14
HK1000509A1 (en)	1998-04-03
SI9210306B (sl)	1998-06-30
AU655436B2 (en)	1994-12-22

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